Michael S Kobor
Biographic Data
| ID | 96786 |
|---|---|
| NAME | Michael S Kobor |
| GIVEN NAMES | Michael S |
| FAMILY NAME | Kobor |
| SIGNATURE | KOBOR M S |
| AFFILIATIONS | Department of Medical Genetics, Faculty of Medicine University of British Columbia Vancouver British Columbia Canada |
| ORCID | 0000-0003-4140-1743 |
| VERIFIED | Yes |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 17 |
| WORKS AS AUTHOR | 9 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2009 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey
Epigenetic clocks estimate biological aging through age‐related DNA methylation patterns and are known to accelerate in response to adversity. While cortisol links stress experiences to cellular aging, the relationship between circadian cortisol and epigenetic age acceleration (EAA) remains unclear. To address this gap, we use data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to explore linear relationships between diurnal saliv…
Cross‐Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress
Cumulative family stress (cumulative FS), characterized by mother‐reported co‐occurring stressors in a family context, may be biologically embedded through DNA methylation (DNAm) and contribute to later health outcomes, including psychopathology. To illuminate tissue specificity in association with cumulative FS across two accessible tissues, we compared epigenome‐wide DNAm associations in buccal epithelial cells (BECs; n = 218) and peripheral bl…
Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines
OBJECTIVES: The drivers of human life expectancy gains over the past 200 years are not well-established, with a potential role for historical reductions in infectious disease. We investigate whether infectious exposures in infancy predict biological aging using DNA methylation-based markers that forecast patterns of morbidity and mortality later in life. METHODS: N = 1450 participants from the Cebu Longitudinal Health and Nutrition Survey-a prosp…
Reply to Nwanaji‐Enwerema , 2023, “Exposome and low birthweight selection bias considerations in early life infections and epigenetic age relationships”
Society to cell
Almost one in three children globally live in households lacking basic necessities, and 356 million of these children were living in extreme poverty as of 2017. Disasters such as the COVID-19 pandemic further increase rates of child poverty due to widespread job and income loss and economic insecurity among families. Poverty leads to unequal distribution of power and resources, which impacts the economic, material, environmental and psychosocial …
Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy
Maternal psychosocial stress increases the risk of adverse birth and postnatal outcomes for the mother and child, but the role of maternal exposure to childhood traumatic events (CTE) and multi-domain psychosocial stressors for the level and rise of placental Corticotrophin-Releasing Hormone (pCRH) across pregnancy has been understudied. In a sociodemographically and racially diverse sample of 1303 women (64% Black, 36% White/others) with low-med…
Genome‐wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood
OBJECTIVES: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines. METHODS: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal He…
The Potential of Social Epigenetics for Child Health Policy
Developing public policies aimed at improving child health and well-being in Canada is an important objective. Social epigenetic research can be an insightful additional source of evidence in pursuing this endeavour. Social epigenetics is the study of the molecular mechanisms by which early-life experiences influence gene expression and have persistent effects on human physiology and health. Findings so far suggest that epigenetic mechanisms migh…
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling
Children reared in unfavorable socioeconomic circumstances show increased susceptibility to the chronic diseases of aging when they reach the fifth and sixth decades of life. One mechanistic hypothesis for this phenomenon suggests that social adversity in early life programs biological systems in a manner that persists across decades and thereby accentuates vulnerability to disease. Here we examine the basic tenets of this hypothesis by performin…
Genome‐wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood
OBJECTIVES: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines. METHODS: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal He…
Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy
Maternal psychosocial stress increases the risk of adverse birth and postnatal outcomes for the mother and child, but the role of maternal exposure to childhood traumatic events (CTE) and multi-domain psychosocial stressors for the level and rise of placental Corticotrophin-Releasing Hormone (pCRH) across pregnancy has been understudied. In a sociodemographically and racially diverse sample of 1303 women (64% Black, 36% White/others) with low-med…
The Potential of Social Epigenetics for Child Health Policy
Developing public policies aimed at improving child health and well-being in Canada is an important objective. Social epigenetic research can be an insightful additional source of evidence in pursuing this endeavour. Social epigenetics is the study of the molecular mechanisms by which early-life experiences influence gene expression and have persistent effects on human physiology and health. Findings so far suggest that epigenetic mechanisms migh…
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling
Children reared in unfavorable socioeconomic circumstances show increased susceptibility to the chronic diseases of aging when they reach the fifth and sixth decades of life. One mechanistic hypothesis for this phenomenon suggests that social adversity in early life programs biological systems in a manner that persists across decades and thereby accentuates vulnerability to disease. Here we examine the basic tenets of this hypothesis by performin…
The Potential of Social Epigenetics for Child Health Policy
Developing public policies aimed at improving child health and well-being in Canada is an important objective. Social epigenetic research can be an insightful additional source of evidence in pursuing this endeavour. Social epigenetics is the study of the molecular mechanisms by which early-life experiences influence gene expression and have persistent effects on human physiology and health. Findings so far suggest that epigenetic mechanisms migh…
Genome‐wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood
OBJECTIVES: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines. METHODS: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal He…
Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy
Maternal psychosocial stress increases the risk of adverse birth and postnatal outcomes for the mother and child, but the role of maternal exposure to childhood traumatic events (CTE) and multi-domain psychosocial stressors for the level and rise of placental Corticotrophin-Releasing Hormone (pCRH) across pregnancy has been understudied. In a sociodemographically and racially diverse sample of 1303 women (64% Black, 36% White/others) with low-med…
Society to cell
Almost one in three children globally live in households lacking basic necessities, and 356 million of these children were living in extreme poverty as of 2017. Disasters such as the COVID-19 pandemic further increase rates of child poverty due to widespread job and income loss and economic insecurity among families. Poverty leads to unequal distribution of power and resources, which impacts the economic, material, environmental and psychosocial …
Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines
OBJECTIVES: The drivers of human life expectancy gains over the past 200 years are not well-established, with a potential role for historical reductions in infectious disease. We investigate whether infectious exposures in infancy predict biological aging using DNA methylation-based markers that forecast patterns of morbidity and mortality later in life. METHODS: N = 1450 participants from the Cebu Longitudinal Health and Nutrition Survey-a prosp…
Reply to Nwanaji‐Enwerema , 2023, “Exposome and low birthweight selection bias considerations in early life infections and epigenetic age relationships”
Cross‐Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress
Cumulative family stress (cumulative FS), characterized by mother‐reported co‐occurring stressors in a family context, may be biologically embedded through DNA methylation (DNAm) and contribute to later health outcomes, including psychopathology. To illuminate tissue specificity in association with cumulative FS across two accessible tissues, we compared epigenome‐wide DNAm associations in buccal epithelial cells (BECs; n = 218) and peripheral bl…
Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey
Epigenetic clocks estimate biological aging through age‐related DNA methylation patterns and are known to accelerate in response to adversity. While cortisol links stress experiences to cellular aging, the relationship between circadian cortisol and epigenetic age acceleration (EAA) remains unclear. To address this gap, we use data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to explore linear relationships between diurnal saliv…
Birth, Development, and Health (5 works) · Epigenetics and DNA Methylation (5 works) · Medicine (5 works) · Biology (4 works) · DNA methylation (4 works) · Environmental health (3 works) · Epigenetics (3 works) · Gene (3 works) · Genetics (3 works) · Psychology (3 works)