Maolin Hu
Biographic Data
| ID | 7954654 |
|---|---|
| NAME | Maolin Hu |
| GIVEN NAMES | Maolin |
| FAMILY NAME | Hu |
| SIGNATURE | HU M |
| AFFILIATIONS | Wuhan University |
| ORCID | 0000-0001-8477-9928 |
| VERIFIED | Yes |
| TOTAL WORKS | 8 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 8 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2018 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Altered resting-state prefrontal activity and network topology in adolescents with depression
Compared with HC, the DD group exhibited elevated prefrontal fALFF in multiple channels (e.g., ch11, ch26, ch31), reduced average functional connectivity within and between bilateral frontal regions (including FPA and Broca's area), and lower clustering coefficient, local efficiency, and global efficiency relative to healthy controls, whereas path length and small-worldness were preserved. Region-specific associations with cognition were observed…
A transdiagnostic network analysis of psychosocial-clinical-cognitive functioning in young people with bipolar and major depressive disorders
This study delineates a transdiagnostic network architecture in young people's mood disorders, identifying critical central and bridge nodes as intervention targets. The findings advocate for a dimensional, cognitive-informed approach to understanding and treating BD and MDD
Establishment of local norms and standardization of the Matrics consensus cognitive battery in Chinese adolescents
This study establishes the first locally representative normative standards for the MCCB in Chinese adolescents, addressing a crucial gap in culturally sensitive cognitive assessment tools. Our findings demonstrate the complex interplay of age, gender, and educational factors in cognitive development, providing clinically valuable benchmarks for early detection of schizophrenia in this population
Association of evening chronotype, sleep quality and cognitive impairment in patients with major depressive disorder
Our findings suggest that evening chronotype, poor sleep quality, and their interaction are important contributors to cognitive impairment in patients with MDD, alongside the severity of depression and first episode status. These results emphasize the need for integrated approaches targeting circadian rhythm disruptions and sleep disturbances in the treatment of cognitive dysfunction in MDD
Striatum-related spontaneous coactivation patterns predict treatment response on positive symptoms of drug-naive first-episode schizophrenia with risperidone monotherapy
This study is the first to combine striatal CAPs and fMRI to explore treatment response-related biomarkers in the early phase of schizophrenia. Our findings suggest that dynamic changes in CAP states in the putamen-thalamus circuit may be potential biomarkers for predicting patients' variation in the short-term treatment response of positive symptoms
Longitudinal multi-omics alterations response to 8-week risperidone monotherapy
This study firstly revealed that changes of CT and clinical behaviors after treatment may be transcriptionally and epigenetically underlied. We define a "three-step" roadmap which represents a vital step toward the exploration of treatment- and treatment response-related biomarkers on the basis of multiple omics rather than a single omics type as a strategy for advancing precise care
DNA Methylation Basis in the Effect of White Matter Integrity Deficits on Cognitive Impairments and Psychopathological Symptoms in Drug-Naive First-Episode Schizophrenia
Background: Mounting evidence from diffusion tensor imaging (DTI) and epigenetic studies, respectively, confirmed the abnormal alterations of brain white matter integrity and DNA methylation (DNAm) in schizophrenia. However, few studies have been carried out in the same sample to simultaneously explore the WM pathology relating to clinical behaviors, as well as the DNA methylation basis underlying the WM deficits. Methods: We performed DTI scans …
Comt, 5-HTR2A, and SLC6A4 mRNA Expressions in First-Episode Antipsychotic-Naïve Schizophrenia and Association With Treatment Outcomes
Background: Dopaminergic and serotonergic systems play crucial roles in the pathophysiology of schizophrenia and modulate response to antipsychotic treatment. However, previous studies of dopaminergic and serotonergic genes expression are sparse, and their results have been inconsistent. In this longitudinal study, we aim to investigate the expressions of Catechol-O-methyltransferase ( COMT ), serotonin 2A receptor ( 5-HTR2A ), and serotonin tran…
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Comt, 5-HTR2A, and SLC6A4 mRNA Expressions in First-Episode Antipsychotic-Naïve Schizophrenia and Association With Treatment Outcomes
Background: Dopaminergic and serotonergic systems play crucial roles in the pathophysiology of schizophrenia and modulate response to antipsychotic treatment. However, previous studies of dopaminergic and serotonergic genes expression are sparse, and their results have been inconsistent. In this longitudinal study, we aim to investigate the expressions of Catechol-O-methyltransferase ( COMT ), serotonin 2A receptor ( 5-HTR2A ), and serotonin tran…
DNA Methylation Basis in the Effect of White Matter Integrity Deficits on Cognitive Impairments and Psychopathological Symptoms in Drug-Naive First-Episode Schizophrenia
Background: Mounting evidence from diffusion tensor imaging (DTI) and epigenetic studies, respectively, confirmed the abnormal alterations of brain white matter integrity and DNA methylation (DNAm) in schizophrenia. However, few studies have been carried out in the same sample to simultaneously explore the WM pathology relating to clinical behaviors, as well as the DNA methylation basis underlying the WM deficits. Methods: We performed DTI scans …
Striatum-related spontaneous coactivation patterns predict treatment response on positive symptoms of drug-naive first-episode schizophrenia with risperidone monotherapy
This study is the first to combine striatal CAPs and fMRI to explore treatment response-related biomarkers in the early phase of schizophrenia. Our findings suggest that dynamic changes in CAP states in the putamen-thalamus circuit may be potential biomarkers for predicting patients' variation in the short-term treatment response of positive symptoms
Longitudinal multi-omics alterations response to 8-week risperidone monotherapy
This study firstly revealed that changes of CT and clinical behaviors after treatment may be transcriptionally and epigenetically underlied. We define a "three-step" roadmap which represents a vital step toward the exploration of treatment- and treatment response-related biomarkers on the basis of multiple omics rather than a single omics type as a strategy for advancing precise care
Association of evening chronotype, sleep quality and cognitive impairment in patients with major depressive disorder
Our findings suggest that evening chronotype, poor sleep quality, and their interaction are important contributors to cognitive impairment in patients with MDD, alongside the severity of depression and first episode status. These results emphasize the need for integrated approaches targeting circadian rhythm disruptions and sleep disturbances in the treatment of cognitive dysfunction in MDD
Establishment of local norms and standardization of the Matrics consensus cognitive battery in Chinese adolescents
This study establishes the first locally representative normative standards for the MCCB in Chinese adolescents, addressing a crucial gap in culturally sensitive cognitive assessment tools. Our findings demonstrate the complex interplay of age, gender, and educational factors in cognitive development, providing clinically valuable benchmarks for early detection of schizophrenia in this population
Altered resting-state prefrontal activity and network topology in adolescents with depression
Compared with HC, the DD group exhibited elevated prefrontal fALFF in multiple channels (e.g., ch11, ch26, ch31), reduced average functional connectivity within and between bilateral frontal regions (including FPA and Broca's area), and lower clustering coefficient, local efficiency, and global efficiency relative to healthy controls, whereas path length and small-worldness were preserved. Region-specific associations with cognition were observed…
A transdiagnostic network analysis of psychosocial-clinical-cognitive functioning in young people with bipolar and major depressive disorders
This study delineates a transdiagnostic network architecture in young people's mood disorders, identifying critical central and bridge nodes as intervention targets. The findings advocate for a dimensional, cognitive-informed approach to understanding and treating BD and MDD
Schizophrenia (object-oriented programming (6 works) · Cognition (5 works) · Functional Brain Connectivity Studies (5 works) · Medicine (5 works) · Psychiatry (5 works) · Psychology (5 works) · Schizophrenia research and treatment (5 works) · Biology (3 works) · Genetics (3 works) · Mental Health Research Topics (3 works)