Dan T A Eisenberg
Biographic Data
| ID | 81081 |
|---|---|
| NAME | Dan T A Eisenberg |
| GIVEN NAMES | Dan T A |
| FAMILY NAME | Eisenberg |
| SIGNATURE | EISENBERG D T A |
| AFFILIATIONS | Northwestern University |
| ORCID | 0000-0003-0812-1862 |
| VERIFIED | Yes |
| TOTAL WORKS | 34 |
| TOTAL CITATIONS | 19 |
| AUTHOR COUNT | 34 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1978 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
Relationships Among Maternal Epstein–Barr Virus Antibodies, Covid ‐19, and Stress in Mothers up to 1‐Year Postpartum
OBJECTIVES: Both psychosocial stress and current infection can increase the likelihood of reactivation of latent Epstein-Barr virus (EBV). Pregnancy and infection with SARS-CoV-2 can be stressful and modulate immune function. However, it is unknown how SARS-CoV-2 infection and stress further interact among postpartum women to affect EBV antigen and antibody expression. METHODS: We examined associations among COVID-19 diagnosis, self-reported stre…
The Attention‐Deficit/Hyperactivity Disorder‐Associated DRD4 7R Allele Predicts Household Economic Status but Not Nutritional Status in Northern Kenyan Rendille Children
OBJECTIVES: Around 11% of U.S. children are diagnosed with attention-deficit/hyperactivity disorder (ADHD). One hypothesis for ADHD's relatively high prevalence is that behaviors associated with ADHD were advantageous in past environments where they were positively selected for. A previous study showed that an allele associated with ADHD-the 7R allele of the gene encoding the D(4) dopamine receptor (DRD4)-had a positive effect on the nutritional …
Telomere length analysis from minimally‐invasively collected samples: Methods development and meta‐analysis of the validity of different sampling techniques
Predictors of maternal‐origin microchimerism in young women in the Philippines
OBJECTIVES: Microchimerism is the presence of a small quantity of cells or DNA from a genetically distinct individual. This phenomenon occurs with bidirectional maternal-fetal exchange during pregnancy. Microchimerism can persist for decades after delivery and have long-term health implications. However, little is known about why microchimerism is detectable at varying levels in different individuals. We examine the variability and the following …
Evolutionary life history theory as an organising framework for cohort studies: Insights from the Cebu Longitudinal Health and Nutrition Survey
By tracking a group of individuals through time, cohort studies provide fundamental insights into the developmental time course and causes of health and disease. Evolutionary life history theory seeks to explain patterns of growth, development, reproduction and senescence, and inspires a range of hypotheses that are testable using the longitudinal data from cohort studies. Here we review two decades of life history theory-motivated work conducted…
Testing for paternal influences on offspring telomere length in a human cohort in the Philippines
OBJECTIVES: Telomeres, emerging biomarkers of aging, are comprised of DNA repeats located at chromosomal ends that shorten with cellular replication and age in most human tissues. In contrast, spermatocyte telomeres lengthen with age. These changes in telomere length (TL) appear to be heritable, as older paternal ages of conception (PAC) predict longer offspring TL. Mouse-model studies raise questions about the potential for effects of paternal e…
Telomere Depletion
Early life growth and adult telomere length in a Filipino cohort study
OBJECTIVE: We investigated the relationship between early life growth patterns and blood telomere length (TL) in adulthood using conditional measures of lean and fat mass growth to evaluate potentially sensitive periods of early life growth. METHODS: This study included data from 1562 individuals (53% male; age 20-22 years) participating in the Cebu Longitudinal Health and Nutrition Survey, located in metropolitan Cebu, Philippines. Primary expos…
Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines
OBJECTIVES: Psychosocial stress is postulated to hasten senescence in part by accelerating the shortening of telomere length (TL). One pathway through which this may happen is via increasing inflammation and innate immune system activation-a pathway which recent studies suggest acts more strongly for those who grew up in low microbial environments. Thus, we hypothesized that: (1) Psychosocial stress will be inversely associated with TL, (2) early…
Dental enamel defects predict adolescent health indicators: A cohort study among the Tsimane’ of Bolivia
Objectives Bioarchaeological findings have linked defective enamel formation in preadulthood with adult mortality. We investigated how defective enamel formation in infancy and childhood is associated with risk factors for adult morbidity and mortality in adolescents. Methods This cohort study of 349 Amerindian adolescents (10‐17 years of age) related extent of enamel defects on the central maxillary incisors (none, less than 1/3, 1/3 to 2/3, mor…
Evaluating minimally invasive sample collection methods for telomere length measurement
OBJECTIVES: Telomere length (TL) is a biomarker of aging and age-related decline. Although venous blood is considered the "gold standard" for TL measurement, its collection is often not feasible or desired in nonclinical settings. Saliva and dried blood spots (DBS) have been used as alternatives when venipuncture cannot be performed. However, it is not known whether these sample types yield TL measurements comparable to those obtained from venous…
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies
Androgen receptor CAG repeat polymorphism and hypothalamic‐pituitary‐gonadal function in Filipino young adult males
Androgen receptor polyglutamine repeat length (AR‐CAGn) modulates the effect of testosterone on androgen‐associated somatic traits in Filipino young adult men
Our finding that longer AR-CAGn predicts greater androgen-associated trait expression among high-T men runs counter to in vitro work, but is generally consistent with the few prior studies to evaluate similar interactions in human populations. Collectively, these results raise questions about the applicability of findings derived from in vitro AR-CAGn studies to the receptor's role in maintaining androgen-associated somatic traits in human popula…
Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the P hilippines
OBJECTIVES: Telomeres are repetitive DNA at chromosomes ends that shorten with age due to cellular replication and oxidative stress. As telomeres shorten, this can eventually place limits on cell replication and contribute to senescence. Infections are common during early development and activate cellular immune responses that involve clonal expansion and oxidative stress. As such, a high infectious disease burden might shorten blood telomere len…
Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans
Telomeres are repeating DNA at chromosome ends. Telomere length (TL) declines with age in most human tissues, and shorter TL is thought to accelerate senescence. In contrast, older men have sperm with longer TL; correspondingly, older paternal age at conception (PAC) predicts longer TL in offspring. This PAC-effect could be a unique form of transgenerational genetic plasticity that modifies somatic maintenance in response to cues of recent ancest…
Improving qPCR telomere length assays: Controlling for well position effects increases statistical power
OBJECTIVES: Telomere length (TL) is commonly measured using quantitative PCR (qPCR). Although, easier than the southern blot of terminal restriction fragments (TRF) TL measurement method, one drawback of qPCR is that it introduces greater measurement error and thus reduces the statistical power of analyses. To address a potential source of measurement error, we consider the effect of well position on qPCR TL measurements. METHODS: qPCR TL data fr…
Sibling composition during childhood and adult blood pressure among native Amazonians in Bolivia
Adult obesity: Panel study from native Amazonians
Sibling composition and children's anthropometric indicators of nutritional status: Evidence from native Amazonians in Bolivia
Older brothers and younger sisters were negatively associated with arm measures in girls. This finding may help improve policy interventions that aim to address children's nutritional health and long-term well-being
First Impressions From Faces Among U.S. and Culturally Isolated Tsimane’ People in the Bolivian Rainforest
The authors examined the generalizability of first impressions from faces previously documented in industrialized cultures to the Tsimane’ people in the remote Bolivian rainforest. Tsimane’ as well as U.S. judges showed within-culture agreement in impressions of attractiveness, babyfaceness, and traits (healthy, intelligent/knowledgeable, dominant/respected, and sociable/warm) of own-culture faces. Both groups also showed within-culture agreement…
An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects
Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role in regulating cellular proliferation, and shorten with increasing age in proliferating human tissues. The rate of age‐related shortening of telomeres is highest early in life and decreases with age. Shortened telomeres are thought to limit the proliferation of cells and are associated with increased morbidity and mortality. Although natural selection is widel…
Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries
These findings suggest considerable population variation in BTL in Europe that is not obviously a result of broad measures of population structure or infection/economic exposure measured in early life or in adulthood.Studying telomere dynamics in a wider variety of populations, and with greater attention to life-cycle dynamics, will be important to help elucidate the causes and possible consequences of human population variation in telomere lengt…
Short but catching up: Statural growth among native Amazonian Bolivian children
The ubiquity and consequences of childhood growth stunting ( Z score, HAZ) in rural areas of low‐income nations has galvanized research into the reversibility of stunting, but the shortage of panel data has hindered progress. Using panel data from a native Amazonian society of foragers‐farmers in Bolivia (Tsimane'), we estimate rates of catch‐up growth for stunted children. One hundred forty‐six girls and 158 boys 2 ≤ age ≤ 7 were measured annual…
Prosperity, power, and change: Modeling maize at Postclassic Xaltocan, Mexico
Individual Wealth Rank, Community Wealth Inequality, and Self-Reported Adult Poor Health: A Test of Hypotheses with Panel Data (2002-2006) from Native Amazonians, Bolivia
Growing evidence suggests that economic inequality in a community harms the health of a person. Using panel data from a small-scale, preindustrial rural society, we test whether individual wealth rank and village wealth inequality affects self-reported poor health in a foraging-farming native Amazonian society. A person's wealth rank was negatively but weakly associated with self-reported morbidity. Each step up/year in the village wealth hierarc…
First Impressions From Faces Among U.S. and Culturally Isolated Tsimane’ People in the Bolivian Rainforest
The authors examined the generalizability of first impressions from faces previously documented in industrialized cultures to the Tsimane’ people in the remote Bolivian rainforest. Tsimane’ as well as U.S. judges showed within-culture agreement in impressions of attractiveness, babyfaceness, and traits (healthy, intelligent/knowledgeable, dominant/respected, and sociable/warm) of own-culture faces. Both groups also showed within-culture agreement…
Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history
The ε4 allele of the apolipoprotein E ( APOE ) gene is associated with increased cholesterol levels and heart disease. Population allele frequencies of APOE have previously been shown to vary, with ε4 frequencies generally increasing with latitude. We hypothesize that this trend resulted from natural selection protecting against low‐cholesterol levels. In high‐latitude cold environments and low‐latitude hot environments, metabolic rate is elevate…
Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans
Telomeres are repeating DNA at chromosome ends. Telomere length (TL) declines with age in most human tissues, and shorter TL is thought to accelerate senescence. In contrast, older men have sperm with longer TL; correspondingly, older paternal age at conception (PAC) predicts longer TL in offspring. This PAC-effect could be a unique form of transgenerational genetic plasticity that modifies somatic maintenance in response to cues of recent ancest…
Latin America in World Affairs: The Politics of Inequality
Conflict, Order, and Peace in the Americas. Part I: Dialogues on the Central Issues
A Bibliography of Latin America and the Caribbean: The Hilton Library
Assortative mating and offspring well-being: Theory and empirical findings from a native Amazonian society in Bolivia
Rain, temperature, and child–adolescent height among Native Amazonians in Bolivia
The height of young females and males is well protected from climate events, but protection works less well for boys ages 2-12
The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men
Why no adult stunting penalty or height premium
Short but catching up: Statural growth among native Amazonian Bolivian children
The ubiquity and consequences of childhood growth stunting ( Z score, HAZ) in rural areas of low‐income nations has galvanized research into the reversibility of stunting, but the shortage of panel data has hindered progress. Using panel data from a native Amazonian society of foragers‐farmers in Bolivia (Tsimane'), we estimate rates of catch‐up growth for stunted children. One hundred forty‐six girls and 158 boys 2 ≤ age ≤ 7 were measured annual…
Prosperity, power, and change: Modeling maize at Postclassic Xaltocan, Mexico
Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history
The ε4 allele of the apolipoprotein E ( APOE ) gene is associated with increased cholesterol levels and heart disease. Population allele frequencies of APOE have previously been shown to vary, with ε4 frequencies generally increasing with latitude. We hypothesize that this trend resulted from natural selection protecting against low‐cholesterol levels. In high‐latitude cold environments and low‐latitude hot environments, metabolic rate is elevate…
Individual Wealth Rank, Community Wealth Inequality, and Self-Reported Adult Poor Health: A Test of Hypotheses with Panel Data (2002-2006) from Native Amazonians, Bolivia
Growing evidence suggests that economic inequality in a community harms the health of a person. Using panel data from a small-scale, preindustrial rural society, we test whether individual wealth rank and village wealth inequality affects self-reported poor health in a foraging-farming native Amazonian society. A person's wealth rank was negatively but weakly associated with self-reported morbidity. Each step up/year in the village wealth hierarc…
An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects
Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role in regulating cellular proliferation, and shorten with increasing age in proliferating human tissues. The rate of age‐related shortening of telomeres is highest early in life and decreases with age. Shortened telomeres are thought to limit the proliferation of cells and are associated with increased morbidity and mortality. Although natural selection is widel…
Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries
These findings suggest considerable population variation in BTL in Europe that is not obviously a result of broad measures of population structure or infection/economic exposure measured in early life or in adulthood.Studying telomere dynamics in a wider variety of populations, and with greater attention to life-cycle dynamics, will be important to help elucidate the causes and possible consequences of human population variation in telomere lengt…
Sibling composition during childhood and adult blood pressure among native Amazonians in Bolivia
Adult obesity: Panel study from native Amazonians
Sibling composition and children's anthropometric indicators of nutritional status: Evidence from native Amazonians in Bolivia
Older brothers and younger sisters were negatively associated with arm measures in girls. This finding may help improve policy interventions that aim to address children's nutritional health and long-term well-being
First Impressions From Faces Among U.S. and Culturally Isolated Tsimane’ People in the Bolivian Rainforest
The authors examined the generalizability of first impressions from faces previously documented in industrialized cultures to the Tsimane’ people in the remote Bolivian rainforest. Tsimane’ as well as U.S. judges showed within-culture agreement in impressions of attractiveness, babyfaceness, and traits (healthy, intelligent/knowledgeable, dominant/respected, and sociable/warm) of own-culture faces. Both groups also showed within-culture agreement…
Improving qPCR telomere length assays: Controlling for well position effects increases statistical power
OBJECTIVES: Telomere length (TL) is commonly measured using quantitative PCR (qPCR). Although, easier than the southern blot of terminal restriction fragments (TRF) TL measurement method, one drawback of qPCR is that it introduces greater measurement error and thus reduces the statistical power of analyses. To address a potential source of measurement error, we consider the effect of well position on qPCR TL measurements. METHODS: qPCR TL data fr…
Androgen receptor CAG repeat polymorphism and hypothalamic‐pituitary‐gonadal function in Filipino young adult males
Androgen receptor polyglutamine repeat length (AR‐CAGn) modulates the effect of testosterone on androgen‐associated somatic traits in Filipino young adult men
Our finding that longer AR-CAGn predicts greater androgen-associated trait expression among high-T men runs counter to in vitro work, but is generally consistent with the few prior studies to evaluate similar interactions in human populations. Collectively, these results raise questions about the applicability of findings derived from in vitro AR-CAGn studies to the receptor's role in maintaining androgen-associated somatic traits in human popula…
Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the P hilippines
OBJECTIVES: Telomeres are repetitive DNA at chromosomes ends that shorten with age due to cellular replication and oxidative stress. As telomeres shorten, this can eventually place limits on cell replication and contribute to senescence. Infections are common during early development and activate cellular immune responses that involve clonal expansion and oxidative stress. As such, a high infectious disease burden might shorten blood telomere len…
Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans
Telomeres are repeating DNA at chromosome ends. Telomere length (TL) declines with age in most human tissues, and shorter TL is thought to accelerate senescence. In contrast, older men have sperm with longer TL; correspondingly, older paternal age at conception (PAC) predicts longer TL in offspring. This PAC-effect could be a unique form of transgenerational genetic plasticity that modifies somatic maintenance in response to cues of recent ancest…
Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines
OBJECTIVES: Psychosocial stress is postulated to hasten senescence in part by accelerating the shortening of telomere length (TL). One pathway through which this may happen is via increasing inflammation and innate immune system activation-a pathway which recent studies suggest acts more strongly for those who grew up in low microbial environments. Thus, we hypothesized that: (1) Psychosocial stress will be inversely associated with TL, (2) early…
Dental enamel defects predict adolescent health indicators: A cohort study among the Tsimane’ of Bolivia
Objectives Bioarchaeological findings have linked defective enamel formation in preadulthood with adult mortality. We investigated how defective enamel formation in infancy and childhood is associated with risk factors for adult morbidity and mortality in adolescents. Methods This cohort study of 349 Amerindian adolescents (10‐17 years of age) related extent of enamel defects on the central maxillary incisors (none, less than 1/3, 1/3 to 2/3, mor…
Evaluating minimally invasive sample collection methods for telomere length measurement
OBJECTIVES: Telomere length (TL) is a biomarker of aging and age-related decline. Although venous blood is considered the "gold standard" for TL measurement, its collection is often not feasible or desired in nonclinical settings. Saliva and dried blood spots (DBS) have been used as alternatives when venipuncture cannot be performed. However, it is not known whether these sample types yield TL measurements comparable to those obtained from venous…
Medicine (20 works) · Biology (18 works) · Demography (16 works) · Genetics (12 works) · Birth, Development, and Health (11 works) · Telomeres, Telomerase, and Senescence (11 works) · Telomere (10 works) · Internal Medicine (9 works) · Gerontology (8 works) · Population (8 works)