A E Aiello
Dados Biográficos
| ID | 632791 |
|---|---|
| NOME | A E Aiello |
| PRENOMES | A E |
| SOBRENOME | Aiello |
| ASSINATURA | AIELLO A E |
| AFILIAÇÕES | University of North Carolina at Chapel Hill |
| ORCID | 0000-0001-7029-2537 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 62 |
| TOTAL DE CITAÇÕES | 144 |
| TOTAL COMO AUTOR | 62 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2007 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 6 |
Life course socioeconomic disadvantage and persistent infection burden
Persistent SES disadvantage was consistently associated with higher infection burden and more aged immune cell profiles before midlife. Understanding this link is key for addressing health disparities
Stress-responsive biomarkers and sexual behaviors among young women in rural South Africa
BACKGROUND: Adolescence is a critical period when youth develop their decision-making skills and may engage in their first sexual encounters. Stress during this time can affect decision making; however, limited research has examined the relationship between biological stress correlates and sexual behavior among adolescent girls and young women (AGYW) in high-HIV incidence areas. PURPOSE: To examine whether stress-responsive biomarkers are longitu…
Trajectories of intimate partner violence and their relationship to stress among young women in South Africa
BACKGROUND: One in four South African women will experience intimate partner violence (IPV) in their lifetime, potentially increasing their biological stress. In South Africa, limited IPV and stress research has utilized multiple timepoints or examined modifying factors. Cash transfers (CTs) are associated with reduced IPV and stress and may be an intervention target. AIMS: We used data-driven methods to identify longitudinal IPV trajectory group…
Indicators of inequity
Examines two types of area-level indicators commonly used in structural racism and health research.•Uses choropleth maps to assess the spatial patterning of the area-level indicators.•Offers methodological considerations for using area-level indicators.•Highlights the prospects and limits of using area-level indicators as proxies of structural racism
Sociodemographic patterns in biomarkers of aging in the Add Health cohort
Biomarkers in population health research serve as indicators of incremental physiological deterioration and contribute to our understanding of mechanisms through which social disparities in health unfold over time. Yet, few population-based studies incorporate biomarkers of aging in early midlife, when disease risks may emerge and progress across the life course. We describe the distributions of several biomarkers of inflammation and neurodegener…
The association between incarceration and housing insecurity and advanced immune age during late life
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Intimate partner violence is associated with cytomegalovirus among young women in rural South Africa
Stressful life circumstances (e.g. violence and poverty) have been associated with elevated biomarkers, including C-reactive protein (CRP), cytomegalovirus (CMV), and herpes simplex virus type-1 (HSV-1), among older adults in high-income settings. Yet, it remains unknown whether these relationships exist among younger populations in resource-limited settings. We therefore utilised a cohort of 1,279 adolescent girls and young women (AGYW) from the…
An Early and Unequal Decline
Objectives: Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. Methods: We conducted integrative data analysis of four large U.S. population-based longitudinal studies of individuals aged 12 to 105 followed over two decades and modeled age trajectories of …
Age, period and cohort-related trends in prescription opioid use in the USA, 1999–2018
Background To provide insight into the longitudinal dynamics of opioid use throughout the overdose crisis, this study estimated the separate influences of age, period and cohort on prescription opioid use during 1999–2018 in the USA. Methods Data from 10 cycles of the cross-sectional National Health and Nutrition Examination Survey were used to conduct an age–period–cohort analysis of the prevalence of prescription opioid use (n=63 500 across 199…
Patterns and Life Course Determinants of Black–White Disparities in Biological Age Acceleration
Despite the prominence of the weathering hypothesis as a mechanism underlying racialized inequities in morbidity and mortality, the life course social and economic determinants of Black–White disparities in biological aging remain inadequately understood. This study uses data from the Health and Retirement Study (n = 6,782), multivariable regression, and Kitagawa–Blinder–Oaxaca decomposition to assess Black–White disparities across three measures…
Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort
Posttraumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, PTSD has been implicated in the development of a variety of chronic conditions, including cardiovascular and metabolic diseases, suggesting the biological alterations associated with the disorder can manifest as c…
Sars-CoV-2 seroprevalence and risk factors among meat packing, produce processing, and farm workers
Meat packing, produce processing, and farm workers are known to have an elevated risk of COVID-19, but occupational risk factors in this population are unclear. We performed an observational cohort study of meat packing, produce processing, and farm workers in North Carolina in fall 2020. Blood, saliva, and nasal turbinate samples were collected to assess for SARS-CoV-2 seropositivity. Risk factors for SARS-CoV-2 seropositivity were investigated …
Occupational cognitive stimulation, socioeconomic status, and cognitive functioning in young adulthood
Our results indicate that even in adulthood, activities that stimulate the mind can contribute to improved cognitive function, and the most beneficial forms of occupational stimulation are those that use analytic skills and involve social interaction (particularly among young men)
Associations between a Universal Free Breakfast Policy and School Breakfast Program Participation, School Attendance, and Weight Status
Breakfast consumption among youth is associated with improved diet quality, weight, cognition, and behavior. However, not all youth in the United States consume breakfast. Participation in the School Breakfast Program (SBP) is also low relative to the lunch program. Universal free breakfast (UFB) policies have been implemented to increase breakfast participation by reducing cost and stigma associated with the SBP. This study examined whether a UF…
Social Relationships, Wealth, and Cardiometabolic Risk
Objectives: To investigate multiple dimensions of social relationships related to biomarkers of cardiometabolic health and how their associations vary by wealth in older adults. Methods: Growth curve models were used to investigate the longitudinal associations between measures of both positive and negative social relationships and cardiometabolic risk (CMR) over a 10-year period from 2006 to 2016 and the moderation of this association by wealth …
Adolescent neighborhood disadvantage and memory performance in young adulthood
Gestational exposure to neighborhood police-reported crime and early childhood blood pressure in Durham, NC
Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study
The differential age patterns of cognitive decline predicting dementia incidences identified in this study suggest variation in the course of cognitive aging in older adults that may inform future etiological and intervention studies
Adolescent and Adult Correlates of Prescription Opioid Use and Misuse in Adulthood
Objective: Given continued increases in “deaths of despair”, there is a need to examine associations of factors across multiple domains of despair (i.e. cognitive, emotional, behavioral, biological) with opioid-related behaviors. An understanding of current and early life correlates of prescription opioid behaviors can help inform clinical care, public health interventions, and future life course research. Methods: Using data from Waves I (1994–1…
At-home testing to mitigate community transmission of Sars-CoV-2
This is the first large-scale, public health intervention implementing rapid, at-home SARS-CoV-2 self-testing in the United States. The program consists of a novel combination of an at-home testing program, a broad communications and community engagement strategy, an ecological study to assess impact, and a research substudy of the behavioral aspects of testing. The findings from the SYCT project will provide insights into innovative methods to m…
Demographic and sociocultural risk factors for adulthood weight gain in Hispanic/Latinos
Using self-reported and weight history data in a diverse sample of US Hispanic/Latinos, we revealed that both demographic and sociocultural factors were associated with the patterning of adulthood weight gain in this sample. Given the steep rate of weight gain in this population and the fact that many Hispanic/Latinos living in the US immigrated as adults, efforts to promote weight maintenance across the life course, including after immigration, …
Sars-CoV-2 testing in North Carolina
SARS-CoV-2 testing data in North Carolina during the first three months of the state's COVID-19 pandemic were analyzed to determine if there were disparities among intersecting axes of identity including race, Latinx ethnicity, age, urban-rural residence, and residence in a medically underserved area. Demographic and residential data were used to reconstruct patterns of testing metrics (including tests per capita, positive tests per capita, and t…
Associations among neighborhood poverty, perceived neighborhood environment, and depressed mood are mediated by physical activity, perceived individual control, and loneliness
Life Course Socioeconomic Disadvantage and the Aging Immune System
CMV IgG levels in older adults are associated with both early-life and adult SES. Life course socioeconomic disadvantage may contribute to disparities in immunological aging
The legacy of redlining in the effect of foreclosures on Detroit residents’ self-rated health
Early origins of health disparities
The Association Between Food Insecurity and Inflammation in the US Adult Population
Objectives. To expand the understanding of potential pathways through which food insecurity is associated with adverse health outcomes, we investigated whether food insecurity is associated with nutritional levels, inflammatory response, and altered immune function. Methods. We performed a cross-sectional analysis of the National Health and Nutrition Examination Survey (1999–2006) with 12 191 participants. We assessed food insecurity using the US…
Perceived discrimination and depressive symptoms among US Latinos
US Latinos suffer a high burden of depressive symptoms, and discrimination may be an important driver of this burden. Our results suggest that effortful coping strategies, such as achieving high education despite high perceived discrimination, may magnify discrimination's adverse effect on Latino mental health
Life-span Socioeconomic Trajectory, Nativity, and Cognitive Aging in Mexican Americans
Heterogeneity of cognitive aging among diverse race/ethnic groups may be influenced by intergenerational changes in SES, cultural norms, and behaviors and changes in health related to changes in the social and physical environment
Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting
To quantify the effect of hand-hygiene interventions on rates of gastrointestinal and respiratory illnesses and to identify interventions that provide the greatest efficacy, we searched 4 electronic databases for hand-hygiene trials published from January 1960 through May 2007 and conducted meta-analyses to generate pooled rate ratios across interventions (N=30 studies). Improvements in hand hygiene resulted in reductions in gastrointestinal illn…
Analysis of social epidemiology research on infectious diseases
BACKGROUND: Despite the many triumphs of biomedical research over infectious diseases, human pathogens continue to impact profoundly populations deprived of social resources. Correspondingly, health researchers have advocated a social determinants approach to the study and prevention of infectious diseases. However, it is unknown whether this call has resulted in an increase in the number of studies examining social determinants of infectious out…
An Early and Unequal Decline
Objectives: Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. Methods: We conducted integrative data analysis of four large U.S. population-based longitudinal studies of individuals aged 12 to 105 followed over two decades and modeled age trajectories of …
Patterns and Life Course Determinants of Black–White Disparities in Biological Age Acceleration
Despite the prominence of the weathering hypothesis as a mechanism underlying racialized inequities in morbidity and mortality, the life course social and economic determinants of Black–White disparities in biological aging remain inadequately understood. This study uses data from the Health and Retirement Study (n = 6,782), multivariable regression, and Kitagawa–Blinder–Oaxaca decomposition to assess Black–White disparities across three measures…
Neighborhood disadvantage across the transition from adolescence to adulthood and risk of metabolic syndrome
Early life socioeconomic position and immune response to persistent infections among elderly Latinos
Life-Course Exposure to Early Socioeconomic Environment, Education in Relation to Late-Life Cognitive Function Among Older Mexicans and Mexican Americans
Adult educational attainment mediates the effect of childhood socioeconomic status on late-life cognition. Migration plays a role in shaping cognitive aging
Life Course Socioeconomic Disadvantage and the Aging Immune System
CMV IgG levels in older adults are associated with both early-life and adult SES. Life course socioeconomic disadvantage may contribute to disparities in immunological aging
Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study
The differential age patterns of cognitive decline predicting dementia incidences identified in this study suggest variation in the course of cognitive aging in older adults that may inform future etiological and intervention studies
The Great Recession and Immune Function
The Great Recession precipitated unprecedented home foreclosures increases, but documentation of related neighborhood changes and population health is scant. Using the Detroit Neighborhood Health Study ( N = 277), we examined associations between neighborhood-level recession indicators and thymic function, a life course immunological health indicator. In covariate-adjusted multilevel models, each 10 percentage point increase in abandoned home pre…
Cardiometabolic Risk, Socio-Psychological Factors, and Trajectory of Grip Strength Among Older Japanese Adults
In older adults, GS and its rate of decline are selectively associated with both cardiometabolic risk and socio-psychological characteristics. Cardiometabolic risk mediates educational disparities in GS but not differences in subjective assessments of health
Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness
Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between gen…
Socioeconomic Position and Inflammatory and Immune Biomarkers of Cardiovascular Disease
Biomarkers are an important aspect of research linking psychosocial stress and health. This article aims to characterize the biological pathways that may mediate the relationship between socioeconomic position (SEP) and cardiovascular disease (CVD) and address opportunities for further research within the Panel Study of Income Dynamics (PSID), with a focus on psychosocial stressors related to SEP. We review the literature on CVD biomarkers, inclu…
Sociodemographic patterns in biomarkers of aging in the Add Health cohort
Biomarkers in population health research serve as indicators of incremental physiological deterioration and contribute to our understanding of mechanisms through which social disparities in health unfold over time. Yet, few population-based studies incorporate biomarkers of aging in early midlife, when disease risks may emerge and progress across the life course. We describe the distributions of several biomarkers of inflammation and neurodegener…
The association between incarceration and housing insecurity and advanced immune age during late life
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Sars-CoV-2 testing in North Carolina
SARS-CoV-2 testing data in North Carolina during the first three months of the state's COVID-19 pandemic were analyzed to determine if there were disparities among intersecting axes of identity including race, Latinx ethnicity, age, urban-rural residence, and residence in a medically underserved area. Demographic and residential data were used to reconstruct patterns of testing metrics (including tests per capita, positive tests per capita, and t…
Analysis of social epidemiology research on infectious diseases
BACKGROUND: Despite the many triumphs of biomedical research over infectious diseases, human pathogens continue to impact profoundly populations deprived of social resources. Correspondingly, health researchers have advocated a social determinants approach to the study and prevention of infectious diseases. However, it is unknown whether this call has resulted in an increase in the number of studies examining social determinants of infectious out…
Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting
To quantify the effect of hand-hygiene interventions on rates of gastrointestinal and respiratory illnesses and to identify interventions that provide the greatest efficacy, we searched 4 electronic databases for hand-hygiene trials published from January 1960 through May 2007 and conducted meta-analyses to generate pooled rate ratios across interventions (N=30 studies). Improvements in hand hygiene resulted in reductions in gastrointestinal illn…
Socio-economic status, cortisol and allostatic load
BACKGROUND: The notion that chronic stress contributes to health inequalities by socio-economic status (SES) through physiological wear and tear has received widespread attention. This article reviews the literature testing associations between SES and cortisol, an important biomarker of stress, as well as the summary index of allostatic load (AL). METHODS: A search of all published literature on the PubMed and ISI Web of Knowledge literature sea…
Neoliberalism, Globalization and Inequalities
Vicente Navarro. Published by Baywood Publishing CompanyAmityville 2007 $75 ISBN 978-0-89503-338-3 (hbk) $54 ISBN 978-0-89503-344-4 (pbk) The overall goal of Neoliberalism, Globalization and Inequalities is to address the ideology and aetiology of “neoliberalism” and its effects on health and quality of life by critically analysing policies of the Western World that are used to stimulate human development, specifically reductions in the role of t…
Early origins of health disparities
Socioeconomic Position and Inflammatory and Immune Biomarkers of Cardiovascular Disease
Biomarkers are an important aspect of research linking psychosocial stress and health. This article aims to characterize the biological pathways that may mediate the relationship between socioeconomic position (SEP) and cardiovascular disease (CVD) and address opportunities for further research within the Panel Study of Income Dynamics (PSID), with a focus on psychosocial stressors related to SEP. We review the literature on CVD biomarkers, inclu…
Self-reported experiences of everyday discrimination are associated with elevated C-reactive protein levels in older African-American adults
The influence of persistent pathogens on circulating levels of inflammatory markers
High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen
Comparison of three methods for diabetes screening in a rural clinic in Honduras
Both the screening equation and POC-A1c are reasonable alternatives to an FPG test for identifying patients with diabetes. Given the barriers to currently recommended screening procedures, these options could have important public health benefits in Latin America
Demographic and socioeconomic determinants of influenza vaccination disparities among university students
BACKGROUND: The Advisory Committee on Immunization Practices encourages dormitory residents to receive influenza vaccination. To our knowledge, there are no studies that have directly examined factors associated with vaccination uptake among university students residing in dormitories. We therefore sought to examine the influence of demographic, social and health behaviours on influenza vaccination coverage among college dormitory students. METHO…
Life-Course Exposure to Early Socioeconomic Environment, Education in Relation to Late-Life Cognitive Function Among Older Mexicans and Mexican Americans
Adult educational attainment mediates the effect of childhood socioeconomic status on late-life cognition. Migration plays a role in shaping cognitive aging
Life-span Socioeconomic Trajectory, Nativity, and Cognitive Aging in Mexican Americans
Heterogeneity of cognitive aging among diverse race/ethnic groups may be influenced by intergenerational changes in SES, cultural norms, and behaviors and changes in health related to changes in the social and physical environment
Stress, adherence to preventive measures for reducing influenza transmission and influenza-like illness
BACKGROUND: Using data from a randomised intervention trial of facemask use and hand hygiene for reducing transmission of seasonal influenza among university students, we examined if levels of perceived stress were negatively associated with adherence to these preventive measures and incidence of influenza-like illness (ILI). METHODS: Longitudinal analyses using generalised estimating equations were examined. Perceived stress was self-reported at…
The Association Between Food Insecurity and Inflammation in the US Adult Population
Objectives. To expand the understanding of potential pathways through which food insecurity is associated with adverse health outcomes, we investigated whether food insecurity is associated with nutritional levels, inflammatory response, and altered immune function. Methods. We performed a cross-sectional analysis of the National Health and Nutrition Examination Survey (1999–2006) with 12 191 participants. We assessed food insecurity using the US…
Prevalence of Sexual Violence and Posttraumatic Stress Disorder in an Urban African-American Population
Gowda et al. Respond
We are delighted that our article has stimulated novel analyses regarding the relationship between food insecurity and well-being. Theall et al. describe how there were no significant associations found between food security and inflammation among a younger age group (adolescents aged 12–17 years) of the National Health and Nutrition Examination Survey study population 1999–2006 that we used to investigate these relationships in adults (aged ≥ 18…
Gowda et al. Respond
Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness
Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health. We conducted a pilot investigation to assess whether SEP, measured as educational attainment, modifies the association between gen…
Sex Differences in the Association Between Depression, Anxiety, and Type 2 Diabetes Mellitus
BACKGROUND: Depression and anxiety have been inconsistently associated with diabetes. Sex differences in the biological and behavioral correlates of these forms of distress could partially explain these inconsistencies. We investigated sex-specific associations between depression/anxiety symptoms and diabetes in two separate samples. METHODS: The First National Health and Nutrition Examination Survey enrolled 3233 participants aged 25 to 74 years…
Cardiometabolic Risk, Socio-Psychological Factors, and Trajectory of Grip Strength Among Older Japanese Adults
In older adults, GS and its rate of decline are selectively associated with both cardiometabolic risk and socio-psychological characteristics. Cardiometabolic risk mediates educational disparities in GS but not differences in subjective assessments of health
Income and Markers of Immunological Cellular Aging
OBJECTIVE: Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8…
Bias with respect to socioeconomic status
In 2010, 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the US for prevention of invasive pneumococcal disease in children. Individual-level socioeconomic status (SES) is a potential confounder of the estimated effectiveness of PCV13 and is often controlled for in observational studies using zip code as a proxy. We assessed the utility of zip code matching for control of SES in a post-licensure evaluation of the effectiveness …
Population Distributions of Thymic Function in Adults
The thymus is critical for mounting an effective immune response and maintaining health. However, epidemiologic studies characterizing thymic function in the population setting are lacking. Using data from 263 adults in the Detroit Neighborhood Health Study, we examined thymic function as measured by the number of signal joint T-cell receptor excision circles (sjTREC) and assessed associations with established indicators of physiological health. …
Early life socioeconomic position and immune response to persistent infections among elderly Latinos
Socioeconomic status in childhood and C reactive protein in adulthood
Medicine (58 obras) · Psychology (34 obras) · Demography (33 obras) · Gerontology (33 obras) · Environmental health (30 obras) · Demography (25 obras) · Population (24 obras) · Internal Medicine (20 obras) · Psychiatry (20 obras) · Health disparities and outcomes (19 obras)