Mathieu Nacher
Dados Biográficos
| ID | 140257 |
|---|---|
| NOME | Mathieu Nacher |
| PRENOMES | Mathieu |
| SOBRENOME | Nacher |
| ASSINATURA | NACHER M |
| AFILIAÇÕES | University of French Guiana |
| ORCID | 0000-0001-9397-3204 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 49 |
| TOTAL DE CITAÇÕES | 1 |
| TOTAL COMO AUTOR | 43 |
| TOTAL COMO EDITOR | 6 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2010 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 1 |
Querying Q fever
BACKGROUND: . French Guiana, largely covered by the Amazon rainforest, is considered a hyper-endemic region. While ruminants are the primary reservoirs worldwide, the reservoir in French Guiana remains debated, likely relying on wild fauna. This study aimed to identify spatiotemporal clusters of human Q fever in the Cayenne area and investigate their relationships with environmental factors using remote sensing data. METHODS: A retrospective stud…
A multicentric cross-sectional survey to assess cardiovascular risk factors among persons working in informal gold mines in French-Guiana
Cardiovascular diseases are the leading cause of death worldwide. French Guiana has a high prevalence of these diseases, responsible for high morbidity. The persons involved in informal gold mining sites in French Guiana are subject to poor health determinants. Various studies have shown their precariousness and their susceptibility to infectious diseases. However, no studies have ever assessed their cardiovascular risk factors. The aim of this w…
Post-traumatic stress disorder in French Guiana
Background The context of French Guiana—characterized by frequent violence and intense immigration from regions where traumatic events are common—may lead to a different epidemiology of post-traumatic stress disorder (PTSD) compared with mainland France. In the absence of prior data, we aimed to estimate the overall prevalence of PTSD in the general population of French Guiana, along with its prevalence across different sociodemographic groups. M…
The Spectrum of Violence
Migrant women are vulnerable to violence and face specific challenges in terms of sexual and reproductive health and rights. In the Americas, the number of vulnerable migrants has risen considerably. This review aims to present a synthesis of research published between 2014 and 2024 on the sexual reproductive health and rights of migrant women in the Americas, focusing on gender-based violence. This scoping review is based on scientific articles …
Prevalence of lead poisoning among artisanal gold miners in French Guiana in 2022
This study is registered on ClinicalTrials.gov under the identifier NCT05540470 (registered on September 12, 2022)
Prevalence and risk factors of food insecurity during pregnancy
This study highlights a frequently overlooked situation in French Guiana that is likely to affect the health of children at the very beginning of their lives. Peer-based programs or government financial assistance programs could help strengthen the ability of the poorest households with pregnant women to cope with food insecurity
Use and health effects of herbal medicine Ocotea guianensis during pregnancy in French Guiana
Contrasted life trajectories
In French Guiana, life expectancy is between 2 and 3 years below that of France, reflecting differences in mortality rates that are largely sensitive to primary healthcare and thus preventable. However, because poverty affects half of the population in French Guiana, global measurements of life expectancy presumably conflate at least two distinct situations: persons who have similar life expectancies as in mainland France and persons living in pr…
Desert dust episodes during pregnancy are associated with increased preterm delivery in French Guiana
Preterm deliveries are a major multifactorial public health problem in French Guiana. Desert dust episodes have been associated with preterm delivery in Guadeloupe, a territory with similarities to French Guiana. We thus tried to replicate this finding in the context of French Guiana. A retrospective ecological cohort study combined daily PM10 concentration measurements during pregnancy and term at delivery extracted from French Guiana’s computer…
Asthma Is an Independent Risk Factor for Acute Chest Syndrome in Children with Sickle Cell Disease in French Guiana
Background/Objectives: The overall incidence of asthma in children with sickle cell disease in French Guiana is unknown. Asthma is common in children with sickle cell disease and is associated with increased morbidity and mortality. This study aimed to describe the impact of asthma on the occurrence of acute chest syndrome in children with sickle cell disease who were followed up in French Guiana. Methods: We performed a multicenter nested case-c…
Tuberculosis in prison
Continued screening on entry, in combination with annual radiological and clinical screening, and reinforced follow-up on release seem indicated to improve patient management and the search for possible LTI
Involving hard-to-reach populations is pivotal for the tailoring and implementation of an epidemiological study in cross-border communities of French Guiana and Suriname
Background: Hard-to-reach, vulnerable and cross-border populations are often disproportionately affected by communicable diseases. Epidemiological data on viral hepatitis in French Guiana and Suriname are available for urban areas, but not for remote communities. The Maroni River, which separates FG and Suriname, is home to Tribal and Indigenous communities. Reaching these populations is challenging due to logistical constraints, cultural and lan…
Vulnerability of the HIV cascade of care in an Amazonian town
The HIV care cascade spans from diagnosis to patient linkage and retention in health services for treatment. Brazil has made substantial efforts to optimize the cascade of care. However, despite these advances, there are striking regional differences and difficulties from testing to treatment, particularly in the north and northeast regions, often reflecting social inequalities. Oiapoque, a highly affected city in the state of Amapá, shares its b…
Sexually transmitted infections on the border between Brazil and French Guiana
Purpose: The border between the State of Amapa, Brazil, and French Guiana is mostly primary forest. In the Oyapock basin, socioeconomic circumstances have fueled sex work, gold mining and the circulation of sexually transmitted infections. Given the lack of comprehensive data on this border area, we describe the different sexually transmitted infections along the Brazil/French Guiana border and the testing and care activity. Methods: We conducted…
Social determinants of health among people working on informal gold mines in French Guiana
INTRODUCTION: Social determinants of health, such as living and working conditions, economical and environmental context and access to care, combine to impact the health of individuals and communities. In French Guiana (FG), the persons working in informal artisanal and small-scale gold mining in the rainforest are a particularly vulnerable population which lives in precarious conditions and far from the health system. Previous studies have demon…
Detection of acute dengue virus infection, with and without concurrent malaria infection, in a cohort of febrile children in Kenya, 2014–2019, by clinicians or machine learning algorithms
Poor access to diagnostic testing in resource limited settings restricts surveillance for emerging infections, such as dengue virus (DENV), to clinician suspicion, based on history and exam observations alone. We investigated the ability of machine learning to detect DENV based solely on data available at the clinic visit. We extracted symptom and physical exam data from 6,208 pediatric febrile illness visits to Kenyan public health clinics from …
Cost-effectiveness evaluation of routine histoplasmosis screening among people living with advanced HIV disease in Latin America and the Caribbean
Histoplasma antigen can be detected in people with advanced HIV disease (AHD), allowing for early and accurate diagnosis of histoplasmosis. The aim of this analysis was to assess the cost-effectiveness of routine histoplasmosis screening using antigen detection, among people with AHD. We developed a decision analytic model to evaluate Histoplasma antigen screening among people with AHD. The model estimated the costs, effectiveness, and cost-effec…
Patient reported experience measures on HIV viral load testing at public health facilities in Dar es Salaam, Tanzania
While viral load (VL) testing is critical to effective treatment of human immunodeficiency virus (HIV), little is known about patients’ experiences with, and barriers to VL-testing in the context of HIV infection. We assessed patient reported experience measures (PREMs) on VL-testing in public HIV clinics in Tanzania. In a cross-sectional convergent mixed method study, we collected information on VL test related PREMs, clinical and sociodemograph…
Complex Sex Differences in Life Expectancy in French Guiana
In the complex context of French Guiana, different vulnerabilities and different risk factors between genders may lead to complex differences in health outcomes, mortality, and life expectancy. Our aim was, thus, to compare male and female mortality and life expectancy, to compare it between French Guiana and mainland France, and to look at temporal trends and the main specific causes of death in order to identify actionable singularities. Nation…
Cardiovascular Risk Assessment among Farmers in French Guiana in 2018—A Screening Program
HBP (53.1%), obesity (30.3%) and diabetes (13.5%) prevalence are particularly worrying and underline the importance of policies to reduce cardiovascular morbimortality among farmers
Determination of different social groups’ level of knowledge about malaria in a multicultural Amazonian cross-border context
This study is the first to describe the poor level of knowledge about malaria in populations living in the malaria endemic border area along the Oyapock river in French Guiana. Results will allow to reinforce, to diversify and to culturally adapt prevention messages and health promotion to increase their effectiveness with a view to quickly reaching the goal of malaria elimination through empowerment
A Prospective Comparative Study of Health Inequalities and the Epidemiology of Stroke in French Guiana and Dijon, France
Background In French Guiana poverty is widespread and specialized care is lacking. We aimed to compare strokes between precarious and non-precarious patients within French Guiana and to compare the epidemiology of ischemic strokes and their outcomes between French Guiana and mainland France. Methods A multicenter prospective cohort examined the influence of social inequalities on stroke characteristics. Consecutive patients aged > 18 years admitt…
The Evolution of HIV Patient Retention and Care in French Guiana
BACKGROUND: Although the simplification of antiretroviral (AVR) treatment regimens and follow-up has led to fewer constraints for patients with HIV, their follow-up remains of paramount importance to optimize AVR therapy, to detect and prevent HIV-related morbidity, and prevent secondary infections. The problem of follow-up interruption in French Guiana has been persistent and seemingly impervious to efforts to alleviate it. OBJECTIVE: The object…
Assessing the effectiveness of malaria interventions at the regional level in Ghana using a mathematical modelling application
Supporting malaria control with interfaced applications of mathematical models that enables investigating effectiveness of various interventions as well as their cost implications could be useful. Through their usage for planning, these applications may improve the prospects of attaining various set targets such as those of the National Strategic Plan policies for malaria control in Ghana. A malaria model was adapted and used for simulating the i…
Global estimates of pregnancies at risk of Plasmodium falciparum and Plasmodium vivax infection in 2020 and changes in risk patterns since 2000
Background Women are at risk of severe adverse pregnancy outcomes attributable to Plasmodium spp . infection in malaria-endemic areas. Malaria control efforts since 2000 have aimed to reduce this burden of disease. Methods We used data from the Malaria Atlas Project and WorldPop to calculate global pregnancies at-risk of Plasmodium spp . infection. We categorised pregnancies as occurring in areas of stable and unstable P . falciparum and P . viva…
HIV-testing among female sex workers on the border between Brazil and French Guiana
The border between Brazil and French Guiana is a place of economic, cultural, social and sexual exchange. Female sex workers represent a high risk population for HIV in this area where sexual tourism is particularly developed. HIV testing seems to be an important element in the fight against the epidemic. Indeed, early HIV testing gives access to treatments and prevention. An HIV/AIDS knowledge, attitudes, behaviors and practices survey was condu…
Predictive factors and incidence of anxiety and depression in a cohort of HIV-positive patients in French Guiana
A retrospective cohort study was conducted to determine the predictive factors and the incidence of anxiety and depression in a cohort of patients followed in French Guiana. A total of 2315 patients were followed for a total of 9116 years of follow-up. The incidence rate of first observed depression was 1.89 per 100 person years. The incidence rate of first observed generalized anxiety was 1.27 per 100 person years. A single failure Cox proportio…
Knowledge of free voluntary HIV testing centres and willingness to do a test among migrants in Cayenne, French Guiana
In Cayenne, French Guiana, 80% of HIV-positive patients followed at the hospital are migrants. Behavioural information is crucial for optimising HIV testing for this vulnerable group. Predictors of ignorance of the existence of free voluntary counselling and testing (VCT) centre and willingness to get tested were investigated in 2006 among 398 migrants from Haiti, Guyana, Suriname and Brazil using a structured questionnaire. Only 27% of migrants …
Predictive factors of antiretroviral treatment <4 weeks among HIV-infected pregnant women in Cayenne, French Guiana
French Guiana is the French territory where the HIV epidemic is most preoccupying. In Cayenne, the mother to child HIV transmission rate was 6% in 2006-2008. Despite free testing and treatment, HIV pregnant women often have delayed or insufficient access to care. The aim of this study was to identify predictive factors of antiretroviral treatment<4 weeks in HIV pregnant women in Cayenne (French Guiana) and then to describe their attitudes, practi…
Prevalence and predictive factors of stigmatizing attitudes towards people living with HIV in the remote villages on the Maroni River in French Guiana
The Maroni basin, an isolated region which lies between Suriname and French Guiana, has been affected by the HIV epidemic 10 years after coastal French Guiana. However, the rise in HIV prevalence was sharp with a prevalence exceeding 1% within 10 years. Stigma and discrimination towards people living with HIV (PLWHIV) or "suspected to have HIV" is rampant as reported by health professionals or non-governmental organisations. The objective of this…
Prevalence and risk factors of early onset of sexual intercourse in a random sample of a multiethnic adolescent population in French Guiana
French Guiana, a French overseas department in South America, has been classified epidemic for HIV. This territory is consisting of a very young population with almost 45% of them being younger than 20 years of age. Delaying the onset of first sexual intercourse (SI) is one of the major objectives to fight HIV infection in adolescents. The objective of this study is to identify the age of first SI and the risk factors of early onset. A behavioura…
Knowledge, attitudes, behaviors, and practices differences regarding HIV in populations living along the Maroni river
The Maroni basin, an isolated region delineating the border between Suriname and French Guiana has been affected by the human immunodeficiency virus (HIV) epidemic 10 years after coastal French Guiana. However, the rise in HIV prevalence was sharp, exceeding 1% within 10 years. The aim of the present study is to compare, using the first quantitative data from the general population in remote villages, the knowledge, attitudes, and behaviors regar…
HIV-testing among female sex workers on the border between Brazil and French Guiana
The border between Brazil and French Guiana is a place of economic, cultural, social and sexual exchange. Female sex workers represent a high risk population for HIV in this area where sexual tourism is particularly developed. HIV testing seems to be an important element in the fight against the epidemic. Indeed, early HIV testing gives access to treatments and prevention. An HIV/AIDS knowledge, attitudes, behaviors and practices survey was condu…
Genetic modulators of sickle cell disease in French Guiana
OBJECTIVES: Sickle cell disease (SCD) is the leading genetic disease in French Guiana, reflecting the predominantly African ancestry of the Guianese population. Our purpose was to characterize the genetic modulators of SCD in order to retrace the origin of the population in light of the slave trade. METHODS: We have studied the sickle cell genotype, the βS haplotypes, the alpha and beta thalassemia and the UGT1A1 promoter polymorphisms in 224 Gui…
The use of structural equation modelling and behavioural theory to target priority interventions to increase condom use among the intimate partners of sex workers in French Guiana
French Guiana is the French overseas territory that is most affected by HIV. Sex work seems to be an important driver of the epidemic. Although female sex workers are informed by local NGOs, they still have risky behaviours, including not using condoms with their intimate partner despite knowing HIV is highly prevalent. The objective of this study was to find intervention targets on this specific behaviour. For this, a structural equation model (…
Transactional sex among men who have sex with men in the French Antilles and French Guiana
The French Antilles (Martinique, Saint Martin and Guadeloupe) and French Guiana are the French territories most affected by the HIV epidemic. Some population groups such as men who have sex with men (MSM), especially those involved in transactional sex, are thought to be particularly vulnerable to HIV but few data exist to help characterize their health-related needs and thus implement relevant prevention interventions. To fill this knowledge gap…
Population movements and the HIV cascade in recently diagnosed patients at the French Guiana -Suriname border
Border areas are particular “hot spots” generating high levels of HIV vulnerability and facing great challenges to control epidemics. The objective of this study is to describe the sociodemographic, clinical and biological profiles of newly HIV diagnosed people at the French Guiana - Suriname border, to construct an HIV care cascade and compare it with the Surinamese one. HIV-patients aged over 15 years newly diagnosed in western French Guiana in…
The singular epidemiology of HPV infection among French Guianese women with normal cytology
HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America
Illegal gold miners in French Guiana
Clinical trial registration PRS N° NCT02903706 . Retrospectively registered 09/13/2016
Factors associated with sexual risk taking behavior by precarious urban migrants in French Guiana
BACKGROUND: French Guiana is highly affected by HIV. The migrant population is particularly susceptible. The objective of this study was to evaluate the level of risk of HIV transmission and its perception among migrants in French Guiana and to identify predictive factors. METHODS: An HIV/AIDS Knowledge, Attitudes, Behaviors and Practices study was conducted in 2012 among migrants living in precarious neighborhoods of French Guiana. RESULTS: Of t…
Global Emergence of Buruli Ulcer
Spatial dynamics and epidemiology for Aids in remote areas in French Guiana
Although AIDS care is generally improving in French Guiana, disparities among regions and certain key populations remain significant. The purpose of this study was to describe the spatial and clinical characteristics of people living with HIV (PLHIV) in remote areas in comparison to those followed in hospitals on the urban coast of French Guiana. The data presented were obtained from outpatient on primary care centers located in rural regions awa…
Air Drep—A Retrospective Study Evaluating the Influence of Weather Conditions and Viral Epidemics on Vaso-Occlusive Crises in Patients with Sickle Cell Disease Living in French Guiana
(1) Objectives: French Guiana is the French territory most affected by sickle cell disease (SCD). This study investigates the associations between different environmental factors relative to climate, infectious outbreaks, and emergency visits or weekly hospital admissions for vaso-occlusive crisis (VOC). The identification of risk factors would lead to better patient care and patient management, and more targeted prevention and therapeutic educat…
Knowledge, attitudes, practices about HIV and implications in risk and stigma prevention among French Guianese and Brazilian border inhabitants
These results illustrate the need for initiatives to improve HIV prevention among autochthonous populations on both sides of this border area. Cross-border collaboration on health policies could produce common key messages adapted to the education level and multi-linguistic populations who live in this area
Returning to care after incarceration with HIV
The risk of HIV-follow-up interruption is high, after an incarceration with HIV. ART supply should be sufficient to cover the timespan following release, several months if possible. Those not on ART at the time of incarceration may require special attention, especially those newly HIV-diagnosed while in custody. Comprehensive programs are necessary to support ex-offenders to stay on ART after incarceration
The Epidemiology of Covid 19 in the Amazon and the Guianas
Background: The COVID 19 epidemic submerged many health systems in the Amazon. The objective of the present study was to focus on the epidemic curves of the COVID 19 epidemic in different centers, and to look at testing and mortality data. Methods: Publicly available datasets were used. The log 10 of the daily cumulated number of cases starting from the day the territory reached 100 cumulated cases was plotted to compare the magnitude, shape and …
The impact of Covid-19 pandemic course in the number and severity of hospitalizations for other natural causes in a large urban center in Brazil
The COVID-19 pandemic may indirectly impact hospitalizations for other natural causes. Belo Horizonte is a city with 2.5 million inhabitants in Brazil, one of the most hardly-hit countries by the pandemic, where local authorities monitored hospitalizations daily to guide regulatory measures. In an ecological, time-series study, we investigated how the pandemic impacted the number and severity of public hospitalizations by other natural causes in …
Spatio-Temporal Dynamics of Plasmodium falciparum and Plasmodium vivax in French Guiana
Aims: This study examines the dynamics of malaria as influenced by meteorological factors in French Guiana from 2005 to 2019. It explores spatial hotspots of malaria transmission and aims to determine the factors associated with variation of hotspots with time. Methods : Data for individual malaria cases came from the surveillance system of the Delocalized Centers for Prevention and Care (CDPS) ( n = 17) from 2005-2019. Meteorological data was ac…
A Prospective Comparative Study of Health Inequalities and the Epidemiology of Stroke in French Guiana and Dijon, France
Background In French Guiana poverty is widespread and specialized care is lacking. We aimed to compare strokes between precarious and non-precarious patients within French Guiana and to compare the epidemiology of ischemic strokes and their outcomes between French Guiana and mainland France. Methods A multicenter prospective cohort examined the influence of social inequalities on stroke characteristics. Consecutive patients aged > 18 years admitt…
The Evolution of HIV Patient Retention and Care in French Guiana
BACKGROUND: Although the simplification of antiretroviral (AVR) treatment regimens and follow-up has led to fewer constraints for patients with HIV, their follow-up remains of paramount importance to optimize AVR therapy, to detect and prevent HIV-related morbidity, and prevent secondary infections. The problem of follow-up interruption in French Guiana has been persistent and seemingly impervious to efforts to alleviate it. OBJECTIVE: The object…
Assessing the effectiveness of malaria interventions at the regional level in Ghana using a mathematical modelling application
Supporting malaria control with interfaced applications of mathematical models that enables investigating effectiveness of various interventions as well as their cost implications could be useful. Through their usage for planning, these applications may improve the prospects of attaining various set targets such as those of the National Strategic Plan policies for malaria control in Ghana. A malaria model was adapted and used for simulating the i…
Medicine (44 obras) · Demography (26 obras) · Environmental health (24 obras) · Geography (20 obras) · Population (20 obras) · Internal Medicine (19 obras) · HIV/AIDS Research and Interventions (18 obras) · Public health (16 obras) · Epidemiology (15 obras) · Family medicine (13 obras)