Cristian Koepfli

Biographic Data

ID7779059
NAMECristian Koepfli
GIVEN NAMESCristian
FAMILY NAMEKoepfli
SIGNATUREKOEPFLI C
AFFILIATIONSUniversity of Notre Dame
ORCID0000-0002-9354-0414
VERIFIEDYes
TOTAL WORKS5
TOTAL CITATIONS0
WORKS AS AUTHOR5
WORKS AS EDITOR0
FIRST PUBLICATION YEAR2022
LATEST PUBLICATION YEAR2024
H-INDEX0

  • Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of Plasmodium falciparum

    Open AccessAurel Holzschuh, Anita Lerch et al.ARTICLEPLOS Global Public Health2024

    Genomic epidemiology holds promise for malaria control and elimination efforts, for example by informing on Plasmodium falciparum genetic diversity and prevalence of mutations conferring anti-malarial drug resistance. Limited sequencing infrastructure in many malaria-endemic areas prevents the rapid generation of genomic data. To address these issues, we developed and validated assays for P . falciparum nanopore sequencing in endemic sites using …

  • Altitude, not potential larval habitat availability, explains pronounced variation in Plasmodium falciparum infection prevalence in the western Kenya highlands

    Open AccessColins O Oduma, Maurice Ombok et al.ARTICLEPLOS Global Public Health2023

    Progress in malaria control has stalled over the recent years. Knowledge on main drivers of transmission explaining small-scale variation in prevalence can inform targeted control measures. We collected finger-prick blood samples from 3061 individuals irrespective of clinical symptoms in 20 clusters in Busia in western Kenya and screened for Plasmodium falciparum parasites using qPCR and microscopy. Clusters spanned an altitude range of 207 meter…

  • Performance of highly sensitive and conventional rapid diagnostic tests for clinical and subclinical Plasmodium falciparum infections, and hrp2/3 deletion status in Burundi

    Open AccessDavid Niyukuri, Denis Sinzinkayo et al.ARTICLEPLOS Global Public Health2022

    Rapid diagnostic tests (RDTs) are a key tool for the diagnosis of malaria infections among clinical and subclinical individuals. Low-density infections, and deletions of the P . falciparum hrp2 / 3 genes (encoding the HRP2 and HRP3 proteins detected by many RDTs) present challenges for RDT-based diagnosis. The novel Rapigen Biocredit three-band Plasmodium falciparum HRP2/LDH RDT was evaluated among 444 clinical and 468 subclinical individuals in …

  • QPCR in a suitcase for rapid Plasmodium falciparum and Plasmodium vivax surveillance in Ethiopia

    Open AccessLise Carlier, Sarah Cate Baker et al.ARTICLEPLOS Global Public Health2022

    Many Plasmodium spp. infections, both in clinical and asymptomatic patients, are below the limit of detection of light microscopy or rapid diagnostic test (RDT). Molecular diagnosis by qPCR can be valuable for surveillance, but is often hampered by absence of laboratory capacity in endemic countries. To overcome this limitation, we optimized and tested a mobile qPCR laboratory for molecular diagnosis in Ziway, Ethiopia, where transmission intensi…

  • Burden of malaria, impact of interventions and climate variability in Western Ethiopia

    Open AccessWerissaw Haileselassie, Daniel M Parker et al.ARTICLEBMC Public Health2022

    Malaria was and will remain to be a major public health problem in the area. The social and economic impact of the disease on the local community is clearly pronounced as it is the leading cause of health facility visit and admission including the mortality associated with it. Scale up of effective interventions is quite important. Continuous monitoring of the performance of the vector control tools needs to be done