John Furst
Biographic Data
| ID | 8945895 |
|---|---|
| NAME | John Furst |
| GIVEN NAMES | John |
| FAMILY NAME | Furst |
| SIGNATURE | FURST J |
| AFFILIATIONS | Maths & Physical Sciences University of Newcastle Ourimbah New South Wales Australia |
| VERIFIED | No |
| TOTAL WORKS | 5 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 5 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2017 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 0 |
Biophysical evidence to support and extend the vitamin D‐folate hypothesis as a paradigm for the evolution of human skin pigmentation
Objective To test the “vitamin D‐folate hypothesis for the evolution of human skin pigmentation.” Methods Total ozone mapping spectrometer (TOMS) satellite data were used to examine surface UV‐irradiance in a large ( n = 649) Australian cross‐sectional study population. Genetic analysis was used to score vitamin D‐ and folate‐related gene polymorphisms ( n = 22), along with two pigmentation gene variants ( IRF4 ‐rs12203592/ HERC2‐ rs12913832). Re…
Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes
Objectives Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV‐exposure on late‐life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). Methods Six hun…
Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition
Objectives The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D 3 Levels; (2) to explore whether folate‐related gene variants that influence/alter DNA‐thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate‐v…
UV‐associated decline in systemic folate: Implications for human nutrigenetics, health, and evolutionary processes
OBJECTIVES: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin pigmentation. METHODS: Total Ozone Mapping Spectrometer (TOMS) satellite data were used to examine surface UV-irradiance, as a marker of UV exposure, in a large (n = 649) Australian cross-sectional study population. PCR/RFLP analysi…
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences
Objectives The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene‐latitude effects. METHODS Eighty subjects were examined for VDR gene‐CpG island methylation density. VDR gene variants were also examined…
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UV‐associated decline in systemic folate: Implications for human nutrigenetics, health, and evolutionary processes
OBJECTIVES: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin pigmentation. METHODS: Total Ozone Mapping Spectrometer (TOMS) satellite data were used to examine surface UV-irradiance, as a marker of UV exposure, in a large (n = 649) Australian cross-sectional study population. PCR/RFLP analysi…
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences
Objectives The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene‐latitude effects. METHODS Eighty subjects were examined for VDR gene‐CpG island methylation density. VDR gene variants were also examined…
Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition
Objectives The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D 3 Levels; (2) to explore whether folate‐related gene variants that influence/alter DNA‐thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate‐v…
Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes
Objectives Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV‐exposure on late‐life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). Methods Six hun…
Biophysical evidence to support and extend the vitamin D‐folate hypothesis as a paradigm for the evolution of human skin pigmentation
Objective To test the “vitamin D‐folate hypothesis for the evolution of human skin pigmentation.” Methods Total ozone mapping spectrometer (TOMS) satellite data were used to examine surface UV‐irradiance in a large ( n = 649) Australian cross‐sectional study population. Genetic analysis was used to score vitamin D‐ and folate‐related gene polymorphisms ( n = 22), along with two pigmentation gene variants ( IRF4 ‐rs12203592/ HERC2‐ rs12913832). Re…
Biology (5 works) · Gene (4 works) · Genetics (4 works) · Skin Protection and Aging (4 works) · Vitamin D Research Studies (4 works) · Endocrinology (3 works) · Genotype (3 works) · Internal Medicine (3 works) · Medicine (3 works) · Vitamin (3 works)