Luigi Ferrucci
Dados Biográficos
| ID | 3515025 |
|---|---|
| NOME | Luigi Ferrucci |
| PRENOMES | Luigi |
| SOBRENOME | Ferrucci |
| ASSINATURA | FERRUCCI L |
| AFILIAÇÕES | National Institute on Aging |
| ORCID | 0000-0002-6273-1613 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 48 |
| TOTAL DE CITAÇÕES | 186 |
| TOTAL COMO AUTOR | 48 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1994 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 7 |
Cardiovascular health assessed using Life’s Essential 8 is associated with all-cause and cardiovascular disease mortality among community-dwelling older men and women in the InCHIANTI study
Introduction: The older population is growing fast, and it is important to investigate the cardiovascular health factors and behaviors that are associated with cardiovascular disease (CVD) and mortality among older individuals. Methods: A total of 920 older adults (mean age: 74 years, 55% women) from the InCHIANTI study were included for analysis. Cardiovascular health (CVH) was assessed using the Life's Essential 8 (LE8) developed by the America…
Sleep Duration Polygenic Risk and Phenotype
We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data on self-reported sleep ( n = 567) or genotype ( n = 367). Outcomes included: Intrinsic Horvath age, Hannum age, PhenoAge, GrimAge, and DNAm-based estimates of plasminogen …
Loneliness and Biomarkers of Alzheimer’s Disease, Axonal Damage, and Astrogliosis
Objectives Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau. …
Carta of Florence Against Ageism
World guidelines for falls prevention and management for older adults
BACKGROUND: falls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. Current guidelines are inconsistent, with no up-to-date, globally applicable ones present. OBJECTIVES: to create a set of evidence- and expert consensus-based falls prevention and management recommendations applicable to older a…
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies
ANCOVA provided the most precise estimates at both study and meta-analytic level and thus seems preferable in the meta-analysis of IPD from non-randomized studies. For the studies that were well-balanced between groups, change score, and ANCOVA performed similarly
Multidimensional frailty and quality of life
Multidimensional frailty was associated with a higher risk of mortality and significantly lower GQoLE, suggesting that the multifactorial nature of frailty is associated not only with mortality, but also poor QoL
International Exercise Recommendations in Older Adults (ICFSR)
The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle func…
When Culture Influences Genes
This study provides the first known evidence that self-perceptions can influence the impact of a gene on cognition. The results underscore the importance of combined psychosocial and biological approaches to understanding cognitive function in older adults
DNA methylation GrimAge strongly predicts lifespan and healthspan
Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …
Chronic inflammation in the etiology of disease across the life span
Inflammageing
An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…
Cardiovascular Health Is Associated With Disability Among Older Community Dwelling Men and Women
Objective: The aim of this study was to investigate whether an index of overall cardiovascular health (CVH) is associated with disability in older individuals. Method: Data on 925 participants of the InCHIANTI study (Invecchiare in Chianti, aging in the Chianti area, ≥65 years, 55% women) with median follow-up of 9 years were used. CVH score was assessed by smoking status, physical activity, body mass index, diet quality, blood pressure, plasma c…
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women
Cardiovascular health, even in the elderly, is inversely associated with mortality
Genetic studies of body mass index yield new insights for obesity biology
Hearing Loss and Cognitive Decline in Older Adults
BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, ≥80) who underwent audiometric testing in…
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
The Trajectory of Depressive Symptoms Across the Adult Life Span
Symptoms of depression follow a U-shaped pattern across adulthood. Older adults experience an increase in distress that is not due solely to declines in physical health or approaching death.
Personality Traits and Leptin
OBJECTIVE: Personality traits related to high neuroticism and low conscientiousness are consistently associated with obesity. Hormones implicated in appetite and metabolism, such as leptin, may also be related to personality and may contribute to the association between these traits and obesity. The present research examined the association between leptin and Five Factor Model personality traits. METHODS: A total of 5214 participants (58% women; …
Performance on Five Times Sit-to-Stand Task as a Predictor of Subsequent Falls and Disability in Older Persons
5tSTS is an easily administered tool which can be used to predict subsequent ADL- and IADL-related disability
Personality Traits and Chronic Disease
Measured concurrently, neuroticism and conscientiousness were associated with greater disease burden. The impulsiveness facet of neuroticism was the strongest predictor of developing disease across the follow-up period: For every standard deviation increase in impulsiveness, there was a 26% increased risk of developing disease and a 36% increased risk of getting more ill. Personality traits changed only modestly with disease: As participants deve…
Five‐Factor Personality Traits and Age Trajectories of Self‐Rated Health
We examined the influence of personality traits on mean levels and age trends in 4 single‐item measures of self‐rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community‐dwelling participants ( N = 1,683) completed 7,474 self‐rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age‐associated declines differed across the 4 health i…
Personality and Reduced Incidence of Walking Limitation in Late Life
Findings suggest that personality dimensions, specifically higher openness to experience, may contribute to functional resilience in late life
Is Self-Rated Health Comparable across Cultures and Genders
Self-rated health is a frequently used health indicator, but there is little data on its comparability across cultures. We employed samples from Tampere, Finland, and Florence, Italy, of the European Longitudinal Study on Aging to examine the cultural and gender differences in self-rated health. Personal interview data was used and vital status ascertained after 7 years. After adjusting for several health-related variables, we found no substantia…
Exploring the effect of depression on physical disability
OBJECTIVES: This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. METHODS: A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily li…
Memory Shaped by Age Stereotypes over Time
This study shows that the adverse influence of negative self-stereotypes on cognitive performance is not limited to a short-term laboratory effect. Rather, the findings demonstrate, for the first time, that stereotypes also predict memory performance over an extended period in the community
Personality and obesity across the adult life span
Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adip…
Personality Traits and Chronic Disease
Measured concurrently, neuroticism and conscientiousness were associated with greater disease burden. The impulsiveness facet of neuroticism was the strongest predictor of developing disease across the follow-up period: For every standard deviation increase in impulsiveness, there was a 26% increased risk of developing disease and a 36% increased risk of getting more ill. Personality traits changed only modestly with disease: As participants deve…
Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population
OBJECTIVES: This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. METHODS: A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. RESULTS: …
Black/White Differences in the Relationship between MMSE Scores and Disability
The purpose of this article is to examine Black/White differences among older women in the relationship between physical functional difficulties and variations in cognitive status, measured within the low to high normal range of the Mini-Mental State Examination (MMSE). We studied 3,585 women with MMSE scores of 18 and above from a population-based random sample of 3,841 community-dwelling women aged 65 and older living in East Baltimore, Marylan…
Personality traits and subjective health in the later years
Personality and Reduced Incidence of Walking Limitation in Late Life
Findings suggest that personality dimensions, specifically higher openness to experience, may contribute to functional resilience in late life
Associations of Openness and Conscientiousness With Walking Speed Decline
These findings extend the body of evidence suggesting a protective association between conscientiousness and physical function to performance-based assessment of gait speed. Future studies are needed to confirm these associations and to explore mechanisms that underlie the conscientiousness mobility connection in aging adults
Associations between personality traits, physical activity level, and muscle strength
When Culture Influences Genes
This study provides the first known evidence that self-perceptions can influence the impact of a gene on cognition. The results underscore the importance of combined psychosocial and biological approaches to understanding cognitive function in older adults
Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women
Cardiovascular health, even in the elderly, is inversely associated with mortality
Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment
BACKGROUND: Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI). METHODS: 1604 and 1345 eligible participants from the Baltimore Longitudinal Study of Aging (BLSA) were followed after age 50 for a median time of around 25 years, to examine the incidence of dementia (n=259) and MCI (n=138), respectively. Statin use (ever-use and time-dependent use), total cholesterol levels …
Lower body osteoarticular pain and dose of analgesic medications in older disabled women
OBJECTIVES: This study assessed use and dosage of analgesic medications in relation to severity of osteoarticular pain. METHODS: The type and dose of analgesic medication and the severity of pain in the lower back, hips, knees, or feet of 1002 older disabled women were assessed. RESULTS: Severe pain and the use of analgesic medications were reported by 48.5% and 78.8% of women, respectively. Among those who had severe pain, 41.2% were using less …
A Short Physical Performance Battery Assessing Lower Extremity Function
BACKGROUND: A short battery of physical performance tests was used to assess lower extremity function in more than 5,000 persons age 71 years and older in three communities. METHODS: Balance, gait, strength, and endurance were evaluated by examining ability to stand with the feet together in the side-by-side, semi-tandem, and tandem positions, time to walk 8 feet, and time to rise from a chair and return to the seated position 5 times. RESULTS: A…
Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability
BACKGROUND: Functional assessment is an important part of the evaluation of elderly persons. We conducted this study to determine whether objective measures of physical function can predict subsequent disability in older persons. METHODS: This prospective cohort study included men and women 71 years of age or older who were living in the community, who reported no disability in the activities of daily living, and who reported that they were able …
Assignement of the fibronectin (FN1) gene to pongo pygmaeus (Organgutan) chromosome 11
Is Self-Rated Health Comparable across Cultures and Genders
Self-rated health is a frequently used health indicator, but there is little data on its comparability across cultures. We employed samples from Tampere, Finland, and Florence, Italy, of the European Longitudinal Study on Aging to examine the cultural and gender differences in self-rated health. Personal interview data was used and vital status ascertained after 7 years. After adjusting for several health-related variables, we found no substantia…
Black/White Differences in the Relationship between MMSE Scores and Disability
The purpose of this article is to examine Black/White differences among older women in the relationship between physical functional difficulties and variations in cognitive status, measured within the low to high normal range of the Mini-Mental State Examination (MMSE). We studied 3,585 women with MMSE scores of 18 and above from a population-based random sample of 3,841 community-dwelling women aged 65 and older living in East Baltimore, Marylan…
Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population
OBJECTIVES: This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. METHODS: A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. RESULTS: …
Exploring the effect of depression on physical disability
OBJECTIVES: This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. METHODS: A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily li…
Lower body osteoarticular pain and dose of analgesic medications in older disabled women
OBJECTIVES: This study assessed use and dosage of analgesic medications in relation to severity of osteoarticular pain. METHODS: The type and dose of analgesic medication and the severity of pain in the lower back, hips, knees, or feet of 1002 older disabled women were assessed. RESULTS: Severe pain and the use of analgesic medications were reported by 48.5% and 78.8% of women, respectively. Among those who had severe pain, 41.2% were using less …
Lower Extremity Function and Subsequent Disability
BACKGROUND: Although it has been demonstrated that physical performance measures predict incident disability in previously nondisabled older persons, the available data have not been fully developed to create usable methods for determining risk profiles in community-dwelling populations. Using several populations and different follow-up periods, this study replicates previous findings by using the Established Populations for the Epidemiologic Stu…
Untangling the Concepts of Disability, Frailty, and Comorbidity
Three terms are commonly used interchangeably to identify vulnerable older adults: comorbidity, or multiple chronic conditions, frailty, and disability. However, in geriatric medicine, there is a growing consensus that these are distinct clinical entities that are causally related. Each, individually, occurs frequently and has high import clinically. This article provides a narrative review of current understanding of the definitions and distingu…
Research Agenda for Frailty in Older Adults
Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults has encouraged investigators from many disciplines to contribute to this emerging field of research. This article reports on the results of the 2004 American Geriatrics Society/National Institute on Aging conference on a Research Agenda on Frailty in Older Adults, which brou…
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâ susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 1…
Persistent Depressive Symptoms and Functional Decline Among Patients With Peripheral Arterial Disease
OBJECTIVE: Because depressive symptoms are prevalent among patients with peripheral arterial disease (PAD), our goal was to study the effect of depressive symptoms over time on functional decline among patients with PAD. METHODS: We conducted a prospective cohort study of 417 patients with PAD followed annually for 2 years. A Geriatric Depression Scale Short Form (GDS-S) score >5 was considered positive for depressive symptoms. Depressive symptom…
Personality Predictors of Longevity
OBJECTIVE: To examine the association between personality traits and longevity. METHODS: Using the Guilford-Zimmerman Temperament Survey, personality traits were assessed in 2359 participants (38% women; age = 17 to 98 years, mean = 50 years) from the Baltimore Longitudinal Study of Aging, starting in 1958. Over the duration of the study, 943 (40%) participants died, on average 18 years after their personality assessment. The association of each …
Personality traits and subjective health in the later years
Age Stereotypes Held Earlier in Life Predict Cardiovascular Events in Later Life
When older individuals apply negative age stereotypes to themselves, they can adversely influence a wide range of outcomes (Levy, Slade, Kunkel, & Kasl, 2002). These outcomes include a greater cardiovascular response to stress and worse health behaviors, such as higher tobacco use (Levy, Hausdorff, Hencke, & Wei, 2000; Levy & Myers, 2004), both of which have been linked to the risk of cardiovascular events (Jiang et al., 1996).
Facets of Personality Linked to Underweight and Overweight
OBJECTIVE: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. METHODS: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years…
Teeth grinding
Memory Shaped by Age Stereotypes over Time
This study shows that the adverse influence of negative self-stereotypes on cognitive performance is not limited to a short-term laboratory effect. Rather, the findings demonstrate, for the first time, that stereotypes also predict memory performance over an extended period in the community
Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment
BACKGROUND: Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI). METHODS: 1604 and 1345 eligible participants from the Baltimore Longitudinal Study of Aging (BLSA) were followed after age 50 for a median time of around 25 years, to examine the incidence of dementia (n=259) and MCI (n=138), respectively. Statin use (ever-use and time-dependent use), total cholesterol levels …
Personality and obesity across the adult life span
Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adip…
Five‐Factor Personality Traits and Age Trajectories of Self‐Rated Health
We examined the influence of personality traits on mean levels and age trends in 4 single‐item measures of self‐rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community‐dwelling participants ( N = 1,683) completed 7,474 self‐rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age‐associated declines differed across the 4 health i…
Personality and Reduced Incidence of Walking Limitation in Late Life
Findings suggest that personality dimensions, specifically higher openness to experience, may contribute to functional resilience in late life
Associations of Openness and Conscientiousness With Walking Speed Decline
These findings extend the body of evidence suggesting a protective association between conscientiousness and physical function to performance-based assessment of gait speed. Future studies are needed to confirm these associations and to explore mechanisms that underlie the conscientiousness mobility connection in aging adults
Associations between personality traits, physical activity level, and muscle strength
Medicine (43 obras) · Psychology (24 obras) · Gerontology (17 obras) · Gerontology (16 obras) · Internal Medicine (15 obras) · Internal Medicine (15 obras) · Disease (13 obras) · Health disparities and outcomes (13 obras) · Personality (12 obras) · Psychiatry (12 obras)