Andrea Novelletto
Biographic Data
| ID | 95876 |
|---|---|
| NAME | Andrea Novelletto |
| GIVEN NAMES | Andrea |
| FAMILY NAME | Novelletto |
| SIGNATURE | NOVELLETTO A |
| AFFILIATIONS | University of Rome Tor Vergata |
| ORCID | 0000-0002-1146-7680 |
| VERIFIED | Yes |
| TOTAL WORKS | 15 |
| TOTAL CITATIONS | 14 |
| AUTHOR COUNT | 15 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2000 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 3 |
Genetic variation patterns of β-thalassemia in Western Andalusia (Spain) reveal a structure of specific mutations within the Iberian Peninsula
The long history of endemic malaria in the study territory, the rather high consanguinity rates among its autochthonous population, and other demographic features have been used here to understand the western Andalusian β-thalassemia molecular portrait
Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations
OBJECTIVES: The 3' regulatory region of the immunoglobulin heavy chain gene (IGH) includes the HS1.2 enhancer displaying length polymorphism with four known variants. The goal of the research was to provide an overview of this variability and of its evolutionary significance across human populations. MATERIALS AND METHODS: We compiled published and original data on HS1.2 polymorphism in 3,100 subjects from 26 human populations. Moreover, we imput…
Paternal lineages in southern Iberia provide time frames for gene flow from mainland Europe and the Mediterranean world
The particular Andalusian R1b-M269 assemblage confirms the shallow topology of the clade. Moreover, the sharing of lineages with the rest of Europe indicates the impact in Iberia of an amount of pre-existing diversity, with the possible exception of R1b-DF27. Lineages such as J2-M172 and G-M201 highlight the importance of maritime travels of early farmers who reached the Iberian Peninsula
A genetic portrait of the South‐Eastern Carpathians based on autosomal short tandem repeats loci used in forensics
OBJECTIVES: This work aimed to describe the genetic landscape of the Balkan Peninsula, as revealed by STR markers commonly used in forensics and spatial methods specifically developed for genetic data. METHODS: We generated and analyzed 16 short tandem repeats (STRs) autosomal genotypes in 287 subjects from ten administrative/geographical regions of Eastern Europe (Romania and the Republic of Moldova). We report estimates of the allele frequencie…
Enlarging the gene-geography of Europe and the Mediterranean area to STR loci of common forensic use
Four of the eight STR loci (or even alleles) considered here can reproducibly capture continental arrangements of diversity. This would, in principle, allow for the exploitation of forensic data to clarify important aspects in the formation of local gene pools
Internal diversification of non‐Sub‐Saharan haplogroups in Sahelian populations and the spread of pastoralism beyond the Sahara
BACKGROUND: Today, African pastoralists are found mainly in the Sahel/Savannah belt spanning 6,000 km from west to east, flanked by the Sahara to the north and tropical rainforests to the south. The most significant group among them are the Fulani who not only keep cattle breeds of possible West Eurasian ancestry, but form themselves a gene pool containing some paternally and maternally-transmitted West Eurasian haplogroups. MATERIALS AND METHODS…
Multiple and differentiated contributions to the male gene pool of pastoral and farmer populations of the African Sahel
The African Sahel is conducive to studies of divergence/admixture genetic events as a result of its population history being so closely related with past climatic changes. Today, it is a place of the co‐existence of two differing food‐producing subsistence systems, i.e., that of sedentary farmers and nomadic pastoralists, whose populations have likely been formed from several dispersed indigenous hunter‐gatherer groups. Using new methodology, we …
The Andalusian population from Huelva reveals a high diversification of Y-DNA paternal lineages from haplogroup E
The haplogroup E among Western Andalusians revealed a complex admixture of genetic markers from the Mediterranean space, with interesting signatures of populations from the Middle East and the Balkan Peninsula and a surprisingly low influence by Berber populations compared to other areas of the Iberian Peninsula
Recurrent mutation in SNPs within Y chromosome E3b (E‐M215) haplogroup
In a previous issue of AJHB, Fernandes et al. (2008. Am J Hum Biol 20:185–190.) describe instances of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E‐M35 sub‐haplogroups. They interpret these findings as evidence for multiple mutational events in at least two loci (M78 and M81). Here, we introduce a novel polymorphic marker (V68), potentially useful to investigate the issue. This marker …
Phylogeography of Y chromosomal haplogroups as reporters of Neolithic and post-Neolithic population processes in the Mediterranean area
The phylogeny of the human Y chromosome as defined by unique event polymorphisms is being worked out in fine detail. The emerging picture of the geographic distribution of different branches of the evolutionary tree (haplogroups), and the possibility of genetically dating their antiquity, are important tools in the reconstruction of major peopling, population resettlement and demographic expansion events. In the last 10 000 years many such events…
Y chromosome variation in Europe
The polymorphism of the male-specific portion of the Y chromosome has been increasingly used to describe the composition of the European gene pool and to reconstruct its formation. Here the theoretical grounds and the limitations of this approach are presented, together with the different views on debated issues. The emerging picture for the composition of the male gene pool of the continent is illustrated, but local peculiarities that represent …
Y‐chromosomal variation in the Czech Republic
To analyze the contribution of the Czech population to the Y‐chromosome diversity landscape of Europe and to reconstruct past demographic events, we typed 257 males from five locations for 21 UEPs. Moreover, 141 carriers of the three most common haplogroups were typed for 10 microsatellites and coalescent analyses applied. Sixteen Hg's characterized by derived alleles were identified, the most common being R1a‐SRY 10831 and P‐DYS257*(xR1a). The p…
A human derived SSADH coding variant is replacing the ancestral allele shared with primates
The analysis of robust correlations based on a large panel of populations is potentially able to identify clusters of genomic regions or genes showing co-evolution of the frequencies of derived alleles
Analysis of three RFLPs of the COL1A2 (Type I Collagen) in the Amhara and the Oromo of Ethiopia
The present findings suggest the presence of a differential level of genetic relatedness with south-Saharan peoples in the two Ethiopian groups, which could reflect their different history and seems to indicate the existence of genetic sub-structure within the country
Tracing European Founder Lineages in the Near Eastern mtDNA Pool
Multiple and differentiated contributions to the male gene pool of pastoral and farmer populations of the African Sahel
The African Sahel is conducive to studies of divergence/admixture genetic events as a result of its population history being so closely related with past climatic changes. Today, it is a place of the co‐existence of two differing food‐producing subsistence systems, i.e., that of sedentary farmers and nomadic pastoralists, whose populations have likely been formed from several dispersed indigenous hunter‐gatherer groups. Using new methodology, we …
Internal diversification of non‐Sub‐Saharan haplogroups in Sahelian populations and the spread of pastoralism beyond the Sahara
BACKGROUND: Today, African pastoralists are found mainly in the Sahel/Savannah belt spanning 6,000 km from west to east, flanked by the Sahara to the north and tropical rainforests to the south. The most significant group among them are the Fulani who not only keep cattle breeds of possible West Eurasian ancestry, but form themselves a gene pool containing some paternally and maternally-transmitted West Eurasian haplogroups. MATERIALS AND METHODS…
Y‐chromosomal variation in the Czech Republic
To analyze the contribution of the Czech population to the Y‐chromosome diversity landscape of Europe and to reconstruct past demographic events, we typed 257 males from five locations for 21 UEPs. Moreover, 141 carriers of the three most common haplogroups were typed for 10 microsatellites and coalescent analyses applied. Sixteen Hg's characterized by derived alleles were identified, the most common being R1a‐SRY 10831 and P‐DYS257*(xR1a). The p…
Tracing European Founder Lineages in the Near Eastern mtDNA Pool
Analysis of three RFLPs of the COL1A2 (Type I Collagen) in the Amhara and the Oromo of Ethiopia
The present findings suggest the presence of a differential level of genetic relatedness with south-Saharan peoples in the two Ethiopian groups, which could reflect their different history and seems to indicate the existence of genetic sub-structure within the country
A human derived SSADH coding variant is replacing the ancestral allele shared with primates
The analysis of robust correlations based on a large panel of populations is potentially able to identify clusters of genomic regions or genes showing co-evolution of the frequencies of derived alleles
Y chromosome variation in Europe
The polymorphism of the male-specific portion of the Y chromosome has been increasingly used to describe the composition of the European gene pool and to reconstruct its formation. Here the theoretical grounds and the limitations of this approach are presented, together with the different views on debated issues. The emerging picture for the composition of the male gene pool of the continent is illustrated, but local peculiarities that represent …
Y‐chromosomal variation in the Czech Republic
To analyze the contribution of the Czech population to the Y‐chromosome diversity landscape of Europe and to reconstruct past demographic events, we typed 257 males from five locations for 21 UEPs. Moreover, 141 carriers of the three most common haplogroups were typed for 10 microsatellites and coalescent analyses applied. Sixteen Hg's characterized by derived alleles were identified, the most common being R1a‐SRY 10831 and P‐DYS257*(xR1a). The p…
Recurrent mutation in SNPs within Y chromosome E3b (E‐M215) haplogroup
In a previous issue of AJHB, Fernandes et al. (2008. Am J Hum Biol 20:185–190.) describe instances of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E‐M35 sub‐haplogroups. They interpret these findings as evidence for multiple mutational events in at least two loci (M78 and M81). Here, we introduce a novel polymorphic marker (V68), potentially useful to investigate the issue. This marker …
Phylogeography of Y chromosomal haplogroups as reporters of Neolithic and post-Neolithic population processes in the Mediterranean area
The phylogeny of the human Y chromosome as defined by unique event polymorphisms is being worked out in fine detail. The emerging picture of the geographic distribution of different branches of the evolutionary tree (haplogroups), and the possibility of genetically dating their antiquity, are important tools in the reconstruction of major peopling, population resettlement and demographic expansion events. In the last 10 000 years many such events…
The Andalusian population from Huelva reveals a high diversification of Y-DNA paternal lineages from haplogroup E
The haplogroup E among Western Andalusians revealed a complex admixture of genetic markers from the Mediterranean space, with interesting signatures of populations from the Middle East and the Balkan Peninsula and a surprisingly low influence by Berber populations compared to other areas of the Iberian Peninsula
Multiple and differentiated contributions to the male gene pool of pastoral and farmer populations of the African Sahel
The African Sahel is conducive to studies of divergence/admixture genetic events as a result of its population history being so closely related with past climatic changes. Today, it is a place of the co‐existence of two differing food‐producing subsistence systems, i.e., that of sedentary farmers and nomadic pastoralists, whose populations have likely been formed from several dispersed indigenous hunter‐gatherer groups. Using new methodology, we …
Internal diversification of non‐Sub‐Saharan haplogroups in Sahelian populations and the spread of pastoralism beyond the Sahara
BACKGROUND: Today, African pastoralists are found mainly in the Sahel/Savannah belt spanning 6,000 km from west to east, flanked by the Sahara to the north and tropical rainforests to the south. The most significant group among them are the Fulani who not only keep cattle breeds of possible West Eurasian ancestry, but form themselves a gene pool containing some paternally and maternally-transmitted West Eurasian haplogroups. MATERIALS AND METHODS…
A genetic portrait of the South‐Eastern Carpathians based on autosomal short tandem repeats loci used in forensics
OBJECTIVES: This work aimed to describe the genetic landscape of the Balkan Peninsula, as revealed by STR markers commonly used in forensics and spatial methods specifically developed for genetic data. METHODS: We generated and analyzed 16 short tandem repeats (STRs) autosomal genotypes in 287 subjects from ten administrative/geographical regions of Eastern Europe (Romania and the Republic of Moldova). We report estimates of the allele frequencie…
Enlarging the gene-geography of Europe and the Mediterranean area to STR loci of common forensic use
Four of the eight STR loci (or even alleles) considered here can reproducibly capture continental arrangements of diversity. This would, in principle, allow for the exploitation of forensic data to clarify important aspects in the formation of local gene pools
Paternal lineages in southern Iberia provide time frames for gene flow from mainland Europe and the Mediterranean world
The particular Andalusian R1b-M269 assemblage confirms the shallow topology of the clade. Moreover, the sharing of lineages with the rest of Europe indicates the impact in Iberia of an amount of pre-existing diversity, with the possible exception of R1b-DF27. Lineages such as J2-M172 and G-M201 highlight the importance of maritime travels of early farmers who reached the Iberian Peninsula
Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations
OBJECTIVES: The 3' regulatory region of the immunoglobulin heavy chain gene (IGH) includes the HS1.2 enhancer displaying length polymorphism with four known variants. The goal of the research was to provide an overview of this variability and of its evolutionary significance across human populations. MATERIALS AND METHODS: We compiled published and original data on HS1.2 polymorphism in 3,100 subjects from 26 human populations. Moreover, we imput…
Genetic variation patterns of β-thalassemia in Western Andalusia (Spain) reveal a structure of specific mutations within the Iberian Peninsula
The long history of endemic malaria in the study territory, the rather high consanguinity rates among its autochthonous population, and other demographic features have been used here to understand the western Andalusian β-thalassemia molecular portrait
Biology (15 works) · Evolutionary biology (12 works) · Geography (12 works) · Forensic and Genetic Research (11 works) · Genetics (11 works) · Population (10 works) · Demography (9 works) · Gene (9 works) · Genetic diversity and population structure (9 works) · Haplotype (8 works)