Gabriel Bedoya
Biographic Data
| ID | 97619 |
|---|---|
| NAME | Gabriel Bedoya |
| GIVEN NAMES | Gabriel |
| FAMILY NAME | Bedoya |
| SIGNATURE | BEDOYA G |
| AFFILIATIONS | Universidad de Antioquia |
| ORCID | 0000-0002-4820-6679 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 25 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2003 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 2 |
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans
Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selectio…
Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos
The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
Relación entre tratamiento hormonal, cirugía-ortodoncia maxilofacial, traumatismos y malformaciones craneofaciales y la asimetría fluctuante
En este trabajo se evalúa la relación entre la asimetría fluctuante facial (AFF) y los tratamientos hormonales, cirugías maxilofaciales, ortodoncia, traumatismos y malformaciones. En el marco del proyecto CANDELA, se tomaron cinco fotografías faciales de 3162 voluntarios entre los 18 y 85 años. Por fotogrametría se colocaron 34 landmarks o puntos en 3D y mediante el método Procrustes ANOVA se obtuvieron valores individuales de asimetría fluctuant…
A global reference for human genetic variation
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized…
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Reconstructing Native American population history
Origen de la mutación G736A del gen Parkin en la población de Peque (noroccidente de Antioquia)
En una gran familia de la población de Peque (Antioquia) se hallaron individuos afectados por la enfermedad de Parkinson juvenil, debido a la mutación G736A localizada en el exón 6 del gen PARK2. Dada la composición triétnica de nuestraspoblaciones mestizas, y dado que esta mutación fue reportada en España, nuestro objetivo fue buscar su origen. Para ello, tipificamos con marcadores moleculares del cromosoma Y a 132 individuos no relacionados de …
Composición genética de una población del suroccidente de Colombia
La población actual del departamento del Cauca es el resultado de la mezcla de tres poblaciones parentales (europea, amerindia y africana). En este estudio se determinó la composición genética de 306 residentes del departamento mediante la utilización de 34 variantes autosómicas, 9 variantes en el cromosoma X, 6 en el ADNmt y 8 en el cromosoma Y. Los análisis de las variantes autosómicas y del cromosoma X revelaron que la población europea y la a…
Comparación de cuatro programas utilizados en la determinación de la composición genética ancestral de la población antioqueña
La población antioqueña posee una estructura genética compleja que refleja su historia de mezclas entre poblaciones europeas, africanas y amerindias. En este estudio se determinó la composición genética de 849 individuos de la población antioqueña, utilizando un panel de 75 marcadores informativos de ancestralidad y 4 programas que implementan métodos bayesianos para inferir la composición de la mezcla ancestral. La contribución europea (60%) fue…
Coancestría de apellidos y linajes del cromosoma Y en el noroeste de Colombia: Una Herramienta Útil Para Establecer Migración Entre Poblaciones
Por medio del análisis de marcadores genéticos del cromosoma Y, se estudió la composición de los linajes y su distribución en los apellidos más comunes en una muestra de 471 hombres provenientes del municipio de Marinilla (Antioquia) y su zona de influencia y del municipio de Aranzazu (Caldas), y en un grupo de muestras de la población general de Medellín. Además de encontrar una tasa variable de coancestría entre apellidos y linajes del cromosom…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
A revertant of the major founder Native American haplogroup C common in populations from northern South America
We examined the mtDNA RFLP diversity of 17 Native American populations from Colombia. Five of the populations studied were found to have variable frequencies of a mtDNA type lacking the characteristic changes of haplogroups A‐D. Sequencing of mtDNA HVS‐I and II showed that this “null” RFLP type carries all the substitutions characteristic of Native American founder lineage C. A back mutation has therefore recreated the +13,259 Hin cII/−13,262 Alu…
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
Relación entre tratamiento hormonal, cirugía-ortodoncia maxilofacial, traumatismos y malformaciones craneofaciales y la asimetría fluctuante
En este trabajo se evalúa la relación entre la asimetría fluctuante facial (AFF) y los tratamientos hormonales, cirugías maxilofaciales, ortodoncia, traumatismos y malformaciones. En el marco del proyecto CANDELA, se tomaron cinco fotografías faciales de 3162 voluntarios entre los 18 y 85 años. Por fotogrametría se colocaron 34 landmarks o puntos en 3D y mediante el método Procrustes ANOVA se obtuvieron valores individuales de asimetría fluctuant…
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas
A revertant of the major founder Native American haplogroup C common in populations from northern South America
We examined the mtDNA RFLP diversity of 17 Native American populations from Colombia. Five of the populations studied were found to have variable frequencies of a mtDNA type lacking the characteristic changes of haplogroups A‐D. Sequencing of mtDNA HVS‐I and II showed that this “null” RFLP type carries all the substitutions characteristic of Native American founder lineage C. A back mutation has therefore recreated the +13,259 Hin cII/−13,262 Alu…
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
Reconstructing Native American population history
Origen de la mutación G736A del gen Parkin en la población de Peque (noroccidente de Antioquia)
En una gran familia de la población de Peque (Antioquia) se hallaron individuos afectados por la enfermedad de Parkinson juvenil, debido a la mutación G736A localizada en el exón 6 del gen PARK2. Dada la composición triétnica de nuestraspoblaciones mestizas, y dado que esta mutación fue reportada en España, nuestro objetivo fue buscar su origen. Para ello, tipificamos con marcadores moleculares del cromosoma Y a 132 individuos no relacionados de …
Composición genética de una población del suroccidente de Colombia
La población actual del departamento del Cauca es el resultado de la mezcla de tres poblaciones parentales (europea, amerindia y africana). En este estudio se determinó la composición genética de 306 residentes del departamento mediante la utilización de 34 variantes autosómicas, 9 variantes en el cromosoma X, 6 en el ADNmt y 8 en el cromosoma Y. Los análisis de las variantes autosómicas y del cromosoma X revelaron que la población europea y la a…
Comparación de cuatro programas utilizados en la determinación de la composición genética ancestral de la población antioqueña
La población antioqueña posee una estructura genética compleja que refleja su historia de mezclas entre poblaciones europeas, africanas y amerindias. En este estudio se determinó la composición genética de 849 individuos de la población antioqueña, utilizando un panel de 75 marcadores informativos de ancestralidad y 4 programas que implementan métodos bayesianos para inferir la composición de la mezcla ancestral. La contribución europea (60%) fue…
Coancestría de apellidos y linajes del cromosoma Y en el noroeste de Colombia: Una Herramienta Útil Para Establecer Migración Entre Poblaciones
Por medio del análisis de marcadores genéticos del cromosoma Y, se estudió la composición de los linajes y su distribución en los apellidos más comunes en una muestra de 471 hombres provenientes del municipio de Marinilla (Antioquia) y su zona de influencia y del municipio de Aranzazu (Caldas), y en un grupo de muestras de la población general de Medellín. Además de encontrar una tasa variable de coancestría entre apellidos y linajes del cromosom…
Ancient human genomes suggest three ancestral populations for present-day Europeans
A global reference for human genetic variation
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized…
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Relación entre tratamiento hormonal, cirugía-ortodoncia maxilofacial, traumatismos y malformaciones craneofaciales y la asimetría fluctuante
En este trabajo se evalúa la relación entre la asimetría fluctuante facial (AFF) y los tratamientos hormonales, cirugías maxilofaciales, ortodoncia, traumatismos y malformaciones. En el marco del proyecto CANDELA, se tomaron cinco fotografías faciales de 3162 voluntarios entre los 18 y 85 años. Por fotogrametría se colocaron 34 landmarks o puntos en 3D y mediante el método Procrustes ANOVA se obtuvieron valores individuales de asimetría fluctuant…
Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos
The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans
Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selectio…
Biology (11 works) · Evolutionary biology (10 works) · Forensic and Genetic Research (10 works) · Gene (10 works) · Demography (9 works) · Genetics (9 works) · Population (9 works) · Allele (5 works) · Genetic Associations and Epidemiology (5 works) · Genetic diversity and population structure (5 works)