Murray Krahn
Dados Biográficos
| ID | 1733322 |
|---|---|
| NOME | Murray Krahn |
| PRENOMES | Murray |
| SOBRENOME | Krahn |
| ASSINATURA | KRAHN M |
| AFILIAÇÕES | University of Toronto |
| ORCID | 0000-0001-5836-397X |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 22 |
| TOTAL DE CITAÇÕES | 8 |
| TOTAL COMO AUTOR | 22 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1993 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 2 |
Emergency department visits for traumatic hand and wrist injuries in Ontario, Canada
Modes of coordination for health technology adoption
Benefits and harms of prostate cancer screening – predictions of the Oncotyrol prostate cancer outcome and policy model
Assumptions about PCa risk and screen-detectable prevalence significantly affect the benefit-harm balance of screening. Based on the assumptions of our model, PCa screening should focus on candidates with familial predisposition with consideration of individual QoL preferences and age. Active surveillance may require treatment initiation before Gleason score progression to 7. Alternative active surveillance strategies should be evaluated in furth…
Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses
IMPORTANCE: Since publication of the report by the Panel on Cost-Effectiveness in Health and Medicine in 1996, researchers have advanced the methods of cost-effectiveness analysis, and policy makers have experimented with its application. The need to deliver health care efficiently and the importance of using analytic techniques to understand the clinical and economic consequences of strategies to improve health have increased in recent years. OB…
Use of forecasted assessment of quality of life to validate time‐trade‐off utilities and a prostate cancer screening decision‐analytic model
PURPOSE: To determine whether the forecasted assessment of how someone would feel in a future health state can be predictive of utilities (e.g. as elicited by the time-trade-off method) and also predictive of optimal decisions as determined by a decision-analytic model. METHODS: We elicited time-trade-off utilities for prostate cancer treatment outcomes from 168 men. We also elicited forecasted assessments, that is, an informal, non-quantitative,…
The Opportunity Cost of Capital
The opportunity cost of the capital invested in pharmaceutical research and development (R&D) to bring a new drug to market makes up as much as half the total cost. However, the literature on the cost of pharmaceutical R&D is mixed on how, exactly, one should calculate this "hidden" cost. Some authors attempt to adopt models from the field of finance, whereas other prominent authors dismiss this practice as biased, arguing that it artificially in…
Adaptation and validation of the Spanish version of the Patient-Oriented Prostate Utility Scale (Porpus)
Health-related quality of life following radical prostatectomy
Conceptualizing global health-related quality of life in bladder cancer
The Effect of Multidisciplinary Heart Failure Clinic Characteristics on 1-Year Postdischarge Health Care Costs
BACKGROUND: Although multidisciplinary heart failure (HF) clinics are efficacious, it is not known how patient factors or HF clinic structural indicators and process measures have an impact on the cumulative health care costs. RESEARCH DESIGN: In this retrospective cohort study using administrative databases in Ontario, Canada, we identified 1216 HF patients discharged alive after an acute care hospitalization in 2006 and treated at a HF clinic. …
A reference set of health utilities for long-term survivors of prostate cancer
Another Look at the Human Papillomavirus Vaccine Experience in Canada
Policy debates about immunization frequently focus on classic trade-offs between individual versus collective well-being. Publicly funded immunization programs are usually justified on the basis of widespread public benefit with minimal individual risk. We discuss the example of the policy process surrounding the adoption of the human papillomavirus (HPV) vaccine in Canada to consider whether public good arguments continue to dominate immunizatio…
Neck pain patients’ preference scores for their current health
Health-related quality-of-life is considerably diminished in NP patients. Depressive symptoms and preference-elicitation methods influence preference scores that NP patients assign to their health
Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
LTC residents with PU had slightly though statistically significantly lower HRQOL than those without PU. Comorbidity contributed substantially to the low HRQOL in these populations. Community-weighted MDS-HSI utilities for LTC residents are useful for cost-effectiveness analyses and help guide health policy development
Marker states and a health state prompt provide modest improvements in the reliability and validity of the standard gamble and rating scale in prostate cancer patients
Utility-based Quality of Life Measures in Alzheimer’s Disease
Responsiveness of disease-specific and generic utility instruments in prostate cancer patients
The Effect of Hepatitis C Virus Infection on Health-Related Quality of Life in Prisoners
Patient and Community Preferences for Outcomes in Prostate Cancer
BACKGROUND: Preferences, or utilities, for health outcomes are central in prostate cancer decision-making. Utilities can be elicited directly from patients using standard techniques, or indirectly, using questionnaires that incorporate preference weights from community members. OBJECTIVES: To evaluate directly elicited and indirectly elicited (questionnaire-derived, community-weighted) utilities for prostate cancer outcomes and the effects of sex…
Content validity for dementia of three generic preference based health related quality of life instruments
Costs and cost-effectiveness of a universal, school-based hepatitis B vaccination program
OBJECTIVES: This study evaluated the costs and cost-effectiveness of a school-based grade 6 universal vaccination program against hepatitis B. METHODS: We performed a descriptive cost study and cost-effectiveness analysis of British Columbia's vaccination program for 1994 and 1995. Since 1992, public health nurses have administered hepatitis B vaccine to grade 6 students in schools. We measured costs of vaccine, vaccine administration, and net pr…
Discounting in the Economic Evaluation of Health Care Interventions
Do economic theories that underlie discounting have specific implications for program evaluation in health? In this study, both the contemporary practice and the theoretical foundations of discounting are reviewed. The social discount rate controversy is considered, and the two major concepts (i.e., opportunity cost and time preference) involved in the formulation of a social discount rate are outlined. Also described are the arguments for discou…
Costs and cost-effectiveness of a universal, school-based hepatitis B vaccination program
OBJECTIVES: This study evaluated the costs and cost-effectiveness of a school-based grade 6 universal vaccination program against hepatitis B. METHODS: We performed a descriptive cost study and cost-effectiveness analysis of British Columbia's vaccination program for 1994 and 1995. Since 1992, public health nurses have administered hepatitis B vaccine to grade 6 students in schools. We measured costs of vaccine, vaccine administration, and net pr…
Modes of coordination for health technology adoption
The Effect of Hepatitis C Virus Infection on Health-Related Quality of Life in Prisoners
Discounting in the Economic Evaluation of Health Care Interventions
Do economic theories that underlie discounting have specific implications for program evaluation in health? In this study, both the contemporary practice and the theoretical foundations of discounting are reviewed. The social discount rate controversy is considered, and the two major concepts (i.e., opportunity cost and time preference) involved in the formulation of a social discount rate are outlined. Also described are the arguments for discou…
Costs and cost-effectiveness of a universal, school-based hepatitis B vaccination program
OBJECTIVES: This study evaluated the costs and cost-effectiveness of a school-based grade 6 universal vaccination program against hepatitis B. METHODS: We performed a descriptive cost study and cost-effectiveness analysis of British Columbia's vaccination program for 1994 and 1995. Since 1992, public health nurses have administered hepatitis B vaccine to grade 6 students in schools. We measured costs of vaccine, vaccine administration, and net pr…
Content validity for dementia of three generic preference based health related quality of life instruments
Patient and Community Preferences for Outcomes in Prostate Cancer
BACKGROUND: Preferences, or utilities, for health outcomes are central in prostate cancer decision-making. Utilities can be elicited directly from patients using standard techniques, or indirectly, using questionnaires that incorporate preference weights from community members. OBJECTIVES: To evaluate directly elicited and indirectly elicited (questionnaire-derived, community-weighted) utilities for prostate cancer outcomes and the effects of sex…
Utility-based Quality of Life Measures in Alzheimer’s Disease
Responsiveness of disease-specific and generic utility instruments in prostate cancer patients
The Effect of Hepatitis C Virus Infection on Health-Related Quality of Life in Prisoners
Marker states and a health state prompt provide modest improvements in the reliability and validity of the standard gamble and rating scale in prostate cancer patients
Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
LTC residents with PU had slightly though statistically significantly lower HRQOL than those without PU. Comorbidity contributed substantially to the low HRQOL in these populations. Community-weighted MDS-HSI utilities for LTC residents are useful for cost-effectiveness analyses and help guide health policy development
Neck pain patients’ preference scores for their current health
Health-related quality-of-life is considerably diminished in NP patients. Depressive symptoms and preference-elicitation methods influence preference scores that NP patients assign to their health
Another Look at the Human Papillomavirus Vaccine Experience in Canada
Policy debates about immunization frequently focus on classic trade-offs between individual versus collective well-being. Publicly funded immunization programs are usually justified on the basis of widespread public benefit with minimal individual risk. We discuss the example of the policy process surrounding the adoption of the human papillomavirus (HPV) vaccine in Canada to consider whether public good arguments continue to dominate immunizatio…
A reference set of health utilities for long-term survivors of prostate cancer
Adaptation and validation of the Spanish version of the Patient-Oriented Prostate Utility Scale (Porpus)
Health-related quality of life following radical prostatectomy
Conceptualizing global health-related quality of life in bladder cancer
The Effect of Multidisciplinary Heart Failure Clinic Characteristics on 1-Year Postdischarge Health Care Costs
BACKGROUND: Although multidisciplinary heart failure (HF) clinics are efficacious, it is not known how patient factors or HF clinic structural indicators and process measures have an impact on the cumulative health care costs. RESEARCH DESIGN: In this retrospective cohort study using administrative databases in Ontario, Canada, we identified 1216 HF patients discharged alive after an acute care hospitalization in 2006 and treated at a HF clinic. …
Use of forecasted assessment of quality of life to validate time‐trade‐off utilities and a prostate cancer screening decision‐analytic model
PURPOSE: To determine whether the forecasted assessment of how someone would feel in a future health state can be predictive of utilities (e.g. as elicited by the time-trade-off method) and also predictive of optimal decisions as determined by a decision-analytic model. METHODS: We elicited time-trade-off utilities for prostate cancer treatment outcomes from 168 men. We also elicited forecasted assessments, that is, an informal, non-quantitative,…
The Opportunity Cost of Capital
The opportunity cost of the capital invested in pharmaceutical research and development (R&D) to bring a new drug to market makes up as much as half the total cost. However, the literature on the cost of pharmaceutical R&D is mixed on how, exactly, one should calculate this "hidden" cost. Some authors attempt to adopt models from the field of finance, whereas other prominent authors dismiss this practice as biased, arguing that it artificially in…
Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses
IMPORTANCE: Since publication of the report by the Panel on Cost-Effectiveness in Health and Medicine in 1996, researchers have advanced the methods of cost-effectiveness analysis, and policy makers have experimented with its application. The need to deliver health care efficiently and the importance of using analytic techniques to understand the clinical and economic consequences of strategies to improve health have increased in recent years. OB…
Benefits and harms of prostate cancer screening – predictions of the Oncotyrol prostate cancer outcome and policy model
Assumptions about PCa risk and screen-detectable prevalence significantly affect the benefit-harm balance of screening. Based on the assumptions of our model, PCa screening should focus on candidates with familial predisposition with consideration of individual QoL preferences and age. Active surveillance may require treatment initiation before Gleason score progression to 7. Alternative active surveillance strategies should be evaluated in furth…
Modes of coordination for health technology adoption
Emergency department visits for traumatic hand and wrist injuries in Ontario, Canada
Medicine (19 obras) · Health Systems, Economic Evaluations, Quality of Life (12 obras) · Internal Medicine (12 obras) · Cancer (10 obras) · Public health (9 obras) · Quality of life (healthcare (9 obras) · Health related quality of life (8 obras) · Nursing (8 obras) · Prostate cancer (8 obras) · Environmental health (7 obras)