Thorkild IA Sørensen
Dados Biográficos
| ID | 5456774 |
|---|---|
| NOME | Thorkild IA Sørensen |
| PRENOMES | Thorkild IA |
| SOBRENOME | Sørensen |
| ASSINATURA | SØRENSEN T I |
| AFILIAÇÕES | Copenhagen University Hospital |
| ORCID | 0000-0003-4821-430X |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 28 |
| TOTAL DE CITAÇÕES | 8 |
| TOTAL COMO AUTOR | 28 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1983 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 1 |
Development and rigorous multistep validation of a psychometric tool to measure food noise
Worldwide trends in underweight and obesity from 1990 to 2022
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI 2 SD above the median). FINDINGS: From 1990 to 20…
Severity of respiratory tract infections depends on the infectious dose. Perspectives for the next pandemic
During the COVID-19 pandemic, much has been said about the importance of host-specific and virus-specific factors as predictors of the risk of infection and severity of disease. For example, host factors such as increased age, male gender, ethnicity, and comorbidities such as metabolic and pulmonary disorders have been recognized as risk factors for severe disease, whereas host immunity stemming from prior infection or vaccination against severe …
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Overweight in childhood of exclusively breastfed infants with a high weight at 5 months
High infant weight increases the risk of childhood overweight, while breastfeeding may reduce the risk. However, some infants have a very high weight gain even though they are exclusively breastfed. We examined the risk of a high body mass index (BMI) and overweight in childhood for infants ≥2.5 SD above the median weight-for-age (WAZ) at age 5 months according to duration of exclusive breastfeeding (≤2, >2 to 2 to <4 or ≥4 months had adjusted od…
Breastfeeding duration in infancy and adult risks of type 2 diabetes in a high‐income country
Observed associations between breastfeeding and reduced risk of type 2 diabetes in adulthood may be confounded. We examined if the duration of breastfeeding in infancy was associated with the risk of type 2 diabetes in adulthood after adjustment for a range of prenatal and postnatal risk factors. We prospectively followed 6,044 individuals from the Copenhagen Perinatal Cohort born 1959-1961. Duration of any breastfeeding (≤0.5, >0.5-1, >1-2, >2-4…
Delayed age at transfer of adoptees to adoptive parents is associated with increased mortality irrespective of social class of the adoptive parents
Transfer to an adoptive family later than at the time of birth may have adverse long-term consequences affecting overall and cause-specific mortality. These effects were not modified by the environment provided by the adoptive family as indicated by the social class of these families
Association between birth weight and educational attainment
BACKGROUND: There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. METHODS: The data were derived from nine twin …
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Dietary n -6 Pufa, carbohydrate
Objective To investigate the association between the intake of n -6 PUFA and subsequent change in body weight and waist circumference at different levels of the carbohydrate:protein ratio. Design Follow-up study with anthropometric measurements at recruitment and on average 5·3 years later. Dietary intake was determined at recruitment by using an FFQ that was designed for the study and validated. We applied linear regression models with 5-year ch…
Consumption of predefined ‘Nordic’ dietary items in ten European countries – an investigation in the European Prospective Investigation into Cancer and Nutrition (Epic) cohort
Objective Health-beneficial effects of adhering to a healthy Nordic diet index have been suggested. However, it has not been examined to what extent the included dietary components are exclusively related to the Nordic countries or if they are part of other European diets as well, suggesting a broader preventive potential. The present study describes the intake of seven a priori defined healthy food items (apples/pears, berries, cabbages, dark br…
The influence of early exposure to vitamin D for development of diseases later in life
The results of the study will contribute to our current understanding of the significance of supplementation with vitamin D. More specifically, they will enable new research in related fields, including interventional research designed to assess supplementation needs for different subgroups of pregnant women. Also, other health outcomes can subsequently be studied to generate multiple health research opportunities involving vitamin D. Finally, th…
Aetiological factors behind adipose tissue inflammation
Objective Despite extensive research into the biological mechanisms behind obesity-related inflammation, knowledge of environmental and genetic factors triggering such mechanisms is limited. In the present narrative review we present potential determinants of adipose tissue inflammation and suggest ways ahead for future research in the field. Design We searched the literature for potential determinants of obesity with inflammation through MEDLINE…
The levelling off of the obesity epidemic since the year 1999 – a review of evidence and perspectives
The purpose was to investigate a possible levelling off in the obesity epidemic, by systematically reviewing literature and web‐based sources. Eligible studies and data sources were required to have at least two measures of obesity prevalence since 1999. A literature and Internet search resulted in 52 studies from 25 different countries. The findings supported an overall levelling off of the epidemic in children and adolescents from Australia, Eu…
Impact of Psychological Stress on the Associations Between Apolipoprotein E Variants and Metabolic Traits
OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have b…
Parental socioeconomic position and development of overweight in adolescence
The levels of overweight and obesity among adolescents are high and continue to rise. Results from this study suggest that the inverse social gradient in overweight becomes steeper for girls and emerges for boys in late adolescence (age span 15 to 21 years). Late adolescence seems to be an important window of opportunity in reducing the social inequality in overweight among Danish adolescents
Infant weight gain, duration of exclusive breast-feeding and childhood BMI – two similar follow-up cohorts
Objective To describe the association between duration of exclusive breast-feeding (EBF), weight gain in infancy and childhood BMI in two populations with a long duration of EBF. Design Cohort study with follow-up in childhood. Breast-feeding status was reported monthly during infancy. Weight and length were measured at birth, 2, 6 and 12 months of age, as well as in childhood at 6 or 10 years of age. Setting Iceland and Denmark. Subjects Randoml…
Genetic regulation of growth from birth to 18 years of age
Growth is a complex process, and only little is known on the genetic regulation of it. We analyzed the effect of genetic and environmental factors on growth in a longitudinal Swedish cohort of 231 monozygotic and 144 dizygotic twin pairs born 1973–1979 with length or height measured annually from birth to age 18. The data were analyzed by two different multivariate variance component models for twin data using the Mx statistical package. At birth…
Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood
BACKGROUND: The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown. METHODS: We investigated the association between body-mass index (BMI) in childhood (7 through 13 years of age) and CHD in adulthood (25 years of age or older), wit…
Psychosocial and Demographic Determinants of Regional Differences in the Prevalence of Obesity
Differences in the prevalence of obesity between adjacent regions are quite common, but usually unexplained. This study examined whether birth place, selective migration, intelligence or education – which are both inversely and possibly causally related to obesity – are determinants of such differences. This population-based case-control study (case-cohort design) took place in the greater Copenhagen area (region 1) and surrounding provincial are…
Large heterogeneity of the obesity epidemic in Danish adults
Objective: To examine to what extent the obesity epidemic is a general phenomenon in adults by assessing the secular change, by birth cohort and age, in the prevalence of obesity and median body mass index (BMI) in Danish men and women measured between 1964 and 1994. Design: Multiple cross-sectional population surveys. Setting: The greater Copenhagen area of Denmark. Subjects: The study included 17 065 men (30 336 observations) and 13 417 women (…
The association between nutritional conditions during World War II and childhood anthropometric variables in the Nordic countries
The Nordic children were affected by WWII in terms of a transient reduction in temporal trends in height and weight, and the magnitude of this decrease was associated with the severity of the energy restriction prevailing in the respective country during the war. These findings warrant further studies of the chronic diseases associated with height and weight for cohorts being in their growth periods during WWII
Secular trends in development of obesity in childhood
Influence of fatness, intelligence, education and sociodemographic factors on response rate in a health survey
STUDY OBJECTIVE: The aim was to investigate the characteristics of non-responders to an invitation to attend a health examination. DESIGN: Taking advantage of an ongoing study of obesity, this was a survey of a cohort of severely obese men, with a randomly selected control group. PARTICIPANTS: The participants were draftees to the compulsory Danish military draft board examination between 1943 and 1977. Among 362,200 draftees, 1940 were identifie…
Association between birth weight and educational attainment
BACKGROUND: There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. METHODS: The data were derived from nine twin …
Educational attainment and social class in adoptees
The number of years of schooling and adult social class of 1417 adoptees are found to correlate with the social class of both their biological and adoptive fathers. For female adoptees the effect of both paternal social class values upon own social class appears to be mediated through the influence of the former upon years of schooling. For male adoptees, some residual direct correlations of paternal social class with offspring's social class, in…
Intelligence test performance in obesity in relation to educational attainment and parental Social Class
In the population of 242,633 draftees examined in the Copenhagen area for the period 1956–77, 1143 were extremely overweight. Compared to 2123 controls, selected at random from the remaining draftee population, the obese had a lower educational attainment, even at each level of intelligence test score. Conversely, at each educational level, the obese did not differ from the controls in intelligence test score. When taking into account, by regress…
Secular trends in development of obesity in childhood
Influence of fatness, intelligence, education and sociodemographic factors on response rate in a health survey
STUDY OBJECTIVE: The aim was to investigate the characteristics of non-responders to an invitation to attend a health examination. DESIGN: Taking advantage of an ongoing study of obesity, this was a survey of a cohort of severely obese men, with a randomly selected control group. PARTICIPANTS: The participants were draftees to the compulsory Danish military draft board examination between 1943 and 1977. Among 362,200 draftees, 1940 were identifie…
Psychosocial and Demographic Determinants of Regional Differences in the Prevalence of Obesity
Differences in the prevalence of obesity between adjacent regions are quite common, but usually unexplained. This study examined whether birth place, selective migration, intelligence or education – which are both inversely and possibly causally related to obesity – are determinants of such differences. This population-based case-control study (case-cohort design) took place in the greater Copenhagen area (region 1) and surrounding provincial are…
Large heterogeneity of the obesity epidemic in Danish adults
Objective: To examine to what extent the obesity epidemic is a general phenomenon in adults by assessing the secular change, by birth cohort and age, in the prevalence of obesity and median body mass index (BMI) in Danish men and women measured between 1964 and 1994. Design: Multiple cross-sectional population surveys. Setting: The greater Copenhagen area of Denmark. Subjects: The study included 17 065 men (30 336 observations) and 13 417 women (…
The association between nutritional conditions during World War II and childhood anthropometric variables in the Nordic countries
The Nordic children were affected by WWII in terms of a transient reduction in temporal trends in height and weight, and the magnitude of this decrease was associated with the severity of the energy restriction prevailing in the respective country during the war. These findings warrant further studies of the chronic diseases associated with height and weight for cohorts being in their growth periods during WWII
Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood
BACKGROUND: The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown. METHODS: We investigated the association between body-mass index (BMI) in childhood (7 through 13 years of age) and CHD in adulthood (25 years of age or older), wit…
Genetic regulation of growth from birth to 18 years of age
Growth is a complex process, and only little is known on the genetic regulation of it. We analyzed the effect of genetic and environmental factors on growth in a longitudinal Swedish cohort of 231 monozygotic and 144 dizygotic twin pairs born 1973–1979 with length or height measured annually from birth to age 18. The data were analyzed by two different multivariate variance component models for twin data using the Mx statistical package. At birth…
The levelling off of the obesity epidemic since the year 1999 – a review of evidence and perspectives
The purpose was to investigate a possible levelling off in the obesity epidemic, by systematically reviewing literature and web‐based sources. Eligible studies and data sources were required to have at least two measures of obesity prevalence since 1999. A literature and Internet search resulted in 52 studies from 25 different countries. The findings supported an overall levelling off of the epidemic in children and adolescents from Australia, Eu…
Impact of Psychological Stress on the Associations Between Apolipoprotein E Variants and Metabolic Traits
OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have b…
Parental socioeconomic position and development of overweight in adolescence
The levels of overweight and obesity among adolescents are high and continue to rise. Results from this study suggest that the inverse social gradient in overweight becomes steeper for girls and emerges for boys in late adolescence (age span 15 to 21 years). Late adolescence seems to be an important window of opportunity in reducing the social inequality in overweight among Danish adolescents
Infant weight gain, duration of exclusive breast-feeding and childhood BMI – two similar follow-up cohorts
Objective To describe the association between duration of exclusive breast-feeding (EBF), weight gain in infancy and childhood BMI in two populations with a long duration of EBF. Design Cohort study with follow-up in childhood. Breast-feeding status was reported monthly during infancy. Weight and length were measured at birth, 2, 6 and 12 months of age, as well as in childhood at 6 or 10 years of age. Setting Iceland and Denmark. Subjects Randoml…
The influence of early exposure to vitamin D for development of diseases later in life
The results of the study will contribute to our current understanding of the significance of supplementation with vitamin D. More specifically, they will enable new research in related fields, including interventional research designed to assess supplementation needs for different subgroups of pregnant women. Also, other health outcomes can subsequently be studied to generate multiple health research opportunities involving vitamin D. Finally, th…
Aetiological factors behind adipose tissue inflammation
Objective Despite extensive research into the biological mechanisms behind obesity-related inflammation, knowledge of environmental and genetic factors triggering such mechanisms is limited. In the present narrative review we present potential determinants of adipose tissue inflammation and suggest ways ahead for future research in the field. Design We searched the literature for potential determinants of obesity with inflammation through MEDLINE…
Consumption of predefined ‘Nordic’ dietary items in ten European countries – an investigation in the European Prospective Investigation into Cancer and Nutrition (Epic) cohort
Objective Health-beneficial effects of adhering to a healthy Nordic diet index have been suggested. However, it has not been examined to what extent the included dietary components are exclusively related to the Nordic countries or if they are part of other European diets as well, suggesting a broader preventive potential. The present study describes the intake of seven a priori defined healthy food items (apples/pears, berries, cabbages, dark br…
Dietary n -6 Pufa, carbohydrate
Objective To investigate the association between the intake of n -6 PUFA and subsequent change in body weight and waist circumference at different levels of the carbohydrate:protein ratio. Design Follow-up study with anthropometric measurements at recruitment and on average 5·3 years later. Dietary intake was determined at recruitment by using an FFQ that was designed for the study and validated. We applied linear regression models with 5-year ch…
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Delayed age at transfer of adoptees to adoptive parents is associated with increased mortality irrespective of social class of the adoptive parents
Transfer to an adoptive family later than at the time of birth may have adverse long-term consequences affecting overall and cause-specific mortality. These effects were not modified by the environment provided by the adoptive family as indicated by the social class of these families
Association between birth weight and educational attainment
BACKGROUND: There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. METHODS: The data were derived from nine twin …
Breastfeeding duration in infancy and adult risks of type 2 diabetes in a high‐income country
Observed associations between breastfeeding and reduced risk of type 2 diabetes in adulthood may be confounded. We examined if the duration of breastfeeding in infancy was associated with the risk of type 2 diabetes in adulthood after adjustment for a range of prenatal and postnatal risk factors. We prospectively followed 6,044 individuals from the Copenhagen Perinatal Cohort born 1959-1961. Duration of any breastfeeding (≤0.5, >0.5-1, >1-2, >2-4…
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Overweight in childhood of exclusively breastfed infants with a high weight at 5 months
High infant weight increases the risk of childhood overweight, while breastfeeding may reduce the risk. However, some infants have a very high weight gain even though they are exclusively breastfed. We examined the risk of a high body mass index (BMI) and overweight in childhood for infants ≥2.5 SD above the median weight-for-age (WAZ) at age 5 months according to duration of exclusive breastfeeding (≤2, >2 to 2 to <4 or ≥4 months had adjusted od…
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Medicine (23 obras) · Demography (19 obras) · Obesity, Physical Activity, Diet (13 obras) · Obesity (12 obras) · Environmental health (11 obras) · Population (11 obras) · Birth, Development, and Health (10 obras) · Body mass index (10 obras) · Internal Medicine (10 obras) · Overweight (9 obras)