Bryan Greenhouse
Biographic Data
| ID | 9063517 |
|---|---|
| NAME | Bryan Greenhouse |
| GIVEN NAMES | Bryan |
| FAMILY NAME | Greenhouse |
| SIGNATURE | GREENHOUSE B |
| AFFILIATIONS | University of California, San Francisco |
| ORCID | 0000-0003-0287-9111 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2021 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Imported malaria predominates in near-elimination settings in Southwestern Uganda
Malaria transmission in southwestern Uganda is low, but persists despite control efforts. Identifying whether infections are locally sustained or imported by travelers is critical for guiding interventions. We integrated epidemiologic surveillance with parasite genomics to characterize imported malaria episodes at three health facilities in southwestern Uganda. Between January 2023 and June 2024, we enrolled microscopy-confirmed malaria cases at …
Target product profiles of laboratory and data analytical frameworks for genotyping to monitor antimalarial efficacy
Therapeutic efficacy studies (TESs) are the standard to evaluate antimalarial drug efficacy and guide malaria treatment policy. TESs are particularly relevant now, with resistance to first-line regimens emerging in sub-Saharan Africa. For TESs, a range of parasite genotyping and data analyses are available for genotype correction, a process to distinguish whether recurrent parasitemia after therapy is due to recrudescence of initially infecting p…
Targeting malaria in high-risk populations in low endemic regions in northern Namibia
BACKGROUND: Agricultural worksites are rarely targeted by malaria control programmes, yet may play a role in maintaining local transmission due to workers' high mobility, low intervention coverage and occupational exposures. METHODS: A quasi-experimental controlled intervention study was carried out in farming and cattle herding populations in northern Namibia to evaluate the impact of a targeted malaria intervention package. Eight health facilit…
Feasibility and effectiveness of tailored interventions for two populations at high-risk of malaria in Senegal
Senegal has made significant progress in reducing the malaria burden over the last decade. However, malaria remains a major cause of morbidity in some regions and key challenges exist among high-risk populations who have high exposure to mosquitos, but low coverage and use of vector control measures and limited access to healthcare. Two identified high-risk populations are goldminers and talibés (Koranic school students). We conducted a controlle…
Disentangling the roles of different vector species during a malaria resurgence in Eastern Uganda
In 2021–23, a resurgence of malaria occurred in the Tororo District of Uganda following a change in formulations used for indoor residual spraying of insecticide (IRS). Prior analyses showed that this increase was temporally associated with the replacement of Anopheles gambiae sensu lato by An. funestus as the dominant local vector. To investigate this association, we used data from a cohort of 422 children in 94 households from 2021-2023 in Toro…
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda
Tororo District, Uganda experienced a dramatic decrease in malaria burden from 2015–19 during 5 years of indoor residual spraying (IRS) with carbamate (Bendiocarb) and then organophosphate (Actellic) insecticides. However, a marked resurgence occurred in 2020, which coincided with a change to a clothianidin-based IRS formulations (Fludora Fusion/SumiShield). To quantify the magnitude of the resurgence, investigate causes, and evaluate the impact …
Mapping malaria incidence using routine health facility surveillance data in Uganda
INTRODUCTION: Maps of malaria risk are important tools for allocating resources and tracking progress. Most maps rely on cross-sectional surveys of parasite prevalence, but health facilities represent an underused and powerful data source. We aimed to model and map malaria incidence using health facility data in Uganda. METHODS: Using 24 months (2019-2020) of individual-level outpatient data collected from 74 surveillance health facilities locate…
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized that metagenomic next-generation sequencing (mNGS), which allows for broad genomic-level detection of infectious agents in a biological sample, can systematically identify potential causes of non-malarial fevers. The 212 participants in this study were of all ages and were enrolled in a longitudinal malaria cohort in eastern Uganda. Between December 2020 and …
Resurgence of malaria in Uganda despite sustained indoor residual spraying and repeated long lasting insecticidal net distributions
Five years of sustained indoor residual spraying (IRS) of insecticide from 2014 to 2019, first using a carbamate followed by an organophosphate, was associated with a marked reduction in the incidence of malaria in five districts of Uganda. We assessed changes in malaria incidence over an additional 21 months, corresponding to a change in IRS formulations using clothianidin with and without deltamethrin. Using enhanced health facility surveillanc…
Effectiveness and safety of reactive focal mass drug administration (rfMDA) using dihydroartemisinin–piperaquine to reduce malaria transmission in the very low-endemic setting of Eswatini
INTRODUCTION: To reduce malaria transmission in very low-endemic settings, screening and treatment near index cases (reactive case detection (RACD)), is widely practised, but the rapid diagnostic tests (RDTs) used miss low-density infections. Reactive focal mass drug administration (rfMDA) may be safe and more effective. METHODS: We conducted a pragmatic cluster randomised controlled trial in Eswatini, a very low-endemic setting. 77 clusters were…
No prominent works on this page.
Effectiveness and safety of reactive focal mass drug administration (rfMDA) using dihydroartemisinin–piperaquine to reduce malaria transmission in the very low-endemic setting of Eswatini
INTRODUCTION: To reduce malaria transmission in very low-endemic settings, screening and treatment near index cases (reactive case detection (RACD)), is widely practised, but the rapid diagnostic tests (RDTs) used miss low-density infections. Reactive focal mass drug administration (rfMDA) may be safe and more effective. METHODS: We conducted a pragmatic cluster randomised controlled trial in Eswatini, a very low-endemic setting. 77 clusters were…
Resurgence of malaria in Uganda despite sustained indoor residual spraying and repeated long lasting insecticidal net distributions
Five years of sustained indoor residual spraying (IRS) of insecticide from 2014 to 2019, first using a carbamate followed by an organophosphate, was associated with a marked reduction in the incidence of malaria in five districts of Uganda. We assessed changes in malaria incidence over an additional 21 months, corresponding to a change in IRS formulations using clothianidin with and without deltamethrin. Using enhanced health facility surveillanc…
Mapping malaria incidence using routine health facility surveillance data in Uganda
INTRODUCTION: Maps of malaria risk are important tools for allocating resources and tracking progress. Most maps rely on cross-sectional surveys of parasite prevalence, but health facilities represent an underused and powerful data source. We aimed to model and map malaria incidence using health facility data in Uganda. METHODS: Using 24 months (2019-2020) of individual-level outpatient data collected from 74 surveillance health facilities locate…
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized that metagenomic next-generation sequencing (mNGS), which allows for broad genomic-level detection of infectious agents in a biological sample, can systematically identify potential causes of non-malarial fevers. The 212 participants in this study were of all ages and were enrolled in a longitudinal malaria cohort in eastern Uganda. Between December 2020 and …
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda
Tororo District, Uganda experienced a dramatic decrease in malaria burden from 2015–19 during 5 years of indoor residual spraying (IRS) with carbamate (Bendiocarb) and then organophosphate (Actellic) insecticides. However, a marked resurgence occurred in 2020, which coincided with a change to a clothianidin-based IRS formulations (Fludora Fusion/SumiShield). To quantify the magnitude of the resurgence, investigate causes, and evaluate the impact …
Targeting malaria in high-risk populations in low endemic regions in northern Namibia
BACKGROUND: Agricultural worksites are rarely targeted by malaria control programmes, yet may play a role in maintaining local transmission due to workers' high mobility, low intervention coverage and occupational exposures. METHODS: A quasi-experimental controlled intervention study was carried out in farming and cattle herding populations in northern Namibia to evaluate the impact of a targeted malaria intervention package. Eight health facilit…
Feasibility and effectiveness of tailored interventions for two populations at high-risk of malaria in Senegal
Senegal has made significant progress in reducing the malaria burden over the last decade. However, malaria remains a major cause of morbidity in some regions and key challenges exist among high-risk populations who have high exposure to mosquitos, but low coverage and use of vector control measures and limited access to healthcare. Two identified high-risk populations are goldminers and talibés (Koranic school students). We conducted a controlle…
Disentangling the roles of different vector species during a malaria resurgence in Eastern Uganda
In 2021–23, a resurgence of malaria occurred in the Tororo District of Uganda following a change in formulations used for indoor residual spraying of insecticide (IRS). Prior analyses showed that this increase was temporally associated with the replacement of Anopheles gambiae sensu lato by An. funestus as the dominant local vector. To investigate this association, we used data from a cohort of 422 children in 94 households from 2021-2023 in Toro…
Imported malaria predominates in near-elimination settings in Southwestern Uganda
Malaria transmission in southwestern Uganda is low, but persists despite control efforts. Identifying whether infections are locally sustained or imported by travelers is critical for guiding interventions. We integrated epidemiologic surveillance with parasite genomics to characterize imported malaria episodes at three health facilities in southwestern Uganda. Between January 2023 and June 2024, we enrolled microscopy-confirmed malaria cases at …
Target product profiles of laboratory and data analytical frameworks for genotyping to monitor antimalarial efficacy
Therapeutic efficacy studies (TESs) are the standard to evaluate antimalarial drug efficacy and guide malaria treatment policy. TESs are particularly relevant now, with resistance to first-line regimens emerging in sub-Saharan Africa. For TESs, a range of parasite genotyping and data analyses are available for genotype correction, a process to distinguish whether recurrent parasitemia after therapy is due to recrudescence of initially infecting p…
Malaria (9 works) · Malaria Research and Control (9 works) · Medicine (7 works) · Mosquito-borne diseases and control (7 works) · Environmental health (6 works) · Immunology (5 works) · Plasmodium falciparum (4 works) · Biology (3 works) · Cohort (3 works) · Indoor residual spraying (3 works)