Samir K Saha
Dados Biográficos
| ID | 6455895 |
|---|---|
| NOME | Samir K Saha |
| PRENOMES | Samir K |
| SOBRENOME | Saha |
| ASSINATURA | SAHA S K |
| AFILIAÇÕES | Dhaka Shishu Hospital |
| ORCID | 0000-0003-3820-0748 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 19 |
| TOTAL DE CITAÇÕES | 3 |
| TOTAL COMO AUTOR | 19 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2008 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 1 |
Misdiagnosis of bronchiolitis and misuse of antibiotics – experience from the largest paediatric hospital of Bangladesh
Background: Bronchiolitis remains the commonest acute lower respiratory tract infection in younger children globally. Bronchiolitis is often misdiagnosed as World Health Organization (WHO)-classified pneumonia due to closely related clinical manifestations. Our primary objective was to assess the prevalence of viral bronchiolitis among WHO-classified pneumonia, and the secondary objective was to evaluate their management. Methods: This was a pros…
Causes and risk factors for deaths in young infants in South Asia
INTRODUCTION: Strategies for reducing infant mortality require accurate, local, population-level data. We conducted a population-based observational study in three countries in South Asia to describe risk factors, causes and rates of mortality in young infants. METHODS: Pregnancies, births and pregnancy outcomes were determined through household surveillance, and cause of deaths was ascertained by verbal autopsy. Cox regression was used to identi…
Health consequences of small-scale industrial pollution
Coal-fired brick kilns have spread rapidly in Bangladesh, where they are one of the largest sources of air pollution. The adverse health impacts of air pollution have been widely documented, yet there is little empirical evidence on the externalities of this important industry. We conducted a field study in Bangladesh to quantify the contribution of brick kilns to fine particulate matter (PM2.5) and estimate the association with child asthma symp…
Risk factors for community-acquired bacterial infection among young infants in South Asia
OBJECTIVE: Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship. METHODS: Five sites in Bangladesh, India and Pakistan enrolled mother-child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic …
Derivation and validation of a novel risk assessment tool to identify children aged 2–59 months at risk of hospitalised pneumonia-related mortality in 20 countries
INTRODUCTION: Existing risk assessment tools to identify children at risk of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was to derive and validate a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality across various settings. METHODS: We used primary, baseline, patient-level data from 11 studies, incl…
Unlocking the global health potential of dried blood spot cards
A key challenge to providing care for newborn infants in low- and middle-income countries (LMICs) is the lack of timely diagnostic testing due to weak local infrastructures such as laboratory capacity and imaging technologies. To address this challenge, low-cost diagnostic testing that does not require extensive laboratory processing or costly storage procedures has been prioritised. [...]
Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm
Background: The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed to collate an individual patient-level data set from large, high-quality pre-existing studies on pneumonia in children to identify a set of signs and symptoms with greater validity in the diagnosis, prognosis, and possible trea…
Covid-19 rise in Bangladesh correlates with increasing detection of B.1.351 variant
After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apopto…
New waves, new variants, old inequity
box Bangladesh, a country of 166 million people, continues to be severely impacted by the COVID-19 pandemic. The first three cases of COVID-19 in Bangladesh were detected on 8 March 2020 among a group of travellers. Since then, the country has experienced two waves—in June 2020 and April 2021. In July 2021, less than 3 months after the second wave, Bangladesh is currently fighting its third and by far the deadliest wave. Like most other countries…
Predictors for detecting chronic respiratory diseases in community surveys
BACKGROUND: Our previous scoping review revealed limitations and inconsistencies in population surveys of chronic respiratory disease. Informed by this review, we piloted a cross-sectional survey of adults in four South/South-East Asian low-and middle-income countries (LMICs) to assess survey feasibility and identify variables that predicted asthma or chronic obstructive pulmonary disease (COPD). METHODS: We administered relevant translations of …
External validation of the Risc, Risc-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia
BACKGROUND: Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was to externally validate three such risk scores. METHODS: We applied the Respiratory Index of Severity in Children (RISC) for HIV-negative children, the RISC-Malawi, and the Pneumonia Etiology Research for Child Health (PERCH) scores to hospitalized children in the Pneumonia REsearch Partnerships to …
Validation of community health worker identification of maternal puerperal sepsis using a clinical diagnostic algorithm in Bangladesh and Pakistan
BACKGROUND: Puerperal sepsis (PP sepsis) is a leading cause of maternal mortality globally. The majority of maternal sepsis cases and deaths occur at home and remain undiagnosed and under-reported. In this paper, we present findings from a nested case-control study in Bangladesh and Pakistan which sought to assess the validity of community health worker (CHW) identification of PP sepsis using a clinical diagnostic algorithm with physician assessm…
Nasopharyngeal pneumococcal carriage in South Asian infants
BACKGROUND: Nasopharyngeal pneumococcal carriage (NPC) is a prerequisite for invasive pneumococcal disease and reduced carriage of vaccine serotypes is a marker for the protection offered by the pneumococcal conjugate vaccine (PCV). The present study reports NPC during the first year of life in a vaccinated (with PCV10) cohort in Bangladesh and an unvaccinated cohort in India. METHODS: A total of 450 and 459 infants were recruited from India and …
Operational definitions of paediatric asthma used in epidemiological studies
Respire
Can facility delivery reduce the risk of intrapartum complications-related perinatal mortality? Findings from a cohort study
BACKGROUND: Intrapartum complications increase the risk of perinatal deaths. However, population-based data from developing countries assessing the contribution of intrapartum complications to perinatal deaths is scarce. METHODS: Using data from a cohort of pregnant women followed between 2011 and 2013 in Bangladesh, this study examined the rate and types of intrapartum complications, the association of intrapartum complications with perinatal mo…
Study protocol of a 4- parallel arm, superiority, community based cluster randomized controlled trial comparing paper and e-platform based interventions to improve accuracy of recall of last menstrual…
ClinicalTrials.gov NCT02944747 . The trial has been registered before starting enrolment on 24 October 2016
Epidemiology and risk factors for pneumonia severity and mortality in Bangladeshi children <5 years of age before 10-valent pneumococcal conjugate vaccine introduction
Modifiable factors for severe pneumonia and mortality included low weight for age and access to safe drinking water. Improving vaccination status could decrease disease severity
Effect of community-based newborn-care intervention package implemented through two service-delivery strategies in Sylhet district, Bangladesh
Health consequences of small-scale industrial pollution
Coal-fired brick kilns have spread rapidly in Bangladesh, where they are one of the largest sources of air pollution. The adverse health impacts of air pollution have been widely documented, yet there is little empirical evidence on the externalities of this important industry. We conducted a field study in Bangladesh to quantify the contribution of brick kilns to fine particulate matter (PM2.5) and estimate the association with child asthma symp…
Effect of community-based newborn-care intervention package implemented through two service-delivery strategies in Sylhet district, Bangladesh
Epidemiology and risk factors for pneumonia severity and mortality in Bangladeshi children <5 years of age before 10-valent pneumococcal conjugate vaccine introduction
Modifiable factors for severe pneumonia and mortality included low weight for age and access to safe drinking water. Improving vaccination status could decrease disease severity
Respire
Can facility delivery reduce the risk of intrapartum complications-related perinatal mortality? Findings from a cohort study
BACKGROUND: Intrapartum complications increase the risk of perinatal deaths. However, population-based data from developing countries assessing the contribution of intrapartum complications to perinatal deaths is scarce. METHODS: Using data from a cohort of pregnant women followed between 2011 and 2013 in Bangladesh, this study examined the rate and types of intrapartum complications, the association of intrapartum complications with perinatal mo…
Study protocol of a 4- parallel arm, superiority, community based cluster randomized controlled trial comparing paper and e-platform based interventions to improve accuracy of recall of last menstrual…
ClinicalTrials.gov NCT02944747 . The trial has been registered before starting enrolment on 24 October 2016
Covid-19 rise in Bangladesh correlates with increasing detection of B.1.351 variant
After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apopto…
New waves, new variants, old inequity
box Bangladesh, a country of 166 million people, continues to be severely impacted by the COVID-19 pandemic. The first three cases of COVID-19 in Bangladesh were detected on 8 March 2020 among a group of travellers. Since then, the country has experienced two waves—in June 2020 and April 2021. In July 2021, less than 3 months after the second wave, Bangladesh is currently fighting its third and by far the deadliest wave. Like most other countries…
Predictors for detecting chronic respiratory diseases in community surveys
BACKGROUND: Our previous scoping review revealed limitations and inconsistencies in population surveys of chronic respiratory disease. Informed by this review, we piloted a cross-sectional survey of adults in four South/South-East Asian low-and middle-income countries (LMICs) to assess survey feasibility and identify variables that predicted asthma or chronic obstructive pulmonary disease (COPD). METHODS: We administered relevant translations of …
External validation of the Risc, Risc-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia
BACKGROUND: Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was to externally validate three such risk scores. METHODS: We applied the Respiratory Index of Severity in Children (RISC) for HIV-negative children, the RISC-Malawi, and the Pneumonia Etiology Research for Child Health (PERCH) scores to hospitalized children in the Pneumonia REsearch Partnerships to …
Validation of community health worker identification of maternal puerperal sepsis using a clinical diagnostic algorithm in Bangladesh and Pakistan
BACKGROUND: Puerperal sepsis (PP sepsis) is a leading cause of maternal mortality globally. The majority of maternal sepsis cases and deaths occur at home and remain undiagnosed and under-reported. In this paper, we present findings from a nested case-control study in Bangladesh and Pakistan which sought to assess the validity of community health worker (CHW) identification of PP sepsis using a clinical diagnostic algorithm with physician assessm…
Nasopharyngeal pneumococcal carriage in South Asian infants
BACKGROUND: Nasopharyngeal pneumococcal carriage (NPC) is a prerequisite for invasive pneumococcal disease and reduced carriage of vaccine serotypes is a marker for the protection offered by the pneumococcal conjugate vaccine (PCV). The present study reports NPC during the first year of life in a vaccinated (with PCV10) cohort in Bangladesh and an unvaccinated cohort in India. METHODS: A total of 450 and 459 infants were recruited from India and …
Operational definitions of paediatric asthma used in epidemiological studies
Risk factors for community-acquired bacterial infection among young infants in South Asia
OBJECTIVE: Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship. METHODS: Five sites in Bangladesh, India and Pakistan enrolled mother-child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic …
Derivation and validation of a novel risk assessment tool to identify children aged 2–59 months at risk of hospitalised pneumonia-related mortality in 20 countries
INTRODUCTION: Existing risk assessment tools to identify children at risk of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was to derive and validate a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality across various settings. METHODS: We used primary, baseline, patient-level data from 11 studies, incl…
Unlocking the global health potential of dried blood spot cards
A key challenge to providing care for newborn infants in low- and middle-income countries (LMICs) is the lack of timely diagnostic testing due to weak local infrastructures such as laboratory capacity and imaging technologies. To address this challenge, low-cost diagnostic testing that does not require extensive laboratory processing or costly storage procedures has been prioritised. [...]
Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm
Background: The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed to collate an individual patient-level data set from large, high-quality pre-existing studies on pneumonia in children to identify a set of signs and symptoms with greater validity in the diagnosis, prognosis, and possible trea…
Health consequences of small-scale industrial pollution
Coal-fired brick kilns have spread rapidly in Bangladesh, where they are one of the largest sources of air pollution. The adverse health impacts of air pollution have been widely documented, yet there is little empirical evidence on the externalities of this important industry. We conducted a field study in Bangladesh to quantify the contribution of brick kilns to fine particulate matter (PM2.5) and estimate the association with child asthma symp…
Causes and risk factors for deaths in young infants in South Asia
INTRODUCTION: Strategies for reducing infant mortality require accurate, local, population-level data. We conducted a population-based observational study in three countries in South Asia to describe risk factors, causes and rates of mortality in young infants. METHODS: Pregnancies, births and pregnancy outcomes were determined through household surveillance, and cause of deaths was ascertained by verbal autopsy. Cox regression was used to identi…
Misdiagnosis of bronchiolitis and misuse of antibiotics – experience from the largest paediatric hospital of Bangladesh
Background: Bronchiolitis remains the commonest acute lower respiratory tract infection in younger children globally. Bronchiolitis is often misdiagnosed as World Health Organization (WHO)-classified pneumonia due to closely related clinical manifestations. Our primary objective was to assess the prevalence of viral bronchiolitis among WHO-classified pneumonia, and the secondary objective was to evaluate their management. Methods: This was a pros…
Medicine (16 obras) · Internal Medicine (9 obras) · Environmental health (8 obras) · Pediatrics (6 obras) · Pneumonia and Respiratory Infections (6 obras) · Intensive care medicine (5 obras) · Pneumonia (5 obras) · Respiratory viral infections research (5 obras) · Antibiotics (4 obras) · Biology (4 obras)