H Simon Schaaf
Dados Biográficos
| ID | 6077904 |
|---|---|
| NOME | H Simon Schaaf |
| PRENOMES | H Simon |
| SOBRENOME | Schaaf |
| ASSINATURA | SCHAAF H S |
| AFILIAÇÕES | Desmond Tutu HIV Foundation |
| ORCID | 0000-0001-5755-4133 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 9 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 9 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2009 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis
Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…
A historical narrative review of the emerging priority of acceptability in tuberculosis treatment in children
Children affected by tuberculosis (TB) are a historically neglected group. In the past two decades, researchers have made significant advances towards developing new drugs and formulations for treating and preventing TB in children. Organizations like the World Health Organization (WHO) and Stop TB Partnership have advocated for the development of child-friendly antituberculosis treatment (ATT) regimens. However, ATT is notoriously unpalatable, t…
Navigating complex care pathways–healthcare workers’ perspectives on health system barriers for children with tuberculous meningitis in Cape Town, South Africa
Tuberculous meningitis (TBM) occurs when tuberculosis (TB) bacilli disseminate and seed into the meninges, triggering a severe inflammatory response that often leads to brain infarction. It is the most severe and debilitating form of childhood TB with high mortality, and children who survive TBM often suffer lifelong physical and neuro-disability resulting in emotional, social, and economic burdens for families. In the early stages the symptoms m…
Holistic acceptability of an adult levofloxacin formulation in children and adolescents on a tuberculosis preventive treatment trial
Drug-resistant tuberculosis (TB) is threatening global TB control. Although formulations designed for children are a priority, adult levofloxacin formulations are widely used in TB treatment and prevention. TB-CHAMP was a cluster-randomised, placebo-controlled trial evaluating the efficacy and safety of 24 weeks of daily levofloxacin to prevent TB in child and adolescent household contacts of adults with infectious multidrug-resistant TB. Nested …
Perinatal tuberculosis—An approach to an under-recognized diagnosis
Tuberculosis (TB) in young infants (<3 months of age), often referred to as perinatal TB, is underdiagnosed, leading to severe morbidity and high mortality. Perinatal TB includes both congenital and postnatal transmission of Mycobacterium tuberculosis . We aimed to increase an awareness of TB in neonates and young infants and to provide guidance on the assessment and management when in contact with mothers with TB during or soon after pregnancy. …
Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children
Diagnostic tools for paediatric tuberculosis remain limited, with heavy reliance on clinical algorithms which include chest x-ray. Computer aided detection (CAD) for tuberculosis on chest x-ray has shown promise in adults. We aimed to measure and optimise the performance of an adult CAD system, CAD4TB, to identify tuberculosis on chest x-rays from children with presumptive tuberculosis. Chest x-rays from 620 children
Toward a conceptual framework of the acceptability of tuberculosis treatment in children using a theory generative approach
To describe an early-stage holistic framework towards evaluating factors that impact the overall acceptability of TB treatment along the TB care cascade in children. We developed a conceptual framework utilising a theory generative approach. Domains were developed through review of existing definitions and analysis of existing qualitative data undertaken in acceptability studies of TB treatment in children. Clarity of domain definitions was achie…
Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children
The burden and spectrum of childhood TB disease managed at referral hospital level in high burden settings is substantial. Hospital-based surveillance in addition to routine TB surveillance is essential to provide a complete picture of the burden, spectrum and impact of childhood TB in settings where hospitals are not TB reporting units
Surveillance of Antituberculosis Drug Resistance Among Children From the Western Cape Province of South Africa—An Upward Trend
Objectives. We assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa. Methods. Drug susceptibility testing for isoniazid and rifampin was prospectively done on all children with culture-confirmed TB at Tygerberg Children's Hospital, Cape Town, from March 2005 through February 2007. Survey results were compared with results from 2 previous surveys. Results. We…
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Surveillance of Antituberculosis Drug Resistance Among Children From the Western Cape Province of South Africa—An Upward Trend
Objectives. We assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa. Methods. Drug susceptibility testing for isoniazid and rifampin was prospectively done on all children with culture-confirmed TB at Tygerberg Children's Hospital, Cape Town, from March 2005 through February 2007. Survey results were compared with results from 2 previous surveys. Results. We…
Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children
The burden and spectrum of childhood TB disease managed at referral hospital level in high burden settings is substantial. Hospital-based surveillance in addition to routine TB surveillance is essential to provide a complete picture of the burden, spectrum and impact of childhood TB in settings where hospitals are not TB reporting units
Toward a conceptual framework of the acceptability of tuberculosis treatment in children using a theory generative approach
To describe an early-stage holistic framework towards evaluating factors that impact the overall acceptability of TB treatment along the TB care cascade in children. We developed a conceptual framework utilising a theory generative approach. Domains were developed through review of existing definitions and analysis of existing qualitative data undertaken in acceptability studies of TB treatment in children. Clarity of domain definitions was achie…
Perinatal tuberculosis—An approach to an under-recognized diagnosis
Tuberculosis (TB) in young infants (<3 months of age), often referred to as perinatal TB, is underdiagnosed, leading to severe morbidity and high mortality. Perinatal TB includes both congenital and postnatal transmission of Mycobacterium tuberculosis . We aimed to increase an awareness of TB in neonates and young infants and to provide guidance on the assessment and management when in contact with mothers with TB during or soon after pregnancy. …
Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children
Diagnostic tools for paediatric tuberculosis remain limited, with heavy reliance on clinical algorithms which include chest x-ray. Computer aided detection (CAD) for tuberculosis on chest x-ray has shown promise in adults. We aimed to measure and optimise the performance of an adult CAD system, CAD4TB, to identify tuberculosis on chest x-rays from children with presumptive tuberculosis. Chest x-rays from 620 children
Navigating complex care pathways–healthcare workers’ perspectives on health system barriers for children with tuberculous meningitis in Cape Town, South Africa
Tuberculous meningitis (TBM) occurs when tuberculosis (TB) bacilli disseminate and seed into the meninges, triggering a severe inflammatory response that often leads to brain infarction. It is the most severe and debilitating form of childhood TB with high mortality, and children who survive TBM often suffer lifelong physical and neuro-disability resulting in emotional, social, and economic burdens for families. In the early stages the symptoms m…
Holistic acceptability of an adult levofloxacin formulation in children and adolescents on a tuberculosis preventive treatment trial
Drug-resistant tuberculosis (TB) is threatening global TB control. Although formulations designed for children are a priority, adult levofloxacin formulations are widely used in TB treatment and prevention. TB-CHAMP was a cluster-randomised, placebo-controlled trial evaluating the efficacy and safety of 24 weeks of daily levofloxacin to prevent TB in child and adolescent household contacts of adults with infectious multidrug-resistant TB. Nested …
A historical narrative review of the emerging priority of acceptability in tuberculosis treatment in children
Children affected by tuberculosis (TB) are a historically neglected group. In the past two decades, researchers have made significant advances towards developing new drugs and formulations for treating and preventing TB in children. Organizations like the World Health Organization (WHO) and Stop TB Partnership have advocated for the development of child-friendly antituberculosis treatment (ATT) regimens. However, ATT is notoriously unpalatable, t…
Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis
Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…
Tuberculosis Research and Epidemiology (9 obras) · Medicine (8 obras) · Tuberculosis (8 obras) · Internal Medicine (5 obras) · Pediatrics (5 obras) · Pathology (4 obras) · Infectious Diseases and Tuberculosis (3 obras) · Pneumonia and Respiratory Infections (3 obras) · COVID-19 diagnosis using AI (2 obras) · Disease (2 obras)