Rafael G Dos Santos
Dados Biográficos
| ID | 3693521 |
|---|---|
| NOME | Rafael G Dos Santos |
| PRENOMES | Rafael G |
| SOBRENOME | Dos Santos |
| ASSINATURA | DOS SANTOS R G |
| AFILIAÇÕES | Universidade de São Paulo |
| ORCID | 0000-0003-2388-4745 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 18 |
| TOTAL DE CITAÇÕES | 8 |
| TOTAL COMO AUTOR | 18 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2007 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
Ayahuasca and Public Health III
Ayahuasca, a traditional Amazonian psychoactive brew, has gained increasing attention for its potential health benefits; however, no previous research has investigated its use in Portugal. This study aims to evaluate the health status, lifestyle behaviors, and psychosocial well-being of Portuguese ayahuasca users, comparing their self-reported health indicators with population norms. A cross-sectional online survey was conducted among 203 Portugu…
Comparative effects of ayahuasca and breathwork on self-reported cognitive flexibility, emotion regulation, positive affect, and sleep quality
Background and aimsResearch on classical psychedelics like ayahuasca is increasingly focused on treating mental disorders and enhancing well-being. Ayahuasca has shown promise in improving cognitive flexibility, emotion regulation, and sleep, though findings are mixed and further research is needed. This study tracked participants over three months, assessing cognitive flexibility, positive affect, emotion regulation, and sleep before and after a…
Why N,N-dimethyltryptamine matters
Iracema comes with the pot full of the green liquor. The shaman decrees the dreams to each warrior and distributes the wine of jurema, which carries the brave Tabajara to heaven." José de Alencar, in his poetic novel “Iracema” (1865)1. IntroductionThe "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin and melatonin. Widely found in plants and anima…
Underground ibogaine use for the treatment of substance use disorders
Hallucinations and Hallucinogens
Ayahuasca and Public Health II
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that countries should address. This study evaluates the impact of regular ayahuasca ceremony participation on health by assessing the health status of 377 participants in ayahuasca ceremonies in the Netherlands using validated health indicators. A questionnaire was developed and administered to study participan…
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the Covid-19 Confinement
Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs h…
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Ayahuasca and Public Health
Assessing the health status of ayahuasca users has been challenging due to the limitations involved in randomized clinical trials and psychometric approaches. The main objective of this study is the implementation of an approach based on public health indicators. We developed a self-administered questionnaire that was administered to long-term ayahuasca users around Spain. The questionnaire was administrated face-to-face to participants ( n = 380…
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
Effects of the Natural β -Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression
Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on reg…
Effects of Ayahuasca and its Alkaloids on Drug Dependence
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression
OBJECTIVES: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. METHODS: Open-label trial conducted in an inpatient psychiatric unit. RESULTS: Statistically significant re…
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression
OBJECTIVES: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. METHODS: Open-label trial conducted in an inpatient psychiatric unit. RESULTS: Statistically significant re…
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression
Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on reg…
Effects of Ayahuasca and its Alkaloids on Drug Dependence
Effects of the Natural β -Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Ayahuasca and Public Health
Assessing the health status of ayahuasca users has been challenging due to the limitations involved in randomized clinical trials and psychometric approaches. The main objective of this study is the implementation of an approach based on public health indicators. We developed a self-administered questionnaire that was administered to long-term ayahuasca users around Spain. The questionnaire was administrated face-to-face to participants ( n = 380…
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the Covid-19 Confinement
Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs h…
Ayahuasca and Public Health II
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that countries should address. This study evaluates the impact of regular ayahuasca ceremony participation on health by assessing the health status of 377 participants in ayahuasca ceremonies in the Netherlands using validated health indicators. A questionnaire was developed and administered to study participan…
Underground ibogaine use for the treatment of substance use disorders
Hallucinations and Hallucinogens
Why N,N-dimethyltryptamine matters
Iracema comes with the pot full of the green liquor. The shaman decrees the dreams to each warrior and distributes the wine of jurema, which carries the brave Tabajara to heaven." José de Alencar, in his poetic novel “Iracema” (1865)1. IntroductionThe "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin and melatonin. Widely found in plants and anima…
Comparative effects of ayahuasca and breathwork on self-reported cognitive flexibility, emotion regulation, positive affect, and sleep quality
Background and aimsResearch on classical psychedelics like ayahuasca is increasingly focused on treating mental disorders and enhancing well-being. Ayahuasca has shown promise in improving cognitive flexibility, emotion regulation, and sleep, though findings are mixed and further research is needed. This study tracked participants over three months, assessing cognitive flexibility, positive affect, emotion regulation, and sleep before and after a…
Ayahuasca and Public Health III
Ayahuasca, a traditional Amazonian psychoactive brew, has gained increasing attention for its potential health benefits; however, no previous research has investigated its use in Portugal. This study aims to evaluate the health status, lifestyle behaviors, and psychosocial well-being of Portuguese ayahuasca users, comparing their self-reported health indicators with population norms. A cross-sectional online survey was conducted among 203 Portugu…
Psychedelics and Drug Studies (15 obras) · Psychology (14 obras) · Psychiatry (13 obras) · Medicine (12 obras) · Ayahuasca (11 obras) · Hallucinogen (9 obras) · Clinical Psychology (7 obras) · Biochemical Analysis and Sensing Techniques (6 obras) · Cannabis and Cannabinoid Research (6 obras) · Forensic Toxicology and Drug Analysis (5 obras)