Muthoni Mathai
Dados Biográficos
| ID | 5014900 |
|---|---|
| NOME | Muthoni Mathai |
| PRENOMES | Muthoni |
| SOBRENOME | Mathai |
| ASSINATURA | MATHAI M |
| AFILIAÇÕES | University of Nairobi |
| ORCID | 0000-0002-1480-5833 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 19 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 19 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2012 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Preliminary Effectiveness of the Youth Empowerment Digital Intervention (Yedi)
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
An evaluation of non-specialist training and delivery of a brief cognitive-behavioral therapy-based transdiagnostic intervention for adolescents with depression and anxiety in Nairobi, Kenya
Objective: This study evaluated 1) foundational helping competencies for Non-Specialist Providers (NSPs) trained in a transdiagnostic CBT-based intervention (PRO-ACT) for adolescents with anxiety and depression in Nairobi, Kenya and 2) preliminary clinical outcomes for adolescents receiving PRO-ACT.Method: Seventeen NSPs were trained and assessed using role plays at pre-training, post-training, and post-supervision using the Enhancing Assessment …
Adolescents’ awareness of and attitudes towards alcohol and substance use in Kenya
Alcohol and substance use disorders (ASUD) are highly prevalent among adolescents in sub-Saharan Africa and co-occur with mental health disorders. This study aimed to understand adolescents’ awareness of and attitudes toward ASUD and their mental health literacy, with the long-term goal of informing the development of a preventive intervention. An exploratory qualitative study included 144 adolescents (aged 15–19) in 12 focus group discussions (F…
Factors associated with fluoxetine adherence among outpatients with common mental disorders in Western Kenya
OBJECTIVE: Non-adherence to antidepressants has been linked to increased symptom severity, relapse and hospitalisation from common mental disorders. However, there is limited knowledge of factors associated with antidepressant adherence in low-income and middle-income countries, especially in public sector, primary care settings. METHODS: We quantified fluoxetine adherence using the medication possession ratio. A limitation of this measure is tha…
Productivity benefits of treatment of depression and post-traumatic stress disorder in Kenya
INTRODUCTION: Depression and post-traumatic stress disorder (PTSD) significantly contribute to the global disease burden, adversely affecting health, medical costs and economic productivity. The SMART-DAPPER project in western Kenya approached this challenge by deploying trained non-specialists to administer proven depression and PTSD treatments. METHODS: Participants were public sector primary care outpatients at Kiumu County Hospital with major…
Cumulative adverse childhood experiences and their association with depression and anxiety
Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, are linked to adverse mental health outcomes, particularly among adolescents and young adults living in informal urban settlements, where poverty, unemployment, and exposure to violence exacerbate early life adversity. Despite this, research on ACEs and mental health in these contexts remains limited, especially among youth living in informal urban settlement…
A pilot study of alcohol and substance use, mental health symptoms and social vulnerabilities among youth in Nairobi’s informal settlements
Alcohol and Substance Use (ASU) and mental ill-health among youths is today a global public health concern especially among the urban poor. This pilot study examined the prevalence, patterns and mental health associations of ASU among youths in urban slums. Baseline cross-section data were collected from 94 participants aged 15–24 in two informal settlements in Nairobi. Descriptive statistics analyzed demographic, substance use and mental health …
Defining a screening tool for post-traumatic stress disorder in East Africa
Background: Scalable PTSD screening strategies must be brief, accurate and capable of administration by a non-specialized workforce. Methods: We used PTSD as determined by the structured clinical interview as our gold standard and considered predictors sets of (a) Posttraumatic Stress Checklist-5 (PCL-5), (b) Primary Care PTSD Screen for the DSM-5 (PC-PTSD) and, (c) PCL-5 and PC-PTSD questions to identify the optimal items for PTSD screening for …
“The peace that I wanted, I got”
SMART DAPPER is an implementation science study responding to mental health treatment gaps for depression and trauma-related disorders in Sub-Saharan Africa (SSA). We report on patient experiences in a study using a Sequential, Multiple Assignment Randomized Trial (SMART) design to test first and second line non-specialist treatment using psychotherapy (Interpersonal Psychotherapy [IPT] or medication (fluoxetine [FLX]), integrated within public s…
Training community health volunteers to use mobile platform during the Covid-19 pandemic
This study describes an alternative to face-to-face training method for community health volunteers (CHVs) as used by a collaborative group from the University of Nairobi, University of Washington and the Nairobi Metropolitan Mental Health Team during the COVID-19 lockdown in Kenya. This qualitative study describes the experiences of 17 CHVs enrolled in a training study, required to utilize different digital platforms (Google Meet or Jitsi) as a …
Awareness of and willingness to use oral HIV self-test kits among Kenyan young adults living in informal urban settlements
Self-administered HIV testing may be a promising strategy to improve testing in hard-to-reach young adults, provided they are aware of and willing to use oral HIV self-testing (HIVST). This study examined awareness of and willingness to use oral HIVST among 350 high-risk young adults, aged 18-22, living in Kenya's informal urban settlements. Bivariate and multivariate logistic regressions were used to examine differences in HIVST awareness and wi…
Burden of HIV-Related Stigma and Post-Partum Depression
Background: We look at how various HIV-related stigma subtypes, especially internalizing types, interact with postpartum depression (PPD) among women living with HIV. Additionally, we identify key psychosocial risk factors that influence stigma and PPD among women attending Prevention of Mother-to-Child Transmission (PMTCT) clinics. Methods: In this cross-sectional design, 123 women living with HIV were recruited. Participants ages between 18 and…
Trauma among Kenyan School Children in Urban and Rural Settings
Efficacy of a group tobacco cessation behavioral intervention among tobacco users with concomitant mental illness in Kenya
Trial registration number: NCT04013724. Name of registry: ClinicalTrials.gov. URL of registry: https://register.clinicaltrials.gov Date of registration: 9 July 2019 (retrospectively registered). Date of enrolment of the first participant to the trial: 5th September 2017. Protocol version: 2.0
Economic Context and HIV Vulnerability in Adolescents and Young Adults Living in Urban Slums in Kenya
Risk factors for postpartum depression in women living with HIV attending prevention of mother-to-child transmission clinic at Kenyatta National Hospital, Nairobi
Mothers with HIV are at high risk of a range of psychosocial issues that may impact HIV disease progression for themselves and their children. Stigma has also become a substantial barrier to accessing HIV/AIDS care and prevention services. The study objective was to determine the prevalence and severity of postpartum depression (PPD) among women living with HIV and to further understand the impact of stigma and other psychosocial factors in 123 w…
Haven of safety’ and ‘secure base’
Secure attachment in childhood and adolescence protects children from engagement in high risk behaviors and development of mental health problems over the life span. Poverty has been shown to create impoverishment in certain aspects of caregiving and correspondingly to compromise development of secure attachment in children. Nineteen children 8 to 14 years old from two schools in a middle income area and an urban informal settlement area of Nairo…
Psychiatric morbidity among HIV-infected children and adolescents in a resource-poor Kenyan urban community
The course of HIV/AIDS in children has been transformed from an acute to a chronic one with the advent of Anti-Retroviral Therapy. The aim of this study was to determine the prevalence and pattern of psychiatric morbidity in HIV-infected children and adolescents between 6 and 18 years of age and the relationship between their socio-demographic factors, immune suppression and psychiatric morbidity. The study was conducted at a paediatric HIV clini…
Improving adherence to ante-retroviral treatment for people with harmful alcohol use in Kariobangi, Kenya through participatory research and action
We propose that PRA could be useful in improving communication between the health workers and the clients attending primary health care (PHC) facilities and can be applied to strengthen involvement of support groups and community health workers in follow up and counselling. Integrating these features into primary health care (PHC) would be important not only to PLWHA but also to other diseases in the PHC setting . Longer term follow up is needed …
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Psychiatric morbidity among HIV-infected children and adolescents in a resource-poor Kenyan urban community
The course of HIV/AIDS in children has been transformed from an acute to a chronic one with the advent of Anti-Retroviral Therapy. The aim of this study was to determine the prevalence and pattern of psychiatric morbidity in HIV-infected children and adolescents between 6 and 18 years of age and the relationship between their socio-demographic factors, immune suppression and psychiatric morbidity. The study was conducted at a paediatric HIV clini…
Improving adherence to ante-retroviral treatment for people with harmful alcohol use in Kariobangi, Kenya through participatory research and action
We propose that PRA could be useful in improving communication between the health workers and the clients attending primary health care (PHC) facilities and can be applied to strengthen involvement of support groups and community health workers in follow up and counselling. Integrating these features into primary health care (PHC) would be important not only to PLWHA but also to other diseases in the PHC setting . Longer term follow up is needed …
Risk factors for postpartum depression in women living with HIV attending prevention of mother-to-child transmission clinic at Kenyatta National Hospital, Nairobi
Mothers with HIV are at high risk of a range of psychosocial issues that may impact HIV disease progression for themselves and their children. Stigma has also become a substantial barrier to accessing HIV/AIDS care and prevention services. The study objective was to determine the prevalence and severity of postpartum depression (PPD) among women living with HIV and to further understand the impact of stigma and other psychosocial factors in 123 w…
Haven of safety’ and ‘secure base’
Secure attachment in childhood and adolescence protects children from engagement in high risk behaviors and development of mental health problems over the life span. Poverty has been shown to create impoverishment in certain aspects of caregiving and correspondingly to compromise development of secure attachment in children. Nineteen children 8 to 14 years old from two schools in a middle income area and an urban informal settlement area of Nairo…
Economic Context and HIV Vulnerability in Adolescents and Young Adults Living in Urban Slums in Kenya
Trauma among Kenyan School Children in Urban and Rural Settings
Efficacy of a group tobacco cessation behavioral intervention among tobacco users with concomitant mental illness in Kenya
Trial registration number: NCT04013724. Name of registry: ClinicalTrials.gov. URL of registry: https://register.clinicaltrials.gov Date of registration: 9 July 2019 (retrospectively registered). Date of enrolment of the first participant to the trial: 5th September 2017. Protocol version: 2.0
Burden of HIV-Related Stigma and Post-Partum Depression
Background: We look at how various HIV-related stigma subtypes, especially internalizing types, interact with postpartum depression (PPD) among women living with HIV. Additionally, we identify key psychosocial risk factors that influence stigma and PPD among women attending Prevention of Mother-to-Child Transmission (PMTCT) clinics. Methods: In this cross-sectional design, 123 women living with HIV were recruited. Participants ages between 18 and…
Awareness of and willingness to use oral HIV self-test kits among Kenyan young adults living in informal urban settlements
Self-administered HIV testing may be a promising strategy to improve testing in hard-to-reach young adults, provided they are aware of and willing to use oral HIV self-testing (HIVST). This study examined awareness of and willingness to use oral HIVST among 350 high-risk young adults, aged 18-22, living in Kenya's informal urban settlements. Bivariate and multivariate logistic regressions were used to examine differences in HIVST awareness and wi…
Defining a screening tool for post-traumatic stress disorder in East Africa
Background: Scalable PTSD screening strategies must be brief, accurate and capable of administration by a non-specialized workforce. Methods: We used PTSD as determined by the structured clinical interview as our gold standard and considered predictors sets of (a) Posttraumatic Stress Checklist-5 (PCL-5), (b) Primary Care PTSD Screen for the DSM-5 (PC-PTSD) and, (c) PCL-5 and PC-PTSD questions to identify the optimal items for PTSD screening for …
“The peace that I wanted, I got”
SMART DAPPER is an implementation science study responding to mental health treatment gaps for depression and trauma-related disorders in Sub-Saharan Africa (SSA). We report on patient experiences in a study using a Sequential, Multiple Assignment Randomized Trial (SMART) design to test first and second line non-specialist treatment using psychotherapy (Interpersonal Psychotherapy [IPT] or medication (fluoxetine [FLX]), integrated within public s…
Training community health volunteers to use mobile platform during the Covid-19 pandemic
This study describes an alternative to face-to-face training method for community health volunteers (CHVs) as used by a collaborative group from the University of Nairobi, University of Washington and the Nairobi Metropolitan Mental Health Team during the COVID-19 lockdown in Kenya. This qualitative study describes the experiences of 17 CHVs enrolled in a training study, required to utilize different digital platforms (Google Meet or Jitsi) as a …
Factors associated with fluoxetine adherence among outpatients with common mental disorders in Western Kenya
OBJECTIVE: Non-adherence to antidepressants has been linked to increased symptom severity, relapse and hospitalisation from common mental disorders. However, there is limited knowledge of factors associated with antidepressant adherence in low-income and middle-income countries, especially in public sector, primary care settings. METHODS: We quantified fluoxetine adherence using the medication possession ratio. A limitation of this measure is tha…
Productivity benefits of treatment of depression and post-traumatic stress disorder in Kenya
INTRODUCTION: Depression and post-traumatic stress disorder (PTSD) significantly contribute to the global disease burden, adversely affecting health, medical costs and economic productivity. The SMART-DAPPER project in western Kenya approached this challenge by deploying trained non-specialists to administer proven depression and PTSD treatments. METHODS: Participants were public sector primary care outpatients at Kiumu County Hospital with major…
Cumulative adverse childhood experiences and their association with depression and anxiety
Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, are linked to adverse mental health outcomes, particularly among adolescents and young adults living in informal urban settlements, where poverty, unemployment, and exposure to violence exacerbate early life adversity. Despite this, research on ACEs and mental health in these contexts remains limited, especially among youth living in informal urban settlement…
A pilot study of alcohol and substance use, mental health symptoms and social vulnerabilities among youth in Nairobi’s informal settlements
Alcohol and Substance Use (ASU) and mental ill-health among youths is today a global public health concern especially among the urban poor. This pilot study examined the prevalence, patterns and mental health associations of ASU among youths in urban slums. Baseline cross-section data were collected from 94 participants aged 15–24 in two informal settlements in Nairobi. Descriptive statistics analyzed demographic, substance use and mental health …
Preliminary Effectiveness of the Youth Empowerment Digital Intervention (Yedi)
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
An evaluation of non-specialist training and delivery of a brief cognitive-behavioral therapy-based transdiagnostic intervention for adolescents with depression and anxiety in Nairobi, Kenya
Objective: This study evaluated 1) foundational helping competencies for Non-Specialist Providers (NSPs) trained in a transdiagnostic CBT-based intervention (PRO-ACT) for adolescents with anxiety and depression in Nairobi, Kenya and 2) preliminary clinical outcomes for adolescents receiving PRO-ACT.Method: Seventeen NSPs were trained and assessed using role plays at pre-training, post-training, and post-supervision using the Enhancing Assessment …
Adolescents’ awareness of and attitudes towards alcohol and substance use in Kenya
Alcohol and substance use disorders (ASUD) are highly prevalent among adolescents in sub-Saharan Africa and co-occur with mental health disorders. This study aimed to understand adolescents’ awareness of and attitudes toward ASUD and their mental health literacy, with the long-term goal of informing the development of a preventive intervention. An exploratory qualitative study included 144 adolescents (aged 15–19) in 12 focus group discussions (F…
Medicine (12 obras) · Psychiatry (10 obras) · Mental health (8 obras) · Public health (8 obras) · Environmental health (6 obras) · Mental Health Treatment and Access (6 obras) · Psychology (6 obras) · Psychological intervention (5 obras) · Anxiety (4 obras) · Child and Adolescent Psychosocial and Emotional Development (4 obras)