Xiaochen Dai

Biographic Data

ID7701360
NAMEXiaochen Dai
GIVEN NAMESXiaochen
FAMILY NAMEDai
SIGNATUREDAI X
AFFILIATIONSUniversity of Washington
ORCID0000-0002-0289-7814
VERIFIEDYes
TOTAL WORKS30
TOTAL CITATIONS0
AUTHOR COUNT30
EDITOR COUNT0
FIRST PUBLICATION YEAR2016
LATEST PUBLICATION YEAR2025
H-INDEX0

  • Pre-pregnancy and gestational cardiometabolic disorders and risk of preterm birth and infant mortality

    Open AccessYangyang Cheng, Mika Kivimäki et al.ARTICLEJournal of Global Health2025

    Background: Cardiometabolic disorders (CMDs) are common in pregnancy and can harm the offspring's health. While prior studies have explored clustered cardiometabolic risks in pregnancy, most have focused on a limited number of conditions or a single period. We aimed to examine the associations of individual, multiple, and separate and combined patterns of six pre-pregnancy and gestational CMDs with preterm birth and infant mortality. Methods: Usi…

  • Pregnancy with multiple high-risk factors

    Open AccessYue Zhang, Weijie Ding et al.ARTICLEJournal of Global Health2025

  • Healthcare utilization in the departments of obstetrics and gynecology during the first two years of the Covid-19 pandemic

    Open AccessYao He, Hong Xiao et al.ARTICLEBMC Public Health2025

    The COVID-19 pandemic led to sizable disruptions in routine delivery and utilization of obstetrics and gynecology care. Disruptions were particularly substantial during the initial wave of the outbreak, and full recovery to pre-pandemic levels has not yet been achieved. The impact was more dramatic for women from rural areas, highlighting the need for policies and programs that address inequities in pandemic response and preparedness

  • Burden of disease scenarios for 204 countries and territories, 2022–2050

    Open AccessStein Emil Vollset, Hazim S Ababneh et al.ARTICLEThe Lancet2024

    BACKGROUND: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternativ…

  • Global burden of bacterial antimicrobial resistance 1990–2021

    Open AccessMohsen Naghavi, Stein Emil Vollset et al.ARTICLEThe Lancet2024

    BACKGROUND: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for several WHO regions by country. To date, there have been no studies that produce comprehensive estimates of AMR burden across locations that encompass historical trends and future for…

  • Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021

    Open AccessMichael Brauer, Gregory A Roth et al.ARTICLEThe Lancet2024

    BACKGROUND: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 ri…

  • Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021

    Open AccessMohsen Naghavi, Kanyin Liane Ong et al.ARTICLEThe Lancet2024

    BACKGROUND: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mort…

  • Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (Dalys), and healthy life expectancy (Hale) for 371 diseases and injuries in 204 countries and territor…

    Open AccessAlize J Ferrari, Damian Francesco Santomauro et al.ARTICLEThe Lancet2024

    BACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to im…

  • Global, regional, and national burden of disorders affecting the nervous system, 1990–2021

    Open AccessJaimie D Steinmetz, Katrin Seeher et al.ARTICLEThe Lancet Neurology2024

    BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by…

  • Burden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women

    Open AccessYue Zhang, Weijie Ding et al.ARTICLEJournal of Global Health2024

    Background: The prevalence of high-risk pregnancy increased after the implementation of two-child policy in China, but the impact of this policy change on the burden and profile of multiple high-risk factors in pregnancy (MHFP) has been insufficiently explored. We hypothesised that the profile of MHFP might have changed after the two-child policy was implemented and aimed to estimate the prevalence, intercorrelation, and outcomes of MHFP before a…

  • Global burden and attributable risk factors of breast cancer in young women

    Open AccessMengqi Yuan, Yi Zhu et al.ARTICLEJournal of Global Health2024

    Background: Breast cancer in young women (BCY) is much less common but has significant health sequelae and societal costs. We aimed to evaluate the global and regional burden of breast cancer in women aged 15-39 years from 1990 to 2019. Methods: We collected detailed data on breast cancer from the Global Burden of Disease Study 2019 (GBD 2019) Data Resources. The age-standardised incidence rate (ASIR), age-standardised mortality rate (ASMR), age-…

  • Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050

    Open AccessKanyin Liane Ong, Lauryn K Stafford et al.ARTICLEThe Lancet2023

    BACKGROUND: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes…

  • Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050

    Open AccessEmma Nichols, Jaimie D Steinmetz et al.ARTICLEThe Lancet Public Health2022

    BACKGROUND: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of…

  • Pandemic preparedness and Covid-19

    Open AccessThomas J Bollyky, Erin N Hulland et al.ARTICLEThe Lancet2022

    BACKGROUND: National rates of COVID-19 infection and fatality have varied dramatically since the onset of the pandemic. Understanding the conditions associated with this cross-country variation is essential to guiding investment in more effective preparedness and response for future pandemics. METHODS: Daily SARS-CoV-2 infections and COVID-19 deaths for 177 countries and territories and 181 subnational locations were extracted from the Institute …

  • Estimating excess mortality due to the Covid-19 pandemic

    Open AccessHaidong Wang, Katherine R Paulson et al.ARTICLEThe Lancet2022

    BACKGROUND: Mortality statistics are fundamental to public health decision making. Mortality varies by time and location, and its measurement is affected by well known biases that have been exacerbated during the COVID-19 pandemic. This paper aims to estimate excess mortality from the COVID-19 pandemic in 191 countries and territories, and 252 subnational units for selected countries, from Jan 1, 2020, to Dec 31, 2021. METHODS: All-cause mortalit…

  • Population-level risks of alcohol consumption by amount, geography, age, sex, and year

    Open AccessDana Bryazka, Marissa B Reitsma et al.ARTICLEThe Lancet2022

    BACKGROUND: The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. METHODS: For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to esti…

  • Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019

    Open AccessGlobal Burden of Disease Cancer Collaboration, Jonathan Kocarnik et al.ARTICLEJAMA Oncology2022

    IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used t…

  • Change of serum uric acid and progression of cardiometabolic multimorbidity among middle aged and older adults

    Open AccessDuanhui Li, Danyang Wang et al.ARTICLEFrontiers in Public Health2022

    Background: Hyperuricemia is prevalent and associated with individual cardiometabolic diseases, highlighting the potential role of serum uric acid (SUA) in the development and progression of cardiometabolic multimorbidity (CMM, the coexistence of diabetes, heart disease, or stroke). This study aimed to examine the role of SUA change in the progression of CMM. Methods: This prospective cohort study used data from the China Health and Retirement Lo…

  • Evolution of the global smoking epidemic over the past half century

    Xiaochen Dai, Emmanuela Gakidou et al.ARTICLETobacco Control2022

    XD and EG received funding through grant projects from Bloomberg Philanthropies (funding no. 66-9468) and the Bill & Melinda Gates Foundation (funding no. 63-3452)

  • Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health

    Open AccessKatherine R Paulson, Katherine Paulson et al.ARTICLEThe Lancet2021

    BACKGROUND: Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, a…

  • Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to Vision 2020

    Open AccessJaimie D Steinmetz, Rupert R A Bourne et al.ARTICLEThe Lancet Global Health2021

    BACKGROUND: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidab…

  • Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019

    Open AccessMarissa B Reitsma, Parkes J Kendrick et al.ARTICLEThe Lancet2021

    BACKGROUND: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. METHODS: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global B…

  • Trends in prevalence of blindness and distance and near vision impairment over 30 years

    Open AccessRupert Bourne, Jaimie D Steinmetz et al.ARTICLEThe Lancet Global Health2021

    BACKGROUND: To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990-2020, and forecasts for 2050. METHODS: We did a systematic review and meta-analysis of population-based surveys of eye disease from Janua…

  • Hearing loss prevalence and years lived with disability, 1990–2019

    Open AccessLydia M Haile, Kaloyan Kamenov et al.ARTICLEThe Lancet2021

    BACKGROUND: Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability. METHODS: We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested…

  • Global, regional, and national burden of stroke and its risk factors, 1990–2019

    Open AccessValery L Feigin, Benjamin A Stark et al.ARTICLEThe Lancet Neurology2021

    BACKGROUND: Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national leve…