Daniel P Howrigan
Dados Biográficos
| ID | 5082667 |
|---|---|
| NOME | Daniel P Howrigan |
| PRENOMES | Daniel P |
| SOBRENOME | Howrigan |
| ASSINATURA | HOWRIGAN D P |
| AFILIAÇÕES | Broad Institute |
| ORCID | 0000-0002-7721-4838 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 4 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 4 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2019 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2024 |
| ÍNDICE H | 0 |
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
Data within biobanks capture broad yet detailed indices of human variation, but biobank-wide insights can be difficult to extract due to complexity and scale. Here, using large-scale factor analysis, we distill hundreds of variables (diagnoses, assessments and survey items) into 35 latent constructs, using data from unrelated individuals with predominantly estimated European genetic ancestry in UK Biobank. These factors recapitulate known disease…
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in…
Identification of common genetic risk variants for autism spectrum disorder
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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in…
Identification of common genetic risk variants for autism spectrum disorder
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
Data within biobanks capture broad yet detailed indices of human variation, but biobank-wide insights can be difficult to extract due to complexity and scale. Here, using large-scale factor analysis, we distill hundreds of variables (diagnoses, assessments and survey items) into 35 latent constructs, using data from unrelated individuals with predominantly estimated European genetic ancestry in UK Biobank. These factors recapitulate known disease…
Biology (4 obras) · Gene (4 obras) · Genetic Associations and Epidemiology (4 obras) · Computational biology (3 obras) · Genetics (3 obras) · Genome (2 obras) · Genome-wide association study (2 obras) · Genomic variations and chromosomal abnormalities (2 obras) · Genotype (2 obras) · Phenotype (2 obras)