Chris Drakeley
Datos Biográficos
| ID | 9065871 |
|---|---|
| NOMBRE | Chris Drakeley |
| NOMBRES | Chris |
| APELLIDO | Drakeley |
| FIRMA | DRAKELEY C |
| AFILIACIONES | London School of Hygiene & Tropical Medicine |
| ORCID | 0000-0003-4863-075X |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 11 |
| TOTAL DE CITAS | 0 |
| TOTAL COMO AUTOR | 11 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2019 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 0 |
Integrating forest data and health facility surveys to optimise risk-based malaria surveillance in the Philippines
Introduction: Malaria transmission is highly spatially heterogeneous. Within Southeast Asia, forested landscapes are associated both with increased malaria transmission and reduced healthcare access. Identifying environments with malaria foci is a priority for control and elimination programmes. Methods: Here, we integrate health facility and environmental data to identify optimal surveillance approaches across a forested district in the Philippi…
Self-reported Covid-19 severity among persons with tuberculosis infection in western Kenya, 2021
Whilst a quarter of the world’s population is estimated to be infected with Mycobacterium tuberculosis , it is unknown whether TB infection (TBI) increases the risk of severe COVID-19, which is relevant in TB-endemic settings, especially where HIV co-infection is also common. A convenience cohort of symptomatic and asymptomatic COVID-19 patients aged 8–80 years in western Kenya was followed daily for 14 days to assess disease progression using th…
Freedom from infection
Assessing elimination of malaria locally requires a surveillance system with high sensitivity and specificity to detect its presence without ambiguity. Currently, the WHO standard criteria of observing the absence of locally acquired cases for 3 consecutive years, combined with a health systems assessment, are used to justify claims of malaria elimination. However, relying on a qualitative framework to support the application of this guideline ca…
Brazil towards malaria elimination
Malaria is a global health challenge, and international efforts are underway to alleviate its impact by 2035. Within the 249 million global cases, 0.6 million occur in the Americas, mainly in Venezuela, Brazil, and Colombia. Considering Brazil’s geographical proximity to malaria-endemic countries in South America, this study objective is to analyze the epidemiological characteristics and time trends of imported malaria cases in Brazil from 2007 t…
Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023
In Brazil, 99% of malaria cases occur in the Amazon region, mainly caused by Plasmodium vivax (~83%) and Plasmodium falciparum ( Pf ) species. Aligned with the Sustainable Development Goals, Brazil aims to eliminate autochthonous malaria by 2035. This study aims to analyse epidemiological patterns of malaria in Brazil to discuss if Brazil is on track to meet malaria control targets. A time-series study was conducted analysing autochthonous malari…
Assessing seroprevalence and associated risk factors for multiple infectious diseases in Sabah, Malaysia using serological multiplex bead assays
Background: Infectious diseases continue to burden populations in Malaysia, especially among rural communities where resources are limited and access to health care is difficult. Current epidemiological trends of several neglected tropical diseases in these populations are at present absent due to the lack of habitual and efficient surveillance. To date, various studies have explored the utility of serological multiplex beads to monitor numerous …
Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey
Background Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Haiti is an island nation …
House design and risk of malaria, acute respiratory infection and gastrointestinal illness in Uganda
House construction is rapidly modernizing across Africa but the potential benefits for human health are poorly understood. We hypothesised that improvements to housing would be associated with reductions in malaria, acute respiratory infection (ARI) and gastrointestinal illness in an area of low malaria endemicity in Uganda. Data were analysed from a cohort study of male and female child and adult residents (n = 531) of 80 randomly-selected house…
Reactive focal drug administration associated with decreased malaria transmission in an elimination setting
Efforts to eliminate malaria transmission need evidence-based strategies. However, accurately assessing end-game malaria elimination strategies is challenging due to the low level of transmission and the rarity of infections. We hypothesised that presumptively treating individuals during reactive case detection (RCD) would reduce transmission and that serology would more sensitively detect this change over standard approaches. We conducted a clus…
Comparison of Commercial Elisa Kits to Confirm the Absence of Transmission in Malaria Elimination Settings
Background Antimalarial antibody measurements are useful because they reflect historical and recent exposure to malaria. As such, they may provide additional information to assess ongoing transmission in low endemic or pre-elimination settings where cases are rare. In addition, the absence of antibody responses in certain individuals can indicate the cessation of transmission. Commercial malaria enzyme-linked immunosorbent assays (ELISA) detect a…
Long-Tailed Macaque Response to Deforestation in a Plasmodium knowlesi-Endemic Area
Land-use changes can impact infectious disease transmission by increasing spatial overlap between people and wildlife disease reservoirs. In Malaysian Borneo, increases in human infections by the zoonotic malaria Plasmodium knowlesi are hypothesised to be due to increasing contact between people and macaques due to deforestation. To explore how macaque responses to environmental change impact disease risks, we analysed movement of a GPS-collared …
Sin obras prominentes en esta página.
Long-Tailed Macaque Response to Deforestation in a Plasmodium knowlesi-Endemic Area
Land-use changes can impact infectious disease transmission by increasing spatial overlap between people and wildlife disease reservoirs. In Malaysian Borneo, increases in human infections by the zoonotic malaria Plasmodium knowlesi are hypothesised to be due to increasing contact between people and macaques due to deforestation. To explore how macaque responses to environmental change impact disease risks, we analysed movement of a GPS-collared …
Comparison of Commercial Elisa Kits to Confirm the Absence of Transmission in Malaria Elimination Settings
Background Antimalarial antibody measurements are useful because they reflect historical and recent exposure to malaria. As such, they may provide additional information to assess ongoing transmission in low endemic or pre-elimination settings where cases are rare. In addition, the absence of antibody responses in certain individuals can indicate the cessation of transmission. Commercial malaria enzyme-linked immunosorbent assays (ELISA) detect a…
Assessing seroprevalence and associated risk factors for multiple infectious diseases in Sabah, Malaysia using serological multiplex bead assays
Background: Infectious diseases continue to burden populations in Malaysia, especially among rural communities where resources are limited and access to health care is difficult. Current epidemiological trends of several neglected tropical diseases in these populations are at present absent due to the lack of habitual and efficient surveillance. To date, various studies have explored the utility of serological multiplex beads to monitor numerous …
Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey
Background Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Haiti is an island nation …
House design and risk of malaria, acute respiratory infection and gastrointestinal illness in Uganda
House construction is rapidly modernizing across Africa but the potential benefits for human health are poorly understood. We hypothesised that improvements to housing would be associated with reductions in malaria, acute respiratory infection (ARI) and gastrointestinal illness in an area of low malaria endemicity in Uganda. Data were analysed from a cohort study of male and female child and adult residents (n = 531) of 80 randomly-selected house…
Reactive focal drug administration associated with decreased malaria transmission in an elimination setting
Efforts to eliminate malaria transmission need evidence-based strategies. However, accurately assessing end-game malaria elimination strategies is challenging due to the low level of transmission and the rarity of infections. We hypothesised that presumptively treating individuals during reactive case detection (RCD) would reduce transmission and that serology would more sensitively detect this change over standard approaches. We conducted a clus…
Freedom from infection
Assessing elimination of malaria locally requires a surveillance system with high sensitivity and specificity to detect its presence without ambiguity. Currently, the WHO standard criteria of observing the absence of locally acquired cases for 3 consecutive years, combined with a health systems assessment, are used to justify claims of malaria elimination. However, relying on a qualitative framework to support the application of this guideline ca…
Brazil towards malaria elimination
Malaria is a global health challenge, and international efforts are underway to alleviate its impact by 2035. Within the 249 million global cases, 0.6 million occur in the Americas, mainly in Venezuela, Brazil, and Colombia. Considering Brazil’s geographical proximity to malaria-endemic countries in South America, this study objective is to analyze the epidemiological characteristics and time trends of imported malaria cases in Brazil from 2007 t…
Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023
In Brazil, 99% of malaria cases occur in the Amazon region, mainly caused by Plasmodium vivax (~83%) and Plasmodium falciparum ( Pf ) species. Aligned with the Sustainable Development Goals, Brazil aims to eliminate autochthonous malaria by 2035. This study aims to analyse epidemiological patterns of malaria in Brazil to discuss if Brazil is on track to meet malaria control targets. A time-series study was conducted analysing autochthonous malari…
Integrating forest data and health facility surveys to optimise risk-based malaria surveillance in the Philippines
Introduction: Malaria transmission is highly spatially heterogeneous. Within Southeast Asia, forested landscapes are associated both with increased malaria transmission and reduced healthcare access. Identifying environments with malaria foci is a priority for control and elimination programmes. Methods: Here, we integrate health facility and environmental data to identify optimal surveillance approaches across a forested district in the Philippi…
Self-reported Covid-19 severity among persons with tuberculosis infection in western Kenya, 2021
Whilst a quarter of the world’s population is estimated to be infected with Mycobacterium tuberculosis , it is unknown whether TB infection (TBI) increases the risk of severe COVID-19, which is relevant in TB-endemic settings, especially where HIV co-infection is also common. A convenience cohort of symptomatic and asymptomatic COVID-19 patients aged 8–80 years in western Kenya was followed daily for 14 days to assess disease progression using th…
Immunology (9 obras) · Medicine (9 obras) · Malaria (8 obras) · Environmental health (7 obras) · Malaria Research and Control (7 obras) · Mosquito-borne diseases and control (6 obras) · Population (5 obras) · Biology (4 obras) · Antibody (3 obras) · Computer Science (3 obras)