Michelle Bosquet Enlow
Dados Biográficos
| ID | 5714331 |
|---|---|
| NOME | Michelle Bosquet Enlow |
| PRENOMES | Michelle Bosquet |
| SOBRENOME | Enlow |
| ASSINATURA | ENLOW M B |
| AFILIAÇÕES | Boston Children's Hospital |
| ORCID | 0000-0003-2598-3894 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 26 |
| TOTAL DE CITAÇÕES | 5 |
| TOTAL COMO AUTOR | 26 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2009 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 1 |
Neural correlates of child temperament
BACKGROUND: Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. METHODS: Using a longitudinal cohort followed from infancy to age 7 (N = 749 collected at infancy), we assessed temp…
The development of electroencephalography microstates from infancy into middle childhood and their associations with behavior
Microstates reflect rapid changes in neural activity with specific scalp topographies. Microstates have been colloquially referred to as the "atoms of thought" and temporal properties of microstates are thought to be associated with mental health and cognition. However, little work has characterized the longitudinal developmental changes and associations with behavior across the infancy and middle childhood period. In this study, we examined deve…
Maternal caregiving moderates relations between maternal childhood maltreatment and infant cortisol regulation
BACKGROUND: Children of maltreated mothers are at increased risk for adverse physical and psychological health. Both prenatal and postnatal alterations in offspring biological stress systems have been proposed as mechanisms contributing to such transmission. The aim of the current study was to assess whether maternal postnatal care of the infant moderated any effect of maternal childhood maltreatment on infant cortisol output during a mild stress…
EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood
BACKGROUND: Anxiety and depression are highly prevalent in youth and can cause significant distress and functional impairment. The presence of maternal anxiety and depression are well-established risk factors for child internalizing psychopathology, yet the responsible mechanisms linking the two remain unclear. METHODS: We examined the potential mediating and moderating roles of EEG frontal alpha asymmetry (FAA) in the intergenerational transmiss…
The association between temperament and polygenic score for psychopathology from infancy to middle childhood
BACKGROUND: Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study e…
Caregiving stress and maternal mental health during the Covid‐19 pandemic
It has now been extensively documented that parental mental health has deteriorated since the beginning of the COVID‐19 pandemic. Although pandemic‐related stress has been widespread, parents faced the unique challenge of navigating remote schooling. Parental oversight of children's education, loss of access to school supportive resources, and the challenges of remote learning may have been most problematic for parents of children with or at elev…
Longitudinal interactions between maternal depression symptoms and familial stressful life events on child anxiety symptoms at 5 years of age
In the current study we identified salient parental factors for child anxiety symptoms by considering the role of stressful life events, maternal anxiety symptoms, maternal depressive symptoms, and maternal neuroticism. Families ( N = 399) in an urban area in the United States were participants in a longitudinal study beginning in infancy. Mothers completed measures of stressful life events (Revised Life Events Questionnaire at all visits), mater…
Longitudinal Trajectories of Aperiodic EEG Activity in Early to Middle Childhood
Aperiodic electroencephalography (EEG) activity is hypothesized to index biological mechanisms that underpin brain functioning. This longitudinal study characterized the developmental trajectories of the aperiodic slope (i.e., aperiodic exponent) and offset from infancy to 7 years of age in a US community sample (N = 391, 46.5% female, predominantly White; data collection 2013-2023). The study further examined whether differential developmental t…
Associations between a metal mixture and infant negative affectivity
In-utero exposures interact in complex ways that influence neurodevelopment. Animal research demonstrates that fetal sex moderates the impact of joint exposure to metals and prenatal stress measures, including cortisol, on offspring socioemotional outcomes. Further research is needed in humans. We evaluated the joint association of prenatal exposures to a metal mixture and cortisol with infant negative affectivity, considering sex differences. An…
Prenatal iodine intake and infant temperament in a multiethnic US cohort
Objective: Maternal iodine plays a central role in fetal neurodevelopment. It is recommended that pregnant women consume sufficient levels of iodine to accommodate increased need for mother and fetus. We examined associations among prenatal dietary and supplemental iodine intake and infant temperament. Design: The PRogramming of Intergenerational Stress Mechanisms (PRISM) study is an ongoing longitudinal pregnancy cohort. Data from 2011 to 2020 w…
Associations among temperament characteristics and telomere length and attrition rate in early childhood
There is growing interest in telomere length as an indicator of current and future health. Although early childhood is a period of rapid telomere attrition, little is known about the factors that influence telomere biology during this time. Adult research suggests that telomere length is influenced by psychological characteristics. This study's goal was to test associations among repeated measures of temperament and telomere length in a community…
Frontal asymmetry assessed in infancy using functional near-infrared spectroscopy is associated with emotional and behavioral problems in early childhood
Frontal asymmetry (FA), the difference in brain activity between the left versus right frontal areas, is thought to reflect approach versus avoidance motivation. This study (2012–2021) used functional near-infrared spectroscopy to investigate if infant (Mage = 7.63 months; N = 90; n = 48 male; n = 75 White) FA in the dorsolateral prefrontal cortex relates to psychopathology in later childhood (Mage = 62.05 months). Greater right FA to happy faces…
Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems
This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental i…
A biomarker discovery framework for childhood anxiety
This study suggests that latent factors extracted from EEG recordings in childhood are promising candidate biomarkers for anxiety and for externalizing disorders if chosen at appropriate ages
Infants’ neural responses to emotional faces are related to maternal anxiety
BACKGROUND: Postnatal maternal anxiety is common (estimates as high as 40% prevalence) and is associated with altered mother-infant interactions (e.g., reduced maternal emotional expression and engagement). Neural circuitry supporting infants' face and emotion processing develops in their first year. Thus, early exposure to maternal anxiety may impact infants' developing understanding of emotional displays. We examine whether maternal anxiety is …
Temperament and psychopathology
We utilized a community detection approach to longitudinally (a) identify distinct groups of children with common temperament profiles in infancy and at 2 and 3 years of age and (b) determine whether co-occurrence of certain temperament traits may be early predictors of internalizing problems at 5 years of age. Seven hundred and seventy-four infants (360 girls; 88.6% White, 9.8% Hispanic, and 1.6% other races) were recruited from the Boston area.…
Early Adverse Experiences and Repeated Wheezing From 6 to 30 Months of Age
This study examined associations among early adversity, diurnal cortisol, child sex, and caregiver sensitivity at age 6 months in relation to wheezing in children (47% male) followed to 30 months. Analyses included 676 mother-child dyads, 393 of whom completed an observational caregiver sensitivity measure. Participants were primarily ethnic minorities (42.7% Black, 25.4% Hispanic); 22.1% of children had ≥ 1 wheezing episode. Higher adversity was…
Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain
Pediatric chronic pain is common and responsible for significant healthcare burden. However, the mechanisms underlying the development and/or maintenance of pediatric chronic pain remain poorly understood. Allostatic load (AL), or wear and tear on the nervous system following significant or prolonged stress, has been proposed to play a role in the maintenance of chronic pain, but minimal research has examined this possibility. This gap in researc…
Disentangling Associations Among Maternal Lifetime and Prenatal Stress, Psychological Functioning During Pregnancy, Maternal Race/Ethnicity, and Infant Negative Affectivity at Age 6 Months
Purpose: Maternal stress and psychological dysfunction in pregnancy are independently linked with fetal neurodevelopment. Stress encompasses environmental stressors and psychological and physiological responses. Stressors and psychopathology co-occur with patterns differing by race/ethnicity. We aimed to extend environmental mixtures methodology to elucidate prenatal stress associations with infant negative affectivity (NA) in a racially/ethnical…
Associations of Maternal Trait Anger Expression and Lifetime Traumatic and Non-traumatic Experiences with Preterm Birth
Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity
Little research has examined the impact of maternal lifetime trauma exposure on infant temperament. We examined associations between maternal trauma history and infant negative affectivity and modification by prenatal cortisol exposure in a sociodemographically diverse sample of mother–infant dyads. During pregnancy, mothers completed measures of lifetime trauma exposure and current stressors. Third‐trimester cortisol output was assessed from mat…
Childhood abuse is associated with increased hair cortisol levels among urban pregnant women
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis activity is known to be altered following events such as childhood abuse. However, despite potential adverse consequences for the offspring of women who have experienced abuse, very little is known about altered HPA axis activity during pregnancy. METHODS: During pregnancy, 180 women from diverse racial/ethnic backgrounds reported on their exposure to emotional, physical and/or sexual abuse be…
Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population
Objective To assess sociodemographic correlates of micronutrient intakes from food and dietary supplements in an urban, ethnically diverse sample of pregnant women in the USA. Design Cross-sectional analyses of data collected using a validated semi-quantitative FFQ. Associations between racial, ethnic and sociodemographic factors and micronutrient intakes were examined using logistic regression controlling for pre-pregnancy BMI, maternal age and …
Interpersonal trauma exposure and cognitive development in children to age 8 years
BACKGROUND: Childhood trauma exposure has been associated with deficits in cognitive functioning. The influence of timing of exposure on the magnitude and persistence of deficits is not well understood. The impact of exposure in early development has been especially under-investigated. This study examined the impact of interpersonal trauma exposure (IPT) in the first years of life on childhood cognitive functioning. METHODS: Children (N=206) part…
Cumulative stress and cortisol disruption among Black and Hispanic pregnant women in an urban cohort
While adult hypothalamic-pituitary-adrenocortical (HPA) axis functioning is thought to be altered by traumatic experiences, little data exist on the effects of cumulative stress on HPA functioning among pregnant women or among specific racial and ethnic groups. Individuals may be increasingly vulnerable to physiological alterations when experiencing cumulative effects of multiple stressors. These effects may be particularly relevant in urban poor…
Interpersonal trauma exposure and cognitive development in children to age 8 years
BACKGROUND: Childhood trauma exposure has been associated with deficits in cognitive functioning. The influence of timing of exposure on the magnitude and persistence of deficits is not well understood. The impact of exposure in early development has been especially under-investigated. This study examined the impact of interpersonal trauma exposure (IPT) in the first years of life on childhood cognitive functioning. METHODS: Children (N=206) part…
Associations of Maternal Lifetime Trauma and Perinatal Traumatic Stress Symptoms With Infant Cardiorespiratory Reactivity to Psychological Challenge
Objective: To examine associations of maternal lifetime trauma and related psychological symptoms in the perinatal period with infant cardiorespiratory reactivity and behavioral distress in response to a laboratory stressor, using a novel advanced system recently adapted for infants. Methods: Participants were mothers and their 6-month-old infants. Assessments included mothers’ self-reported lifetime exposure to trauma, perinatal traumatic stress…
Cumulative stress and cortisol disruption among Black and Hispanic pregnant women in an urban cohort
While adult hypothalamic-pituitary-adrenocortical (HPA) axis functioning is thought to be altered by traumatic experiences, little data exist on the effects of cumulative stress on HPA functioning among pregnant women or among specific racial and ethnic groups. Individuals may be increasingly vulnerable to physiological alterations when experiencing cumulative effects of multiple stressors. These effects may be particularly relevant in urban poor…
Interpersonal trauma exposure and cognitive development in children to age 8 years
BACKGROUND: Childhood trauma exposure has been associated with deficits in cognitive functioning. The influence of timing of exposure on the magnitude and persistence of deficits is not well understood. The impact of exposure in early development has been especially under-investigated. This study examined the impact of interpersonal trauma exposure (IPT) in the first years of life on childhood cognitive functioning. METHODS: Children (N=206) part…
Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population
Objective To assess sociodemographic correlates of micronutrient intakes from food and dietary supplements in an urban, ethnically diverse sample of pregnant women in the USA. Design Cross-sectional analyses of data collected using a validated semi-quantitative FFQ. Associations between racial, ethnic and sociodemographic factors and micronutrient intakes were examined using logistic regression controlling for pre-pregnancy BMI, maternal age and …
Childhood abuse is associated with increased hair cortisol levels among urban pregnant women
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis activity is known to be altered following events such as childhood abuse. However, despite potential adverse consequences for the offspring of women who have experienced abuse, very little is known about altered HPA axis activity during pregnancy. METHODS: During pregnancy, 180 women from diverse racial/ethnic backgrounds reported on their exposure to emotional, physical and/or sexual abuse be…
Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity
Little research has examined the impact of maternal lifetime trauma exposure on infant temperament. We examined associations between maternal trauma history and infant negative affectivity and modification by prenatal cortisol exposure in a sociodemographically diverse sample of mother–infant dyads. During pregnancy, mothers completed measures of lifetime trauma exposure and current stressors. Third‐trimester cortisol output was assessed from mat…
Disentangling Associations Among Maternal Lifetime and Prenatal Stress, Psychological Functioning During Pregnancy, Maternal Race/Ethnicity, and Infant Negative Affectivity at Age 6 Months
Purpose: Maternal stress and psychological dysfunction in pregnancy are independently linked with fetal neurodevelopment. Stress encompasses environmental stressors and psychological and physiological responses. Stressors and psychopathology co-occur with patterns differing by race/ethnicity. We aimed to extend environmental mixtures methodology to elucidate prenatal stress associations with infant negative affectivity (NA) in a racially/ethnical…
Associations of Maternal Trait Anger Expression and Lifetime Traumatic and Non-traumatic Experiences with Preterm Birth
Early Adverse Experiences and Repeated Wheezing From 6 to 30 Months of Age
This study examined associations among early adversity, diurnal cortisol, child sex, and caregiver sensitivity at age 6 months in relation to wheezing in children (47% male) followed to 30 months. Analyses included 676 mother-child dyads, 393 of whom completed an observational caregiver sensitivity measure. Participants were primarily ethnic minorities (42.7% Black, 25.4% Hispanic); 22.1% of children had ≥ 1 wheezing episode. Higher adversity was…
Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain
Pediatric chronic pain is common and responsible for significant healthcare burden. However, the mechanisms underlying the development and/or maintenance of pediatric chronic pain remain poorly understood. Allostatic load (AL), or wear and tear on the nervous system following significant or prolonged stress, has been proposed to play a role in the maintenance of chronic pain, but minimal research has examined this possibility. This gap in researc…
Infants’ neural responses to emotional faces are related to maternal anxiety
BACKGROUND: Postnatal maternal anxiety is common (estimates as high as 40% prevalence) and is associated with altered mother-infant interactions (e.g., reduced maternal emotional expression and engagement). Neural circuitry supporting infants' face and emotion processing develops in their first year. Thus, early exposure to maternal anxiety may impact infants' developing understanding of emotional displays. We examine whether maternal anxiety is …
Temperament and psychopathology
We utilized a community detection approach to longitudinally (a) identify distinct groups of children with common temperament profiles in infancy and at 2 and 3 years of age and (b) determine whether co-occurrence of certain temperament traits may be early predictors of internalizing problems at 5 years of age. Seven hundred and seventy-four infants (360 girls; 88.6% White, 9.8% Hispanic, and 1.6% other races) were recruited from the Boston area.…
Frontal asymmetry assessed in infancy using functional near-infrared spectroscopy is associated with emotional and behavioral problems in early childhood
Frontal asymmetry (FA), the difference in brain activity between the left versus right frontal areas, is thought to reflect approach versus avoidance motivation. This study (2012–2021) used functional near-infrared spectroscopy to investigate if infant (Mage = 7.63 months; N = 90; n = 48 male; n = 75 White) FA in the dorsolateral prefrontal cortex relates to psychopathology in later childhood (Mage = 62.05 months). Greater right FA to happy faces…
Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems
This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental i…
A biomarker discovery framework for childhood anxiety
This study suggests that latent factors extracted from EEG recordings in childhood are promising candidate biomarkers for anxiety and for externalizing disorders if chosen at appropriate ages
Associations between a metal mixture and infant negative affectivity
In-utero exposures interact in complex ways that influence neurodevelopment. Animal research demonstrates that fetal sex moderates the impact of joint exposure to metals and prenatal stress measures, including cortisol, on offspring socioemotional outcomes. Further research is needed in humans. We evaluated the joint association of prenatal exposures to a metal mixture and cortisol with infant negative affectivity, considering sex differences. An…
Prenatal iodine intake and infant temperament in a multiethnic US cohort
Objective: Maternal iodine plays a central role in fetal neurodevelopment. It is recommended that pregnant women consume sufficient levels of iodine to accommodate increased need for mother and fetus. We examined associations among prenatal dietary and supplemental iodine intake and infant temperament. Design: The PRogramming of Intergenerational Stress Mechanisms (PRISM) study is an ongoing longitudinal pregnancy cohort. Data from 2011 to 2020 w…
Associations among temperament characteristics and telomere length and attrition rate in early childhood
There is growing interest in telomere length as an indicator of current and future health. Although early childhood is a period of rapid telomere attrition, little is known about the factors that influence telomere biology during this time. Adult research suggests that telomere length is influenced by psychological characteristics. This study's goal was to test associations among repeated measures of temperament and telomere length in a community…
Maternal caregiving moderates relations between maternal childhood maltreatment and infant cortisol regulation
BACKGROUND: Children of maltreated mothers are at increased risk for adverse physical and psychological health. Both prenatal and postnatal alterations in offspring biological stress systems have been proposed as mechanisms contributing to such transmission. The aim of the current study was to assess whether maternal postnatal care of the infant moderated any effect of maternal childhood maltreatment on infant cortisol output during a mild stress…
EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood
BACKGROUND: Anxiety and depression are highly prevalent in youth and can cause significant distress and functional impairment. The presence of maternal anxiety and depression are well-established risk factors for child internalizing psychopathology, yet the responsible mechanisms linking the two remain unclear. METHODS: We examined the potential mediating and moderating roles of EEG frontal alpha asymmetry (FAA) in the intergenerational transmiss…
The association between temperament and polygenic score for psychopathology from infancy to middle childhood
BACKGROUND: Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study e…
Caregiving stress and maternal mental health during the Covid‐19 pandemic
It has now been extensively documented that parental mental health has deteriorated since the beginning of the COVID‐19 pandemic. Although pandemic‐related stress has been widespread, parents faced the unique challenge of navigating remote schooling. Parental oversight of children's education, loss of access to school supportive resources, and the challenges of remote learning may have been most problematic for parents of children with or at elev…
Longitudinal interactions between maternal depression symptoms and familial stressful life events on child anxiety symptoms at 5 years of age
In the current study we identified salient parental factors for child anxiety symptoms by considering the role of stressful life events, maternal anxiety symptoms, maternal depressive symptoms, and maternal neuroticism. Families ( N = 399) in an urban area in the United States were participants in a longitudinal study beginning in infancy. Mothers completed measures of stressful life events (Revised Life Events Questionnaire at all visits), mater…
Longitudinal Trajectories of Aperiodic EEG Activity in Early to Middle Childhood
Aperiodic electroencephalography (EEG) activity is hypothesized to index biological mechanisms that underpin brain functioning. This longitudinal study characterized the developmental trajectories of the aperiodic slope (i.e., aperiodic exponent) and offset from infancy to 7 years of age in a US community sample (N = 391, 46.5% female, predominantly White; data collection 2013-2023). The study further examined whether differential developmental t…
Neural correlates of child temperament
BACKGROUND: Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. METHODS: Using a longitudinal cohort followed from infancy to age 7 (N = 749 collected at infancy), we assessed temp…
Psychology (20 obras) · Clinical Psychology (18 obras) · Medicine (18 obras) · Psychiatry (18 obras) · Maternal Mental Health During Pregnancy and Postpartum (12 obras) · Anxiety (11 obras) · Developmental psychology (11 obras) · Pregnancy (9 obras) · Child and Adolescent Psychosocial and Emotional Development (8 obras) · Child Abuse and Trauma (6 obras)