Puneetpal Singh
Dados Biográficos
| ID | 3973483 |
|---|---|
| NOME | Puneetpal Singh |
| PRENOMES | Puneetpal |
| SOBRENOME | Singh |
| ASSINATURA | SINGH P |
| AFILIAÇÕES | Punjabi University |
| ORCID | 0000-0003-2154-4261 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 21 |
| TOTAL DE CITAÇÕES | 1 |
| TOTAL COMO AUTOR | 21 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1998 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2024 |
| ÍNDICE H | 1 |
Burden of disease scenarios for 204 countries and territories, 2022–2050
BACKGROUND: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternativ…
Genetic Risk Scores for the Determination of Type 2 Diabetes Mellitus (T2DM) in North India
Several polymorphisms were associated with T2DM risk. PRS based on even a limited number of loci improves the prediction of the disease. This may provide a useful method for determining T2DM susceptibility for clinical and public health applications
Prevalence and Predictors of Osteoporosis and Osteopenia in Postmenopausal Women of Punjab, India
The prevalence and predictors of osteoporosis and osteopenia remain to be examined in the postmenopausal women of Punjab, India. The present cross-sectional study screened 1628 postmenopausal women during September 2019 to March 2020. Osteoporosis and osteopenia were confirmed on the basis of T-scores using dual energy X-ray absorptiometry (DXA) at the hip (femoral neck) and lumbar spine regions (L1−L4 vertebrae). The prevalence of osteoporosis a…
Multifactorial Landscape Parses to Reveal a Predictive Model for Knee Osteoarthritis
The present study attempted to investigate whether concerted contributions of significant risk variables, pro-inflammatory markers, and candidate genes translate into a predictive marker for knee osteoarthritis (KOA). The present study comprised 279 confirmed osteoarthritis patients (Kellgren and Lawrence scale >2) and 287 controls. Twenty SNPs within five genes (CRP, COL1A1, IL-6, VDR, and eNOS), four pro-inflammatory markers (interleukin-6 (IL-…
Genetic Scores of eNOS, ACE and Vegfa Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women
The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase ( eNOS ), angiotensin converting enzyme ( ACE ) and vascular endothelial growth factor ( VEGFA ) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were ex…
Genetic variation and differentiation among a native British and five migrant South Asian populations of the East Midlands (UK) based on Codis forensic STR loci
FGA locus was most polymorphic and discriminatory among migrant populations demonstrating it as the marker with the highest potential in forensic analyses. These results could be useful for population and forensic genomic studies
Genetic analysis of novel Alu insertion polymorphisms in selected indian populations
Objectives Indian subpopulations (Chenchu, Koya, and Lobana Sikh) were analyzed at the genetic level for 12 Alu polymorphisms. These markers were then utilized to establish levels of genetic identity between the Indian populations and more widely between the Indian populations and a European population. Methods Previously collected blood samples were extracted using the phenol‐chloroform method. The samples were utilized as templates for PCR usin…
The Prevalence and Predictors of Depression in Type 2 Diabetic Population of Punjab
Apoe distribution in world populations with new data from India and the UK
Overall APOE allelic variation in UK and Indian populations is comparable to previous studies but in tribal populations *E4 allele frequency was very low or absent. At a global level allelic variation shows that geography, isolation by distance, genetic drift and possibly pre-historical selection are responsible for shaping the spectrum of genetic variation at the APOE gene. Overall, APOE is a good anthropogenetic and clinical diagnostic marker
Role of Media in Aids Awakening
Molecular genetic variation in the East Midlands, England
The allele frequency spectrum and inter-population comparisons show that there is significant genetic variation in the five contiguous regional populations of the East Midlands. Some of this variation may be due to local geographical barriers, genetic drift and possibly the settlement patterns of Continental European invaders
Population genetic study of the STR loci (HUMCSF1PO, HUMTPOX, HUMTHO1, HUMLPL, Humf13A01, Humf13B, HSFESFPS and HUMVWA) in North Indians
The allele frequency spectrum, heterozygosity, probability of exclusion, match probability and discrimination probability estimates show interesting variation and suggest the usefulness of these loci for anthropogenetic, paternity and forensic investigations in Indian populations
Genetic Variation of Apolipoproteins in North Indians
Genetic variation at three apolipoprotein loci (APOA4, APOH, and APOE) has been examined in nine endogamous populations of Punjab, North India. The overall pattern of allele frequency variation at different loci is compatible with that of European populations, but observed microvariation differentiates the populations according to their position in the Indian caste structure. The most common allele at the APOA4 locus was APOA4*1 with a narrow fre…
Genetic heterogeneity of Apo CII locus in North India
Apolipoprotein CII genotypes were determined in Brahmins, Banias, Jat Sikhs, Khatris, Ramgarhia, Ramdasia and Scheduled Castes of Punjab, North India (n = 930). The Apo CII exhibits three common polymorphic alleles CII*1, CII*2 and CII*3 with pooled frequencies 0.883, 0.114 and 0.003, respectively. CII*3 was absent in Brahmins. Distribution of Apo CII isoforms highlights a considerable variation among different ethnic groups across the world. The…
Apolipoprotein E polymorphism in India
High resolution two dimensional gel electrophoresis with the combination of isoelectric focusing (IEF) and density gradient sodium dodecyl-polyacrylamide gel electrophoresis (DG-PAGE) have been employed to investigate the distribution of APOE in Ramgarhia (n = 80) and Ramdasia (n = 70) of Punjab, India. Three alleles APOE*E2, APOE*E3 and APOE*E4 were observed in Ramgarhia and Ramdasia with the frequencies of 0.031, 0.913, 0.056 and 0.043, 0.886 a…
Apolipoprotein A-IV Polymorphism in Five Punjabi Populations
Apolipoprotein A-IV genotypes were determined in five population groups (Brahmins, Banias, Jatsikhs, Khatris and ‘Others’) of Punjab (n-780) by two dimensional gel electrophoresis. The apo A-IV exhibits two common polymorphic alleles AIV-1 and AIV-2 with pooled frequencies 0.903 and 0.097 respectively. Distribution of apo A-IV isoforrms highlight considerable variation among different ethnic groups across the world. Average heterozygosity of Punj…
Do Distances Play Role in Aids Info? Decreasing Vigilance towards Countryside
AIDS awareness was investigated in 180 individuals through telephonic conversation in 32 villages in four directions (Forms 0-40 kms) of Ludhiana city of Punjab. Clear cut decreasing trend of AIDS consciousness away from the city in all the four directions was evident that is, towards. North (y = – 0.379x + 14.59, r = 0.9596),South (y = –0.403x + 14.28, r = 0.9610), East (y = –0.4187x + 15.14, r = 0.9671) and West (y = –0.4037x + 14.71,r – 0.9675…
Genetic Evaluation of proteins with High Resolution Two Dimensional (2D) Gel Electrophoresis
High resolution two dimensional gel electrophoresis with the combination of isoelectric focusing (IEF) and density gradient SDS polyacrylamide gel electrophoresis (DGSDS-PAGE) is a highly sensitive technique in population genetic, biochemical genetic and medical genetic studies. 2-D gel electrophoresis separates protein according to differences in both isoelectric point and molecular weight. The technique is so impressive and significant that on …
Apolipoprotein Polymorphism in Man – It’s Role in Health and Disease
Apolipo proteins play an important role in lipid transport in human body; starting from absorption of processed dietary lipids from the exogenous pathway in intestines to the endogenous transport involving extra hepatic cells and processing them in the liver. Along with various enzymes the binding characteristics of apolipoproteins are the main determinants in lipid metabolism in the body. The binding characteristics are in turn dependent on the …
Study of Some Morphological, Physiological and Serological Parameters in Twins
The present study was conducted on 18 pairs of twins. The similarity method was used for zygosity determination. Eight pairs were found to be monozygotic and the rest dizygotic. Intra-pair differences regarding various morphological and physiological parameters were observed in these twins. MZ twin pairs showed very small differences for morpholo gical parameters than DZ, confirming that MZ twins have similar genetic make up. Physiological parame…
Menarcheal Status and Physical Structure of Punjabi Girls
The present study has been conducted on 301 Punjabi adolescent girls with a view to exploring the relationship between sexual maturity and physical structure. Data in respect of anthropometric measurements and menarcheal status were collected from Ropar District of Punjab during April 1990. Anthropometric measurements have been taken following the standard techniques given by IBP/HA sub committee (Tanner et al., 1969). Status quo information rega…
Genetic Variation of Apolipoproteins in North Indians
Genetic variation at three apolipoprotein loci (APOA4, APOH, and APOE) has been examined in nine endogamous populations of Punjab, North India. The overall pattern of allele frequency variation at different loci is compatible with that of European populations, but observed microvariation differentiates the populations according to their position in the Indian caste structure. The most common allele at the APOA4 locus was APOA4*1 with a narrow fre…
Menarcheal Status and Physical Structure of Punjabi Girls
The present study has been conducted on 301 Punjabi adolescent girls with a view to exploring the relationship between sexual maturity and physical structure. Data in respect of anthropometric measurements and menarcheal status were collected from Ropar District of Punjab during April 1990. Anthropometric measurements have been taken following the standard techniques given by IBP/HA sub committee (Tanner et al., 1969). Status quo information rega…
Apolipoprotein Polymorphism in Man – It’s Role in Health and Disease
Apolipo proteins play an important role in lipid transport in human body; starting from absorption of processed dietary lipids from the exogenous pathway in intestines to the endogenous transport involving extra hepatic cells and processing them in the liver. Along with various enzymes the binding characteristics of apolipoproteins are the main determinants in lipid metabolism in the body. The binding characteristics are in turn dependent on the …
Study of Some Morphological, Physiological and Serological Parameters in Twins
The present study was conducted on 18 pairs of twins. The similarity method was used for zygosity determination. Eight pairs were found to be monozygotic and the rest dizygotic. Intra-pair differences regarding various morphological and physiological parameters were observed in these twins. MZ twin pairs showed very small differences for morpholo gical parameters than DZ, confirming that MZ twins have similar genetic make up. Physiological parame…
Apolipoprotein A-IV Polymorphism in Five Punjabi Populations
Apolipoprotein A-IV genotypes were determined in five population groups (Brahmins, Banias, Jatsikhs, Khatris and ‘Others’) of Punjab (n-780) by two dimensional gel electrophoresis. The apo A-IV exhibits two common polymorphic alleles AIV-1 and AIV-2 with pooled frequencies 0.903 and 0.097 respectively. Distribution of apo A-IV isoforrms highlight considerable variation among different ethnic groups across the world. Average heterozygosity of Punj…
Do Distances Play Role in Aids Info? Decreasing Vigilance towards Countryside
AIDS awareness was investigated in 180 individuals through telephonic conversation in 32 villages in four directions (Forms 0-40 kms) of Ludhiana city of Punjab. Clear cut decreasing trend of AIDS consciousness away from the city in all the four directions was evident that is, towards. North (y = – 0.379x + 14.59, r = 0.9596),South (y = –0.403x + 14.28, r = 0.9610), East (y = –0.4187x + 15.14, r = 0.9671) and West (y = –0.4037x + 14.71,r – 0.9675…
Genetic Evaluation of proteins with High Resolution Two Dimensional (2D) Gel Electrophoresis
High resolution two dimensional gel electrophoresis with the combination of isoelectric focusing (IEF) and density gradient SDS polyacrylamide gel electrophoresis (DGSDS-PAGE) is a highly sensitive technique in population genetic, biochemical genetic and medical genetic studies. 2-D gel electrophoresis separates protein according to differences in both isoelectric point and molecular weight. The technique is so impressive and significant that on …
Apolipoprotein E polymorphism in India
High resolution two dimensional gel electrophoresis with the combination of isoelectric focusing (IEF) and density gradient sodium dodecyl-polyacrylamide gel electrophoresis (DG-PAGE) have been employed to investigate the distribution of APOE in Ramgarhia (n = 80) and Ramdasia (n = 70) of Punjab, India. Three alleles APOE*E2, APOE*E3 and APOE*E4 were observed in Ramgarhia and Ramdasia with the frequencies of 0.031, 0.913, 0.056 and 0.043, 0.886 a…
Population genetic study of the STR loci (HUMCSF1PO, HUMTPOX, HUMTHO1, HUMLPL, Humf13A01, Humf13B, HSFESFPS and HUMVWA) in North Indians
The allele frequency spectrum, heterozygosity, probability of exclusion, match probability and discrimination probability estimates show interesting variation and suggest the usefulness of these loci for anthropogenetic, paternity and forensic investigations in Indian populations
Genetic Variation of Apolipoproteins in North Indians
Genetic variation at three apolipoprotein loci (APOA4, APOH, and APOE) has been examined in nine endogamous populations of Punjab, North India. The overall pattern of allele frequency variation at different loci is compatible with that of European populations, but observed microvariation differentiates the populations according to their position in the Indian caste structure. The most common allele at the APOA4 locus was APOA4*1 with a narrow fre…
Genetic heterogeneity of Apo CII locus in North India
Apolipoprotein CII genotypes were determined in Brahmins, Banias, Jat Sikhs, Khatris, Ramgarhia, Ramdasia and Scheduled Castes of Punjab, North India (n = 930). The Apo CII exhibits three common polymorphic alleles CII*1, CII*2 and CII*3 with pooled frequencies 0.883, 0.114 and 0.003, respectively. CII*3 was absent in Brahmins. Distribution of Apo CII isoforms highlights a considerable variation among different ethnic groups across the world. The…
Role of Media in Aids Awakening
Molecular genetic variation in the East Midlands, England
The allele frequency spectrum and inter-population comparisons show that there is significant genetic variation in the five contiguous regional populations of the East Midlands. Some of this variation may be due to local geographical barriers, genetic drift and possibly the settlement patterns of Continental European invaders
Apoe distribution in world populations with new data from India and the UK
Overall APOE allelic variation in UK and Indian populations is comparable to previous studies but in tribal populations *E4 allele frequency was very low or absent. At a global level allelic variation shows that geography, isolation by distance, genetic drift and possibly pre-historical selection are responsible for shaping the spectrum of genetic variation at the APOE gene. Overall, APOE is a good anthropogenetic and clinical diagnostic marker
Genetic analysis of novel Alu insertion polymorphisms in selected indian populations
Objectives Indian subpopulations (Chenchu, Koya, and Lobana Sikh) were analyzed at the genetic level for 12 Alu polymorphisms. These markers were then utilized to establish levels of genetic identity between the Indian populations and more widely between the Indian populations and a European population. Methods Previously collected blood samples were extracted using the phenol‐chloroform method. The samples were utilized as templates for PCR usin…
The Prevalence and Predictors of Depression in Type 2 Diabetic Population of Punjab
Genetic variation and differentiation among a native British and five migrant South Asian populations of the East Midlands (UK) based on Codis forensic STR loci
FGA locus was most polymorphic and discriminatory among migrant populations demonstrating it as the marker with the highest potential in forensic analyses. These results could be useful for population and forensic genomic studies
Multifactorial Landscape Parses to Reveal a Predictive Model for Knee Osteoarthritis
The present study attempted to investigate whether concerted contributions of significant risk variables, pro-inflammatory markers, and candidate genes translate into a predictive marker for knee osteoarthritis (KOA). The present study comprised 279 confirmed osteoarthritis patients (Kellgren and Lawrence scale >2) and 287 controls. Twenty SNPs within five genes (CRP, COL1A1, IL-6, VDR, and eNOS), four pro-inflammatory markers (interleukin-6 (IL-…
Genetic Scores of eNOS, ACE and Vegfa Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women
The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase ( eNOS ), angiotensin converting enzyme ( ACE ) and vascular endothelial growth factor ( VEGFA ) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were ex…
Prevalence and Predictors of Osteoporosis and Osteopenia in Postmenopausal Women of Punjab, India
The prevalence and predictors of osteoporosis and osteopenia remain to be examined in the postmenopausal women of Punjab, India. The present cross-sectional study screened 1628 postmenopausal women during September 2019 to March 2020. Osteoporosis and osteopenia were confirmed on the basis of T-scores using dual energy X-ray absorptiometry (DXA) at the hip (femoral neck) and lumbar spine regions (L1−L4 vertebrae). The prevalence of osteoporosis a…
Genetic Risk Scores for the Determination of Type 2 Diabetes Mellitus (T2DM) in North India
Several polymorphisms were associated with T2DM risk. PRS based on even a limited number of loci improves the prediction of the disease. This may provide a useful method for determining T2DM susceptibility for clinical and public health applications
Burden of disease scenarios for 204 countries and territories, 2022–2050
BACKGROUND: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternativ…
Biology (15 obras) · Medicine (14 obras) · Gene (13 obras) · Genetics (13 obras) · Population (13 obras) · Demography (10 obras) · Allele (9 obras) · Demography (7 obras) · Genotype (7 obras) · Internal Medicine (7 obras)