James A McCubbin
Biographic Data
| ID | 8870959 |
|---|---|
| NAME | James A McCubbin |
| GIVEN NAMES | James A |
| FAMILY NAME | McCubbin |
| SIGNATURE | MCCUBBIN J A |
| AFFILIATIONS | Clemson University |
| ORCID | 0000-0002-1803-4589 |
| VERIFIED | Yes |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 12 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1985 |
| LATEST PUBLICATION YEAR | 2018 |
| H-INDEX | 0 |
Blood Pressure, Emotional Dampening, and Risk Behavior
OBJECTIVE: Elevated resting blood pressure (BP) is associated with risk for hypertension and emotional dampening, including reduced responses to emotionally meaningful stimuli. Perception of threat is a critical motivator in avoidance of risky health-damaging behavior. We hypothesize that BP-associated dampening of threat appraisal may increase risk-taking behavior. METHODS: We measured resting BP, perception of affect, and risk behavior in 92 he…
Cardiovascular-Emotional Dampening
Objective: Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample. Methods: Participants were 106 African American men and women (55 women; mean age = 52.8 years), mainly low in socioeconomic sta…
Stress effects on bilingual language professionals' performance
The work of bilingual language professionals (e.g., translators, diplomats, intelligence analysts) involves substantial use of two or more languages, and often, as well, substantial amounts of stress. This stress can come from many sources, including the language tasks themselves and difficult working conditions. Yet, little is known about how the stressors that bilingual language professionals (BLPs) face influence their language performance or …
Opioid Analgesia in Persons at Risk for Hypertension
OBJECTIVE: Acute pain sensitivity is reduced in clinical hypertension, but the precise relationship between pain perception and altered blood pressure control is not well-characterized. A negative correlation between resting blood pressure and pain sensitivity is observed throughout the normotensive range, suggesting links between basic mechanisms of blood pressure control and pain regulation. The opioid peptides are important endogenous analgesi…
Elevated Resting Blood Pressure and Dampened Emotional Response
OBJECTIVE: Increased blood pressure is associated with decreased reports of aversiveness for both physical pain and psychosocial stressors. Based on these findings, higher blood pressure could be associated with altered emotional responses to a broader range of stimuli. There are at least 3 ways this could happen: a) less dire response to negative stimuli with no change in response to positive stimuli; b) more positive responses to both negative …
Endogenous Opioids Inhibit Ambulatory Blood Pressure During Naturally Occurring Stress
OBJECTIVE: Laboratory experiments suggest that endogenous opioids inhibit blood pressure responses during psychological stress. Moreover, there seem to be considerable individual differences in the efficacy of opioid blood pressure inhibition, and these differences may be involved in the expression of risk for cardiovascular disease. To further evaluate the possible role of opioid mechanisms in cardiovascular control, the present study sought to …
Opioidergic inhibition of circulatory and endocrine stress responses in cynomolgus monkeys
Twenty-five female cynomolgus monkeys (Macaca fascicularis) were exposed to psychological stress (threat of capture) after blockade of endogenous opioids with naloxone and after saline control injections. Heart rates were monitored continuously and blood samples were obtained for determination of plasma levels of cortisol and beta-endorphin-like immunoreactivity. Results indicate that the stress manipulation resulted in increased heart rates as w…
Gender effects on blood pressures obtained during an on-campus screening
In a blood pressure screening of 167 male and female college students, we varied the gender of the screener to evaluate gender effects on blood pressure. Four repeated determinations of resting systolic and diastolic blood pressure were obtained with an automated oscillometric device in a quiet semi-darkened room. Analysis of systolic blood pressure indicated a significant interaction between screener gender, subject gender, and repeated determin…
Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice
The genetically obese mouse (C57BL/6J ob/ob) is a commonly used animal model of non-insulin-dependent diabetes mellitus. These mice show exaggerated glycemic responses during behavioral stress and adrenergic stimulation, but the precise glucoregulatory mechanisms are not well characterized. The ob/ob mice have multiple endocrine abnormalities, including elevated pituitary and circulating beta-endorphin levels; and a relationship between hyperglyc…
Opioid dysfunction and risk for hypertension
Opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential hypertension (McCubbin et al: Hypertension 7:808, 1985). The opiate antagonist naloxone increases blood pressure responses during psychological stress in young adults with low causal blood pressure, but has no pressor effect in subjects with high casual blood pressure. The purpose of the present study was to determine the role of alter…
Alprazolam reduces stress hyperglycemia in ob/ob mice
We have shown that the C57BL/6J ob/ob (obese) mouse, a commonly used model of type II diabetes mellitus, is not in fact consistently hyperglycemic except when exposed to environmental stress. In an attempt to modify stress hyperglycemia in this animal, we administered either a 5 mg/kg dose of the benzodiazepine alprazolam or vehicle (propylene glycol) intraperitoneally to both obese mice and their lean littermates prior to a rest and a stress per…
Classically conditioned hyperglycemia in the obese mouse
The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. It has recently been demonstrated that this mouse is not consistently hyperglycemic, however, unless it is subjected to environmental stress. In the present study, hyperglycemia in obese mice was induced by classical conditioning. Obese diabetic mice and lean control animals were exposed to shaking stress. All animals developed hyperglycem…
No prominent works on this page.
Classically conditioned hyperglycemia in the obese mouse
The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. It has recently been demonstrated that this mouse is not consistently hyperglycemic, however, unless it is subjected to environmental stress. In the present study, hyperglycemia in obese mice was induced by classical conditioning. Obese diabetic mice and lean control animals were exposed to shaking stress. All animals developed hyperglycem…
Alprazolam reduces stress hyperglycemia in ob/ob mice
We have shown that the C57BL/6J ob/ob (obese) mouse, a commonly used model of type II diabetes mellitus, is not in fact consistently hyperglycemic except when exposed to environmental stress. In an attempt to modify stress hyperglycemia in this animal, we administered either a 5 mg/kg dose of the benzodiazepine alprazolam or vehicle (propylene glycol) intraperitoneally to both obese mice and their lean littermates prior to a rest and a stress per…
Opioid dysfunction and risk for hypertension
Opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential hypertension (McCubbin et al: Hypertension 7:808, 1985). The opiate antagonist naloxone increases blood pressure responses during psychological stress in young adults with low causal blood pressure, but has no pressor effect in subjects with high casual blood pressure. The purpose of the present study was to determine the role of alter…
Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice
The genetically obese mouse (C57BL/6J ob/ob) is a commonly used animal model of non-insulin-dependent diabetes mellitus. These mice show exaggerated glycemic responses during behavioral stress and adrenergic stimulation, but the precise glucoregulatory mechanisms are not well characterized. The ob/ob mice have multiple endocrine abnormalities, including elevated pituitary and circulating beta-endorphin levels; and a relationship between hyperglyc…
Gender effects on blood pressures obtained during an on-campus screening
In a blood pressure screening of 167 male and female college students, we varied the gender of the screener to evaluate gender effects on blood pressure. Four repeated determinations of resting systolic and diastolic blood pressure were obtained with an automated oscillometric device in a quiet semi-darkened room. Analysis of systolic blood pressure indicated a significant interaction between screener gender, subject gender, and repeated determin…
Opioidergic inhibition of circulatory and endocrine stress responses in cynomolgus monkeys
Twenty-five female cynomolgus monkeys (Macaca fascicularis) were exposed to psychological stress (threat of capture) after blockade of endogenous opioids with naloxone and after saline control injections. Heart rates were monitored continuously and blood samples were obtained for determination of plasma levels of cortisol and beta-endorphin-like immunoreactivity. Results indicate that the stress manipulation resulted in increased heart rates as w…
Endogenous Opioids Inhibit Ambulatory Blood Pressure During Naturally Occurring Stress
OBJECTIVE: Laboratory experiments suggest that endogenous opioids inhibit blood pressure responses during psychological stress. Moreover, there seem to be considerable individual differences in the efficacy of opioid blood pressure inhibition, and these differences may be involved in the expression of risk for cardiovascular disease. To further evaluate the possible role of opioid mechanisms in cardiovascular control, the present study sought to …
Elevated Resting Blood Pressure and Dampened Emotional Response
OBJECTIVE: Increased blood pressure is associated with decreased reports of aversiveness for both physical pain and psychosocial stressors. Based on these findings, higher blood pressure could be associated with altered emotional responses to a broader range of stimuli. There are at least 3 ways this could happen: a) less dire response to negative stimuli with no change in response to positive stimuli; b) more positive responses to both negative …
Stress effects on bilingual language professionals' performance
The work of bilingual language professionals (e.g., translators, diplomats, intelligence analysts) involves substantial use of two or more languages, and often, as well, substantial amounts of stress. This stress can come from many sources, including the language tasks themselves and difficult working conditions. Yet, little is known about how the stressors that bilingual language professionals (BLPs) face influence their language performance or …
Opioid Analgesia in Persons at Risk for Hypertension
OBJECTIVE: Acute pain sensitivity is reduced in clinical hypertension, but the precise relationship between pain perception and altered blood pressure control is not well-characterized. A negative correlation between resting blood pressure and pain sensitivity is observed throughout the normotensive range, suggesting links between basic mechanisms of blood pressure control and pain regulation. The opioid peptides are important endogenous analgesi…
Cardiovascular-Emotional Dampening
Objective: Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample. Methods: Participants were 106 African American men and women (55 women; mean age = 52.8 years), mainly low in socioeconomic sta…
Blood Pressure, Emotional Dampening, and Risk Behavior
OBJECTIVE: Elevated resting blood pressure (BP) is associated with risk for hypertension and emotional dampening, including reduced responses to emotionally meaningful stimuli. Perception of threat is a critical motivator in avoidance of risky health-damaging behavior. We hypothesize that BP-associated dampening of threat appraisal may increase risk-taking behavior. METHODS: We measured resting BP, perception of affect, and risk behavior in 92 he…
Internal Medicine (11 works) · Internal Medicine (11 works) · Medicine (11 works) · Blood pressure (7 works) · Psychology (6 works) · Endocrinology (5 works) · Endocrinology (5 works) · Opioid (5 works) · Stress Responses and Cortisol (5 works) · Endogenous opioid (4 works)