Marc De Braekeleer

Biographic Data

ID853724
NAMEMarc De Braekeleer
GIVEN NAMESMarc
FAMILY NAMEDe Braekeleer
SIGNATUREDE BRAEKELEER M
AFFILIATIONSUniversité du Québec à Chicoutimi
ORCID0000-0002-5165-2207
VERIFIEDYes
TOTAL WORKS10
TOTAL CITATIONS4
WORKS AS AUTHOR10
WORKS AS EDITOR0
FIRST PUBLICATION YEAR1992
LATEST PUBLICATION YEAR2001
H-INDEX1

  • Genetics and Public Health in the 21st Century. Using Genetic Information to Improve Health and Prevent Disease

    Open AccessMarc De Braekeleer, M J Khoury et al.ARTICLEPopulation2001Cited by: 4

  • Mucoviscidose et fecondite des couples porteurs du gene au Saguenay

    Open AccessMarc De Braekeleer, Gil Bellis et al.ARTICLEPopulation2000

    De Braekeleer Marc, Bellis G., Gaimard M., Rault G., Milot M., Simard F. Mucoviscidose et fécondité des couples porteurs du gène au Saguenay-Lac-Saint-Jean (Québec, Canada). In: Population, 55e année, n°2, 2000. pp. 359-365

  • Mucoviscidose et fécondité des couples porteurs du gène au Saguenay-Lac-Saint-Jean (Québec, Canada)

    Open AccessF Simard, Marcel Milot et al.ARTICLEPopulation2000

  • Genealogy and geographical distribution of CFTR mutations in Saguenay Lac-Saint-Jean (Quebec, Canada)

    Open AccessMarc De Braekeleer, J Daigneault et al.ARTICLEAnnals of Human Biology1996

    Saguenay Lac-Saint-Jean (SLSJ), a region located in northeastern Quebec, has a high incidence of cystic fibrosis (CF). During the past few years the majority of the CF patients have been genotyped. The geographical distribution of the birth places of the patients and obligate carriers of the 621 + 1G-->T, the A455E and the delta F508 mutations (which accounted for 89% of the CF chromosomes) showed differences that can be explained by some degree …

  • Autosomal recessive disorders in Saguenay-Lac-Saint-Jean (Quebec, Canada)

    Open AccessMarc De BraekeleerARTICLEAnnals of Human Biology1996

    The total inbreeding coefficient of a group of 574 individuals with autosomal recessive disorders (ARD) from Saguenay-Lac-Saint-Jean, a geographically isolated region of northeastern Quebec, was estimated from isonymy and compared to the mean inbreeding coefficient calculated from the genealogies. Its value was compared to that of 1722 matched controls. The total inbreeding coefficient was similar in both ARD and control groups, but higher than t…

  • Geographic distribution of 18 autosomal recessive disorders in the French Canadian population of Saguenay-Lac-Saint-Jean, Quebec

    Open AccessMarc De BraekeleerARTICLEAnnals of Human Biology1995

    We analysed the geographic distribution of 770 patients and 1084 obligate carriers of 18 autosomal recessive disorders that have a high incidence in Saguenay-Lac-Saint-Jean (SLSJ) (Quebec). The places of birth of the patients and the obligate carriers were found to be unevenly distributed in SLSJ. A statistically significant higher number of places of birth than expected (p < or = 0.05) was observed in Saguenay and Lac-Saint-Jean (LSJ) East, wher…

  • A prevalence and fertility study of haemochromatosis in Saguenay-Lac-Saint-Jean

    Open AccessMarc De BraekeleerARTICLEAnnals of Human Biology1993

    The prevalence of hereditary haemochromatosis (HH) in Saguenay-Lac-St-Jean (SLSJ), a geographically isolated region of northeastern Québec, was estimated at 0.014; the heterozygote frequency was 0.21. These are among the highest frequencies found thus far in white populations. The fertility study completed in SLSJ showed that carriers of the HH gene tended to have more children than non-carriers. However, since these differences were not statisti…

  • Inbreeding effects on prereproductive mortality

    Open AccessMichael B Edmond, M Edmond et al.ARTICLEAnnals of Human Biology1993

    Effects of inbreeding on the prereproductive mortality, excluding spontaneous abortions, were investigated among offspring of 251 marriages between first-degree cousins (2:2) and 358 marriages between first-degree cousins once removed (2:3) from Saguenay-Lac-Saint-Jean. A control group matched on the demographic and socioeconomic characteristics of the consanguineous marriages was created. The mortality rates were calculated from a computerized p…

  • Inbreeding effects on fertility and sterility

    Open AccessMichael B Edmond, M Edmond et al.ARTICLEAnnals of Human Biology1993

    Effects of inbreeding on couples' fertility and primary sterility were investigated in five marriages between uncle and niece, 251 marriages between first-degree cousins, and 358 marriages between first-degree cousins once removed from Saguenay-Lac-Saint-Jean. Three control groups matched on the demographic and socioeconomic characteristics of the consanguineous couples were created. The number of children born to each couple was extracted from a…

  • Inbreeding and kinship in Saguenay-Lac-St-Jean

    Open AccessMarc De BraekeleerARTICLEAnnals of Human Biology1992

    Samples of individuals born between 1956 and 1971 proportional to the population size of each parish of Saguenay-Lac-St-Jean (SLSJ) were extracted from a computerized population register. The mean inbreeding and kinship coefficients were calculated for each sample. Our results showed that inbreeding and kinship were unevenly distributed in the SLSJ region. The highest values of inbreeding and kinship were found in Bas-Saguenay, an isolated subreg…