Hans-Jörgen Grabe

• Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

  Open Access•Aysu Okbay, Yeda Wu et al.•ARTICLE•Nature Genetics•2022

  Incluir item

  We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…

• Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder

  Open Access•Sarah Kittel‐Schneider, Sarah Kittel-Schneider et al.•ARTICLE•Frontiers in Psychiatry•2020

  Incluir item

  When controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures …

• Genome-wide association study identifies 74 loci associated with educational attainment

  Open Access•Aysu Okbay, Jonathan P Beauchamp et al.•ARTICLE•Nature•2016

  Incluir item

• Genetic studies of body mass index yield new insights for obesity biology

  Open Access•The Lifelines Cohort Study, Adam E Locke et al.•ARTICLE•Nature•2015

  Incluir item

• Genetic studies of body mass index yield new insights for obesity biology

  Open Access•The Lifelines Cohort Study, Adam E Locke et al.•ARTICLE•Nature•2015

  Incluir item

• Genome-wide association study identifies 74 loci associated with educational attainment

  Open Access•Aysu Okbay, Jonathan P Beauchamp et al.•ARTICLE•Nature•2016

  Incluir item

• Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder

  Open Access•Sarah Kittel‐Schneider, Sarah Kittel-Schneider et al.•ARTICLE•Frontiers in Psychiatry•2020

  Incluir item

  When controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures …

• Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

  Open Access•Aysu Okbay, Yeda Wu et al.•ARTICLE•Nature Genetics•2022

  Incluir item

  We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…

Biology (3 obras) · Genetic Associations and Epidemiology (3 obras) · Birth, Development, and Health (2 obras) · Body mass index (2 obras) · Gene (2 obras) · Genetic association (2 obras) · Genetics (2 obras) · Genome (2 obras) · Genome-wide association study (2 obras) · Genotype (2 obras)