Martin Kuchař
Biographic Data
| ID | 7953648 |
|---|---|
| NAME | Martin Kuchař |
| GIVEN NAMES | Martin |
| FAMILY NAME | Kuchař |
| SIGNATURE | KUCHAŘ M |
| AFFILIATIONS | University of Chemistry and Technology, Prague |
| ORCID | 0000-0002-7616-6352 |
| VERIFIED | Yes |
| TOTAL WORKS | 5 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 5 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2017 |
| LATEST PUBLICATION YEAR | 2019 |
| H-INDEX | 0 |
Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings
Background: Neuroactive steroids (NAS) affect neurotransmitter systems and cognition; thus, they play role in etiopathogenesis of psychiatric disorders. Aims: The primary aim was to examine cognition and effects of NAS on cognitive functioning in first-episode psychosis patients and in their healthy siblings. The secondary aims were to verify whether cognitive deficit is an endophenotype of psychosis and whether higher NAS levels represent a high…
Mephedrone (4-Methylmethcathinone)
Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH's and its primary metabolite nor-mephedrone's (nor-MEPH) pharmacokinetics and bio-distribution to four different substrates (serum, brain, lungs, and liver), as well as comparative analysis of their effects on locomotion [open field test (OFT)] and sensorimotor gating [prepulse i…
Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat
3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. We report a comprehensive and detailed description of the effects of subcutaneous MDPV (1-4 mg/kg) on pharmacokinetics, biodistribution and metabolism, acute effects on thermoregulation under isolated and aggregated conditions, locomotion (open field) and sensory gating (prepulse inhibition, PPI). All studies used m…
Pharmacokinetic, Ambulatory, and Hyperthermic Effects of 3,4-Methylenedioxy-N-Methylcathinone (Methylone) in Rats
Methylone (3,4-methylenedioxy- N -methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal effects of methylone and …
Obtaining Black Carbon—A Simple Method for the Safe Removal of Mineral Components from Soils and Archaeological Layers
In this study, we present a novel, safe method for how to remove inorganic components from soil samples studied for archaeological purposes, in order to improve studies of the distribution of black carbon in the sedimentary record. As the depositional history of this material depends on the interaction between humans and the natural environment, this method can be widely used in archaeology, landscape archaeology, palaeoecology, environmental geo…
No prominent works on this page.
Pharmacokinetic, Ambulatory, and Hyperthermic Effects of 3,4-Methylenedioxy-N-Methylcathinone (Methylone) in Rats
Methylone (3,4-methylenedioxy- N -methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal effects of methylone and …
Obtaining Black Carbon—A Simple Method for the Safe Removal of Mineral Components from Soils and Archaeological Layers
In this study, we present a novel, safe method for how to remove inorganic components from soil samples studied for archaeological purposes, in order to improve studies of the distribution of black carbon in the sedimentary record. As the depositional history of this material depends on the interaction between humans and the natural environment, this method can be widely used in archaeology, landscape archaeology, palaeoecology, environmental geo…
Mephedrone (4-Methylmethcathinone)
Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH's and its primary metabolite nor-mephedrone's (nor-MEPH) pharmacokinetics and bio-distribution to four different substrates (serum, brain, lungs, and liver), as well as comparative analysis of their effects on locomotion [open field test (OFT)] and sensorimotor gating [prepulse i…
Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat
3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. We report a comprehensive and detailed description of the effects of subcutaneous MDPV (1-4 mg/kg) on pharmacokinetics, biodistribution and metabolism, acute effects on thermoregulation under isolated and aggregated conditions, locomotion (open field) and sensory gating (prepulse inhibition, PPI). All studies used m…
Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings
Background: Neuroactive steroids (NAS) affect neurotransmitter systems and cognition; thus, they play role in etiopathogenesis of psychiatric disorders. Aims: The primary aim was to examine cognition and effects of NAS on cognitive functioning in first-episode psychosis patients and in their healthy siblings. The secondary aims were to verify whether cognitive deficit is an endophenotype of psychosis and whether higher NAS levels represent a high…
Chemistry (3 works) · Forensic Toxicology and Drug Analysis (3 works) · Internal Medicine (3 works) · Medicine (3 works) · Neurotransmitter Receptor Influence on Behavior (3 works) · Pharmacokinetics (3 works) · Pharmacology (3 works) · Psychedelics and Drug Studies (3 works) · Amphetamine (2 works) · Cathinone (2 works)