Mara Pilmane
Biographic Data
| ID | 78142 |
|---|---|
| NAME | Mara Pilmane |
| GIVEN NAMES | Mara |
| FAMILY NAME | Pilmane |
| SIGNATURE | PILMANE M |
| AFFILIATIONS | Riga Stradiņš University |
| ORCID | 0000-0001-9804-4666 |
| VERIFIED | Yes |
| TOTAL WORKS | 29 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 29 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2012 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Longitudinal Growth Patterns in Boys and Girls Aged 9–14 Years by Birth Season
Immunomodulatory Tissue Factors in the Gallbladder Walls of Pediatric Patients with Chronic Calculous Cholecystitis
An increased number of NFkBp65, IL-12, and HSP60 positive cells in patient gallbladder tissue suggests a significant role of these tissue factors in driving immune modulation and sustaining the inflammation in pediatric chronic calculous cholecystitis. The noticeable expression of SHH in patient gallbladder tissue indicates its part in tissue regeneration and repair processes, as well as in modulating inflammation and vascular responses in calcul…
Craniofacial Measurements and Indices Trends in Latvian Children Aged 1–15
This study provides valuable insights into the craniofacial development of Latvian children, highlighting the measurements, cranial and facial types, and their variations across age groups
Antimicrobial Peptides and Interleukins in Cleft Soft Palate
Cleft palate is one of the most common and well-studied congenital anomalies; however, the role of protective tissue factors in its pathophysiology is still debated. The aim of our study was to evaluate interleukin and antimicrobial peptide appearance and distribution in cleft palate. Eight soft palate samples were obtained during veloplasty procedures. Immunohistochemical staining was applied to detect HBD-2-, HBD-3-, HBD-4-, LL-37-, IL-10-, and…
Comparison of Bone Quality in Middle Ages and Late Modern Period Human Skeletons from Latvia
The analysis of bone microstructure and histological examination currently provides valuable insights into various facets of bone biology, ancient human existence, and bone-related diseases. This study aims to scrutinize the microstructure of historic Latvian bones, with three bone element groups selected (humerus, radius, and ulna) from a skeletal collection spanning from the Middle Ages to the Late Modern Period, procured through an archaeologi…
Fate and future of the medical students in Ukraine: A silently bubbling educational crisis
Jain et al. reflect on the Russia‐Ukraine war and argue that although there is a broad consensus on the need for intervention, focus should be on providing immediate accommodative measures
The Evaluation of FGFR1, FGFR2 and Foxo1 in Orofacial Cleft Tissue
Although cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies worldwide, the morphopathogenesis of non-syndromic orofacial clefts is still unclear. Many candidate genes have been proposed to play a causal role; however, only a few have been confirmed, leaving many still to be assessed. Taking into account the significance of FGFR1 , FGFR2 and FOXO1 in embryogenesis, the aim of this work was to detect and co…
Growth factors and chromogranin A in intra-abdominal adhesions of children
Pathogenesis of adhesions is still unclear and does not give a clear response whether the morphopathogenetic mechanisms of congenital and acquired adhesions in children are different or not. Thus, we searched for the appearance and distribution of growth factors, their receptors and chromogranins in adhesions of children in the ontogenetic aspect. Tissues were obtained from 17 children of group 1 (1 day to 3 years old) and 10 children of group 2 …
Facilitating Student Understanding through Incorporating Digital Images and 3D-Printed Models in a Human Anatomy Course
Combining classical educational methods with interactive three-dimensional (3D) visualization technology has great power to support and provide students with a unique opportunity to use them in the study process, training, and/or simulation of different medical procedures in terms of a Human Anatomy course. In 2016, Rīga Stradiņš University (RSU) offered students the 3D Virtual Dissection Table “Anatomage” with possibilities of virtual dissection…
Quantification of Cytokines in Lip Tissue from Infants Affected by Congenital Cleft Lip and Palate
Cleft lip and palate are amongst the most common congenital malformations worldwide presenting with variable manifestations. Previous research has been primarily focused on the genetical aspects of its complex and multifactorial etiology. In the present study, we investigated the role of cytokines as mediators of epithelial-mesenchymal crosstalk and local site inflammation in cleft affected infants. Lip material was obtained from 12 children aged…
Complex Evaluation of Tissue Factors in Pediatric Cholesteatoma
The aim of this study was to describe the appearance and distribution of tissue remodeling markers (MMP-2, MMP-9, TIMP-2, TIMP-4), Sonic hedgehog gene protein (Shh), pro- and anti-inflammatory cytokines (IL-1, IL-10), transcription factor (NF-κβ), proliferation marker (Ki-67), angiogenetic factor (VEGF), tissue defensins (HβD-2, HβD-4) of the pediatric cholesteatoma. Sixteen cholesteatoma samples were obtained from children, eleven skin controls …
Theatrum Anatomicum Rigense MCMXX and the historical collection of teaching and research exponates in the Institute of Anatomy and Anthropology of Riga Stradiņš University
The Institute of Anatomy and Anthropology (AAI) of Riga Stradiņš University (RSU) displays a remarkable historical collection of educational and scientific materials on anatomy and embryology, 8381 items in total. The creation of the collection started in 2002, and nowadays it integrates 16 sub-collections: the main exhibits of P. Stradiņš's collection; the collection of pathological exhibits from Gailezers Hospital with 542 items; the collection…
Factors affecting facial development and formation of cleft lip and palate: A literature review
The craniofacial region forms in a complicated developmental process regulated by multiple genes and growth factors. Disruption and dysregulation during facial development can lead to multiple congenital facial anomalies including cleft lip and palate. This literature review collects and analyses the existing information about the interaction of multiple growth factors and genes within the developing facial region and their association with facia…
Evaluation of innervation in cleft affected oral mucosa
Orofacial clefts are one of the most common pathologies present at birth. The aim of the study was to evaluate the presence of PGP 9.5, substance P, VIP, CGRP, myelin and NFG in cleft affected mucosa of alveolar process, soft and hard palate, vomer and lip. Methods. Orofacial cleft affected mucosa tissue samples were obtained during surgical cleft correction from 21 children aged from 2 months to 9 years and 10 months. Prepared tissue sections we…
Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate
Introduction. Midline orofacial defects bear a high degree of morbidity for the affected individual, often associated with retardation in neonatal development and the need for surgical intervention. The etiology of the deformities, despite their high prevalence, remains, however, largely unknown. We report on the evaluation and quantification of proliferative and inflammatory markers in the cleft affected soft palate. Material and methods. This s…
Characterization of morphology in healthy, traumatized and aged knee meniscus of different species: A pilot study
Meniscus is a fibrocartilaginous anatomical structure that realizes complicated biomechanical functions in the knee joint. However, no comparative morphology studies have been done on different species and conditions regarding the meniscus. Thus, the aim of our pilot study was to compare the morphology of traumatized and aged human and healthy deer meniscus to reveal the tissue ground, growth, degeneration, cell death and inflammation factors. Th…
Characterisation of blood vessels used for coronary artery bypass surgery
Saphenous veins are commonly used as coronary artery bypass grafts. Therefore, it is important to understand the vein wall morphology used for the bypass grafts. Methods. Ten specimens of saphenous veins were obtained from 10 patients admitted to the Heart Surgery Centre of P. Stradiņš Clinical University Hospital for coronary artery bypass surgery and a histopathological study was conducted. The slides were processed for histological routine and…
Teaching and learning innovation in present and future of human anatomy course at RSU
With the emerging presence of IT based technologies in medical education, virtual anatomy has become a part of medical teaching, learning and healthcare. Building on the foundation of strong basic sciences, teaching and learning, Rīga Stradiņš University (RSU) offers its students the Anatomage Table. The Department of Morphology enabled new possibilities and allowed students to learn anatomy through a high-quality and interactive 3D tool.The aim …
COPD affected lung tissue remodelling due to the local distribution of MMP-2, Timp-2, TGF-β1 and HSP-70
Chronic obstructive pulmonary disease (COPD) is strongly associated with progressive airway limitation where the key mechanism is abnormal airway remodelling of bronchial mucosa maintained by complex crosstalk of tissue remodelling and regulatory factors. The aim of this study was to determine the appearance and local distribution of tissue remodelling factors in COPD-affected lung tissue and to compare the findings with the control group. In thi…
Molecular events in the Wharton's jelly and blood vessels of human umbilical cord
The umbilical cord is seen as the main junction between the developing embryo or fetus and placenta. We studied the antimicrobial response, the presence of undifferentiated cells and TGF-α, as well as tissue degeneration and compensatory remodelling processes in the cells of human umbilical cord.Seven umbilical cord tissue samples obtained during premature and full term births were stained with hematoxylin and eosin and by immunohistochemistry fo…
Pathogenesis of congenital adhesions: Cytokines and Human Β-Defensin 2
Intestinal malrotation is a failure of the bowel to attain the correct position during 5th to 10th week of embryogenesis that results in fixation of caecum to the upper part on the right side of abdominal wall with congenital peritoneal adhesions also known as Ladd’s bands. There are several factors speculated to have an impact on formation of the congenital adhesions, including intrauterine mesothelial trauma due to ischemia or an infectious age…
Expression of TGFβ-3, PAX9, RYK, matrix metalloproteinases and their tissue inhibitors in human cleft-affected tissue
Formation of mammalian lip and palate involves multiple developmental steps that finally lead to the fusion of the two bilateral palatal shelves along the facial midline. Recent studies confirm that on the basis successful orofacial formation is coordinated interactions of several factors including genes, growth factors, enzymes and their natural inhibitors. The aim of our study was to investigate cleft disordered tissue in children with cleft li…
Defensins and cytokins in nail unit affected by onychomycosis: A Pilot Study
Onychomycosis is a chronic infection disease that is induced by different types of fungi. Changes of nail color, shape and thickness are disease clinical findings. The disease affects all ages and genders of people, however higher incidence is observed in the people who have reduced immunity.To study natural immunity of the nail, 22 nail biopsies from onychomycosis patients were taken. Material was stained with hematoxilin and eosin and immunohis…
Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin
Psoriasis is a chronic, inflammatory, proliferative condition of the skin, clinically characterized by red, scaly plaques. Psoriasis has a large and heterogenous genetic and immunologic background with the dysregulation of the host defense system. The human keratinocytes obtained from psoriasis lesions are a very rich source to various antimicrobial peptides. Both Th 17 and Th 1 pathways play a role in the pathogenesis of psoriasis. Our aim of th…
GFAP and NF expression in brain tissue in children and adults after fatal traumatic brain injury
Background and objectives. Still, there is almost no information about the role of biomarkers in the pathological processes of the brain in those patients, which die immediately after the injury, and those, which die several hours after the trauma. Design and Settings. A retrospective study. The human brain tissue material from the archive of the Institute of Anatomy and Anthropology in Riga Stradins University (RSU). Methods. We used the brain t…
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Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin
Psoriasis is a chronic, inflammatory, proliferative condition of the skin, clinically characterized by red, scaly plaques. Psoriasis has a large and heterogenous genetic and immunologic background with the dysregulation of the host defense system. The human keratinocytes obtained from psoriasis lesions are a very rich source to various antimicrobial peptides. Both Th 17 and Th 1 pathways play a role in the pathogenesis of psoriasis. Our aim of th…
GFAP and NF expression in brain tissue in children and adults after fatal traumatic brain injury
Background and objectives. Still, there is almost no information about the role of biomarkers in the pathological processes of the brain in those patients, which die immediately after the injury, and those, which die several hours after the trauma. Design and Settings. A retrospective study. The human brain tissue material from the archive of the Institute of Anatomy and Anthropology in Riga Stradins University (RSU). Methods. We used the brain t…
Immunohistochemical distribution of IGF-1, bFGF and their receptors in decidual, embryonic and tubal human pregnancy tissue
Embryo implantation is a complicated process involving mother and conceptus cells differentiation, proliferation and invasion that are essential for successful pregnancy. Almost every cell in the human body is affected by IGF-1 that is one of the most potent natural activators of cell growth and multiplication, and also a potent inhibitor of the programmed cell death. bFGF, acting via its receptor FGFR1, is one of the factors involved in mediatin…
Relation between serum enzymes and liver histopathology in mink with hepatitis
The dystrophy of the mink liver is widely distributed in mink farms of Latvia. However, clinical diagnostics of the liver dystrophy is quite difficult. The hypothesis of this study was to clarify the indicators of ALT (alanine aminotransferase) and ALP (alkaline phosphatase) as the criteria in the early diagnostics of the mink liver injury. The goal of this study was to determine the potential correlation between the expressed functional indicato…
Distribution of neuropeptides in nasal and nasopharyngeal mucosa in patients with the post nasal drip syndrome
OBJECTIVE The post nasal drip is a very common symptom of sinusitis, allergic rhinosinusopathy, the gastroesophageal reflux disease, but there are some patients, who have a post nasal drip, sensation of a foreign body in the nasopharynx and a non-specific irritant cough with no other symptoms or signs of sinus inflammations or allergy. In the posterior rhinoscopy mucus discharge is seen. Ethiology and pathogenesis of this syndrome evolution are s…
Local expression of inflammatory cytokines in the facial tissue of children with a cleft lip and palate
The cleft lip and/or palate are among the most common congenital anomalies that occur in early development. Cytokines play an important role in the proliferation, growth, differentiation, survival and the functional activity of many cells and the upregulation of cytokines might be involved in the pathological processes of the maxillofacial region. The purpose of our study was to evaluate the expression of pro-inflammatory and anti-inflammatory cy…
Defensins and cytokins in nail unit affected by onychomycosis: A Pilot Study
Onychomycosis is a chronic infection disease that is induced by different types of fungi. Changes of nail color, shape and thickness are disease clinical findings. The disease affects all ages and genders of people, however higher incidence is observed in the people who have reduced immunity.To study natural immunity of the nail, 22 nail biopsies from onychomycosis patients were taken. Material was stained with hematoxilin and eosin and immunohis…
Pathogenesis of congenital adhesions: Cytokines and Human Β-Defensin 2
Intestinal malrotation is a failure of the bowel to attain the correct position during 5th to 10th week of embryogenesis that results in fixation of caecum to the upper part on the right side of abdominal wall with congenital peritoneal adhesions also known as Ladd’s bands. There are several factors speculated to have an impact on formation of the congenital adhesions, including intrauterine mesothelial trauma due to ischemia or an infectious age…
Expression of TGFβ-3, PAX9, RYK, matrix metalloproteinases and their tissue inhibitors in human cleft-affected tissue
Formation of mammalian lip and palate involves multiple developmental steps that finally lead to the fusion of the two bilateral palatal shelves along the facial midline. Recent studies confirm that on the basis successful orofacial formation is coordinated interactions of several factors including genes, growth factors, enzymes and their natural inhibitors. The aim of our study was to investigate cleft disordered tissue in children with cleft li…
Teaching and learning innovation in present and future of human anatomy course at RSU
With the emerging presence of IT based technologies in medical education, virtual anatomy has become a part of medical teaching, learning and healthcare. Building on the foundation of strong basic sciences, teaching and learning, Rīga Stradiņš University (RSU) offers its students the Anatomage Table. The Department of Morphology enabled new possibilities and allowed students to learn anatomy through a high-quality and interactive 3D tool.The aim …
COPD affected lung tissue remodelling due to the local distribution of MMP-2, Timp-2, TGF-β1 and HSP-70
Chronic obstructive pulmonary disease (COPD) is strongly associated with progressive airway limitation where the key mechanism is abnormal airway remodelling of bronchial mucosa maintained by complex crosstalk of tissue remodelling and regulatory factors. The aim of this study was to determine the appearance and local distribution of tissue remodelling factors in COPD-affected lung tissue and to compare the findings with the control group. In thi…
Molecular events in the Wharton's jelly and blood vessels of human umbilical cord
The umbilical cord is seen as the main junction between the developing embryo or fetus and placenta. We studied the antimicrobial response, the presence of undifferentiated cells and TGF-α, as well as tissue degeneration and compensatory remodelling processes in the cells of human umbilical cord.Seven umbilical cord tissue samples obtained during premature and full term births were stained with hematoxylin and eosin and by immunohistochemistry fo…
Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate
Introduction. Midline orofacial defects bear a high degree of morbidity for the affected individual, often associated with retardation in neonatal development and the need for surgical intervention. The etiology of the deformities, despite their high prevalence, remains, however, largely unknown. We report on the evaluation and quantification of proliferative and inflammatory markers in the cleft affected soft palate. Material and methods. This s…
Characterization of morphology in healthy, traumatized and aged knee meniscus of different species: A pilot study
Meniscus is a fibrocartilaginous anatomical structure that realizes complicated biomechanical functions in the knee joint. However, no comparative morphology studies have been done on different species and conditions regarding the meniscus. Thus, the aim of our pilot study was to compare the morphology of traumatized and aged human and healthy deer meniscus to reveal the tissue ground, growth, degeneration, cell death and inflammation factors. Th…
Characterisation of blood vessels used for coronary artery bypass surgery
Saphenous veins are commonly used as coronary artery bypass grafts. Therefore, it is important to understand the vein wall morphology used for the bypass grafts. Methods. Ten specimens of saphenous veins were obtained from 10 patients admitted to the Heart Surgery Centre of P. Stradiņš Clinical University Hospital for coronary artery bypass surgery and a histopathological study was conducted. The slides were processed for histological routine and…
Factors affecting facial development and formation of cleft lip and palate: A literature review
The craniofacial region forms in a complicated developmental process regulated by multiple genes and growth factors. Disruption and dysregulation during facial development can lead to multiple congenital facial anomalies including cleft lip and palate. This literature review collects and analyses the existing information about the interaction of multiple growth factors and genes within the developing facial region and their association with facia…
Evaluation of innervation in cleft affected oral mucosa
Orofacial clefts are one of the most common pathologies present at birth. The aim of the study was to evaluate the presence of PGP 9.5, substance P, VIP, CGRP, myelin and NFG in cleft affected mucosa of alveolar process, soft and hard palate, vomer and lip. Methods. Orofacial cleft affected mucosa tissue samples were obtained during surgical cleft correction from 21 children aged from 2 months to 9 years and 10 months. Prepared tissue sections we…
Facilitating Student Understanding through Incorporating Digital Images and 3D-Printed Models in a Human Anatomy Course
Combining classical educational methods with interactive three-dimensional (3D) visualization technology has great power to support and provide students with a unique opportunity to use them in the study process, training, and/or simulation of different medical procedures in terms of a Human Anatomy course. In 2016, Rīga Stradiņš University (RSU) offered students the 3D Virtual Dissection Table “Anatomage” with possibilities of virtual dissection…
Quantification of Cytokines in Lip Tissue from Infants Affected by Congenital Cleft Lip and Palate
Cleft lip and palate are amongst the most common congenital malformations worldwide presenting with variable manifestations. Previous research has been primarily focused on the genetical aspects of its complex and multifactorial etiology. In the present study, we investigated the role of cytokines as mediators of epithelial-mesenchymal crosstalk and local site inflammation in cleft affected infants. Lip material was obtained from 12 children aged…
Complex Evaluation of Tissue Factors in Pediatric Cholesteatoma
The aim of this study was to describe the appearance and distribution of tissue remodeling markers (MMP-2, MMP-9, TIMP-2, TIMP-4), Sonic hedgehog gene protein (Shh), pro- and anti-inflammatory cytokines (IL-1, IL-10), transcription factor (NF-κβ), proliferation marker (Ki-67), angiogenetic factor (VEGF), tissue defensins (HβD-2, HβD-4) of the pediatric cholesteatoma. Sixteen cholesteatoma samples were obtained from children, eleven skin controls …
Theatrum Anatomicum Rigense MCMXX and the historical collection of teaching and research exponates in the Institute of Anatomy and Anthropology of Riga Stradiņš University
The Institute of Anatomy and Anthropology (AAI) of Riga Stradiņš University (RSU) displays a remarkable historical collection of educational and scientific materials on anatomy and embryology, 8381 items in total. The creation of the collection started in 2002, and nowadays it integrates 16 sub-collections: the main exhibits of P. Stradiņš's collection; the collection of pathological exhibits from Gailezers Hospital with 542 items; the collection…
Fate and future of the medical students in Ukraine: A silently bubbling educational crisis
Jain et al. reflect on the Russia‐Ukraine war and argue that although there is a broad consensus on the need for intervention, focus should be on providing immediate accommodative measures
The Evaluation of FGFR1, FGFR2 and Foxo1 in Orofacial Cleft Tissue
Although cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies worldwide, the morphopathogenesis of non-syndromic orofacial clefts is still unclear. Many candidate genes have been proposed to play a causal role; however, only a few have been confirmed, leaving many still to be assessed. Taking into account the significance of FGFR1 , FGFR2 and FOXO1 in embryogenesis, the aim of this work was to detect and co…
Growth factors and chromogranin A in intra-abdominal adhesions of children
Pathogenesis of adhesions is still unclear and does not give a clear response whether the morphopathogenetic mechanisms of congenital and acquired adhesions in children are different or not. Thus, we searched for the appearance and distribution of growth factors, their receptors and chromogranins in adhesions of children in the ontogenetic aspect. Tissues were obtained from 17 children of group 1 (1 day to 3 years old) and 10 children of group 2 …
Antimicrobial Peptides and Interleukins in Cleft Soft Palate
Cleft palate is one of the most common and well-studied congenital anomalies; however, the role of protective tissue factors in its pathophysiology is still debated. The aim of our study was to evaluate interleukin and antimicrobial peptide appearance and distribution in cleft palate. Eight soft palate samples were obtained during veloplasty procedures. Immunohistochemical staining was applied to detect HBD-2-, HBD-3-, HBD-4-, LL-37-, IL-10-, and…
Medicine (27 works) · Pathology (20 works) · Internal Medicine (16 works) · Biology (15 works) · Immunohistochemistry (13 works) · Cleft Lip and Palate Research (10 works) · Anatomy (9 works) · Craniofacial Disorders and Treatments (8 works) · Immunology (8 works) · Inflammation (6 works)