Olli T Raitakari
Dados Biográficos
| ID | 1734792 |
|---|---|
| NOME | Olli T Raitakari |
| PRENOMES | Olli T |
| SOBRENOME | Raitakari |
| ASSINATURA | RAITAKARI O T |
| AFILIAÇÕES | University of Turku |
| ORCID | 0000-0001-9365-3702 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 49 |
| TOTAL DE CITAÇÕES | 53 |
| TOTAL COMO AUTOR | 49 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1997 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 5 |
Nature's Curriculum
Recent research has identified genes linked to educational attainment, but their effects on subsequent socioeconomic outcomes, particularly in egalitarian Nordic welfare states, remain largely unexplored. We analyze two genetically informed Finnish datasets, encompassing longitudinal register information on earnings, employment, unemployment, occupational status, and social assistance receipt (n = 31,622). We examine the role of a polygenic score…
The associations between intergenerational mobility of income and cognitive function in midlife-The Young Finns Study
Individuals with stable high income may have better midlife cognitive function. This finding highlights the role of life-course SES for disparities in adulthood cognitive function. Understanding the role of early-life determinants of midlife cognitive function is important, as this knowledge may be applied to the early promotion of adulthood cognitive health
Worldwide trends in underweight and obesity from 1990 to 2022
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI 2 SD above the median). FINDINGS: From 1990 to 20…
Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study
The identified gene module and its members can provide new joint biomarkers for depression and CVH
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Economic burden of low physical activity and high sedentary behaviour in Finland
BACKGROUND: Low physical activity and high sedentary behaviour are unquestionably relevant for public health while also increasing direct and indirect costs. METHODS: The authors examined the direct and indirect costs attributable to low physical activity and high sedentary behaviour in Finland in 2017. Costs related to major non-communicable diseases drawn from Finnish registries covered direct costs (outpatient visits, days of inpatient care, m…
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Life-course leisure-time physical activity trajectories in relation to health-related behaviors in adulthood
Not only persistently higher LTPA but also an increasing tendency to engage in LTPA after childhood/adolescence were associated with healthier diet and lower smoking frequency in both genders, having less sleep difficulties in women and lower screen time in increasingly active men. Inactivity and low activity were associated with the accumulation of several unhealthy behaviors in adulthood. Associations were stronger in women
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Do childhood infections affect labour market outcomes in adulthood and, if so, how
A burgeoning body of literature suggests that poor childhood health leads to adverse health outcomes, lower educational attainment and weaker labour market outcomes in adulthood. We focus on an important but under-researched topic, which is the role played by infection-related hospitalization (IRH) in childhood and its links to labour market outcomes later in life. The participants aged 24-30 years in 2001 N = 1706 were drawn from the Young Finns…
Temperament profiles are associated with dietary behavior from childhood to adulthood
A network approach to the analysis of psychosocial risk factors and their association with health
We modeled early psychosocial risks as a network of interconnected variables to study their associations with later depressive symptoms and cardiometabolic outcomes. The participants were a nationally representative sample of 2580 men and women aged 3-18 years in 1980. Their parents reported the psychosocial risks in 1980, including the following: (1) child-specific life events, (2) parental health behavior, (3) parental socioeconomic status, and…
Health endowment and later-life outcomes in the labour market
This paper examines the relationship between health endowment and later-life outcomes in the labour market. The analysis is based on reduced-form models in which labour market outcomes are regressed on genetic variants related to the increased risk of cardiovascular diseases. We use linked Finnish data that have many strengths. Genetic risk scores constitute exogenous measures for health endowment, and accurate administrative tax records on earni…
Associations of Leisure-Time Physical Activity Trajectories with Fruit and Vegetable Consumption from Childhood to Adulthood
A physically active lifestyle and a diet rich in vegetables and fruits have a central role in promoting health. This study examined the associations between leisure-time physical activity (LTPA) trajectories and fruit and vegetable consumption (FVC) from childhood to middle age. The data were drawn from the Cardiovascular Risk in Young Finns Study with six age cohorts. Participants were 9 to 18 years ( n = 3536; 51% females) at baseline in 1980 a…
Parent–child-relationship quality predicts offspring dispositional compassion in adulthood
Compassion is known to predict prosocial behavior and moral judgments related to harm. Despite the centrality of compassion to social life, factors predicting adulthood compassion are largely unknown. We examined whether qualities of parent-child-relationship, namely, emotional warmth and acceptance, predict offspring compassion decades later in adulthood. We used data from the prospective population-based Young Finns Study. Our sample included 2…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Changes in Daily Steps and Body Mass Index and Waist to Height Ratio during Four Year Follow-Up in Adults
Aims: Over the study years, there was a significant increase in body mass index (BMI) and waist-to-height ratio (WtHR) in middle aged Finnish adults. Methods: Data were obtained from 1033 Finnish adults from the Cardiovascular Risk in Young Finns Study in 2007 and 2011. Cohort study participants wore an Omron Walking Style One (HJ-152R-E) pedometer for five days and were grouped into those who increased, maintained and decreased their steps betwe…
Socioeconomic differences in children’s growth trajectories from infancy to early adulthood
BACKGROUND: Height is regarded as a marker of early-life illness, adversity, nutrition and psychosocial stress, but the extent to which differences in height are determined by early-life socioeconomic circumstances, particularly in contemporary populations, is unclear. This study examined socioeconomic differences in children's height trajectories from birth through to 21 years of age in four European countries. METHODS: Data were from six prospe…
Genetic endowments, parental resources and adult health
Gene-environment interactions between education and body mass
The challenges of GxE research
Socioeconomic status and the development of depressive symptoms from childhood to adulthood
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Urban/rural differences in body weight
Socioeconomic differences in children’s growth trajectories from infancy to early adulthood
BACKGROUND: Height is regarded as a marker of early-life illness, adversity, nutrition and psychosocial stress, but the extent to which differences in height are determined by early-life socioeconomic circumstances, particularly in contemporary populations, is unclear. This study examined socioeconomic differences in children's height trajectories from birth through to 21 years of age in four European countries. METHODS: Data were from six prospe…
Neighborhood effects in depressive symptoms, social support, and mistrust
Childhood and adolescence risk factors and development of depressive symptoms
BACKGROUND: Environmental risks in childhood have been shown to predict later depressive symptoms. In this study, we examined whether various environmental risk domains in childhood and adolescence, socioeconomic, psychoemotional, parental lifestyle and life-events, predict depressive symptom trajectories in adulthood individually by domain and as a cumulative risk score across domains. METHODS: Participants were a nationally representative sampl…
A network approach to the analysis of psychosocial risk factors and their association with health
We modeled early psychosocial risks as a network of interconnected variables to study their associations with later depressive symptoms and cardiometabolic outcomes. The participants were a nationally representative sample of 2580 men and women aged 3-18 years in 1980. Their parents reported the psychosocial risks in 1980, including the following: (1) child-specific life events, (2) parental health behavior, (3) parental socioeconomic status, and…
Parent–child-relationship quality predicts offspring dispositional compassion in adulthood
Compassion is known to predict prosocial behavior and moral judgments related to harm. Despite the centrality of compassion to social life, factors predicting adulthood compassion are largely unknown. We examined whether qualities of parent-child-relationship, namely, emotional warmth and acceptance, predict offspring compassion decades later in adulthood. We used data from the prospective population-based Young Finns Study. Our sample included 2…
Economic burden of low physical activity and high sedentary behaviour in Finland
BACKGROUND: Low physical activity and high sedentary behaviour are unquestionably relevant for public health while also increasing direct and indirect costs. METHODS: The authors examined the direct and indirect costs attributable to low physical activity and high sedentary behaviour in Finland in 2017. Costs related to major non-communicable diseases drawn from Finnish registries covered direct costs (outpatient visits, days of inpatient care, m…
Temperament profiles are associated with dietary behavior from childhood to adulthood
Gene-environment interactions between education and body mass
The challenges of GxE research
Early Risk Factors, Job Strain, and Atherosclerosis Among Men in Their 30s
We examined whether preemployment influences confounded the association between job strain and atherosclerosis. We assessed biological, familial, and socioeconomic risk factors of coronary heart disease at 12 to 18 years of age and job strain and carotid artery intima-media thickness at 33 to 39 years of age for a cohort of 358 men. Adolescent risk factors predicted adult intima-media thickness but had little effect on the dose–response relation …
Characteristics of young men with clustering risk factors for coronary heart disease
The majority of coronary heart disease (CHD) arises from a population with only moderately elevated risk factor levels. This study addressed the issue of whether clustering of moderately adverse levels of serum low density lipoprotein cholesterol (LDL-C), serum high density lipoprotein cholesterol (HDL-C), and diastolic blood pressure (DBP) was detectable in children and young adults. Significant clustering of these factors was observed in young …
Longitudinal changes in diet from childhood into adulthood with respect to risk of cardiovascular diseases
Consistent dietary patterns identified from childhood to adulthood
Dietary patterns are useful in nutritional epidemiology, providing a comprehensive alternative to the traditional approach based on single nutrients. The Cardiovascular Risk in Young Finns Study is a prospective cohort study with a 21-year follow-up. At baseline, detailed quantitative information on subjects' food consumption was obtained using a 48 h dietary recall method ( n 1768, aged 3–18 years). The interviews were repeated after 6 and 21 ye…
Physical activity from childhood to adulthood
Job Strain and Early Atherosclerosis
Objective: The purpose of this study was to determine whether job strain and social support are associated with early atherosclerosis measured by carotid intima-media thickness (IMT) in young adults. Methods: The subjects were 478 men and 542 women (mean age 32.3) who were participating in the ongoing prospective Cardiovascular Risk in Young Finns study. Job strain was defined as a joint effect of job demands and job control. Early atherosclerosi…
Depressive Symptoms and Carotid Artery Intima-Media Thickness in Young Adults
OBJECTIVE: Depression and coronary heart disease are often comorbid conditions, but the mechanism behind this link is largely unknown. We tested the hypothesis that a high level of depressive symptoms in healthy young adults would be related to more prevalent preclinical atherosclerosis. METHODS: We studied the association between depressive symptoms and carotid atherosclerosis in 1126 young adults (410 men and 716 women) as part of the ongoing p…
Childhood Hyperactivity as a Predictor of Carotid Artery Intima Media Thickness Over a Period of 21 Years
OBJECTIVE: We investigated whether childhood temperament was able to predict carotid artery intima media thickness (IMT) and/or its risk factors in adulthood 21 years later. METHODS: The subjects were the three youngest age cohorts of the population-based sample of the Cardiovascular Risk in Young Finns study, i.e., those who were aged 3 to 9 years (n = 708) at the baseline. IMT was assessed by ultrasound, and temperament in terms of negative emo…
Socioeconomic Status in Childhood and Adulthood
We examined whether dispositional optimism and pessimism (overall LOT‐R and optimism and pessimism component scores) of 694 adults aged 24 and 27 were associated with socioeconomic status (SES) measured concurrently and in childhood at ages 3 and 6. SES measures included education, occupational status and unemployment, and income. Concurrent adulthood SES was associated with the overall LOT‐R and optimism and the pessimism component scores. Child…
Early Risk Factors, Job Strain, and Atherosclerosis Among Men in Their 30s
We examined whether preemployment influences confounded the association between job strain and atherosclerosis. We assessed biological, familial, and socioeconomic risk factors of coronary heart disease at 12 to 18 years of age and job strain and carotid artery intima-media thickness at 33 to 39 years of age for a cohort of 358 men. Adolescent risk factors predicted adult intima-media thickness but had little effect on the dose–response relation …
Chronic Stress and the Development of Early Atherosclerosis
This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elas…
Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight. The Cardiovascular Risk in Young Finns Study
Objective To investigate the associations of BMI and overweight in adulthood with consumption of sweets and sugar-sweetened soft drinks in childhood and with the change in consumption between childhood and adulthood. Design Longitudinal 21-year follow-up study of Finnish children and adolescents from childhood to adulthood. Setting The Cardiovascular Risk in Young Finns Study, comprising participants from both eastern and western Finland. Subject…
Urban/rural differences in body weight
Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
BACKGROUND: Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS: We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define…
Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms
OBJECTIVE: To examine whether the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in serotonin production, is associated with depressive symptoms. METHODS: The participants were 544 women and 442 men (aged 24-39 years) from the population-based Young Finns Study who participated in a medical examination in 2001 (including IDO and depression) and 2007 (follow-up assessment for depression). RESULTS: At baseline, IDO was associat…
Socioeconomic status and the development of depressive symptoms from childhood to adulthood
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Tracking of Physical Activity from Early Childhood through Youth into Adulthood
PURPOSE: The aim of the study was to investigate the tracking of physical activity (PA) from preschool age to adulthood in six age cohorts of males and females. METHODS: A random sample of 3596 boys and girls age 3-18 yr participated in the Cardiovascular Risks in Young Finns Study in 1980. The follow-up measurements were repeated in 1986, 1992, 2001, and 2007. The PA was measured by mother's report in 3- and 6-yr-olds and self-report in 9-yr-old…
Long-term personality changes and predictive adaptive responses after depressive episodes
Genetic studies of body mass index yield new insights for obesity biology
Childhood and adolescence risk factors and development of depressive symptoms
BACKGROUND: Environmental risks in childhood have been shown to predict later depressive symptoms. In this study, we examined whether various environmental risk domains in childhood and adolescence, socioeconomic, psychoemotional, parental lifestyle and life-events, predict depressive symptom trajectories in adulthood individually by domain and as a cumulative risk score across domains. METHODS: Participants were a nationally representative sampl…
Neighborhood effects in depressive symptoms, social support, and mistrust
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Childhood Psychosocial Cumulative Risks and Carotid Intima-Media Thickness in Adulthood
OBJECTIVE: Adverse experiences in childhood may influence cardiovascular risk in adulthood. We examined the prospective associations between types of psychosocial adversity and having multiple adversities (e.g., cumulative risk) with carotid intima-media thickness (IMT) and its progression among young adults. Higher cumulative risk score in childhood was expected to be associated with higher IMT and its progression. METHODS: Participants were 226…
Stature and long-term labor market outcomes
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Medicine (39 obras) · Demography (29 obras) · Population (22 obras) · Psychology (19 obras) · Environmental health (17 obras) · Obesity, Physical Activity, Diet (17 obras) · Demography (13 obras) · Socioeconomic status (13 obras) · Young adult (13 obras) · Developmental psychology (12 obras)