Diederick E Grobbee
Dados Biográficos
| ID | 5458830 |
|---|---|
| NOME | Diederick E Grobbee |
| PRENOMES | Diederick E |
| SOBRENOME | Grobbee |
| ASSINATURA | GROBBEE D E |
| AFILIAÇÕES | University Medical Center Utrecht |
| ORCID | 0000-0003-4472-4468 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 41 |
| TOTAL DE CITAÇÕES | 26 |
| TOTAL COMO AUTOR | 41 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1995 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
Assessing metrics for evaluating the maternal continuum of care in Ethiopia
Despite Ethiopia’s remarkable progress in reducing maternal mortality between 2000 and 2023, more effort is needed to achieve the Sustainable Development Goal (SDG) target. The government outlined a continuum of care framework for reproductive, maternal, and child healthcare service delivery to positively impact maternal health outcomes. Therefore, it is important to measure and monitor progress in improving women’s access to the continuum of car…
Ethnic inequalities in ischemic stroke occurrence are partly mediated by air pollution
Ethnic disparities in ischemic stroke are substantial and differences in exposure to air pollution have been demonstrated as well. However, the role of air pollution in mediating ethnic disparities in risk of ischemic stroke remains unclear. Understanding this relationship is crucial, as air pollution is a major modifiable risk factor for ischemic stroke. This study aims to determine whether air pollution exposure mediates ischemic stroke risk di…
How do policymakers involve citizens in advancing health? A mixed-method qualitative study in municipalities in the Netherlands
Introduction: Citizen involvement in health policymaking is becoming imperative. Yet, implementing this practice in local policymaking often proves challenging. This study explores how local policymakers in the Netherlands experience and approach citizen involvement in health promotion policymaking. Methods: In 2023, a stratified random sample of 65 out of 342 Dutch municipalities was selected to participate in this mixed-method study, combining …
Pulse oximetry screening for critical congenital heart disease in Tanzanian newborns
Early detection of Critical Congenital Heart Disease (CCHD) is crucial for reducing infant mortality. Pulse oximetry (POX) is widely utilised for screening CCHD in high-resource settings; however, its diagnostic accuracy in low-resource environments, such as sub-Saharan Africa, remains under-researched. This study aimed to assess the diagnostic accuracy of POX in screening Tanzanian newborns for CCHD. This prospective cohort study was conducted i…
Dynamics in ownership, access and use of long-lasting insecticidal nets in Togo
Malaria remains a major public health problem in many countries in Sub Saharan Africa, including Togo, particularly among children under 5 years of age. Therefore, several mass distribution campaigns of long-lasting insecticide-treated bed nets (LLINs), which constitute an essential preventive strategy, have been conducted. The aim of this study is to assess progress in terms of equity of ownership, access and use of LLINs in a context of univers…
Determinants, barriers, and facilitators of healthcare access for patients with hypertension in rural Ghana
BACKGROUND: Hypertension is a major risk factor for cardiovascular diseasemorbidity and mortality, affecting 25% of adults in Ghana. Access to adequate care is critical for effective hypertension management. OBJECTIVE: Evaluate healthcare utilisation among patients with hypertension and identify determinants. METHODS: Guided by the Andersen and Newman model, we examined predisposing, enabling, and need factors affecting HCU. Data were collected f…
Socio-demographic and socio-economic differences in the availability of green space in the Netherlands
We aimed to map the spatial distribution of green space in the Netherlands, and to first comprehensively assess socio-demographic and socio-economic differences in the availability of green space in the Netherlands. Data was analyzed from all registered residents of the Netherlands aged one and above on January 1, 2017 (16,440,620 individuals). Socio-demographic and socio-economic information was derived from Statistics Netherlands. Data on green…
Green space visits among Turkish and South Asian Surinamese women with a high cardiometabolic risk living in disadvantaged neighborhoods in the Netherlands
Motives, means and prerequisites to visit green space of women with a Turkish or South Asian Surinamese background who live in disadvantaged neighborhoods span multiple interacting themes. Future studies examining the relationship between green space and health should consider interactions between motives, means, prerequisites and ethnicity. The possibility of expanding the multifunctionality of green spaces to provide marginalized populations wi…
Differential effects of air pollution on ischemic stroke and ischemic heart disease by ethnicity in a nationwide cohort in the Netherlands
Associations between air pollutants and ischemic stroke or IHD differ notably between ethnic groups in the Netherlands. Policies to reduce air pollution and prevent ischemic stroke should target populations vulnerable to air pollution with a high cardiovascular disease risk
Strategies to improve interpersonal communication along the continuum of maternal and newborn care
Effective interpersonal communication is essential to provide respectful and quality maternal and newborn care (MNC). This scoping review mapped, categorized, and analysed strategies implemented to improve interpersonal communication within MNC up to 42 days after birth. Twelve bibliographic databases were searched for quantitative and qualitative studies that evaluated interventions to improve interpersonal communication between health workers a…
Completion of the Continuum of Maternity Care in the Emerging Regions of Ethiopia
Maternal mortality in Ethiopia was estimated to be 267 per 100,000 live births in 2020. A significant number of maternal deaths occur in the emerging regions of the country: Afar, Somali, Gambela, and Benishangul-Gumuz. Achieving the Sustainable Development Goal (SDG) target requires a dramatic increase in maternal healthcare utilisation during pregnancy, childbirth, and the postpartum period. Yet, there is a paucity of evidence on the continuum …
Tuberculosis treatment and resulting abnormal blood glucose
BACKGROUND: Hyperglycaemia is a risk factor for tuberculosis. Evidence of changes in blood glucose levels during and after tuberculosis treatment is unclear. OBJECTIVE: To compile evidence of changes in blood glucose during and after tuberculosis treatment and the effects of elevated blood glucose changes on treatment outcomes in previously normoglycaemic patients. METHODS: Original research studies (1980 to 2021) were identified in PubMed, Web o…
Alcohol-attributable burden of cancer in Argentina
Most cancer deaths and DALYs were attributable to moderate alcohol consumption (50%). This calls for implementation of population-wide strategies-instead of targeting heavy drinking only-to effectively reduce harmful use of alcohol and its impact on disease burden
Research within international non-governmental organisation programmes in low and middle-income countries
box Over the past decades, enormous efforts have gone into improving access to quality health services in low and middle-income countries (LMICs) through the activities of international non-governmental organisations (INGOs).1 However, for most of these INGO-implemented interventions, responding to health research needs of these populations is not a priority, with a few exceptions.2 In instances where research is of interest, the capacities to ge…
World Health Organization cardiovascular disease risk charts
BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived…
Hypertension in a rural community in South Africa
This study highlights the need for improved health promotion efforts to increase knowledge of hypertension in rural communities, and to address poverty as a major obstacle to healthy life-style choices
Risk thresholds for alcohol consumption
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-inco…
Strengthening dialogic peer feedback aiming for deep learning in SPOCs
This study is focused on how peer feedback in SPOCs (Small Private Online Courses) can effectively lead to deep learning. Promoting deep learning in online courses, such as SPOCs, is often a challenge. We aimed for deep learning by reinforcement of ‘feedback dialogue’ as scalable intervention. Students provided peer feedback as a dialogue, both individually and as a group. They were instructed to rate each other's feedback, which was aimed at dee…
Does body mass index early in pregnancy influence the risk of maternal anaemia? An observational study in Indonesian and Ghanaian women
Higher BMI in early pregnancy is associated with higher haemoglobin levels at antenatal booking and with a reduced risk of anaemia in Indonesian and Ghanaian women
Individual and household level factors associated with presence of multiple non-communicable disease risk factors in Kenyan adults
Majority of Kenyan adults possess more than four NCD risk factors; a clear indication of an emerging epidemic of NCDs in this population. Effective and multi-sectoral interventions targeting multiple risk factors in individuals are required to mitigate especially the behavioural and modifiable NCD risk factors in Kenya
Temporal trends in childhood mortality in Ghana
BACKGROUND: Following the adoption of the Millennium Development Goal 4 (MDG 4) in Ghana to reduce under-five mortality by two-thirds between 1990 and 2015, efforts were made towards its attainment. However, impacts and challenges of implemented intervention programs have not been examined to inform implementation of Sustainable Development Goal 3.2 (SDG 3.2) that seeks to end preventable deaths of newborns and children aged under-five. Thus, thi…
Estimating measures of interaction on an additive scale for preventive exposures
Measures of interaction on an additive scale (relative excess risk due to interaction [RERI], attributable proportion [AP], synergy index [S]), were developed for risk factors rather than preventive factors. It has been suggested that preventive factors should be recoded to risk factors before calculating these measures. We aimed to show that these measures are problematic with preventive factors prior to recoding, and to clarify the recoding met…
The (mis)use of overlap of confidence intervals to assess effect modification
International audience
Change in abdominal obesity and risk of coronary calcification
BACKGROUND: A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC). METHODS: Data on coronary risk factors for 573 postmenopausal women were collected at baseline (1993-1997) and follow-up (2002-2004). At follow-up, the women underwent a multidetector CT to assess coronary calcium using the Agatston score. Markers of abdominal obesity were …
Comparability of Patient-reported Health Status
BACKGROUND: Valid and comparable measures of health outcomes are needed for clinical trials, studies on quality of healthcare, and population health monitoring. OBJECTIVE: To examine comparability of patient-reported health status across populations. RESEARCH DESIGN: Logistic regression analysis of health status across regions, controlling for demographics, risk factors, and clinical event history. SETTING: Multicenter clinical trial in 20 countr…
Employment grade differences in cause specific mortality. A 25 year follow up of civil servants from the first Whitehall study
STUDY OBJECTIVE: To test the hypothesis that the association between socioeconomic status and mortality rates cuts across the major causes of death for middle aged and elderly men. DESIGN: 25 year follow up of mortality in relation to employment grade. SETTING: The first Whitehall study. PARTICIPANTS: 18,001 male civil servants aged 40-69 years who attended the initial screening between 1967 and 1970 and were followed up for at least 25 years. MA…
Physical activity, calcium intake, and bone mineral content in children in The Netherlands
STUDY OBJECTIVE--To examine the relation between physical activity, calcium intake, and bone mineral content in children. DESIGN--Population based, cross sectional study. SETTING--Primary schools in Zoetermeer, The Netherlands. PARTICIPANTS--Altogether 1359 Dutch boys and girls, aged 7 to 11 years (response rate 88%). MEASUREMENTS--Bone mineral content was measured by quantitative roentgen microdensitometry of the midphalanx of the second digit a…
Total and HDL Cholesterol and Risk of Stroke. Eurostroke
Background: Controversy remains on the relation between serum lipids levels and stroke risk. This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies on incidence and risk factors of stroke. EUROSTROKE is designed as a nested case-…
Left Ventricular Hypertrophy and Risk of Fatal and Non-Fatal Stroke. Eurostroke
Background: This study investigated the association between electrocardiographically assessed left ventricular hypertrophy (LVH) and fatal, non-fatal, haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies to investigate differences in incidence of, and risk factors for, stroke between countries. EUROSTROKE is designed as a nested…
Prediction of Stroke in the General Population in Europe (Eurostroke)
Background: To decide whether a person with certain characteristics should be given any kind of intervention to prevent a cardiovascular event, it would be helpful to classify subjects in low, medium and high risk categories. The study evaluated which well known cerebrovascular and cardiovascular correlates, in particular fibrinogen level and ECG characteristics, are able to predict the occurrence of stroke in men of the general population using …
Measuring quality of life in patients with myocardial infarction or stroke
OBJECTIVE--To test in patients with a history of myocardial infarction or stroke the feasibility of four quality of life measurements--the Nottingham health profile (NHP), the heart patients psychological questionnaire (HPPQ), the sickness impact profile (SIP), and the hospital anxiety and depression scale (HAD). DESIGN--Subjects were tested and retested after an interval of 14 days: questionnaires were self assessed. SUBJECTS--Participants were …
Physical activity, calcium intake, and bone mineral content in children in The Netherlands
STUDY OBJECTIVE--To examine the relation between physical activity, calcium intake, and bone mineral content in children. DESIGN--Population based, cross sectional study. SETTING--Primary schools in Zoetermeer, The Netherlands. PARTICIPANTS--Altogether 1359 Dutch boys and girls, aged 7 to 11 years (response rate 88%). MEASUREMENTS--Bone mineral content was measured by quantitative roentgen microdensitometry of the midphalanx of the second digit a…
Routine prenatal screening for congenital heart disease
OBJECTIVES: This study assessed the potential impact of fetal ultrasound screening on the number of newborns affected by cardiac anomalies. METHODS: A decision model was developed that included the prevalence and history of congenital heart disease, characteristics of ultrasound, risk of abortion, and attitude toward pregnancy termination. Probabilities were obtained with a literature survey; sensitivity analysis showed their influence on expecte…
Higher Prevalence of Depressive Symptoms in Middle-Aged Men With Low Serum Cholesterol Levels
OBJECTIVE: Investigators from several studies have reported a positive relationship between low cholesterol levels and death due to violent causes (eg, suicide and accidents), possibly mediated by depressive symptoms, aggression or hostility, or impulsivity. We set out to establish whether middle-aged men with chronically low cholesterol levels ( or =15 or > or =17) than the reference group, even after adjusting for age, energy intake, alcohol us…
Employment grade differences in cause specific mortality. A 25 year follow up of civil servants from the first Whitehall study
STUDY OBJECTIVE: To test the hypothesis that the association between socioeconomic status and mortality rates cuts across the major causes of death for middle aged and elderly men. DESIGN: 25 year follow up of mortality in relation to employment grade. SETTING: The first Whitehall study. PARTICIPANTS: 18,001 male civil servants aged 40-69 years who attended the initial screening between 1967 and 1970 and were followed up for at least 25 years. MA…
Persistent impaired emotional functioning in survivors of a myocardial infarction
Total and HDL Cholesterol and Risk of Stroke. Eurostroke
Background: Controversy remains on the relation between serum lipids levels and stroke risk. This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies on incidence and risk factors of stroke. EUROSTROKE is designed as a nested case-…
Level of Fibrinogen and Risk of Fatal and Non-Fatal Stroke. Eurostroke
Background: It is well established that raised levels of fibrinogen increase the risk of coronary heart disease. For stroke, however, data are much more limited and restricted to overall stroke. This study investigated the association between fibrinogen and fatal, non-fatal, haemorrhagic and ischaemic stroke in three European cohorts participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies …
Left Ventricular Hypertrophy and Risk of Fatal and Non-Fatal Stroke. Eurostroke
Background: This study investigated the association between electrocardiographically assessed left ventricular hypertrophy (LVH) and fatal, non-fatal, haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies to investigate differences in incidence of, and risk factors for, stroke between countries. EUROSTROKE is designed as a nested…
Prediction of Stroke in the General Population in Europe (Eurostroke)
Background: To decide whether a person with certain characteristics should be given any kind of intervention to prevent a cardiovascular event, it would be helpful to classify subjects in low, medium and high risk categories. The study evaluated which well known cerebrovascular and cardiovascular correlates, in particular fibrinogen level and ECG characteristics, are able to predict the occurrence of stroke in men of the general population using …
Academic and behavioral limitations and health-related quality of life in school-age survivors of bacterial meningitis
Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes
Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown. Methods: Within the Utrecht Health Project, an ongoing longitudinal study among inhabitants of a residential area of a large city in The Netherlands, 4747 subjects (age: 39.4 ± 12.5 years) were classified …
Reliability and validity of functional health status and health-related quality of life questionnaires in children with recurrent acute otitis media
In this study the reliability and validity of generic and disease-specific questionnaires has been assessed focusing on responsiveness. This is part of a study on the effects of recurrent acute otitis media (rAOM) on functional health status (FHS) and health-related quality of life (HRQoL) in 383 children with rAOM participating in a randomized clinical trial. The following generic questionnaires were studied: 1. RAND general health rating index,…
Reply to S Voutilainen et al
Clinical Epidemiology
Now updated with new data and examples throughout, Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research, Second Edition is a comprehensive resource that introduces the reader to the basics of clinical epidemiology and explores the principles and methods that can be used to obtain quantitative evidence on the effects of interventions and on the diagnosis, etiology, and prognosis of disease. The everyday challenges of …
P04 Age- and gender-specific risk of death after first hospital admission for heart failure
Objective Heart failure (HF) is an important public health problem. Detailed information on prognosis following hospital admission is crucial for cost-effectiveness analysis and determination of the burden of HF on the health care system. However, such data are scarce. Therefore, the objective of this study was to provide mortality risk following hospital admission stratified by age- and gender. Design Hospital based follow-up study. Setting and …
Estimating measures of interaction on an additive scale for preventive exposures
Measures of interaction on an additive scale (relative excess risk due to interaction [RERI], attributable proportion [AP], synergy index [S]), were developed for risk factors rather than preventive factors. It has been suggested that preventive factors should be recoded to risk factors before calculating these measures. We aimed to show that these measures are problematic with preventive factors prior to recoding, and to clarify the recoding met…
The (mis)use of overlap of confidence intervals to assess effect modification
International audience
Change in abdominal obesity and risk of coronary calcification
BACKGROUND: A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC). METHODS: Data on coronary risk factors for 573 postmenopausal women were collected at baseline (1993-1997) and follow-up (2002-2004). At follow-up, the women underwent a multidetector CT to assess coronary calcium using the Agatston score. Markers of abdominal obesity were …
Comparability of Patient-reported Health Status
BACKGROUND: Valid and comparable measures of health outcomes are needed for clinical trials, studies on quality of healthcare, and population health monitoring. OBJECTIVE: To examine comparability of patient-reported health status across populations. RESEARCH DESIGN: Logistic regression analysis of health status across regions, controlling for demographics, risk factors, and clinical event history. SETTING: Multicenter clinical trial in 20 countr…
Temporal trends in childhood mortality in Ghana
BACKGROUND: Following the adoption of the Millennium Development Goal 4 (MDG 4) in Ghana to reduce under-five mortality by two-thirds between 1990 and 2015, efforts were made towards its attainment. However, impacts and challenges of implemented intervention programs have not been examined to inform implementation of Sustainable Development Goal 3.2 (SDG 3.2) that seeks to end preventable deaths of newborns and children aged under-five. Thus, thi…
Risk thresholds for alcohol consumption
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-inco…
Strengthening dialogic peer feedback aiming for deep learning in SPOCs
This study is focused on how peer feedback in SPOCs (Small Private Online Courses) can effectively lead to deep learning. Promoting deep learning in online courses, such as SPOCs, is often a challenge. We aimed for deep learning by reinforcement of ‘feedback dialogue’ as scalable intervention. Students provided peer feedback as a dialogue, both individually and as a group. They were instructed to rate each other's feedback, which was aimed at dee…
Does body mass index early in pregnancy influence the risk of maternal anaemia? An observational study in Indonesian and Ghanaian women
Higher BMI in early pregnancy is associated with higher haemoglobin levels at antenatal booking and with a reduced risk of anaemia in Indonesian and Ghanaian women
Individual and household level factors associated with presence of multiple non-communicable disease risk factors in Kenyan adults
Majority of Kenyan adults possess more than four NCD risk factors; a clear indication of an emerging epidemic of NCDs in this population. Effective and multi-sectoral interventions targeting multiple risk factors in individuals are required to mitigate especially the behavioural and modifiable NCD risk factors in Kenya
Medicine (33 obras) · Internal Medicine (17 obras) · Population (17 obras) · Environmental health (15 obras) · Internal Medicine (13 obras) · Demography (12 obras) · Cohort (11 obras) · Cohort study (8 obras) · Public health (8 obras) · Demography (7 obras)