Terho Lehtimäki
Dados Biográficos
| ID | 193700 |
|---|---|
| NOME | Terho Lehtimäki |
| PRENOMES | Terho |
| SOBRENOME | Lehtimäki |
| ASSINATURA | LEHTIMÄKI T |
| AFILIAÇÕES | Fimlab (Finland) |
| ORCID | 0000-0002-2555-4427 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 32 |
| TOTAL DE CITAÇÕES | 42 |
| TOTAL COMO AUTOR | 32 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1993 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 3 |
Nature's Curriculum
Recent research has identified genes linked to educational attainment, but their effects on subsequent socioeconomic outcomes, particularly in egalitarian Nordic welfare states, remain largely unexplored. We analyze two genetically informed Finnish datasets, encompassing longitudinal register information on earnings, employment, unemployment, occupational status, and social assistance receipt (n = 31,622). We examine the role of a polygenic score…
The associations between intergenerational mobility of income and cognitive function in midlife-The Young Finns Study
Individuals with stable high income may have better midlife cognitive function. This finding highlights the role of life-course SES for disparities in adulthood cognitive function. Understanding the role of early-life determinants of midlife cognitive function is important, as this knowledge may be applied to the early promotion of adulthood cognitive health
Worldwide trends in underweight and obesity from 1990 to 2022
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI 2 SD above the median). FINDINGS: From 1990 to 20…
Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study
The identified gene module and its members can provide new joint biomarkers for depression and CVH
The relationship of trait-like compassion with epigenetic aging
An association between higher compassion in 1997 and a less accelerated DNAmPhenoAge, which builds on previous work on phenotypic aging, approached statistical significance in a sex-adjusted model ( n = 1,030; b = -0.34; p = 0.050). Compassion in 1997 predicted less accelerated epigenetic aging over and above the control variables ( n = 843; b = -0.47; p = 0.016). There was no relationship between compassion in 2001 ( n = 1108/910) and any of the…
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Does better education mitigate risky health behavior? A mendelian randomization study
Education and risky health behaviors are strongly negatively correlated. Education may affect health behaviors by enabling healthier choices through higher disposable income, increasing information about the harmful effects of risky health behaviors, or altering time preferences. Alternatively, the observed negative correlation may stem from reverse causality or unobserved confounders. Based on the data from the Cardiovascular Risk in Young Finns…
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Do childhood infections affect labour market outcomes in adulthood and, if so, how
A burgeoning body of literature suggests that poor childhood health leads to adverse health outcomes, lower educational attainment and weaker labour market outcomes in adulthood. We focus on an important but under-researched topic, which is the role played by infection-related hospitalization (IRH) in childhood and its links to labour market outcomes later in life. The participants aged 24-30 years in 2001 N = 1706 were drawn from the Young Finns…
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
Health endowment and later-life outcomes in the labour market
This paper examines the relationship between health endowment and later-life outcomes in the labour market. The analysis is based on reduced-form models in which labour market outcomes are regressed on genetic variants related to the increased risk of cardiovascular diseases. We use linked Finnish data that have many strengths. Genetic risk scores constitute exogenous measures for health endowment, and accurate administrative tax records on earni…
Maternal and infant characteristics connected to shared pleasure in dyadic interaction
The aim of the study was to analyze which maternal factors (depressive symptoms, effect of life events, maternal sensitivity and structuring) and infant characteristics (temperament, social withdrawal symptoms, interactive behavior, genotype, gender) contribute to shared pleasure (SP) in parent–infant interaction. Participants were 113 mother–infant dyads. The mothers filled in the Edinburgh Postnatal Depression Scale, the Infant Behavior Questio…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Genetic endowments, parental resources and adult health
Gene-environment interactions between education and body mass
Genetic evidence of assortative mating in humans
The challenges of GxE research
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Stature and long-term labor market outcomes
Genetic studies of body mass index yield new insights for obesity biology
Genetic evidence of assortative mating in humans
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Neighborhood effects in depressive symptoms, social support, and mistrust
Gene-environment interactions between education and body mass
The challenges of GxE research
Development of adulthood hostile attitudes
The effects of the serotonin receptor 2A (HTR2A) and 1A (HTR1A) polymorphisms and maternal caregiving attitudes on child's later hostile attitudes were examined. The sample consisted of 819 Finnish children and adolescents. Nurturance was reported by the mothers during childhood, while hostile attitudes were reported by the participants in adulthood. Caregiving attitudes predicted hostile attitudes (β = −.069, p = .047), but HTR2A and HTR1A were …
Dependence between apolipoprotein E phenotypes and temperament in children, adolescents, and young adults
The association of apolipoprotein E (apoE) polymorphism with temperament and Type A behavior was studied in 1577 randomly selected healthy children, adolescents, and young adults during a follow-up period of 9 years. Temperament was correlated with apoE phenotypes. Motor activity, even hyperactivity, in childhood and mental vitality in adolescence and young adulthood increased significantly with the apoE phenotypes in the order of E2/2, E3/2, E4/…
Genetic Variants in the DRD2 Gene Moderate the Relationship Between Stressful Life Events and Depressive Symptoms in Adults
OBJECTIVE: To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults. Although stressful life events, such as divorce, unemployment, and serious illness in the family, are generally associated with negative health outcomes, including depressive symptoms, there are large individual differences in coping with such events. A number of studies …
Development of adulthood hostile attitudes
The effects of the serotonin receptor 2A (HTR2A) and 1A (HTR1A) polymorphisms and maternal caregiving attitudes on child's later hostile attitudes were examined. The sample consisted of 819 Finnish children and adolescents. Nurturance was reported by the mothers during childhood, while hostile attitudes were reported by the participants in adulthood. Caregiving attitudes predicted hostile attitudes (β = −.069, p = .047), but HTR2A and HTR1A were …
Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms
OBJECTIVE: To examine whether the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in serotonin production, is associated with depressive symptoms. METHODS: The participants were 544 women and 442 men (aged 24-39 years) from the population-based Young Finns Study who participated in a medical examination in 2001 (including IDO and depression) and 2007 (follow-up assessment for depression). RESULTS: At baseline, IDO was associat…
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Motherhood and oxytocin receptor genetic variation are associated with selective changes in electrocortical responses to infant facial expressions
Recent studies suggest that parental caregiving is associated with adaptive changes in neurocognitive responses to emotional cues and oxytocin function, possibly reflecting the increased need of parents to monitor infants' emotional states. In the current study, we investigated whether the changes associated with motherhood and oxytocin receptor genetic variation rs53576 are specific to the processing of infant cues as opposed to a more general i…
Genetic studies of body mass index yield new insights for obesity biology
Neighborhood effects in depressive symptoms, social support, and mistrust
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Stature and long-term labor market outcomes
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Genetic endowments, parental resources and adult health
Gene-environment interactions between education and body mass
Genetic evidence of assortative mating in humans
The challenges of GxE research
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
Health endowment and later-life outcomes in the labour market
This paper examines the relationship between health endowment and later-life outcomes in the labour market. The analysis is based on reduced-form models in which labour market outcomes are regressed on genetic variants related to the increased risk of cardiovascular diseases. We use linked Finnish data that have many strengths. Genetic risk scores constitute exogenous measures for health endowment, and accurate administrative tax records on earni…
Maternal and infant characteristics connected to shared pleasure in dyadic interaction
The aim of the study was to analyze which maternal factors (depressive symptoms, effect of life events, maternal sensitivity and structuring) and infant characteristics (temperament, social withdrawal symptoms, interactive behavior, genotype, gender) contribute to shared pleasure (SP) in parent–infant interaction. Participants were 113 mother–infant dyads. The mothers filled in the Edinburgh Postnatal Depression Scale, the Infant Behavior Questio…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Do childhood infections affect labour market outcomes in adulthood and, if so, how
A burgeoning body of literature suggests that poor childhood health leads to adverse health outcomes, lower educational attainment and weaker labour market outcomes in adulthood. We focus on an important but under-researched topic, which is the role played by infection-related hospitalization (IRH) in childhood and its links to labour market outcomes later in life. The participants aged 24-30 years in 2001 N = 1706 were drawn from the Young Finns…
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Medicine (22 obras) · Demography (15 obras) · Population (14 obras) · Biology (13 obras) · Birth, Development, and Health (12 obras) · Genetic Associations and Epidemiology (12 obras) · Psychology (12 obras) · Environmental health (9 obras) · Gene (9 obras) · Demography (8 obras)