Jane Leserman
Dados Biográficos
| ID | 3923798 |
|---|---|
| NOME | Jane Leserman |
| PRENOMES | Jane |
| SOBRENOME | Leserman |
| ASSINATURA | LESERMAN J |
| AFILIAÇÕES | University of North Carolina at Chapel Hill |
| VERIFICADO | Não |
| TOTAL DE OBRAS | 48 |
| TOTAL DE CITAÇÕES | 55 |
| TOTAL COMO AUTOR | 48 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1980 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2021 |
| ÍNDICE H | 3 |
Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women With Early Life Abuse
OBJECTIVE: Early life abuse (ELAb) initiates pathophysiological cascades resulting in long-term maladaptive stress responsivity, hyperalgesia, and an increased risk of psychopathology. Mindfulness-based stress reduction (MBSR) is effective in modifying psychological and somatic symptoms; thus, we predicted that MBSR would be particularly efficacious for women with ELAb. METHOD: Medically healthy women (mean age = 31 years) with or without a histo…
Relationship between trauma and high-risk behavior among HIV-positive men who do not have sex with men (MDSM)
The incidence of heterosexual HIV transmission continues to increase in the USA. However, little is known about factors that influence high-risk behavior among men who do not have sex with men (MDSM). This study examines the association of childhood sexual abuse and high-risk behaviors among MDSM. The Coping with HIV/AIDS in the Southeast (CHASE) study included 611 HIV-positive individuals in the Southeastern US Bivariate statistics were used to …
Hypothalamic-Pituitary-Thyroid Axis Function in Women With a Menstrually Related Mood Disorder
INTRODUCTION: We previously reported a unique hypothalamic-pituitary-thyroid (HPT) axis profile in women with a menstrually related mood disorder (MRMD) who also had a history of sexual abuse (SA). In the present study, we sought to extend that work by examining the association of an SA history with HPT-axis disturbance in both women with MRMD and women without MRMD. METHODS: Fifty-seven women met the prospective criteria for MRMD (23 with an SA …
Highly stressed
A history of traumatic and/or stressful experiences is prevalent among HIV-infected individuals and has been consistently associated with poorer health outcomes. However, little is known about incident stressful experiences and the factors that predict these experiences among HIV-infected individuals. Data from a longitudinal study of 611 HIV-infected individuals in the Southeastern USA were used to examine the frequency and types of incident str…
Incident Stressful and Traumatic Life Events and Human Immunodeficiency Virus Sexual Transmission Risk Behaviors in a Longitudinal, Multisite Cohort Study
Objective: To assess the association between incident stressful life events (e.g., sexual and physical assault; housing instability; and major financial, employment, and legal difficulties) and unprotected anal or vaginal sexual intercourse (unprotected sex) among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (PLWHA). Methods: We assessed incident stressful events and unprotected sex over 27 months in 61…
Physiological and Psychosocial Factors that Predict HIV-Related Fatigue
Overload
OBJECTIVE: To examine the influence of incident stressful experiences on antiretroviral medication adherence and treatment outcomes. Past trauma history predicts poorer medication adherence and health outcomes. Human immunodeficiency virus (HIV)-infected individuals experience frequently traumatic and stressful events, such as sexual and physical assault, housing instability, and major financial, employment, and legal difficulties. METHODS: We me…
Measuring fatigue in people living with HIV/Aids
In the era of life-prolonging antiretroviral therapy, chronic fatigue is one of the most prevalent and disabling symptoms of people living with HIV/AIDS, yet its measurement remains challenging. No instruments have been developed specifically to describe HIV-related fatigue. We assessed the reliability and construct validity of the HIV-Related Fatigue Scale (HRFS), a 56-item self-report instrument developed through formative qualitative research …
Trauma, stressful life events and depression predict HIV-related fatigue
Despite the fact that fatigue is a common and debilitating symptom among HIV-infected persons, we know little about the predictors of fatigue in this population. The goal of this cross-sectional study was to examine the effects of early childhood trauma, recent stressful life events and depression on intensity and impairment of fatigue in HIV, over and above demographic factors and clinical characteristics. We studied 128 HIV-infected men and wom…
A Road Well Traveled (Although Not Yet a Super Highway)
Departments of Psychiatry and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (Leserman) Department of Medicine, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD (Temoshok) Jane Leserman and Lydia R. Temoshok served as Guest Editors for this special issue. Address correspondence and reprint requests to Jane Leserman, Departments of Psychiatry and Medicine, University of North Carolina at…
Role of Depression, Stress, and Trauma in HIV Disease Progression
Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. Longitudinal studies both before and after the advent of highly active antiretroviral therapies (HAART) are reviewed. To ensure a complete review, PubMed was searched for all English language article…
Relationship of Abuse History to Functional Gastrointestinal Disorders and Symptoms
The primary goals of this article are to review the evidence that links sexual and physical abuse and intimate partner violence (IPV) with functional gastrointestinal (GI) symptoms and disorders and to explore physiological mechanisms that might mediate these health effects. The literature cited in this review has shown strong and consistent relationships of sexual and physical abuse history and IPV with functional GI symptoms and disorders. Amon…
Childhood abuse and initial presentation for HIV care
An alarmingly high prevalence of childhood sexual and physical abuse has been observed in HIV-infected men and women, with rates several times higher than observed in the general population. Childhood abuse history has been associated with worse antiretroviral adherence and negative health behaviours in HIV-infected patients. This study evaluates the relationship between childhood abuse and the timing of presentation for HIV care. Participants in…
Barriers to Antiretroviral Adherence
Among HIV-infected persons, high-level adherence to antiretroviral medications (>90%-95%) is associated with improved immunologic, virologic, and clinical outcomes, and is necessary to prevent the emergence of viral resistance. This study examines whether lifetime traumatic events including physical and sexual abuse, are associated with antiretroviral nonadherence. We present a cross-sectional analysis of the Coping with HIV/AIDS in the Southeast…
Prevalence of Childhood Sexual Abuse and Physical Trauma in an HIV-Positive Sample From the Deep South
We examined prevalence and predictors of trauma among HIV-infected persons in the Deep South using data from the Coping with HIV/AIDS in the Southeast (CHASE) study. Over 50% of CHASE participants were abused during their lives, with approximately 30% experiencing abuse before age 13, regardless of gender. Caregiver characteristics were associated with childhood abuse. Abuse is related to increases in high–HIV-risk activities. The findings help e…
Exploring Lack of Trust in Care Providers and the Government as a Barrier to Health Service Use
Objectives. We examined associations between trust of health care providers and the government and health service use and outcomes. Methods. Interviews with a sample of 611 HIV-positive individuals included an attitudinal assessment measuring beliefs concerning the creation of AIDS, information being withheld about the disease, and trust of care providers. Results. Trust in care providers was associated with increased HIV-related out-patient clin…
Sexual Abuse History
OBJECTIVE: Lifetime history of sexual abuse is estimated to range between 15% and 25% in the general female population. People who are sexually abused are at greater risk for a whole host of physical health disorders that may occur many years after the abusive incident(s). Despite the high prevalence of this trauma and its association with poor health status, abuse history often remains hidden within the context of medical care. The aims of this …
How Trauma, Recent Stressful Events, and PTSD Affect Functional Health Status and Health Utilization in HIV-Infected Patients in the South
OBJECTIVE: In addition to biological markers of human immunodeficiency virus (HIV) disease progression, physical functioning, and utilization of health care may also be important indicators of health status in HIV-infected patients. There is insufficient understanding of the psychosocial predictors of health-related physical functioning and use of health services among those with this chronic disease. Therefore, the current study examines how tra…
Stress, Hostility, and Disease Parameters of Benign Prostatic Hyperplasia
Objective: Psychological factors such as stress are known to influence activity in the sympathetic nervous system and hypothalamic–pituitary–gonadal axis, systems that in turn have been implicated in the development of benign prostatic hyperplasia (BPH). Associations between psychological stress and prostate function have not been directly examined. The objective of this study was to examine associations among stress, hostility, and BPH disease p…
Historical Sexual Abuse and Current Thyroid Axis Profiles in Women With Premenstrual Dysphoric Disorder
Objective: This study investigated whether women with premenstrual dysphoric disorder (PMDD) who also had histories of sexual abuse differed from women with PMDD with no previous sexual abuse and from women without PMDD in hypothalamic-pituitary-thyroid (axis measures). Methods: Ten sexually abused women with PMDD were compared with 18 nonabused women with PMDD and 22 nonabused women without PMDD for hypothalamic-pituitary-thyroid axis hormone co…
Changes in Neuropsychological Functioning with Progression of HIV-1 Infection
HIV disease progression
Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls
OBJECTIVE: To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls. METHODS: Twenty-eight women with prospectively confirmed PMDD were compared with 28 non-PMDD women for cardiovascular and neuroendocrine measures at rest and in response to mental stressors, and for beta-adrenergic receptor responsivity, du…
Progression to Aids, a clinical Aids condition and mortality
Background. The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression. Methods. Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease prog…
Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to Aids
OBJECTIVE: This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection. METHOD: Eighty-two homosexual men with HIV type-1 infection without AIDS or symptoms at baseline were studied every 6 months for up to 7. 5 years. Men were recruited from rural and urban areas in North Carolina, and none was using antiretroviral medications at ent…
Health Outcomes and a New Index of Spiritual Experience
Jared D. Kass, Richard Friedman, Jane Leserman, Patricia C. Zuttermeister, Herbert Benson, Health Outcomes and a New Index of Spiritual Experience, Journal for the Scientific Study of Religion, Vol. 30, No. 2 (Jun., 1991), pp. 203-211
Exploring Lack of Trust in Care Providers and the Government as a Barrier to Health Service Use
Objectives. We examined associations between trust of health care providers and the government and health service use and outcomes. Methods. Interviews with a sample of 611 HIV-positive individuals included an attitudinal assessment measuring beliefs concerning the creation of AIDS, information being withheld about the disease, and trust of care providers. Results. Trust in care providers was associated with increased HIV-related out-patient clin…
Undergraduate Women
Despite the gains of recent years, women continue to be underrepresented in scientific fields at every educational level. In 1981, only 27 percent of the nation's bachelor's degrees in science and mathematics were awarded to women. The gap widens at higher educational levels; in the same year only 17 percent of all science and mathematics doctorates went to women. At the same time, labor force statistics show that in 1980 women represented 13 per…
Prevalence of Childhood Sexual Abuse and Physical Trauma in an HIV-Positive Sample From the Deep South
We examined prevalence and predictors of trauma among HIV-infected persons in the Deep South using data from the Coping with HIV/AIDS in the Southeast (CHASE) study. Over 50% of CHASE participants were abused during their lives, with approximately 30% experiencing abuse before age 13, regardless of gender. Caregiver characteristics were associated with childhood abuse. Abuse is related to increases in high–HIV-risk activities. The findings help e…
Sex differences in the professional orientation of first-year medical students
Sex differences in the professional orientation of first-year medical students
Men and Women in Medical School
Women in Law
Life Change Stress, Psychiatric Symptoms, and Natural Killer Cell Activity
Previous research has linked stress with adverse health change; however, the immunologic mechanisms mediating these changes remain poorly understood. To test whether "stress" was associated with alterations in cell-mediated immunity, we examined the correlations of self-reported life change stress (LCS) and psychiatric symptoms with natural killer cell activity (NKCA) among 114 healthy undergraduate volunteers. Although the bivariate correlation …
Men and Women in Medical School
Undergraduate Women
Despite the gains of recent years, women continue to be underrepresented in scientific fields at every educational level. In 1981, only 27 percent of the nation's bachelor's degrees in science and mathematics were awarded to women. The gap widens at higher educational levels; in the same year only 17 percent of all science and mathematics doctorates went to women. At the same time, labor force statistics show that in 1980 women represented 13 per…
The Efficacy of the Relaxation Response in Preparing for Cardiac Surgery
This study evaluated the efficacy of the relaxation response on the post-operative recovery of 27 cardiac surgery patients randomly assigned to one of two groups. Thirteen experimental group patients received educational information and practiced eliciting the relaxation response before and after surgery. The 14 patients in the control group received only information. Experimental and control groups were compared before and after surgery on both …
Sexual and Physical Abuse in Women with Functional or Organic Gastrointestinal Disorders
STUDY OBJECTIVES: To determine the prevalence of a history of sexual and physical abuse in women seen in a referral-based gastroenterology practice, to determine whether patients with functional gastrointestinal disorders report greater frequencies of abuse than do patients with organic gastrointestinal diseases, and to determine whether a history of abuse is associated with more symptom reporting and health care utilization. DESIGN: A consecutiv…
The rating form of IBD patient concerns
Health status assessment for persons with chronic illness includes not only symptoms, but also an appraisal of the psychosocial concomitants of illness. In this national study of persons with inflammatory bowel disease (IBD), we standardized a disease-specific 25-item measure of perceived health status: the Rating Form of IBD Patient Concerns (RFIPC). Factor analysis yielded four indices: a) impact of disease (e.g., being a burden, loss of energy…
An Inventory of Positive Psychological Attitudes with Potential Relevance to Health Outcomes
This article describes the validation of an Inventory of Positive Psychological Attitudes that has potential relevance to health outcomes and its preliminary testing with chronic pain patients. The inventory taps two attitudinal domains: (1) life purpose and satisfaction and (2) self-confidence during potentially stressful situations. It also provides a total score. The inventory scales, developed using factor analysis, were found to have a stron…
Health Outcomes and a New Index of Spiritual Experience
Jared D. Kass, Richard Friedman, Jane Leserman, Patricia C. Zuttermeister, Herbert Benson, Health Outcomes and a New Index of Spiritual Experience, Journal for the Scientific Study of Religion, Vol. 30, No. 2 (Jun., 1991), pp. 203-211
The Reliability and Validity of a Sexual and Physical Abuse History Questionnaire in Female Patients with Gastrointestinal Disorders
Although the literature on the psychological and medical sequelae of sexual and physical abuse has been growing, researchers have made few attempts to standardize the measurement of abuse history. The authors of this article report the first standardization of a screening instrument to identify sexual and physical abuse in a medical population. Reliability was assessed using test-retest methodology, and validity was supported by comparison with a…
Sexual and Physical Abuse History in Gastroenterology Practice
OBJECTIVE: There is an increasing amount of literature pointing to a relationship between sexual and/or physical abuse history and poor health status, although few studies provide evidence concerning which aspects of abuse may impact on health. In female patients with gastrointestinal (GI) disorders, the present study examined the effects on health status of: 1) history of sexual abuse and physical abuse, 2) invasiveness or seriousness of sexual …
Impact of Sexual and Physical Abuse Dimensions on Health Status
OBJECTIVE: Despite the abundant literature showing a relationship of sexual and/or physical abuse history with poor health status, few studies provide evidence about which dimensions of abuse may have a worse impact on health. In female patients with gastrointestinal (GI) disorders, the present study aims to identify which dimensions of abuse history (eg, number of perpetrators, injury) might predict poor current health status, in order to develo…
The Mind-Body Link
The Influence of Depressive Symptoms on Cognitive Difficulties Affecting Daily Living in Hiv-1 Infection
Silva, S.; Baldewicz, T.; Jackson, E.; Leserman, J.; Perkins, D.O.; Howe, L.; Evans, D.L.; Golden, R.N. Author Information
The Longitudinal Effects of Sexual and Physical Abuse Severity on Daily Functioning
How Multiple Types of Stressors Impact on Health
OBJECTIVE: Although many studies have focused on the relationship between stress and health, few have examined the impact of multiple types of stressors. The current study investigated the health impact of four stressors: sexual and physical abuse history, lifetime losses and traumas, turmoil in childhood family, and recent stressful life events. METHOD: The sample included 239 female patients from a referral-based gastroenterology clinic. RESULT…
Progression to Aids
OBJECTIVE: We examined the effects of stress, depressive symptoms, and social support on the progression of HIV infection. METHODS: Eighty-two HIV-infected gay men without symptoms or AIDS at baseline were followed up every 6 months for up to 5.5 years. Men were recruited from rural and urban areas in North Carolina as part of the Coping in Health and Illness Project. Disease progression was defined using criteria for AIDS (CD4+ lymphocyte count …
Sexual and Physical Abuse Associated With Cardiovascular Response to Stress
Sexual and Physical Abuse Predict Poor Health in Pregnancy and Postpartum
Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to Aids
OBJECTIVE: This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection. METHOD: Eighty-two homosexual men with HIV type-1 infection without AIDS or symptoms at baseline were studied every 6 months for up to 7. 5 years. Men were recruited from rural and urban areas in North Carolina, and none was using antiretroviral medications at ent…
Effects of Coping on Health Outcome Among Women With Gastrointestinal Disorders
Maladaptive coping (eg, catastrophizing) and decreased self-perceived ability to decrease symptoms may adversely affect health outcome and may modify the effect of GI disease type and neuroticism on health outcome
High Versus Low Basal Cortisol Secretion in Asymptomatic, Medication-free HIV-infected Men
The authors hypothesized that HIV-infected men with high basal cortisol secretion would exhibit greater stress-related reductions in the ratio of Th1/Th2 cell-derived cytokines and numbers of CD8+ T and NK lymphocytes than low basal cortisol secretors. A semistructured interview was used to assess life stress during the preceding 6 months of 94 HIV-infected men classified as high and low cortisol secretors (n = 47/group). Increased levels of seve…
Progression to Aids, a clinical Aids condition and mortality
Background. The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression. Methods. Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease prog…
Medicine (41 obras) · Psychology (34 obras) · Psychiatry (32 obras) · Clinical Psychology (30 obras) · HIV/AIDS Research and Interventions (19 obras) · Poison control (17 obras) · Sexual abuse (17 obras) · Internal Medicine (16 obras) · Internal Medicine (16 obras) · Physical abuse (12 obras)