James A Blumenthal
Dados Biográficos
| ID | 1359248 |
|---|---|
| NOME | James A Blumenthal |
| PRENOMES | James A |
| SOBRENOME | Blumenthal |
| ASSINATURA | BLUMENTHAL J A |
| AFILIAÇÕES | Duke University |
| ORCID | 0000-0003-3789-0935 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 71 |
| TOTAL DE CITAÇÕES | 3 |
| TOTAL COMO AUTOR | 71 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1980 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2023 |
| ÍNDICE H | 1 |
Infant Outcomes in Hypertensive Women
Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment
OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity det…
Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults
These findings suggest racial discrimination was associated with blunted β-adrenergic receptor responsiveness, providing further evidence of the potential contribution of racial discrimination to increased CVD risk among African Americans. The adverse effects of discrimination on cardiovascular health may be enhanced in individuals with higher levels of hostility
Effects of Exercise and Sertraline on Measures of Coronary Heart Disease Risk in Patients With Major Depression
OBJECTIVE: To assess the effects of supervised and home-based aerobic exercise training, and antidepressant pharmacotherapy (sertraline) on coronary heart disease (CHD) risk factors in a sample of participants with major depressive disorder (MDD). METHODS: The Standard Medical Intervention versus Long-term Exercise (SMILE)-II study randomized 202 adults (153 women, 49 men) diagnosed as having MDD to one of four interventions, each of 4-month dura…
Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease
OBJECTIVE: To examine the prognostic value of select biobehavioral factors in patients with chronic obstructive pulmonary disease (COPD) in a secondary analysis of participants from the INSPIRE-II trial. METHODS: Three hundred twenty-six outpatients with COPD underwent assessments of pulmonary function, physical activity, body mass index, inflammation, pulmonary symptoms, depression, and pulmonary quality of life and were followed up for up to 5.…
Association of Depressive and Anxiety Symptoms With 24-Hour Urinary Catecholamines in Individuals With Untreated High Blood Pressure
OBJECTIVE: Depression and anxiety are considered risk factors for cardiovascular disease (CVD). The explanatory mechanisms, however, are still to be characterized. One proposed pathophysiological pathway is dysregulation of the autonomic nervous system, including heightened sympathetic nervous system activity. This study examined the relationship between symptoms of depression, anxiety, and sympathetic nervous system activity in individuals with …
The Effects of a Telehealth Coping Skills Intervention on Outcomes in Chronic Obstructive Pulmonary Disease
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and mortality and reduced quality of life (QoL). Novel interventions are needed to improve outcomes in COPD patients. The present study assessed the effects of a telephone-based coping skills intervention on psychological and somatic QoL and on the combined medical end point of COPD-related hospitalizations and all-cause mortality. METHODS: We conducted…
Interactive Associations of Depression and Sleep Apnea With Adverse Clinical Outcomes After Acute Myocardial Infarction
Objective Depression and sleep apnea (SA) are common among patients with a recent acute myocardial infarction (AMI), and both are associated with increased risk for adverse outcomes. We tested the hypothesis that there is an interaction between them in relation to post-AMI prognosis. Methods Participants were patients with a recent AMI, 337 of them were depressed and 379 were nondepressed, who participated in a substudy of the Enhancing Recovery …
Household Responsibilities, Income, and Ambulatory Blood Pressure Among Working Men and Women
OBJECTIVE: To test the hypothesis that a greater perceived responsibility for household tasks and a greater number of hours spent doing these tasks would be associated with elevated ambulatory systolic (SBP) and diastolic blood pressure (DBP). The connection between job characteristics and cardiovascular outcomes has been widely studied. However, less is known about links between household work characteristics and cardiovascular health. METHODS: …
Exercise and Pharmacotherapy in Patients With Major Depression
OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilt…
Phobic Anxiety and Increased Risk of Mortality in Coronary Heart Disease
OBJECTIVES: To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previous findings suggest that phobic anxiety may pose increased risk of cardiac mortality in medically healthy cohorts. METHODS: We performed a prospective cohort study in 947 CHD patients recruited…
Aerobic Exercise and Neurocognitive Performance
OBJECTIVES: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have been hampered by methodological shortcomings and are now outdated as a result of the recent publication of several large-scale, randomized, controlled trials (RCTs). METHODS: We conducted a systematic literature review of RCTs…
Pain Catastrophizing in Patients with Noncardiac Chest Pain
OBJECTIVE: To examine the contributions of chest pain, anxiety, and pain catastrophizing to disability in 97 patients with noncardiac chest pain (NCCP) and to test whether chest pain and anxiety were related indirectly to greater disability via pain catastrophizing. METHODS: Participants completed daily diaries measuring chest pain for 7 days before completing measures of pain catastrophizing, trait anxiety, and disability. Linear path model anal…
History of Depression and Survival After Acute Myocardial Infarction
Objective: To compare survival in post-myocardial (MI) participants from the Enhancing Recovery In Coronary Heart Disease (ENRICHD) clinical trial with a first episode of major depression (MD) and those with recurrent MD, which is a risk factor for mortality after acute MI. Recent reports suggest that the level of risk may depend on whether the comorbid MD is a first or a recurrent episode. Methods: Survival was compared over a median of 29 month…
Dynamic and Syncretic Dimensions to Śāntarakṣita's Presentation of the Two Truths
It is common for philosophers from the Madhyamaka school of Indian Buddhist thought to offer a presentation of the two truths, ultimate truth (paramārthasatya) and conventional truth (saṃvṛtisatya), as a vehicle for presenting their views on the ontological status of entities. Though there is some degree of variance, generally ultimate truths are described as objects known by an awareness of knowing things as they are. Conventional truths are obj…
Response to Letters to the Editor
Blumenthal, James A. PhD; Sherwood, Andrew PhD; Babyak, Michael A. PhD; Doraiswamy, P Murali MD; Hoffman, Benson M. PhD For the SMILE Investigators Author Information
Relationship of Genetic Variability and Depressive Symptoms to Adverse Events After Coronary Artery Bypass Graft Surgery
OBJECTIVE: To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery. METHODS: A total of 427 coronary artery bypass graft (CABG) patients were genotyped for two polymorphisms and assessed for depressive symptoms at three time points, in accordance with the Center for Epidemiol…
Nighttime Heart Rate and Survival in Depressed Patients Post Acute Myocardial Infarction
Objectives: To determine if: 1) depressed patients with a recent acute myocardial infarction (AMI) have higher nighttime heart rate (HR) than nondepressed patients, and 2) elevated nighttime HR is associated with decreased survival post AMI. Depression is a risk factor for mortality post AMI. It is also associated with sleep disturbances and with elevated HR, which may be more pronounced at night. Resting and 24-hour HR have been found to predict…
Cerebrovascular Risk Factors, Vascular Disease, and Neuropsychological Outcomes in Adults With Major Depression
Objective: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depressive disorder (MDD). Neuropsychological deficits are common among adults with MDD, particularly among those with CVRFs and potentially persons with subclinical vascular disease. Methods: CVRFs …
Spirituality, Religion, and Clinical Outcomes in Patients Recovering From an Acute Myocardial Infarction
OBJECTIVE: To assess the prospective relationship between spiritual experiences and health in a sample of patients surviving an acute myocardial infarction (AMI) with depression or low social support. METHODS: A subset of 503 patients participating in the enhancing recovery in coronary heart disease (ENRICHD) trial completed a Daily Spiritual Experiences (DSE) questionnaire within 28 days from the time of their AMI. The questionnaire assessed thr…
Heart Rate Turbulence, Depression, and Survival After Acute Myocardial Infarction
OBJECTIVE: Depression is a risk factor for mortality after acute myocardial infarction (AMI), possibly as a result of altered autonomic nervous system (ANS) modulation of heart rate (HR) and rhythm. The purposes of this study were to determine: a) whether depressed patients are more likely to have an abnormal HR response (i.e., abnormal turbulence) to premature ventricular contractions (VPCs), and b) whether abnormal HR turbulence accounts for th…
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in depression compared to placebo controls. METHODS: Between October 2000 and November 2005, we performed a prospective, randomized controlled trial (SMILE study) with allocation concealment and blind…
Association of Neurocognitive Function and Quality of Life 1 Year After Coronary Artery Bypass Graft (Cabg) Surgery
Objective: Although coronary artery bypass grafting (CABG) has been shown to improve quality of life and functional capacity for many patients, recent studies have demonstrated that a significant number of patients exhibit impairment in cognitive function immediately following surgery and beyond. We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the pati…
Phobic Anxiety, Depression, and Risk of Ventricular Arrhythmias in Patients With Coronary Heart Disease
Objective: Findings of an association between phobic anxiety and elevated risks of sudden cardiac death suggest that phobic anxiety may be related to increased risk of ventricular arrhythmias. The purpose of this study was to examine whether phobic anxiety is associated with ventricular arrhythmias in patients with documented coronary artery disease (CAD). Methods: Phobic anxiety level was measured using the Crown-Crisp phobic anxiety scale in 94…
The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice
Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults
These findings suggest racial discrimination was associated with blunted β-adrenergic receptor responsiveness, providing further evidence of the potential contribution of racial discrimination to increased CVD risk among African Americans. The adverse effects of discrimination on cardiovascular health may be enhanced in individuals with higher levels of hostility
Type As who think they are Type Bs
The study described here explored discrepancies between self‐ratings and interview ratings of Type A behaviour. A total of 281 patients referred for diagnostic coronary angiography underwent a comprehensive psychological assessment including the Type A structured interview (SI), the Minnesota Multiphasic Personality Inventory (MMPI) and two self‐report measures of Type A behaviour, the Jenkins Activity Survey (JAS) and the Type A Self‐Rating Inve…
Type A Behavior, Hostility, and Coronary Atherosclerosis
Type A behavior pattern was assessed using the structured interview and hostility level was assessed using a subscale of the Minnesota Multiphase Personality Inventory in 424 patients who underwent diagnostic coronary arteriography for suspected coronary heart disease. In contrast to non-Type A patients, a significantly greater proportion of Type A patients had at least one artery with a clinically significant occlusion of 75% or greater. In addi…
Effects of Exercise on the Type A (Coronary Prone) Behavior Pattern1
This study presents the initial findings of an attempt to reduce the risk of coronary heart disease (CHD) in a group of health, middle-aged adults by participation in a ten-week, supervised exercise program. Forty-six subjects were classified as Type A or Type B based on their scores on the Jenkins Activity Survey (JAS). Measures of physiologic (blood pressure, serum lipids, body weight, plasminogen activator release, and treadmill performance) a…
Anxiety and Emotions
Self-Ratings of Type A (Coronary Prone) Adults
This study compared self-ratings and interview-band ratings of the type A coronary-prone behavior pattern. A Type A adjective scale was developed from the Gough-Adjective Checklist (ACL), using adjectives rated as characteristic and uncharacteristic of the Type A individual by a panel of 20 Type A researchers. Scores on this scale were compared with Type A ratings based on the structural interview. Results from a sample of 378 employed males indi…
Physiological and Psychological Variables Predict Compliance to Prescribed Exercise Therapy in Patients Recovering from Myocardial Infarction
Previous research has documented high rates of noncompliance to prescribed medical therapy in patients recovering from myocardial infarction (MI). This study was undertaken to determine if patients who subsequently drop out of a structured cardiac rehabilitation program could be prospectively distinguished from those who remain in the program based upon their initial baseline characteristics. Thirty-five consecutive patients with recent MIs under…
Psychological Changes Accompany Aerobic Exercise in Healthy Middle-Aged Adults
An attempt was made to assess the effects of aerobic exercise on the psychological functioning of a nonclinical sample of healthy middle-aged adults. Sixteen subjects participated in a 10-week program of regular walking-jogging, while a matched control group maintained their sedentary life-styles. All subjects completed a battery of psychological tests, including the Profile of Mood States, the State-Trait Anxiety Inventory and a retrospective qu…
Behavioral Assessment of the Type A Behavior Pattern
The present study attempted to assess systematically a set of behavioral subcomponents associated with the Type A behavior pattern. Sixty middle-aged men underwent the structured interview (SI) and a repeated version of the SI after a four-month interval. A high degree of interrater reliability was established for a number of behavioral components including speed and volume of speech, motoric activity, expiratory sighs, response latency, interrup…
Components of Type A, Hostility, and Anger-In
Previous research has linked the Type A coronary-prone behavior pattern to angiographically documented severity of coronary atherosclerosis (CAD). The present study sought through component scoring of the Type A Structured Interview (SI) to determine what elements of the multidimensional Type A pattern are related to coronary disease severity in a selected group of patients with minimal or severe CAD. Multivariate analyses controlling for the maj…
Psychosocial and physical predictors of anginal pain relief with medical management
This study was undertaken to identify psychosocial and physical characteristics that independently predict anginal pain relief. The original study group comprised over 570 patients in whom the characteristics were identified at the time of coronary arteriography and who were followed up after 6 months of standard medical therapy. In the subset of 382 of these patients who were assessed as having NYHA Class III or IV angina at the time of angiogra…
Type As who think they are Type Bs
The study described here explored discrepancies between self‐ratings and interview ratings of Type A behaviour. A total of 281 patients referred for diagnostic coronary angiography underwent a comprehensive psychological assessment including the Type A structured interview (SI), the Minnesota Multiphasic Personality Inventory (MMPI) and two self‐report measures of Type A behaviour, the Jenkins Activity Survey (JAS) and the Type A Self‐Rating Inve…
Relationships between motivation and hostility among type A and type B middle-aged men
Psychological correlates of hostility among patients undergoing coronary angiography
The Cook‐Medley Hostility (Ho) scale (Cook & Medley, 1954) has been associated with increased risk for coronary heart disease (CHD). There is relatively little information about the psychosocial correlates of the Ho scale in clinical or adult populations, however. In this study, 132 patients (mean age = 53 years) referred for diagnostic coronary angiography completed a battery of self‐report questionnaires including the Minnesota Multiphasic Pers…
Exercise training in healthy type A middle-aged men
Thirty-six healthy Type A men (means = 44.4 years) were randomly assigned to either an aerobic exercise training group or a strength and flexibility training group. Subjects completed a comprehensive psychological assessment battery before and after the exercise programs consisting of behavioral, psychometric, and psychophysiological testing. The behavioral assessment consisted of repeated Type A interviews that were videotaped for subsequent com…
Type A behavior and angiographically documented coronary atherosclerosis in a sample of 2,289 patients
To determine the relationship between Type A behavior pattern and angiographically documented coronary atherosclerosis (CAD), we analyzed risk factor, behavioral, and angiographic data collected on 2,289 patients undergoing diagnostic coronary angiography at Duke University Medical Center between 1974 and 1980. Multivariable analyses using ordinal logistic regression techniques showed that Type A behavior as assessed by the structured interview (…
Effects of aerobic exercise training on hemodynamic responses during psychosocial stress in normotensive and borderline hypertensive type A men
This study assessed the effects of aerobic exercise training on cardiovascular responses to a 5-min reaction time competition task. Twenty-seven Type A men (aged 30-56) participated in this randomized study in which 14 underwent supervised aerobic training and 13 strength training, with sessions scheduled three times per week for 12 consecutive weeks. Aerobic exercise training was associated with a 13.6% increase in VO2max compared to 2.9% for th…
Hypertension affects neurobehavioral functioning
This study compared the neurobehavioral performance of hypertensive and normotensive men and women using neuropsychological, information-processing, and psychometric assessments. One hundred subjects, including 68 hypertensive and 32 normotensive individuals, completed a test battery that yielded scores on measures of speed of information processing, verbal and figural memory, psychosocial functioning, Type A behavior, and locus of control. Resul…
Quality of life and recovery after cardiac surgery
Serum Lipids, Neuroendocrine, and Cardiovascular Responses to Stress in Men and Women with Mild Hypertension
In this study, we examined the relation between serum lipid levels, gender, and cardiovascular and neuroendocrine stress reactivity in patients with mild hypertension. Ninety-nine individuals (62 men, 37 women) with mild hypertension performed four mental stress tasks: mental arithmetic, public speaking, cold stress, and a computer videogame. Cardiovascular reactivity scores were computed by subtracting the minimum resting blood pressure (BP) and…
Family History of Hypertension Influences Neurobehavioral Function in Hypertensive Patients
This study examined the influence of family history of hypertension on neurobehavioral performance. Sixty-two hypertensive men and women who reported a family history of hypertension (+FH) were compared with 28 hypertensive individuals without a family history (-FH) and 32 normotensive control subjects. A neurocognitive test battery that included tests of information processing, verbal memory, and figural memory was administered individually to e…
Stress in Employed Women
OBJECTIVE: To evaluate the biological and psychological effects of role overload, we examined the effects of marital (or partnership) status and parental status (defined as having children at home) on daily excretion of urinary catecholamines and cortisol in a sample of 109 employed women. Other measures included work and home strain, and social support. METHODS: Urine collection was conducted on two consecutive workdays in three separate aliquot…
Depression Predicts Left Ventricular Hypertrophy in Hypertensive Individuals
Gullette, Elizabeth C. D.; Babyak, Michael A.; Sherwood, Andrew; Hinderliter, Alan; Blumenthal, James A. Author Information
Blood Pressure Reactivity and Marital Distress in Employed Women
OBJECTIVE: The impact of marital distress on cardiovascular responses to an "ecologically valid" laboratory stressor (a marital conflict recall task) was examined in maritally distressed and non-distressed women. It was hypothesized that the presence of high levels of marital distress would be associated with elevated blood pressure and heart rate responses to a marital conflict task. METHOD: Fifty married, employed women, aged 25-45, were recrui…
Perception of Cognitive Impairment in Older Adults Undergoing Cardiac Surgery
Khatri, Parinda; Babyak, Michael A.; Clancy, Carolina; Davis, Rebecca; Croughwell, Narda; Newman, Mark; Reves, Joseph G.; Mark, Daniel B.; Blumenthal, James A. Author Information
Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy
Recent studies provide clear and convincing evidence that psychosocial factors contribute significantly to the pathogenesis and expression of coronary artery disease (CAD). This evidence is composed largely of data relating CAD risk to 5 specific psychosocial domains: (1) depression, (2) anxiety, (3) personality factors and character traits, (4) social isolation, and (5) chronic life stress. Pathophysiological mechanisms underlying the relationsh…
Exercise Training and Major Depression
Blumenthal, J. A.; Babyak, M.; Moore, K.; Craighead, E.; Herman, S.; Khatri, P.; Napolitano, M.; Doraiswamy, P. M.; Krishnan, K. R. Author Information
Medicine (63 obras) · Internal Medicine (52 obras) · Internal Medicine (49 obras) · Cardiac Health and Mental Health (43 obras) · Psychology (43 obras) · Psychiatry (32 obras) · Cardiology (27 obras) · Depression (economics) (25 obras) · Clinical Psychology (22 obras) · Blood pressure (21 obras)