L K Dobrodeeva
Biographic Data
| ID | 88244 |
|---|---|
| NAME | L K Dobrodeeva |
| GIVEN NAMES | L K |
| FAMILY NAME | Dobrodeeva |
| SIGNATURE | DOBRODEEVA L K |
| AFFILIATIONS | Northern (Arctic) Federal University |
| ORCID | 0000-0001-5080-6502 |
| VERIFIED | Yes |
| TOTAL WORKS | 6 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 6 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2012 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 0 |
Functional Characteristics of Immunoregulatory Blood Proteins in Women of Reproductive Age Residing in the European North and Arctic Regions of the Russian Federation
Aim The purpose of this study was to identify the functional characteristics of blood proteins which are important in assessing reproductive health due to their immunoregulatory effects in women residing in the European North and Arctic regions of the Russian Federation. Methods A total of 557 women aged 21–55 (36.89 ± 0.54), engaged in intellectual professions, born and long‐term residents of the European North (Arkhangelsk Oblast) and Arctic (M…
Intracellular level of HIF-1α as an indicator of the delayed impact of Covid-19 on peripheral blood lymphocytes metabolism
BACKGROUND: COVID-19 infection triggers metabolic alterations that are crucial for both the replication of SARS-CoV-2 and the regulation of the immune response. HIF-1, which is one of the effectors in the PI3K/Akt/mTOR signal transmission pathway, promotes the reprogramming of metabolism by enhancing aerobic glycolysis.AIM: To assess whether the intracellular level of HIF-1 can reflect changes in the metabolism of peripheral blood lymphocytes aft…
Assessment of metabolic activity and energy supply of peripheral blood lymphocytes
BACKGROUND: T-cells have the capability to change their metabolism in response to activation signals. Resting T-cells primarily use the oxidation of higher fatty acids and oxidative phosphorylation in mitochondria for their energy needs, whereas activated T-cells switch to aerobic glycolysis and glutaminolysis, using glucose, and glutamine as substrates, respectively. AIM: To determine the metabolic activity and energy supply of peripheral blood …
Concentrations of Peripheral Blood Lymphocytes Intracellular Metabolic Regulators in Residents of the European North of Russia
Introduction: Metabolic processes controlled by cellular signaling mechanisms influence differentiation, proliferation, functional activity, and phenotypic stability of T cells. Hypoxia-inducible factor 1 (HIF-1) is a positive regulator of glycolysis. HIF-1 can be activated by an oxygen-independent pathway through the transcriptional activator STAT3. Sirtuin-3 (SIRT3) regulates the activity of the mitochondrial processes. Aim: To determine the ch…
Significance of Leptin Level in Assessment of Adaptive Immunity
Adipokine leptin is produced by the adipose tissue in quantities directly proportional to its mass. It is well known as a regulator of energy exchange, which provides control of energy consumption and expenditures. New information becomes available about its participation in control of some other physiological functions including functioning of immune competent cells. We have determined parameters of the immune status and concentration of leptin …
Use of Mathematical Models in Clinical Practice
In the article, the main stages, benefits and possibilities of mathematical modeling use in various fields of medicine have been considered. The literature review has summarized information about a wide range of existing models in clinical practice for prediction of morbidity, in comprehensive assessment of the body functional systems, in differential diagnostics and making medical decisions on strategy and tactics of treatment of patients
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Use of Mathematical Models in Clinical Practice
In the article, the main stages, benefits and possibilities of mathematical modeling use in various fields of medicine have been considered. The literature review has summarized information about a wide range of existing models in clinical practice for prediction of morbidity, in comprehensive assessment of the body functional systems, in differential diagnostics and making medical decisions on strategy and tactics of treatment of patients
Significance of Leptin Level in Assessment of Adaptive Immunity
Adipokine leptin is produced by the adipose tissue in quantities directly proportional to its mass. It is well known as a regulator of energy exchange, which provides control of energy consumption and expenditures. New information becomes available about its participation in control of some other physiological functions including functioning of immune competent cells. We have determined parameters of the immune status and concentration of leptin …
Concentrations of Peripheral Blood Lymphocytes Intracellular Metabolic Regulators in Residents of the European North of Russia
Introduction: Metabolic processes controlled by cellular signaling mechanisms influence differentiation, proliferation, functional activity, and phenotypic stability of T cells. Hypoxia-inducible factor 1 (HIF-1) is a positive regulator of glycolysis. HIF-1 can be activated by an oxygen-independent pathway through the transcriptional activator STAT3. Sirtuin-3 (SIRT3) regulates the activity of the mitochondrial processes. Aim: To determine the ch…
Assessment of metabolic activity and energy supply of peripheral blood lymphocytes
BACKGROUND: T-cells have the capability to change their metabolism in response to activation signals. Resting T-cells primarily use the oxidation of higher fatty acids and oxidative phosphorylation in mitochondria for their energy needs, whereas activated T-cells switch to aerobic glycolysis and glutaminolysis, using glucose, and glutamine as substrates, respectively. AIM: To determine the metabolic activity and energy supply of peripheral blood …
Intracellular level of HIF-1α as an indicator of the delayed impact of Covid-19 on peripheral blood lymphocytes metabolism
BACKGROUND: COVID-19 infection triggers metabolic alterations that are crucial for both the replication of SARS-CoV-2 and the regulation of the immune response. HIF-1, which is one of the effectors in the PI3K/Akt/mTOR signal transmission pathway, promotes the reprogramming of metabolism by enhancing aerobic glycolysis.AIM: To assess whether the intracellular level of HIF-1 can reflect changes in the metabolism of peripheral blood lymphocytes aft…
Functional Characteristics of Immunoregulatory Blood Proteins in Women of Reproductive Age Residing in the European North and Arctic Regions of the Russian Federation
Aim The purpose of this study was to identify the functional characteristics of blood proteins which are important in assessing reproductive health due to their immunoregulatory effects in women residing in the European North and Arctic regions of the Russian Federation. Methods A total of 557 women aged 21–55 (36.89 ± 0.54), engaged in intellectual professions, born and long‐term residents of the European North (Arkhangelsk Oblast) and Arctic (M…
Biology (4 works) · Immunology (4 works) · Medicine (4 works) · Biochemistry (3 works) · Cancer, Hypoxia, and Metabolism (3 works) · CD8 (3 works) · Chemistry (3 works) · Endocrinology (3 works) · Internal Medicine (3 works) · Metabolism (3 works)