Leonid Lecca
Dados Biográficos
| ID | 6285107 |
|---|---|
| NOME | Leonid Lecca |
| PRENOMES | Leonid |
| SOBRENOME | Lecca |
| ASSINATURA | LECCA L |
| AFILIAÇÕES | Harvard University |
| ORCID | 0000-0003-1363-3985 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 21 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 21 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2017 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 0 |
Síntomas depresivos, violencia y discriminación en mujeres transgénero durante la pandemia de Covid-19
A high frequency of depressive symptoms, as well as experiences of gender-based discrimination and violence, was observed among TGW in Lima, Peru, during the COVID-19 pandemic. In addition, significant associations were identified between these experiences and the presence of depressive symptoms. These findings are consistent with existing evidence on the mental health impact of the pandemic, but also suggest a disproportionate burden among TGW a…
Water insecurity and climate change
Latin America faces a severe health crisis, where over 150 million people lack reliable access to water due to climate change. We conducted a mixed-methods study to understand perspectives and experiences surrounding water security and its relationship to climate change among predominantly Indigenous mothers in Maras, a rural Andean district in the Urubamba Province of Peru. A verbal survey was administered to 100 pregnant women and/or caregivers…
Identifying adolescents at risk for suboptimal adherence to tuberculosis treatment
Adolescents account for an estimated 800,000 incident tuberculosis (TB) cases annually and are at risk for suboptimal adherence to TB treatment. Most studies of adolescent TB treatment adherence have used surveillance data with limited psychosocial information. This prospective cohort study aimed to identify risk factors for suboptimal adherence to rifampicin-susceptible TB treatment among adolescents (10–19 years old) in Lima, Peru. We collected…
Accuracy of digital chest x-ray analysis with artificial intelligence software as a triage and screening tool in hospitalized patients being evaluated for tuberculosis in Lima, Peru
Tuberculosis (TB) transmission in healthcare facilities is common in high-incidence countries. Yet, the optimal approach for identifying inpatients who may have TB is unclear. We evaluated the diagnostic accuracy of qXR (Qure.ai, India) computer-aided detection (CAD) software versions 3.0 and 4.0 (v3 and v4) as a triage and screening tool within the FAST (Find cases Actively, Separate safely, and Treat effectively) transmission control strategy. …
Tuberculosis treatment loss to follow-up in children exposed at home
Background: Loss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a significant public health problem. It is important to understand what drives LTFU in children - a population whose treatment and management depend on an adult caregiver - to better provide support services to families affected by TB. Methods: We conducted a prospective cohort study of household contacts in Lima, Peru (2009-12). Using multilevel logistic regression…
Programmatic implementation of depression screening and remote mental health support sessions for persons recently diagnosed with TB in Lima, Peru during the Covid-19 pandemic
Depressive symptoms were common among persons recently diagnosed with TB. We observed improvements in depressive symptoms 6 months later for most participants who received remote sessions of PFA
Búsqueda activa de tuberculosis en tres centros penitenciarios juveniles de Perú
Motivation for the study. With tuberculosis being the leading cause of death due to infectious diseases in the world, and having a detection gap of 20-40%, there is a need to implement active search strategies for the disease in different vulnerable populations such as juvenile correctional facilities. Main findings. We found a screening rate by active search of 1250 per 100,000 screened, being 10 times more than the rate in the general populatio…
A costing framework to compare tuberculosis infection tests
OBJECTIVE: To develop a framework to estimate the practical costs incurred from, and programmatic impact related to, tuberculosis (TB) infection testing-tuberculin skin tests (TST) versus interferon gamma release assay (IGRA)-in a densely populated high-burden TB area. METHODS: We developed a seven-step framework that can be tailored to individual TB programmes seeking to compare TB infection (TBI) diagnostics to inform decision-making. We presen…
Perinatal depression and implementation of the “Thinking Healthy program” support intervention in an impoverished setting of Lima, Peru
Socios En Salud (SES) implemented the Thinking Healthy program (THP) to support women with perinatal depression before and during the COVID-19 pandemic in Lima Norte. We carried out an analysis of the in-person (5 modules) and remote (1 module) THP intervention. Depression was detected using PHQ-9, and THP sessions were delivered in women with a score (PHQ-9 ≥ 5). Depression was reassessed and pre- and post-scores were compared. In the pre-pandem…
Asociación entre sobrepeso/obesidad y tuberculosis multidrogoresistente
Overweight/obesity is not associated with multidrug resistance in tuberculosis. Overweight/obesity is a dynamic process that may influence the relationship between the immune system and the metabolic system
Mobilizing digital technology to implement a population-based psychological support response during the Covid-19 pandemic in Lima, Peru
Digital technology can be used to screen for psychological distress and deliver mental health support for populations affected by the COVID-19 pandemic. More research is needed to determine whether technology contributes to improved mental health outcomes
Community-based accompaniment for adolescents transitioning to adult HIV care in urban Peru
We piloted a community-based intervention to improve outcomes among adolescents living with HIV who were transitioning to adult-oriented care in Lima, Peru. We assessed feasibility and potential effectiveness, including within-person changes in self-reported adherence, psychosocial metrics (NIH Toolbox), and transition readiness ("Am I on TRAC" questionnaire, "Got Transition" checklist). From October 2019 to January 2020, we enrolled 30 adolescen…
Observatorios sociales nacionales y regional de tuberculosis en ocho países de Latinoamérica y el Caribe
Poner fin a la tuberculosis (TB) requiere de un enfoque y participación multisectorial, incluyendo a la sociedad civil organizada. Entonces con el apoyo de un proyecto regional financiado por el Fondo Mundial (OBSERVA TB), desde el año 2019 se conformaron observatorios sociales de tuberculosis en 8 países de Latinoamérica y el Caribe (LAC) (Bolivia, Colombia, El Salvador, Guatemala, Haití, México, Perú y República Dominicana) y un Observatorio So…
Success at Scale
This study is a randomized controlled trial of a 12-week community-based group parenting intervention (“CASITA”) in Lima, Peru. CASITA improved neurodevelopment in a pilot study of 60 Peruvian children and subsequently scaled to 3,000 households throughout the district. The objective of this study was to assess intervention effectiveness when implemented at scale. A total of 347 children ages 6–20 months (52.7% male, 100% identified as “mestizo”)…
Is exclusive breastfeeding for six-months protective against pediatric tuberculosis
Experts recommend exclusive breastfeeding from birth to six months because it protects against deadly childhood illness, including respiratory tract infections and diarrhea. We hypothesized that exclusive breastfeeding would decrease the risk of active tuberculosis (TB) in children. We analyzed cross-sectional data from 279 children in Lima, Peru aged 6 to 59 months with TB symptoms and a close adult contact with TB. Mothers self-reported breastf…
A non-specialist depression care pathway for adolescents living with HIV and transitioning into adult care in Peru
A simple care pathway operationalizing depression screening and non-specialist delivered emotional support is a first step toward integrated depression and HIV care for ALWH
Impacto de la pandemia por Sars-CoV-2 en adolescentes que viven con el VIH en Lima, Perú
Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult …
Toward patient-centered tuberculosis preventive treatment
There is demand for shorter regimens and child-friendly formulations for tuberculosis preventive treatment in high-burden settings. Individual preferences differ, suggesting that patient-centered care would best be supported by having multiple shorter regimens available
The Use of Wearable Technology to Objectively Measure Sleep Quality and Physical Activity Among Pregnant Women in Urban Lima, Peru
Feasibility and Acceptability of an Adolescent-Friendly Rap Video to Improve Health Literacy Among HIV-Positive Youth in Urban Peru
Clinical outcomes among adolescents living with HIV (ALHIV) might be improved by interventions aimed at addressing limited health literacy. We developed a Spanish-language rap video on HIV concepts and examined its acceptability and feasibility as a learning tool among ALHIV in Lima, Peru. Twenty-eight ALHIV receiving care at an urban pediatric hospital and ten stakeholders engaged in the care of adolescents watched the video. Adolescents complet…
Community-Based Accompaniment with Supervised Antiretrovirals for HIV-Positive Adults in Peru
Sem obras proeminentes nesta página.
Community-Based Accompaniment with Supervised Antiretrovirals for HIV-Positive Adults in Peru
The Use of Wearable Technology to Objectively Measure Sleep Quality and Physical Activity Among Pregnant Women in Urban Lima, Peru
Feasibility and Acceptability of an Adolescent-Friendly Rap Video to Improve Health Literacy Among HIV-Positive Youth in Urban Peru
Clinical outcomes among adolescents living with HIV (ALHIV) might be improved by interventions aimed at addressing limited health literacy. We developed a Spanish-language rap video on HIV concepts and examined its acceptability and feasibility as a learning tool among ALHIV in Lima, Peru. Twenty-eight ALHIV receiving care at an urban pediatric hospital and ten stakeholders engaged in the care of adolescents watched the video. Adolescents complet…
Success at Scale
This study is a randomized controlled trial of a 12-week community-based group parenting intervention (“CASITA”) in Lima, Peru. CASITA improved neurodevelopment in a pilot study of 60 Peruvian children and subsequently scaled to 3,000 households throughout the district. The objective of this study was to assess intervention effectiveness when implemented at scale. A total of 347 children ages 6–20 months (52.7% male, 100% identified as “mestizo”)…
Is exclusive breastfeeding for six-months protective against pediatric tuberculosis
Experts recommend exclusive breastfeeding from birth to six months because it protects against deadly childhood illness, including respiratory tract infections and diarrhea. We hypothesized that exclusive breastfeeding would decrease the risk of active tuberculosis (TB) in children. We analyzed cross-sectional data from 279 children in Lima, Peru aged 6 to 59 months with TB symptoms and a close adult contact with TB. Mothers self-reported breastf…
A non-specialist depression care pathway for adolescents living with HIV and transitioning into adult care in Peru
A simple care pathway operationalizing depression screening and non-specialist delivered emotional support is a first step toward integrated depression and HIV care for ALWH
Impacto de la pandemia por Sars-CoV-2 en adolescentes que viven con el VIH en Lima, Perú
Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult …
Toward patient-centered tuberculosis preventive treatment
There is demand for shorter regimens and child-friendly formulations for tuberculosis preventive treatment in high-burden settings. Individual preferences differ, suggesting that patient-centered care would best be supported by having multiple shorter regimens available
Mobilizing digital technology to implement a population-based psychological support response during the Covid-19 pandemic in Lima, Peru
Digital technology can be used to screen for psychological distress and deliver mental health support for populations affected by the COVID-19 pandemic. More research is needed to determine whether technology contributes to improved mental health outcomes
Community-based accompaniment for adolescents transitioning to adult HIV care in urban Peru
We piloted a community-based intervention to improve outcomes among adolescents living with HIV who were transitioning to adult-oriented care in Lima, Peru. We assessed feasibility and potential effectiveness, including within-person changes in self-reported adherence, psychosocial metrics (NIH Toolbox), and transition readiness ("Am I on TRAC" questionnaire, "Got Transition" checklist). From October 2019 to January 2020, we enrolled 30 adolescen…
Observatorios sociales nacionales y regional de tuberculosis en ocho países de Latinoamérica y el Caribe
Poner fin a la tuberculosis (TB) requiere de un enfoque y participación multisectorial, incluyendo a la sociedad civil organizada. Entonces con el apoyo de un proyecto regional financiado por el Fondo Mundial (OBSERVA TB), desde el año 2019 se conformaron observatorios sociales de tuberculosis en 8 países de Latinoamérica y el Caribe (LAC) (Bolivia, Colombia, El Salvador, Guatemala, Haití, México, Perú y República Dominicana) y un Observatorio So…
A costing framework to compare tuberculosis infection tests
OBJECTIVE: To develop a framework to estimate the practical costs incurred from, and programmatic impact related to, tuberculosis (TB) infection testing-tuberculin skin tests (TST) versus interferon gamma release assay (IGRA)-in a densely populated high-burden TB area. METHODS: We developed a seven-step framework that can be tailored to individual TB programmes seeking to compare TB infection (TBI) diagnostics to inform decision-making. We presen…
Perinatal depression and implementation of the “Thinking Healthy program” support intervention in an impoverished setting of Lima, Peru
Socios En Salud (SES) implemented the Thinking Healthy program (THP) to support women with perinatal depression before and during the COVID-19 pandemic in Lima Norte. We carried out an analysis of the in-person (5 modules) and remote (1 module) THP intervention. Depression was detected using PHQ-9, and THP sessions were delivered in women with a score (PHQ-9 ≥ 5). Depression was reassessed and pre- and post-scores were compared. In the pre-pandem…
Asociación entre sobrepeso/obesidad y tuberculosis multidrogoresistente
Overweight/obesity is not associated with multidrug resistance in tuberculosis. Overweight/obesity is a dynamic process that may influence the relationship between the immune system and the metabolic system
Identifying adolescents at risk for suboptimal adherence to tuberculosis treatment
Adolescents account for an estimated 800,000 incident tuberculosis (TB) cases annually and are at risk for suboptimal adherence to TB treatment. Most studies of adolescent TB treatment adherence have used surveillance data with limited psychosocial information. This prospective cohort study aimed to identify risk factors for suboptimal adherence to rifampicin-susceptible TB treatment among adolescents (10–19 years old) in Lima, Peru. We collected…
Accuracy of digital chest x-ray analysis with artificial intelligence software as a triage and screening tool in hospitalized patients being evaluated for tuberculosis in Lima, Peru
Tuberculosis (TB) transmission in healthcare facilities is common in high-incidence countries. Yet, the optimal approach for identifying inpatients who may have TB is unclear. We evaluated the diagnostic accuracy of qXR (Qure.ai, India) computer-aided detection (CAD) software versions 3.0 and 4.0 (v3 and v4) as a triage and screening tool within the FAST (Find cases Actively, Separate safely, and Treat effectively) transmission control strategy. …
Tuberculosis treatment loss to follow-up in children exposed at home
Background: Loss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a significant public health problem. It is important to understand what drives LTFU in children - a population whose treatment and management depend on an adult caregiver - to better provide support services to families affected by TB. Methods: We conducted a prospective cohort study of household contacts in Lima, Peru (2009-12). Using multilevel logistic regression…
Programmatic implementation of depression screening and remote mental health support sessions for persons recently diagnosed with TB in Lima, Peru during the Covid-19 pandemic
Depressive symptoms were common among persons recently diagnosed with TB. We observed improvements in depressive symptoms 6 months later for most participants who received remote sessions of PFA
Búsqueda activa de tuberculosis en tres centros penitenciarios juveniles de Perú
Motivation for the study. With tuberculosis being the leading cause of death due to infectious diseases in the world, and having a detection gap of 20-40%, there is a need to implement active search strategies for the disease in different vulnerable populations such as juvenile correctional facilities. Main findings. We found a screening rate by active search of 1250 per 100,000 screened, being 10 times more than the rate in the general populatio…
Síntomas depresivos, violencia y discriminación en mujeres transgénero durante la pandemia de Covid-19
A high frequency of depressive symptoms, as well as experiences of gender-based discrimination and violence, was observed among TGW in Lima, Peru, during the COVID-19 pandemic. In addition, significant associations were identified between these experiences and the presence of depressive symptoms. These findings are consistent with existing evidence on the mental health impact of the pandemic, but also suggest a disproportionate burden among TGW a…
Water insecurity and climate change
Latin America faces a severe health crisis, where over 150 million people lack reliable access to water due to climate change. We conducted a mixed-methods study to understand perspectives and experiences surrounding water security and its relationship to climate change among predominantly Indigenous mothers in Maras, a rural Andean district in the Urubamba Province of Peru. A verbal survey was administered to 100 pregnant women and/or caregivers…
Medicine (18 obras) · Psychiatry (8 obras) · Environmental health (7 obras) · Tuberculosis (7 obras) · Internal Medicine (6 obras) · Tuberculosis Research and Epidemiology (6 obras) · Family medicine (5 obras) · HIV/AIDS Research and Interventions (5 obras) · Humanities (5 obras) · Pathology (5 obras)