Gathsaurie Neelika Malavige

Biographic Data

ID9064111
NAMEGathsaurie Neelika Malavige
GIVEN NAMESGathsaurie Neelika
FAMILY NAMEMalavige
SIGNATUREMALAVIGE G N
AFFILIATIONSUniversity of Sri Jayewardenepura
ORCID0000-0001-9201-0449
VERIFIEDYes
TOTAL WORKS9
TOTAL CITATIONS0
AUTHOR COUNT7
EDITOR COUNT2
FIRST PUBLICATION YEAR2020
LATEST PUBLICATION YEAR2023
H-INDEX0

  • Facing the escalating burden of dengue

    Open AccessGathsaurie Neelika Malavige, Peter Sjö et al.ARTICLEPLOS Global Public Health2023

    Dengue is the most rapidly emerging mosquito-borne infection and, due to climate change and unplanned urbanization, it is predicted that the global burden of dengue will rise further as the infection spreads to new geographical locations. Dengue-endemic countries are often unable to cope with such increases, with health care facilities becoming overwhelmed during each dengue season. Furthermore, although dengue has been predominantly a childhood …

  • Analytical and diagnostic performance characteristics of reverse-transcriptase loop-mediated isothermal amplification assays for dengue virus serotypes 1–4

    Open AccessPaul Arkell, Dumrong Mairiang et al.ARTICLEPLOS Global Public Health2023

    Dengue is a mosquito-borne disease caused by dengue virus (DENV) serotypes 1–4 which affects 100–400 million adults and children each year. Reverse-transcriptase (RT) quantitative polymerase chain reaction (qPCR) assays are the current gold-standard in diagnosis and serotyping of infections, but their use in low-middle income countries (LMICs) has been limited by laboratory infrastructure requirements. Loop-mediated isothermal amplification (LAMP…

  • Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka

    Open AccessDiyanath Ranasinghe, D M S H K Ranasinghe et al.ARTICLEFrontiers in Public Health2022

    Background The worst SARS-CoV-2 outbreak in Sri Lanka was due to the two Sri Lankan delta sub-lineages AY.28 and AY.104. We proceeded to further characterize the mutations and clinical disease severity of these two sub-lineages. Methods 705 delta SARS-CoV-2 genomes sequenced by our laboratory from mid-May to November 2021 using Illumina and Oxford Nanopore were included in the analysis. The clinical disease severity of 440/705 individuals were fu…

  • Epidemiological and virological factors determining dengue transmission in Sri Lanka during the Covid-19 pandemic

    Open AccessDinuka Ariyaratne, Laksiri Gomes et al.ARTICLEPLOS Global Public Health2022

    With the onset of the COVID-19 pandemic in early 2020 there was a drastic reduction in the number of dengue cases in Sri Lanka, with an increase towards the end of 2021. We sought to study the contribution of virological factors, human mobility, school closure and mosquito factors in affecting these changes in dengue transmission in Sri Lanka during this time. To understand the reasons for the differences in the dengue case numbers in 2020 to 202…

  • Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka

    Open AccessChandima Jeewandara, K A Chintha S Jayampathi et al.ARTICLEPLOS Global Public Health2022

    Background There are limited data regarding the safety and immunogenicity of the Sinopharm/BBIBP-CorV vaccine in pregnancy. Therefore, we sought to investigate the antibody responses and maternal and fetal adverse events following this vaccine in pregnant mothers in Sri Lanka. Methods and findings SARS-CoV-2 receptor binding domain (RBD) specific total antibodies and ACE2 blocking antibodies were measured by ELISA in pregnant mothers (n = 94) who…

  • Seroprevalence of Sars-CoV-2 antibodies in Bali Province

    Open AccessAnak A S Sawitri, Putu Cintya Denny Yuliyatni et al.ARTICLEPLOS Global Public Health2022

    The international tourist destination of Bali reported its first case of Coronavirus Disease 2019 or COVID-19 in March 2020. To better understand the extent of exposure of Bali’s 4.3 million inhabitants to the COVID-19 virus, we performed two repeated cross-sectional serosurveys stratified by urban and rural areas. We used a highly specific multiplex assay that detects antibodies to three different viral antigens. We also assessed demographic and…

  • Seroprevalence of Sars-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka

    Open AccessChandima Jeewandara, Dinuka Guruge et al.ARTICLEFrontiers in Public Health2021

    Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak. Methods: SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence usi…

  • Stronger together

    Open AccessShashika Bandara, Soumyadeep Bhaumik et al.ARTICLEBMJ Global Health2021

    The global increase in COVID-19 cases in 2021 has primarily been due to an uncontrolled surge in South Asia. It is estimated that by 1 September 2021, approximately 1.4 million in South Asians will die due to COVID-19 alone.1 The total number of excess deaths will be much higher—including non-COVID causes, as health systems are on the brink of collapse.2 With 33.4% of South Asians being extremely poor3 and the large-scale loss of livelihood being…

  • Identification of Immune Responses to Japanese Encephalitis Virus Specific T Cell Epitopes

    Open AccessPradeep Darshana Pushpakumara, Chandima Jeewandara et al.ARTICLEFrontiers in Public Health2020

    Background: Due to the similarity between the dengue (DENV) and the Japanese encephalitis virus (JEV) there is potential for immune cross-reaction. We sought to identify T cell epitopes that are specific to JEV and do not cross react with DENV. Methodology: 20mer peptides were synthesized from regions which showed >90% conservation. Using IFNγ cultured ELISpot assays, we investigated JEV-specific T cell responses in DENV- and JEV- non-immune indi…