James A Seddon

Biographic Data

ID7776413
NAMEJames A Seddon
GIVEN NAMESJames A
FAMILY NAMESeddon
SIGNATURESEDDON J A
AFFILIATIONSDesmond Tutu HIV Foundation
ORCID0000-0002-2296-2302
VERIFIEDYes
TOTAL WORKS11
TOTAL CITATIONS0
WORKS AS AUTHOR11
WORKS AS EDITOR0
FIRST PUBLICATION YEAR2015
LATEST PUBLICATION YEAR2026
H-INDEX0

  • Heterogeneity in Mycobacterium tuberculosis immunoreactivity in young children in Blantyre, Malawi

    Open AccessHannah M Rickman, Mphatso D Phiri et al.ARTICLEPLOS Global Public Health2026

    As tuberculosis (TB) incidence declines, transmission becomes increasingly concentrated in vulnerable populations and neighbourhoods. There is an urgent need for affordable surveillance strategies to monitor trends, identify high-risk groups and target interventions. TB disease prevalence surveys are no longer cost-effective in monitoring epidemiological trends as countries target TB elimination, while passive surveillance methodologies such as c…

  • Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis

    Open AccessMegan Palmer, Ineke Derks et al.ARTICLEPLOS Global Public Health2026

    Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…

  • Holistic acceptability of an adult levofloxacin formulation in children and adolescents on a tuberculosis preventive treatment trial

    Open AccessSusan E Purchase, Dillon T Wademan et al.ARTICLEPLOS Global Public Health2024

    Drug-resistant tuberculosis (TB) is threatening global TB control. Although formulations designed for children are a priority, adult levofloxacin formulations are widely used in TB treatment and prevention. TB-CHAMP was a cluster-randomised, placebo-controlled trial evaluating the efficacy and safety of 24 weeks of daily levofloxacin to prevent TB in child and adolescent household contacts of adults with infectious multidrug-resistant TB. Nested …

  • Psychosocial experiences of adolescents with tuberculosis in Cape Town

    Open AccessDillon T Wademan, A L Hufen et al.ARTICLEPLOS Global Public Health2024

    Adolescents (10-19-years-old) account for almost 10% of the annual global tuberculosis (TB) incidence. Adolescents’ experiences of TB care, TB stigma, and the consequences of TB for their relationships, schooling, and mental health are different, and often more severe, compared to younger children and adults. How TB impacts the lives of adolescents is not well described or understood. We aimed to locate adolescents’ experiences of TB relative to …

  • Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children

    Open AccessMegan Palmer, James A Seddon et al.ARTICLEPLOS Global Public Health2023

    Diagnostic tools for paediatric tuberculosis remain limited, with heavy reliance on clinical algorithms which include chest x-ray. Computer aided detection (CAD) for tuberculosis on chest x-ray has shown promise in adults. We aimed to measure and optimise the performance of an adult CAD system, CAD4TB, to identify tuberculosis on chest x-rays from children with presumptive tuberculosis. Chest x-rays from 620 children

  • Reasons for reductions in routine childhood immunisation uptake during the Covid-19 pandemic in low- and middle-income countries

    Open AccessAlexandra Cardoso Pinto, Sameed Shariq et al.ARTICLEPLOS Global Public Health2023

    The coronavirus disease 2019 (COVID-19) pandemic has resulted in a substantial decline in routine immunisation coverage in children globally, especially in low- and middle-income countries (LMICs). This study summarises the reasons for disruptions to routine child immunisations in LMICs. A systematic review (PROSPERO CRD42021286386) was conducted following PRISMA 2020 guidelines. Six databases were searched: MEDLINE, Embase, Global Health, CINAHL…

  • Toward a conceptual framework of the acceptability of tuberculosis treatment in children using a theory generative approach

    Open AccessDillon T Wademan, Megan Palmer et al.ARTICLEPLOS Global Public Health2022

    To describe an early-stage holistic framework towards evaluating factors that impact the overall acceptability of TB treatment along the TB care cascade in children. We developed a conceptual framework utilising a theory generative approach. Domains were developed through review of existing definitions and analysis of existing qualitative data undertaken in acceptability studies of TB treatment in children. Clarity of domain definitions was achie…

  • The global burden of tuberculous meningitis in adults

    Open AccessPeter J Dodd, Muhammad Osman et al.ARTICLEPLOS Global Public Health2021

    Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and mortality of TBM is unknown due to diagnostic challenges and limited disaggregated reporting of treated TBM by existing surveillance systems. We aimed to estimate the incidence and mortality of TBM in adults (15+ years) globally. Using national surveillance data from Brazil, South Africa, the United Kingdom, the United States of America, and Vietnam, we estima…

  • Protecting children in low-income and middle-income countries from Covid-19

    Open AccessSalahuddin Ahmed, Tisungane Mvalo et al.ARTICLEBMJ Global Health2020

    A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), long-standing system vulnerabilities may tragically manifest, and we worry that children will be increasingly impacted, both directly and indirectly. Drawing on our shared child pneumonia experience globally, we highlight these potential im…

  • Why the Convention on the Rights of the Child must become a guiding framework for the realization of the rights of children affected by tuberculosis

    Open AccessRobindra Basu Roy, Nicola Brandt et al.ARTICLEBMC International Health and…2016

    BACKGROUND: Until recently, paediatric tuberculosis (TB) has been relatively neglected by the broader TB and the maternal and child health communities. Human rights-based approaches to children affected by TB could be powerful; however, awareness and application of such strategies is not widespread. DISCUSSION: We summarize the current challenges faced by children affected by TB, including: consideration of their family context; the limitations o…

  • The complex relationship between human immunodeficiency virus infection and death in adults being treated for tuberculosis in Cape Town, South Africa

    Open AccessMuhammad Osman, James A Seddon et al.ARTICLEBMC Public Health2015

    HIV carries an increased risk of death in this study but specific high-risk groups pertaining to the impact of HIV are identified. Innovative strategies to manage these high risk groups may contribute to reduction in HIV-associated death in TB patients