Suzette D Tardif
Dados Biográficos
| ID | 4133450 |
|---|---|
| NOME | Suzette D Tardif |
| PRENOMES | Suzette D |
| SOBRENOME | Tardif |
| ASSINATURA | TARDIF S D |
| AFILIAÇÕES | Texas Biomedical Research Institute |
| ORCID | 0000-0002-3412-7742 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 39 |
| TOTAL DE CITAÇÕES | 21 |
| TOTAL COMO AUTOR | 39 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1984 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2024 |
| ÍNDICE H | 3 |
Genetic characterization of a captive marmoset ( Callithrix jacchus ) colony using genotype‐by‐sequencing
The marmoset is a fundamental nonhuman primate model for the study of aging, neurobiology, and many other topics. Genetic management of captive marmoset colonies is complicated by frequent chimerism in the blood and other tissues, a lack of tools to enable cost‐effective, genome‐wide interrogation of variation, and historic mergers and migrations of animals between colonies. We implemented genotype‐by‐sequencing (GBS) of hair follicle derived DNA…
Advancing Autism Research From Mice to Marmosets
Understanding the mechanism(s) by which maternal immune activation (MIA) during gestation may disrupt neurodevelopment and increase the susceptibility for disorders such as autism spectrum disorder (ASD) or schizophrenia is a critical step in the development of better treatments and preventive measures. A large body of literature has investigated the pathophysiology of MIA in rodents. However, a translatability gap plagues pre-clinical research o…
Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey ( Callithrix jacchus )
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus , is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here,…
A comparative study of litter size and sex composition in a large dataset of callitrichine monkeys
In many birds and mammals, the size and sex composition of litters can have important downstream effects for individual offspring. Primates are model organisms for questions of cooperation and conflict, but the factors shaping interactions among same‐age siblings have been less‐studied in primates because most species bear single young. However, callitrichines (marmosets, tamarins, and lion tamarins) frequently bear litters of two or more, thereb…
Comparative genomics of Bifidobacterium species isolated from marmosets and humans
The genus Bifidobacterium is purported to have beneficial consequences for human health and is a major component of many gastrointestinal probiotics. Although species of Bifidobacterium are generally at low relative frequency in the adult human gastrointestinal tract, they can constitute high proportions of the gastrointestinal communities of adult marmosets. To identify genes that might be important for the maintenance of Bifidobacterium in adul…
The metabolome as a biomarker of mortality risk in the common marmoset
Recently, the common marmoset has been proposed as a non-human primate model of aging. Their short lifespan coupled with pathologies that are similar to humans make them an ideal model to understand the genetic, metabolic, and environmental factors that influence aging and longevity. However, many of the underlying physiological changes that occur with age in the marmoset are unknown. Here, we attempt to determine if individual metabolites are pr…
Age‐related changes in myelin of axons of the corpus callosum and cognitive decline in common marmosets
Executive control is a higher-level cognitive function that involves a range of different processes that are involved in the planning, coordination, execution, and inhibition of responses. Many of the processes associated with executive control, such as response inhibition and mental flexibility, decline with age. Degeneration of white matter architecture is considered to be the one of the key factors underlying cognitive decline associated with …
Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets
The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This cross‐sectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment…
Marmosets as a translational aging model—Introduction
The life history of the common marmoset (Callithrix jacchus) points to this species as a premiere nonhuman primate aging model. In order to take advantage of these features, we require an expanded and refined understanding of aging in this species. The papers in this special issue move this field forward substantially by providing exciting new findings about the aging of the common marmoset and the potential this species offers for revealing agin…
Digestive Efficiency Mediated by Serum Calcium Predicts Bone Mineral Density in the Common Marmoset ( Callithrix jacchus )
Two health problems have plagued captive common marmoset ( Callithrix jacchus ) colonies for nearly as long as those colonies have existed: marmoset wasting syndrome and metabolic bone disease. While marmoset wasting syndrome is explicitly linked to nutrient malabsorption, we propose metabolic bone disease is also linked to nutrient malabsorption, although indirectly. If animals experience negative nutrient balance chronically, critical nutrients…
Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus
Metabolic assessment of a non-human primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as…
Body mass growth in common marmosets
While much is known about adult obesity in nonhuman primates, very little is known regarding development of childhood adiposity. As small monkeys that are easy to handle and have a relatively fast life history, common marmoset monkeys ( Callithrix jacchus ) offer interesting opportunities to examine the question of fat versus lean mass growth in a nonhuman primate. This article provides an overview of our understanding of early life growth in mas…
The Development of Obesity Begins at an Early Age in Captive Common Marmosets ( C allithrix jacchus )
Animal models to study the causes and consequences of obesity during infancy in humans would be valuable. In this study, we examine the patterns of fat mass gain from birth to 12 months in common marmosets ( C allithrix jacchus ). Lean and fat mass was measured by quantitative magnetic resonance at 1, 2, 6, and 12 months for 31 marmosets, 15 considered Normal and 16 considered Fat (>14% body fat) at 12 months. Animals were fed either the regular …
Establishing Meal Patterns by Lickometry in the Marmoset Monkey ( C allithrix jacchus)
The ability to measure and interpret variables associated with feeding behavior and food intake is essential to a variety of nonhuman primate study modalities. The development of a technique to accurately and efficiently measure food intake and meal patterning in captivity will enhance both the interpretation of foraging behavior in the wild as well as our ability to model clinically relevant human feeding pathologies. In this study, we successfu…
Integration of proximate and evolutionary explanation of reproductive strategy
We offer examples of how proximate and evolutionary forms of argument may inform each other in better understanding reproductive strategy in callitrichid primates, the smallest of the anthropoid primates. In addition, we illustrate how comparative approaches, when applied judiciously, can aid in the formulation of hypotheses regarding even seemingly unique traits within a taxonomic group. In the first example, examination of the nature of genetic…
Placental insulin‐like growth factor II (IGF‐II) and its relation to litter size in the common marmoset monkey ( Callithrix jacchus )
The primate placenta produces a wide variety of hormones throughout gestation that regulate placental function and fetal growth. One such hormone is insulin‐like growth factor‐II (IGF‐II), a peptide implicated in cell division, differentiation, and amino acid transport. IGF‐II concentrations were measured in 23 common marmoset ( Callithrix jacchus ) term placentas from twin and triplet litters in order to determine whether previously described di…
Polymorphic microsatellite loci for the common marmoset ( Callithrix jacchus ) designed using a cost‐ and time‐efficient method
We describe a cost‐ and time‐efficient method for designing new microsatellite markers in any species with substantial genomic DNA sequence data available. Using this technique, we report 14 new polymorphic dinucleotide microsatellite loci isolated from the common marmoset. The relative yield of new polymorphisms was higher with less labor than described in previous marmoset studies. Of 20 loci initially evaluated, 14 were polymorphic and amplifi…
Placental efficiency and intrauterine resource allocation strategies in the common marmoset pregnancy
Mothers and fetuses are expected to be in some degree of conflict over the allocation of maternal resources to fetal growth in the intrauterine environment. Variation in placental structure and function may be one way a fetus can communicate need and quality to its mother, potentially manipulating maternal investment in its favor. Whereas common marmosets typically produce twin litters, they regularly give birth to triplet litters in captivity. T…
Pattern of maternal serum corticotropin‐releasing hormone concentration during pregnancy in the common marmoset ( Callithrix jacchus )
Corticotropin‐releasing hormone (CRH), a potent neuropeptide, is produced by the placenta of anthropoid primates. No other mammals, including prosimian primates, are known to produce placental CRH. In humans, placental CRH appears to play an important role in the progression of pregnancy to parturition. Maternal circulating CRH begins to rise early in pregnancy and increases until parturition. Gorillas and chimpanzees share this pattern of increa…
Relations among birth condition, maternal condition, and postnatal growth in captive common marmoset monkeys ( Callithrix jacchus )
The present study characterizes the relations among maternal condition, litter size, birth condition, and growth in body weight for a population of common marmosets. The subjects of the study were marmosets born into a single colony between 1994 and 2001. Three sets of analyses were conducted to answer the following questions: 1) Is there a relationship between litter size, maternal condition, and birth condition? In the study population, materna…
Reproductive output, maternal age, and survivorship in captive common marmoset females ( Callithrix jacchus )
Common marmosets ( Callithrix jacchus ) demonstrate significant variation in reproductive output on both a yearly and lifetime basis in comparison to other anthropoid primates. We explore the factors that may be most important in determining reproductive variation in captive common marmosets. Studies have found that maternal age, maternal condition, and dam survivorship are related to reproductive output; however, these reports are not in agreeme…
Resting energy metabolism of Goeldi's monkey ( Callimico goeldii ) is similar to that of Other callitrichids
The resting metabolic rates (RMRs) of six adult Goeldi's monkeys ( Callimico goeldii ) were measured using standard methods of open circuit respirometry during both the active (daytime) and inactive (nighttime) circadian phases for this species. One subject was measured both while she was pregnant and after she delivered a full‐term, stillborn infant. Inactive‐phase RMR within thermal neutrality (above 27.5°C) averaged 288.5±30.8 ml O 2 /hr; acti…
Does the milk of callitrichid monkeys differ from that of larger anthropoids
The generalization that anthropoid primates produce dilute milks that are low in protein and energy is based primarily on data from large monkeys of the families Cebidae and Cercopithecidae, as well as humans. The marmosets and tamarins (Callitrichidae) are not only much smaller in body size, but also typically raise multiple offspring during a relatively brief lactation. We hypothesized that selection for small body size and high reproductive ra…
The evolution of women
Hager, Lori D., ed. Women in Human Evolution. New York: Routledge, 1997. xiii + 214 pp. including index. $69.95 cloth, $18.95 paper. Morbeck, Mary Ellen, Alison Galloway and Adrienne Zihlman, eds. The Evolving Female: A Life History Perspective. Princeton, NJ: Princeton University Press, 1997. xix + 332 pp. including literature cited and index. $60.00 cloth, $27.95 paper
Ingestion of calcium solutions by common marmosets (Callithrix jacchus)
Callithrix jacchus, the common marmoset, is a small New World primate that feeds on insects, fruit, and gum, and has a high reproductive rate for a primate. Insects are generally a poor source of dietary calcium, while gums may contain significant levels of calcium. Their high reproductive rate also suggests that reproductive female C. jacchus might be susceptible to calcium deficiency. Thus, we hypothesized that common marmosets might find solut…
Placental efficiency and intrauterine resource allocation strategies in the common marmoset pregnancy
Mothers and fetuses are expected to be in some degree of conflict over the allocation of maternal resources to fetal growth in the intrauterine environment. Variation in placental structure and function may be one way a fetus can communicate need and quality to its mother, potentially manipulating maternal investment in its favor. Whereas common marmosets typically produce twin litters, they regularly give birth to triplet litters in captivity. T…
Reproductive factors affecting survivorship in captive callitrichidae
Efforts to breed Callitrichidae in captivity have resulted in high fertility accompanied by high infant mortality. This paper investigates the relationship between reproductive characteristics and survivorship in the Oak Ridge and Associated Universities (ORAU) callitrichid colony. Records of 2,834 individuals were analyzed using Cox Proportional Hazards regression to investigate factors affecting infant survivorship. Species and birth cohort wer…
Species differences in response to conspecific intruders inCallithrix jacchus andSaguinus oedipus
Social implications of gummivory in marmosets
Gummivory or exudate feeding is a major dietary specialization which has received relatively little attention in the literature. While plant exudates contribute to the diet of many primate species, we suggest that the callitrichid species Cebuella pygmaea and Callithrix jacchus are obligate exudate feeders under free‐ranging conditions. Callithrix jacchus provides an excellent model for examining the effects of exudate feeding and foraging upon s…
Kin preference in marmosets and tamarins
Field studies on callitrichid primates have suggested that some species may exhibit a communal breeding system in which two or more males mate with a single female and cooperatively participate in infant rearing. However, high levels of aggression have been observed between males under both laboratory and field conditions. In avian models for communal breeding, cooperating males are often closely related. In a laboratory test of a hypothesis of t…
Body mass growth in common marmosets
While much is known about adult obesity in nonhuman primates, very little is known regarding development of childhood adiposity. As small monkeys that are easy to handle and have a relatively fast life history, common marmoset monkeys ( Callithrix jacchus ) offer interesting opportunities to examine the question of fat versus lean mass growth in a nonhuman primate. This article provides an overview of our understanding of early life growth in mas…
Effects of sibling‐rearing experience on future reproductive success in two species of callitrichidae
The survival rate for offspring of mothers who either had or did not have previous experience rearing younger siblings was compared in two callitrichid species, Callithrix jacchus and Saguinus oedipus . Offspring of mothers with sibling‐rearing experience had a higher survival percentage than offspring of inexperienced mothers in both species. While 50–60% of offspring of inexperienced C. jacchus mothers survived, no offspring of inexperienced S.…
Breeding performance of captive‐born cotton‐top tamarin ( Saguinus oedipus ) females
Successful breeding by captive‐born Saguinus oedipus females has now been reported from several colonies, but a marked parity effect (ie, differences in infant survival with the number of litters produced) is usually observed; survival of infants of primiparous females is extremely low but increases with subsequent litters. This parity effect was not observed in the captive‐born breeding females in the Oak Ridge Associated Universities colony, wi…
Kin preference in marmosets and tamarins
Field studies on callitrichid primates have suggested that some species may exhibit a communal breeding system in which two or more males mate with a single female and cooperatively participate in infant rearing. However, high levels of aggression have been observed between males under both laboratory and field conditions. In avian models for communal breeding, cooperating males are often closely related. In a laboratory test of a hypothesis of t…
Species differences in response to conspecific intruders inCallithrix jacchus andSaguinus oedipus
Infant‐care behavior of mothers and fathers in a communal‐care primate, the cotton‐top tamarin ( Saguinus oedipus )
Infant care behavior was examined for 35 litters of 23 different groups of captive cotton‐top tamarins. The behavior of mothers and fathers was compared to determine the effects of infant number and helper presence on each parent and to determine whether parents differed in responsiveness to infants. For young infants (1–4 weeks), the contribution of fathers to infant carrying was negatively correlated with helpers' contribution; as helpers carri…
Reproductive factors affecting survivorship in captive callitrichidae
Efforts to breed Callitrichidae in captivity have resulted in high fertility accompanied by high infant mortality. This paper investigates the relationship between reproductive characteristics and survivorship in the Oak Ridge and Associated Universities (ORAU) callitrichid colony. Records of 2,834 individuals were analyzed using Cox Proportional Hazards regression to investigate factors affecting infant survivorship. Species and birth cohort wer…
Model life tables for the smaller new world monkeys
Mortality statistics from five populations of small New World monkeys (includinsg Callithrix jaccus, Leontopithecus rosalia, Saguinus fuscicollis , and Saguinus oedipus ) were combined to generate a standard model life table reflecting the mortality patterns of these primates. The model is applied to three individual populations to illustrate a strategy for smoothing and interpolating mortality statistics of varying completeness and quality. © 19…
Relative energetic cost of infant care in small‐bodied neotropical primates and its relation to infant‐care patterns
Small neotropical primates display an array of infant‐care patterns, including maternal care, paternal care, and care by non‐mothers, both male and female. The high energetic cost of infant care has frequently been proposed as the primary determinant of the need for caregivers other than the mother in these species. This report examines the evidence regarding cost associated with infant care in Aotus, Callicebus, Saimiri, Callimico, Saguinus and …
Social and reproductive patterns in neotropical primates
The papers in this issue stem from a symposium presented at the 1992 International Primatological Congress in Strasbourg, France. Due to the paucity of information on social organization, reproduction, and the relation of these to ecology in neotropical primates, we organized this symposium, which included researchers conducting comparative studies and those examining aspects of socioecology in single platyrrhine species. The papers in the sympos…
Social implications of gummivory in marmosets
Gummivory or exudate feeding is a major dietary specialization which has received relatively little attention in the literature. While plant exudates contribute to the diet of many primate species, we suggest that the callitrichid species Cebuella pygmaea and Callithrix jacchus are obligate exudate feeders under free‐ranging conditions. Callithrix jacchus provides an excellent model for examining the effects of exudate feeding and foraging upon s…
Use of ultrasound to monitor prenatal growth and development in the common marmoset ( Callithrix jacchus )
The increasing use of non‐human primates to study fetal development and neonatal management has necessitated the availability of fetuses of known gestational history. In this study, prenatal development and growth were investigated in the common marmoset ( Callithrix jacchus ) using ultrasound. The objectives of this study were: (1) to determine the accuracy of ultrasound for monitoring prenatal growth and development in common marmosets, (2) to …
Number of ovulations in the marmoset monkey (Callithrix jacchus)
The relation between number of ovulations and body weight, age or maternal identity was examined in 69 ovarian cycles from 29 captive-born common marmoset monkeys (Callithrix jacchus). Specifically, we addressed the following questions: was there high repeatability of ovulation number? Most of the variation in ovulation number was within, rather than between subjects. Repeatability in number of ovulations was 0.081 (n = 20 females with 2–6 ovulat…
Interactions between infant growth and survival
The objective of this study is to investigate factors influencing infant survival in captive common marmosets. We investigated the influence of age-specific weight, litter size, caging, and the presence of helpers on survival to 6 months of age in 189 Callithrix jacchus infants. Infant survival was analyzed using Cox Proportional Hazards regression, and fitness functions were plotted to explore the relationship between survival and growth. Result…
Number of ovulations in the marmoset monkey (Callithrix jacchus)
The relation between number of ovulations and body weight, age or maternal identity was examined in 69 ovarian cycles from 29 captive-born common marmoset monkeys (Callithrix jacchus). Specifically, we addressed the following questions: was there high repeatability of ovulation number? Most of the variation in ovulation number was within, rather than between subjects. Repeatability in number of ovulations was 0.081 (n = 20 females with 2-6 ovulat…
Ingestion of calcium solutions by common marmosets (Callithrix jacchus)
Callithrix jacchus, the common marmoset, is a small New World primate that feeds on insects, fruit, and gum, and has a high reproductive rate for a primate. Insects are generally a poor source of dietary calcium, while gums may contain significant levels of calcium. Their high reproductive rate also suggests that reproductive female C. jacchus might be susceptible to calcium deficiency. Thus, we hypothesized that common marmosets might find solut…
The evolution of women
Hager, Lori D., ed. Women in Human Evolution. New York: Routledge, 1997. xiii + 214 pp. including index. $69.95 cloth, $18.95 paper. Morbeck, Mary Ellen, Alison Galloway and Adrienne Zihlman, eds. The Evolving Female: A Life History Perspective. Princeton, NJ: Princeton University Press, 1997. xix + 332 pp. including literature cited and index. $60.00 cloth, $27.95 paper
Does the milk of callitrichid monkeys differ from that of larger anthropoids
The generalization that anthropoid primates produce dilute milks that are low in protein and energy is based primarily on data from large monkeys of the families Cebidae and Cercopithecidae, as well as humans. The marmosets and tamarins (Callitrichidae) are not only much smaller in body size, but also typically raise multiple offspring during a relatively brief lactation. We hypothesized that selection for small body size and high reproductive ra…
Resting energy metabolism of Goeldi's monkey ( Callimico goeldii ) is similar to that of Other callitrichids
The resting metabolic rates (RMRs) of six adult Goeldi's monkeys ( Callimico goeldii ) were measured using standard methods of open circuit respirometry during both the active (daytime) and inactive (nighttime) circadian phases for this species. One subject was measured both while she was pregnant and after she delivered a full‐term, stillborn infant. Inactive‐phase RMR within thermal neutrality (above 27.5°C) averaged 288.5±30.8 ml O 2 /hr; acti…
Relations among birth condition, maternal condition, and postnatal growth in captive common marmoset monkeys ( Callithrix jacchus )
The present study characterizes the relations among maternal condition, litter size, birth condition, and growth in body weight for a population of common marmosets. The subjects of the study were marmosets born into a single colony between 1994 and 2001. Three sets of analyses were conducted to answer the following questions: 1) Is there a relationship between litter size, maternal condition, and birth condition? In the study population, materna…
Reproductive output, maternal age, and survivorship in captive common marmoset females ( Callithrix jacchus )
Common marmosets ( Callithrix jacchus ) demonstrate significant variation in reproductive output on both a yearly and lifetime basis in comparison to other anthropoid primates. We explore the factors that may be most important in determining reproductive variation in captive common marmosets. Studies have found that maternal age, maternal condition, and dam survivorship are related to reproductive output; however, these reports are not in agreeme…
Pattern of maternal serum corticotropin‐releasing hormone concentration during pregnancy in the common marmoset ( Callithrix jacchus )
Corticotropin‐releasing hormone (CRH), a potent neuropeptide, is produced by the placenta of anthropoid primates. No other mammals, including prosimian primates, are known to produce placental CRH. In humans, placental CRH appears to play an important role in the progression of pregnancy to parturition. Maternal circulating CRH begins to rise early in pregnancy and increases until parturition. Gorillas and chimpanzees share this pattern of increa…
Polymorphic microsatellite loci for the common marmoset ( Callithrix jacchus ) designed using a cost‐ and time‐efficient method
We describe a cost‐ and time‐efficient method for designing new microsatellite markers in any species with substantial genomic DNA sequence data available. Using this technique, we report 14 new polymorphic dinucleotide microsatellite loci isolated from the common marmoset. The relative yield of new polymorphisms was higher with less labor than described in previous marmoset studies. Of 20 loci initially evaluated, 14 were polymorphic and amplifi…
Placental efficiency and intrauterine resource allocation strategies in the common marmoset pregnancy
Mothers and fetuses are expected to be in some degree of conflict over the allocation of maternal resources to fetal growth in the intrauterine environment. Variation in placental structure and function may be one way a fetus can communicate need and quality to its mother, potentially manipulating maternal investment in its favor. Whereas common marmosets typically produce twin litters, they regularly give birth to triplet litters in captivity. T…
Integration of proximate and evolutionary explanation of reproductive strategy
We offer examples of how proximate and evolutionary forms of argument may inform each other in better understanding reproductive strategy in callitrichid primates, the smallest of the anthropoid primates. In addition, we illustrate how comparative approaches, when applied judiciously, can aid in the formulation of hypotheses regarding even seemingly unique traits within a taxonomic group. In the first example, examination of the nature of genetic…
Placental insulin‐like growth factor II (IGF‐II) and its relation to litter size in the common marmoset monkey ( Callithrix jacchus )
The primate placenta produces a wide variety of hormones throughout gestation that regulate placental function and fetal growth. One such hormone is insulin‐like growth factor‐II (IGF‐II), a peptide implicated in cell division, differentiation, and amino acid transport. IGF‐II concentrations were measured in 23 common marmoset ( Callithrix jacchus ) term placentas from twin and triplet litters in order to determine whether previously described di…
Biology (38 obras) · Callithrix (30 obras) · Ecology (25 obras) · Marmoset (25 obras) · Primate Behavior and Ecology (23 obras) · Primate (18 obras) · Pregnancy (15 obras) · Zoology (14 obras) · Demography (13 obras) · Genetics (13 obras)