Simon De Lusignan
Dados Biográficos
| ID | 1737463 |
|---|---|
| NOME | Simon De Lusignan |
| PRENOMES | Simon |
| SOBRENOME | De Lusignan |
| ASSINATURA | DE LUSIGNAN S |
| AFILIAÇÕES | University of Oxford |
| ORCID | 0000-0002-8553-2641 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 21 |
| TOTAL DE CITAÇÕES | 5 |
| TOTAL COMO AUTOR | 21 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2007 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 1 |
Exploring the Intensity and Continuity of Hospital Care for Patients With Long Covid
BACKGROUND: Long Covid (LC) is a multisystem condition leading to a wide range of symptoms and often requiring treatment by several different clinical specialties. Patients with LC have reported difficulties in accessing care and a lack of coordination of their care, particularly in a hospital setting. OBJECTIVE: To determine the extent to which the intensity and continuity of hospital care changes for patients after they receive an LC diagnosis.…
Associations between burnout and career disengagement factors among general practitioners
Background: Burnout is associated with career disengagement among general practitioners (GPs), but the underlying mechanisms of this association remain poorly understood. Objective: This study examined the pathways linking burnout to career disengagement factors among GPs. Methods: An 11-item online questionnaire, including validated abbreviated measures of burnout outcomes (single items on emotional exhaustion (EE) and depersonalisation), career…
Pass the tissue
The sensitivity of human tissue and previous instances of misuse have, rightfully, led to the introduction of far-reaching oversight and regulatory mechanisms for accessing, storing and sharing samples. However, these restrictions, in tandem with more broad-based privacy regulations, have had the unintended consequence of obstructing legitimate requests for medical materials. This is of real detriment to ambitions for biomedical research, most no…
Understanding the Clinical Characteristics and Timeliness of Diagnosis for Patients Diagnosed With Long Covid
BACKGROUND: Long Covid is a multisystem condition first identified in the Covid-19 pandemic, characterised by a wide range of symptoms including fatigue, breathlessness and cognitive impairment. Considerable disagreement exists in who is most at risk of developing long Covid, driven in part by incomplete coding of a long Covid diagnosis in medical records. OBJECTIVE: To describe the incidence and impact of long Covid. DESIGN: A retrospective obse…
Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long Covid
BACKGROUND: Recent research has shown that exertion in physical, cognitive, social, and self-care activities triggers symptom severity in individuals with Long COVID. PURPOSE: The current study aimed to investigate whether daily emotional exertions (stress, worry, rumination) were associated with symptom exacerbation, over and above influences of effortful daily activities, in individuals with Long COVID. METHODS: In total, 376 participants were …
Changes in reasons for visits to primary care after the start of the Covid-19 pandemic
Background The COVID-19 pandemic has reshaped healthcare delivery worldwide. Objective To explore potential changes in the reasons for visits and modality of care in primary care settings through the Int ernational Conso r tium of P rimary Care B i g D ata Researchers (INTRePID). Methods We conducted a cross-sectional, retrospective study from 2018–2021. We examined visit volume, modality, and reasons for visits to primary care in Argentina, Aust…
Brand-specific estimates of influenza vaccine effectiveness for the 2021–2022 season in Europe
Introduction: Development of Robust and Innovative Vaccine Effectiveness (DRIVE) was a European public-private partnership (PPP) that aimed to provide annual, brand-specific estimates of influenza vaccine effectiveness (IVE) for regulatory and public health purposes. DRIVE was launched in 2017 under the umbrella of the Innovative Medicines Initiative (IMI) and conducted IVE studies from its pilot season in 2017-2018 to its final season in 2021-20…
Safety of routine childhood vaccine coadministration versus separate vaccination
INTRODUCTION: As new vaccines are developed more vaccine coadministrations vaccines are being offered to make delivery more practical for health systems and patients. We compared the safety of coadministered vaccines with separate vaccination for 20 coadministrations by considering nine types of adverse events following immunisation (AEFI). METHODS: Real-life immunisation and adverse event data for this observational cohort study were extracted f…
Investigating the links between diagnostic uncertainty, emotional exhaustion, and turnover intention in General Practitioners working in the United Kingdom
Diagnostic uncertainty may not only negatively impact on the wellbeing of GPs, but could also have adverse implications on workforce retention in primary care
National influenza surveillance systems in five European countries
This new framework can be used to compare influenza surveillance systems qualitatively between countries to allow the identification of structural differences as well as to evaluate adherence to WHO guidance. The framework may be adapted for other infectious respiratory diseases
Assessing data protection and governance in health information systems
BACKGROUND: Data processing of health research databases often requires a Data Protection Impact Assessment to evaluate the severity of the risk and the appropriateness of measures taken to comply with the European Union (EU) General Data Protection Regulation (GDPR). We aimed to define and apply a comprehensive method for the evaluation of privacy, data governance and ethics among research networks involved in the EU Project Bridge Health. METHO…
Association between Influenza Vaccine Administration and Primary Care Consultations for Respiratory Infections
Influenza, a vaccine preventable disease, is a serious global public health concern which results in a considerable burden on the healthcare system. However, vaccine hesitancy is increasingly becoming a global problem. One prevalent misconception is that influenza vaccinations can cause the flu. We carried out this study to determine whether people undertaking influenza vaccination presented less with acute respiratory tract infection (ARTI) and …
Household presentation of acute gastroenteritis in a primary care sentinel network
The incidence of AGE has changed over time: pre-school children, larger households, and living in London were associated with higher rates, and male gender and higher economic status associated with lower rates
Forecasting the 2017/2018 seasonal influenza epidemic in England using multiple dynamic transmission models
This exercise successfully applied a range of pandemic models to seasonal influenza. Forecasting early in the season remains challenging but represents a crucially important activity to inform planning. Improved knowledge of pre-existing levels of immunity would be valuable
Household presentation of influenza and acute respiratory illnesses to a primary care sentinel network
Patterns of household incidence can be measured from routine data and may provide insights for the modelling of disease transmission and public health policy
The nexus between air pollution, green infrastructure and human health
Cities are constantly evolving and so are the living conditions within and between them. Rapid urbanization and the ever-growing need for housing have turned large areas of many cities into concrete landscapes that lack greenery. Green infrastructure can support human health, provide socio-economic and environmental benefits, and bring color to an otherwise grey urban landscape. Sometimes, benefits come with downsides in relation to its impact on…
Monitoring epidemiological trends in back to school asthma among preschool and school-aged children using real-time syndromic surveillance in England, 2012–2016
BACKGROUND : Back to school (BTS) asthma has been previously reported in children; however, its epidemiology and associated healthcare burden are unclear. We aimed to describe the timing and magnitude of BTS asthma using surveillance data from different health services in England. METHODS : Asthma morbidity data from emergency department attendances and general practitioner (GP) consultations between April 2012 and December 2016 were used from na…
Patients’ experiences of consultations with physician associates in primary care in England
BACKGROUND: Physician associates are new to English general practice and set to expand in numbers. OBJECTIVE: To investigate the patients' perspective on consulting with physician associates in general practice. DESIGN: A qualitative study, using semi-structured interviews, with thematic analysis. SETTING AND PARTICIPANTS: Thirty volunteer patients of 430 who had consulted physician associates for a same-day appointment and had returned a satisfa…
Physician associates in primary health care in England
Referral to a new psychological therapy service is associated with reduced utilisation of healthcare and sickness absence by people with common mental health problems
BACKGROUND: Improving Access to Psychological Therapies (IAPT) is a new programme designed to reduce disease burden to the individual and economic burden to the society of common mental health problems (CMHP). This is the first study to look at the impact of IAPT on health service utilisation and sickness absence using routine data. METHOD: The authors used pseudonymised secure and privately linked (SAPREL) routinely collected primary, secondary …
Coronary heart disease and the management of risk
This paper explores developments in the risk management of coronary heart disease (CHD) that have followed the implementation of the Coronary Heart Disease National Service Framework (NSF) guidelines from the patient's perspective. The CHD NSF introduced in 2000 set national threshold targets for blood pressure and cholesterol levels for primary care managed patients, it also laid down guidelines for the clinical management of those patients deem…
Physician associates in primary health care in England
Referral to a new psychological therapy service is associated with reduced utilisation of healthcare and sickness absence by people with common mental health problems
BACKGROUND: Improving Access to Psychological Therapies (IAPT) is a new programme designed to reduce disease burden to the individual and economic burden to the society of common mental health problems (CMHP). This is the first study to look at the impact of IAPT on health service utilisation and sickness absence using routine data. METHOD: The authors used pseudonymised secure and privately linked (SAPREL) routinely collected primary, secondary …
Coronary heart disease and the management of risk
This paper explores developments in the risk management of coronary heart disease (CHD) that have followed the implementation of the Coronary Heart Disease National Service Framework (NSF) guidelines from the patient's perspective. The CHD NSF introduced in 2000 set national threshold targets for blood pressure and cholesterol levels for primary care managed patients, it also laid down guidelines for the clinical management of those patients deem…
Referral to a new psychological therapy service is associated with reduced utilisation of healthcare and sickness absence by people with common mental health problems
BACKGROUND: Improving Access to Psychological Therapies (IAPT) is a new programme designed to reduce disease burden to the individual and economic burden to the society of common mental health problems (CMHP). This is the first study to look at the impact of IAPT on health service utilisation and sickness absence using routine data. METHOD: The authors used pseudonymised secure and privately linked (SAPREL) routinely collected primary, secondary …
Patients’ experiences of consultations with physician associates in primary care in England
BACKGROUND: Physician associates are new to English general practice and set to expand in numbers. OBJECTIVE: To investigate the patients' perspective on consulting with physician associates in general practice. DESIGN: A qualitative study, using semi-structured interviews, with thematic analysis. SETTING AND PARTICIPANTS: Thirty volunteer patients of 430 who had consulted physician associates for a same-day appointment and had returned a satisfa…
Physician associates in primary health care in England
The nexus between air pollution, green infrastructure and human health
Cities are constantly evolving and so are the living conditions within and between them. Rapid urbanization and the ever-growing need for housing have turned large areas of many cities into concrete landscapes that lack greenery. Green infrastructure can support human health, provide socio-economic and environmental benefits, and bring color to an otherwise grey urban landscape. Sometimes, benefits come with downsides in relation to its impact on…
Monitoring epidemiological trends in back to school asthma among preschool and school-aged children using real-time syndromic surveillance in England, 2012–2016
BACKGROUND : Back to school (BTS) asthma has been previously reported in children; however, its epidemiology and associated healthcare burden are unclear. We aimed to describe the timing and magnitude of BTS asthma using surveillance data from different health services in England. METHODS : Asthma morbidity data from emergency department attendances and general practitioner (GP) consultations between April 2012 and December 2016 were used from na…
Household presentation of acute gastroenteritis in a primary care sentinel network
The incidence of AGE has changed over time: pre-school children, larger households, and living in London were associated with higher rates, and male gender and higher economic status associated with lower rates
Forecasting the 2017/2018 seasonal influenza epidemic in England using multiple dynamic transmission models
This exercise successfully applied a range of pandemic models to seasonal influenza. Forecasting early in the season remains challenging but represents a crucially important activity to inform planning. Improved knowledge of pre-existing levels of immunity would be valuable
Household presentation of influenza and acute respiratory illnesses to a primary care sentinel network
Patterns of household incidence can be measured from routine data and may provide insights for the modelling of disease transmission and public health policy
Assessing data protection and governance in health information systems
BACKGROUND: Data processing of health research databases often requires a Data Protection Impact Assessment to evaluate the severity of the risk and the appropriateness of measures taken to comply with the European Union (EU) General Data Protection Regulation (GDPR). We aimed to define and apply a comprehensive method for the evaluation of privacy, data governance and ethics among research networks involved in the EU Project Bridge Health. METHO…
Association between Influenza Vaccine Administration and Primary Care Consultations for Respiratory Infections
Influenza, a vaccine preventable disease, is a serious global public health concern which results in a considerable burden on the healthcare system. However, vaccine hesitancy is increasingly becoming a global problem. One prevalent misconception is that influenza vaccinations can cause the flu. We carried out this study to determine whether people undertaking influenza vaccination presented less with acute respiratory tract infection (ARTI) and …
Safety of routine childhood vaccine coadministration versus separate vaccination
INTRODUCTION: As new vaccines are developed more vaccine coadministrations vaccines are being offered to make delivery more practical for health systems and patients. We compared the safety of coadministered vaccines with separate vaccination for 20 coadministrations by considering nine types of adverse events following immunisation (AEFI). METHODS: Real-life immunisation and adverse event data for this observational cohort study were extracted f…
Investigating the links between diagnostic uncertainty, emotional exhaustion, and turnover intention in General Practitioners working in the United Kingdom
Diagnostic uncertainty may not only negatively impact on the wellbeing of GPs, but could also have adverse implications on workforce retention in primary care
National influenza surveillance systems in five European countries
This new framework can be used to compare influenza surveillance systems qualitatively between countries to allow the identification of structural differences as well as to evaluate adherence to WHO guidance. The framework may be adapted for other infectious respiratory diseases
Brand-specific estimates of influenza vaccine effectiveness for the 2021–2022 season in Europe
Introduction: Development of Robust and Innovative Vaccine Effectiveness (DRIVE) was a European public-private partnership (PPP) that aimed to provide annual, brand-specific estimates of influenza vaccine effectiveness (IVE) for regulatory and public health purposes. DRIVE was launched in 2017 under the umbrella of the Innovative Medicines Initiative (IMI) and conducted IVE studies from its pilot season in 2017-2018 to its final season in 2021-20…
Changes in reasons for visits to primary care after the start of the Covid-19 pandemic
Background The COVID-19 pandemic has reshaped healthcare delivery worldwide. Objective To explore potential changes in the reasons for visits and modality of care in primary care settings through the Int ernational Conso r tium of P rimary Care B i g D ata Researchers (INTRePID). Methods We conducted a cross-sectional, retrospective study from 2018–2021. We examined visit volume, modality, and reasons for visits to primary care in Argentina, Aust…
Associations between burnout and career disengagement factors among general practitioners
Background: Burnout is associated with career disengagement among general practitioners (GPs), but the underlying mechanisms of this association remain poorly understood. Objective: This study examined the pathways linking burnout to career disengagement factors among GPs. Methods: An 11-item online questionnaire, including validated abbreviated measures of burnout outcomes (single items on emotional exhaustion (EE) and depersonalisation), career…
Pass the tissue
The sensitivity of human tissue and previous instances of misuse have, rightfully, led to the introduction of far-reaching oversight and regulatory mechanisms for accessing, storing and sharing samples. However, these restrictions, in tandem with more broad-based privacy regulations, have had the unintended consequence of obstructing legitimate requests for medical materials. This is of real detriment to ambitions for biomedical research, most no…
Understanding the Clinical Characteristics and Timeliness of Diagnosis for Patients Diagnosed With Long Covid
BACKGROUND: Long Covid is a multisystem condition first identified in the Covid-19 pandemic, characterised by a wide range of symptoms including fatigue, breathlessness and cognitive impairment. Considerable disagreement exists in who is most at risk of developing long Covid, driven in part by incomplete coding of a long Covid diagnosis in medical records. OBJECTIVE: To describe the incidence and impact of long Covid. DESIGN: A retrospective obse…
Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long Covid
BACKGROUND: Recent research has shown that exertion in physical, cognitive, social, and self-care activities triggers symptom severity in individuals with Long COVID. PURPOSE: The current study aimed to investigate whether daily emotional exertions (stress, worry, rumination) were associated with symptom exacerbation, over and above influences of effortful daily activities, in individuals with Long COVID. METHODS: In total, 376 participants were …
Exploring the Intensity and Continuity of Hospital Care for Patients With Long Covid
BACKGROUND: Long Covid (LC) is a multisystem condition leading to a wide range of symptoms and often requiring treatment by several different clinical specialties. Patients with LC have reported difficulties in accessing care and a lack of coordination of their care, particularly in a hospital setting. OBJECTIVE: To determine the extent to which the intensity and continuity of hospital care changes for patients after they receive an LC diagnosis.…
Medicine (17 obras) · Internal Medicine (9 obras) · Family medicine (7 obras) · Demography (6 obras) · Environmental health (6 obras) · Pediatrics (6 obras) · Epidemiology (5 obras) · Influenza Virus Research Studies (5 obras) · Nursing (5 obras) · Business (4 obras)