Robert E Ferrell
Biographic Data
| ID | 88564 |
|---|---|
| NAME | Robert E Ferrell |
| GIVEN NAMES | Robert E |
| FAMILY NAME | Ferrell |
| SIGNATURE | FERRELL R E |
| AFFILIATIONS | University of Pittsburgh |
| VERIFIED | No |
| TOTAL WORKS | 24 |
| TOTAL CITATIONS | 119 |
| AUTHOR COUNT | 24 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1972 |
| LATEST PUBLICATION YEAR | 2008 |
| H-INDEX | 4 |
Immunoglobulin allotypes in Southwest Asia
Southwest Asia has a long history of contact with Central Asian and with Sub‐Saharan African populations. Is the genetic structure of these populations reflective of these historical facts? To study this, data was generated on the immunoglobulin heavy chain (GM) and light chain (KM) allotypes from seven Arab and three non‐Arab populations in SW Asia to examine the relationship of these populations to SE European, NW Indian, Sub‐Saharan African, a…
The Khatri Sikh Diabetes Study (SDS)
Non-insulin-dependent diabetes mellitus, or type 2 diabetes (T2DM), has become a major public health problem in India. The high prevalence, relatively young age of onset, and strong familial aggregation of T2DM in some Indian communities remains to be explained. Many of the traditional risk factors established for European populations do not appear to be present in Asian Indians. Phase I of the Sikh Diabetes Study (SDS) was launched to build the …
Heart Rate Variability Is Associated With Polymorphic Variation in the Choline Transporter Gene
OBJECTIVE: The objective of this study was to determine whether interindividual variation in parasympathetic (cholinergic) and sympathetic (adrenergic) regulation of heart rate (as estimated by frequency components of heart rate variability [HRV]) may be accounted for, in part, by genetic variation in the choline transporter, a component of acetylcholine neurotransmission. METHODS: Resting HRV estimates of high- (HF) and low-frequency (LF) power …
Geographic Microsatellite Variability in Central American Howling Monkeys
Allelic Variation in the Serotonin Transporter Gene-Linked Polymorphic Region (5-HTTLPR) and Cardiovascular Reactivity in Young Adult Male and Female Twins of European-American Descent
OBJECTIVE: To examine the effect of length variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on individual differences in cardiovascular response to psychological challenge. METHODS: Heart rate (HR) and systolic and diastolic blood pressure (SBP, DBP) responses to computerized versions of two psychological challenges, the Stroop Color-Word Interference Test and mental arithmetic, were measured among 131 monozygotic …
Mitochondrial DNA variation is an indicator of Austronesian influence in Island Melanesia
Past studies have shown a consistent association of a specific set of mitochondrial DNA 9 base pair (bp) deletion haplotypes with Polynesians and their Austronesian-speaking relatives, and the total lack of the deletion in a short series of New Guinea Highlanders. Utilizing plasma and DNA samples from various old laboratory collections, we have extended population screening for the 9-bp deletion into "Island Melanesia," an area notorious for its …
Mitochondrial DNA variation is an indicator of Austronesian influence in Island Melanesia
Past studies have shown a consistent association of a specific set of mitochondrial DNA 9 base pair (bp) deletion haplotypes with Polynesians and their Austronesian-speaking relatives, and the total lack of the deletion in a short series of New Guinea Highlanders. Utilizing plasma and DNA samples from various old laboratory collections, we have extended population screening for the 9-bp deletion into “Island Melanesia,” an area notorious for its …
Estimating African American Admixture Proportions by Use of Population-Specific Alleles
Mitochondrial versus nuclear admixture estimates demonstrate a past history of directional mating
Six blood group antigens (ABO, RH, MNS, KK, KP, FY) and five plasma proteins (HP, GC, APOA4, FXIIIB, C1R) were typed in 790 individuals, and 12 mtDNA RFLP and deletion polymorphisms were typed in 657 individuals from the San Luis Valley, Colorado. The 790 nuclear typings were conducted on 399 Anglos and 391 Hispanics, while the 657 mitochondrial haplotypes were generated from 207 Anglos and 450 Hispanics. Chakraborty's ADMIX2 FORTRAN program was …
Distribution of the four founding lineage haplotypes in native Americans suggests a single wave of migration for the New World
The distribution of the four founding lineage haplogroups in Native Americans from North, Central, and South America shows a north to south increase in the frequency of lineage B and a North to South decrease in the frequency of lineage A. All four founding lineage haplogroups were detected in North, Central, and South America, and in Greenberg et al.'s ([1986] Curr. Anthropol. 27: 477–497) three major linguistic groups (Amerind, NaDene, and Eska…
Molecular studies of the genetics of non–insulin‐dependent diabetes mellitus
Non–insulin‐dependent mellitus (NIDDM) is a common, multifactorial disease with a significant genetic component to disease susceptibility. Biometrical analysis of family data has consistently found evidence of the action of a major gene in determining susceptibility to NIDDM in families. However, the identity of the gene or genes that contribute to NIDDM in the general population is still not known. Recent advances in molecular biology have given…
Allele sharing at six VNTR loci and genetic distances among three ethnically defined human populations
Because of their high degree of polymorphisms, the variable number of tandem repeat (VNTR) loci have become extremely useful in studies involving gene mapping, determination of identity and relatedness of individuals, and evolutionary relationships among populations. However, there are some concerns regarding whether or not the patterns of such genetic variation can be studied by the classical population models that are developed for studying gen…
DNA “fingerprinting” and the genetic management of a captive chimpanzee population ( Pan troglodytes )
DNA fingerprinting probes are cloned sequences which simultaneously detect a large number of similar hypervariable loci in the target DNA. The resulting highly polymorphic pattern visualized on an autoradiograph allows resolution of questions concerning individual identification and parentage. M13 bacteriophage has been used as a DNA fingerprinting probe for paternity ascertainment among captive chimpanzees housed in multi‐male groups as part of …
Genetic studies of human apolipoproteins. XVII
Variation in human apolipoprotein genes is a major source of phenotypic differences in human lipid metabolism. Data regarding genetic variation at apolipoprotein loci in various populations are only beginning to accumulate, and they suggest that different populations vary widely in distribution of apolipoprotein alleles. Using isoelectric focusing‐immunoblotting techniques, we screened 67 serum samples from self‐identified Samoan residents of Ame…
Application of molecular techniques to the study of human physiological variation
Physiological differences between human populatios, manifest as apparent adaptation to extreme environments, as differences in patterna of growth and development, and as differences in prevalence of common disease, are a mofer subject area of human biology. The approach of the geneticist interested in understanding these difference has been largely that of the proverbial drunk looking for has lost keys. We have characterized those genes whose pro…
Genetic variation in the Aleuts of the Pribilof Islands and the Eskimos of Kodiak Island
A sample of Aleuts residing in the Pribilof Islands of St. Paul (N = 163) and St. George (N = 62) and Eskimo residents of Kodiak Island (N = 294) have been typed for genetic variation at 31 discrete genetic markers. Of these, 16 were polymorphic and 15 were monomorphic. Several private polymorphisms previously reported in Eskimo or Alaskan Amerindian populations were absent in both the Aleuts and Kodiak Island Eskimos. Genetic distance analysis s…
Individual admixture estimates
The ethnic and geographic distributions of several common chronic diseases show distinct patterns that are consistent with the distribution of genes and genetic admixture. For example, diabetes and gallbladder disease occur most frequently among Amerindians, while those genetically admixed with them (such as Mexican‐Americans) have intermediate rates, and lowest rates are found among Whites and Blacks. Because there will be heterogeneity from ind…
A linkage study of protein‐coding loci in Macaca mulatta and Macaca fascicularis
Genealogical and gene marker data from the closely related species Macaca mulatta and Macaca fascicularis have been used to search for linkage between genes coding for the blood proteins albumin, carbonic anhydrase 1 and 2, diaphorase 1 and 2, group‐specific component, glucose phosphate isomerase, hemoglobin alpha chains, isocitrate dehydrogenase, prealbumin, and transferrin. The results are consistent with conservation of the linkage between the…
A population genetic study in the Ochamchir Region, Abkhazia, SSR
The reported longevity of residents of the Soviet Socialist Republic of the Caucasus has focused considerable attention on this population. However, little is known of the genetic composition of this population. With this in mind, several village populations of the Ochamchir Region, Abkhazia, SSR, were typed for 37 discrete genetic blood groups, erythrocyte and plasma protein loci. Gene and haplotype frequencies calculated for the polymorphic mar…
The St. Lawrence Island Eskimos
The Eskimos of St. Lawrence Island have been typed for genetic variation at 44 discrete genetic loci. Three private polymorphisms, at the 2,3‐diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations. Genetic distance analysis reveals a close relationship between the St. Lawrence Island Eskim…
A family study of the hemoglobin polymorphism in Macaca fascicularis
Paternity exclusion in primates
Two strategies for the use of polymorphic biochemical and serological markers in paternity testing problems in non‐human primate groups, where pedigree information is incomplete, are discussed. The positive approach, of attempting to prove paternity, is shown to be impracticable given the levels of detectable genetic variation among primates. The more conventional approach of paternity exclusion is examined and found to be useful under certain co…
The blacks of Panama
Panama's black citizens are culturally and historically divisible into two groups, the Spanish‐speaking coloniales and the English‐speaking anglos or afro‐antillanos. Until recently these groups have been geographically as well as culturally isolated one from the other, although both are predominantly of West and Southwest African origin. Assessment of the genetic diversity within‐villages and within language groups reveals as much, possibly some…
Differential rates of evolution in the carbonic anhydrase isozymes of catarrhine primates
Distribution of the four founding lineage haplotypes in native Americans suggests a single wave of migration for the New World
The distribution of the four founding lineage haplogroups in Native Americans from North, Central, and South America shows a north to south increase in the frequency of lineage B and a North to South decrease in the frequency of lineage A. All four founding lineage haplogroups were detected in North, Central, and South America, and in Greenberg et al.'s ([1986] Curr. Anthropol. 27: 477–497) three major linguistic groups (Amerind, NaDene, and Eska…
Individual admixture estimates
The ethnic and geographic distributions of several common chronic diseases show distinct patterns that are consistent with the distribution of genes and genetic admixture. For example, diabetes and gallbladder disease occur most frequently among Amerindians, while those genetically admixed with them (such as Mexican‐Americans) have intermediate rates, and lowest rates are found among Whites and Blacks. Because there will be heterogeneity from ind…
The St. Lawrence Island Eskimos
The Eskimos of St. Lawrence Island have been typed for genetic variation at 44 discrete genetic loci. Three private polymorphisms, at the 2,3‐diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations. Genetic distance analysis reveals a close relationship between the St. Lawrence Island Eskim…
Genetic studies of human apolipoproteins. XVII
Variation in human apolipoprotein genes is a major source of phenotypic differences in human lipid metabolism. Data regarding genetic variation at apolipoprotein loci in various populations are only beginning to accumulate, and they suggest that different populations vary widely in distribution of apolipoprotein alleles. Using isoelectric focusing‐immunoblotting techniques, we screened 67 serum samples from self‐identified Samoan residents of Ame…
The blacks of Panama
Panama's black citizens are culturally and historically divisible into two groups, the Spanish‐speaking coloniales and the English‐speaking anglos or afro‐antillanos. Until recently these groups have been geographically as well as culturally isolated one from the other, although both are predominantly of West and Southwest African origin. Assessment of the genetic diversity within‐villages and within language groups reveals as much, possibly some…
Genetic variation in the Aleuts of the Pribilof Islands and the Eskimos of Kodiak Island
A sample of Aleuts residing in the Pribilof Islands of St. Paul (N = 163) and St. George (N = 62) and Eskimo residents of Kodiak Island (N = 294) have been typed for genetic variation at 31 discrete genetic markers. Of these, 16 were polymorphic and 15 were monomorphic. Several private polymorphisms previously reported in Eskimo or Alaskan Amerindian populations were absent in both the Aleuts and Kodiak Island Eskimos. Genetic distance analysis s…
A population genetic study in the Ochamchir Region, Abkhazia, SSR
The reported longevity of residents of the Soviet Socialist Republic of the Caucasus has focused considerable attention on this population. However, little is known of the genetic composition of this population. With this in mind, several village populations of the Ochamchir Region, Abkhazia, SSR, were typed for 37 discrete genetic blood groups, erythrocyte and plasma protein loci. Gene and haplotype frequencies calculated for the polymorphic mar…
Paternity exclusion in primates
Two strategies for the use of polymorphic biochemical and serological markers in paternity testing problems in non‐human primate groups, where pedigree information is incomplete, are discussed. The positive approach, of attempting to prove paternity, is shown to be impracticable given the levels of detectable genetic variation among primates. The more conventional approach of paternity exclusion is examined and found to be useful under certain co…
A linkage study of protein‐coding loci in Macaca mulatta and Macaca fascicularis
Genealogical and gene marker data from the closely related species Macaca mulatta and Macaca fascicularis have been used to search for linkage between genes coding for the blood proteins albumin, carbonic anhydrase 1 and 2, diaphorase 1 and 2, group‐specific component, glucose phosphate isomerase, hemoglobin alpha chains, isocitrate dehydrogenase, prealbumin, and transferrin. The results are consistent with conservation of the linkage between the…
Differential rates of evolution in the carbonic anhydrase isozymes of catarrhine primates
Differential rates of evolution in the carbonic anhydrase isozymes of catarrhine primates
The blacks of Panama
Panama's black citizens are culturally and historically divisible into two groups, the Spanish‐speaking coloniales and the English‐speaking anglos or afro‐antillanos. Until recently these groups have been geographically as well as culturally isolated one from the other, although both are predominantly of West and Southwest African origin. Assessment of the genetic diversity within‐villages and within language groups reveals as much, possibly some…
Paternity exclusion in primates
Two strategies for the use of polymorphic biochemical and serological markers in paternity testing problems in non‐human primate groups, where pedigree information is incomplete, are discussed. The positive approach, of attempting to prove paternity, is shown to be impracticable given the levels of detectable genetic variation among primates. The more conventional approach of paternity exclusion is examined and found to be useful under certain co…
A family study of the hemoglobin polymorphism in Macaca fascicularis
The St. Lawrence Island Eskimos
The Eskimos of St. Lawrence Island have been typed for genetic variation at 44 discrete genetic loci. Three private polymorphisms, at the 2,3‐diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations. Genetic distance analysis reveals a close relationship between the St. Lawrence Island Eskim…
A linkage study of protein‐coding loci in Macaca mulatta and Macaca fascicularis
Genealogical and gene marker data from the closely related species Macaca mulatta and Macaca fascicularis have been used to search for linkage between genes coding for the blood proteins albumin, carbonic anhydrase 1 and 2, diaphorase 1 and 2, group‐specific component, glucose phosphate isomerase, hemoglobin alpha chains, isocitrate dehydrogenase, prealbumin, and transferrin. The results are consistent with conservation of the linkage between the…
A population genetic study in the Ochamchir Region, Abkhazia, SSR
The reported longevity of residents of the Soviet Socialist Republic of the Caucasus has focused considerable attention on this population. However, little is known of the genetic composition of this population. With this in mind, several village populations of the Ochamchir Region, Abkhazia, SSR, were typed for 37 discrete genetic blood groups, erythrocyte and plasma protein loci. Gene and haplotype frequencies calculated for the polymorphic mar…
Individual admixture estimates
The ethnic and geographic distributions of several common chronic diseases show distinct patterns that are consistent with the distribution of genes and genetic admixture. For example, diabetes and gallbladder disease occur most frequently among Amerindians, while those genetically admixed with them (such as Mexican‐Americans) have intermediate rates, and lowest rates are found among Whites and Blacks. Because there will be heterogeneity from ind…
Genetic variation in the Aleuts of the Pribilof Islands and the Eskimos of Kodiak Island
A sample of Aleuts residing in the Pribilof Islands of St. Paul (N = 163) and St. George (N = 62) and Eskimo residents of Kodiak Island (N = 294) have been typed for genetic variation at 31 discrete genetic markers. Of these, 16 were polymorphic and 15 were monomorphic. Several private polymorphisms previously reported in Eskimo or Alaskan Amerindian populations were absent in both the Aleuts and Kodiak Island Eskimos. Genetic distance analysis s…
Application of molecular techniques to the study of human physiological variation
Physiological differences between human populatios, manifest as apparent adaptation to extreme environments, as differences in patterna of growth and development, and as differences in prevalence of common disease, are a mofer subject area of human biology. The approach of the geneticist interested in understanding these difference has been largely that of the proverbial drunk looking for has lost keys. We have characterized those genes whose pro…
DNA “fingerprinting” and the genetic management of a captive chimpanzee population ( Pan troglodytes )
DNA fingerprinting probes are cloned sequences which simultaneously detect a large number of similar hypervariable loci in the target DNA. The resulting highly polymorphic pattern visualized on an autoradiograph allows resolution of questions concerning individual identification and parentage. M13 bacteriophage has been used as a DNA fingerprinting probe for paternity ascertainment among captive chimpanzees housed in multi‐male groups as part of …
Genetic studies of human apolipoproteins. XVII
Variation in human apolipoprotein genes is a major source of phenotypic differences in human lipid metabolism. Data regarding genetic variation at apolipoprotein loci in various populations are only beginning to accumulate, and they suggest that different populations vary widely in distribution of apolipoprotein alleles. Using isoelectric focusing‐immunoblotting techniques, we screened 67 serum samples from self‐identified Samoan residents of Ame…
Allele sharing at six VNTR loci and genetic distances among three ethnically defined human populations
Because of their high degree of polymorphisms, the variable number of tandem repeat (VNTR) loci have become extremely useful in studies involving gene mapping, determination of identity and relatedness of individuals, and evolutionary relationships among populations. However, there are some concerns regarding whether or not the patterns of such genetic variation can be studied by the classical population models that are developed for studying gen…
Molecular studies of the genetics of non–insulin‐dependent diabetes mellitus
Non–insulin‐dependent mellitus (NIDDM) is a common, multifactorial disease with a significant genetic component to disease susceptibility. Biometrical analysis of family data has consistently found evidence of the action of a major gene in determining susceptibility to NIDDM in families. However, the identity of the gene or genes that contribute to NIDDM in the general population is still not known. Recent advances in molecular biology have given…
Distribution of the four founding lineage haplotypes in native Americans suggests a single wave of migration for the New World
The distribution of the four founding lineage haplogroups in Native Americans from North, Central, and South America shows a north to south increase in the frequency of lineage B and a North to South decrease in the frequency of lineage A. All four founding lineage haplogroups were detected in North, Central, and South America, and in Greenberg et al.'s ([1986] Curr. Anthropol. 27: 477–497) three major linguistic groups (Amerind, NaDene, and Eska…
Mitochondrial versus nuclear admixture estimates demonstrate a past history of directional mating
Six blood group antigens (ABO, RH, MNS, KK, KP, FY) and five plasma proteins (HP, GC, APOA4, FXIIIB, C1R) were typed in 790 individuals, and 12 mtDNA RFLP and deletion polymorphisms were typed in 657 individuals from the San Luis Valley, Colorado. The 790 nuclear typings were conducted on 399 Anglos and 391 Hispanics, while the 657 mitochondrial haplotypes were generated from 207 Anglos and 450 Hispanics. Chakraborty's ADMIX2 FORTRAN program was …
Estimating African American Admixture Proportions by Use of Population-Specific Alleles
Mitochondrial DNA variation is an indicator of Austronesian influence in Island Melanesia
Past studies have shown a consistent association of a specific set of mitochondrial DNA 9 base pair (bp) deletion haplotypes with Polynesians and their Austronesian-speaking relatives, and the total lack of the deletion in a short series of New Guinea Highlanders. Utilizing plasma and DNA samples from various old laboratory collections, we have extended population screening for the 9-bp deletion into "Island Melanesia," an area notorious for its …
Mitochondrial DNA variation is an indicator of Austronesian influence in Island Melanesia
Past studies have shown a consistent association of a specific set of mitochondrial DNA 9 base pair (bp) deletion haplotypes with Polynesians and their Austronesian-speaking relatives, and the total lack of the deletion in a short series of New Guinea Highlanders. Utilizing plasma and DNA samples from various old laboratory collections, we have extended population screening for the 9-bp deletion into “Island Melanesia,” an area notorious for its …
Allelic Variation in the Serotonin Transporter Gene-Linked Polymorphic Region (5-HTTLPR) and Cardiovascular Reactivity in Young Adult Male and Female Twins of European-American Descent
OBJECTIVE: To examine the effect of length variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on individual differences in cardiovascular response to psychological challenge. METHODS: Heart rate (HR) and systolic and diastolic blood pressure (SBP, DBP) responses to computerized versions of two psychological challenges, the Stroop Color-Word Interference Test and mental arithmetic, were measured among 131 monozygotic …
Geographic Microsatellite Variability in Central American Howling Monkeys
Heart Rate Variability Is Associated With Polymorphic Variation in the Choline Transporter Gene
OBJECTIVE: The objective of this study was to determine whether interindividual variation in parasympathetic (cholinergic) and sympathetic (adrenergic) regulation of heart rate (as estimated by frequency components of heart rate variability [HRV]) may be accounted for, in part, by genetic variation in the choline transporter, a component of acetylcholine neurotransmission. METHODS: Resting HRV estimates of high- (HF) and low-frequency (LF) power …
The Khatri Sikh Diabetes Study (SDS)
Non-insulin-dependent diabetes mellitus, or type 2 diabetes (T2DM), has become a major public health problem in India. The high prevalence, relatively young age of onset, and strong familial aggregation of T2DM in some Indian communities remains to be explained. Many of the traditional risk factors established for European populations do not appear to be present in Asian Indians. Phase I of the Sikh Diabetes Study (SDS) was launched to build the …
Immunoglobulin allotypes in Southwest Asia
Southwest Asia has a long history of contact with Central Asian and with Sub‐Saharan African populations. Is the genetic structure of these populations reflective of these historical facts? To study this, data was generated on the immunoglobulin heavy chain (GM) and light chain (KM) allotypes from seven Arab and three non‐Arab populations in SW Asia to examine the relationship of these populations to SE European, NW Indian, Sub‐Saharan African, a…
Biology (23 works) · Genetics (20 works) · Genetics (18 works) · Gene (17 works) · Population (14 works) · Demography (13 works) · Evolutionary biology (13 works) · Geography (10 works) · Genotype (9 works) · Allele (8 works)