Shi Zhao
Dados Biográficos
| ID | 6679673 |
|---|---|
| NOME | Shi Zhao |
| PRENOMES | Shi |
| SOBRENOME | Zhao |
| ASSINATURA | ZHAO S |
| AFILIAÇÕES | Chinese University of Hong Kong |
| ORCID | 0000-0001-8722-6149 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 19 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 19 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2020 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 0 |
Interpretable machine learning method to predict the risk of pre-diabetes using a national-wide cross-sectional data
The constructed model comprises nine easily accessible predictive factors, which prove highly effective in forecasting the risk of pre-diabetes. Concurrently, we have quantified the specific impact of each predictive factor on the risk and ranked them based on their influence. This result may serve as a convenient tool for early identification of individuals at high risk of pre-diabetes, providing effective guidance for preventing the progression…
Kidney failure-related excess mortality during the first three years of the Covid-19 pandemic in the United States
Our study observed high levels of excess kidney failure-related mortality during the first two years of the pandemic, followed by a notable decline in the third year. This highlights the effectiveness of current policies and prevention measures implemented to mitigate the impact of the pandemic
Outcomes and Hospital Service Use Among Patients With COPD in a Nurse- and Allied Health–Led Clinic
In this cohort study, the use of a nurse- and allied health-led clinic in primary care settings was associated with reduced risks of mortality and use of hospital services among patients with COPD. These findings emphasize the important role of health care workers other than physicians in disease management in the primary care setting. The NAHC-Respiratory model and service components can be used to help improve primary care programs to benefit m…
Greenbelt investment with temporal preference in uncertain environments
Changes in all-cause and cause-specific excess mortality before and after the Omicron outbreak of Covid-19 in Hong Kong
Background: While coronavirus 2019 (COVID-19) deaths were generally underestimated in many countries, Hong Kong may show a different trend of excess mortality due to stringent measures, especially for deaths related to respiratory diseases. Nevertheless, the Omicron outbreak in Hong Kong evolved into a territory-wide transmission, similar to other settings such as Singapore, South Korea, and recently, mainland China. We hypothesized that the exce…
Case clustering, contact stratification, and transmission heterogeneity of Sars-CoV-2 Omicron BA.5 variants in Urumqi, China
Background: From August to September 2022, Urumqi, the capital of the Xinjiang Uygur Autonomous Region in China, faced its largest COVID-19 outbreak caused by the emergence of the SARS-CoV-2 Omicron BA.5.2 variants. Although the superspreading of COVID-19 played an important role in triggering large-scale outbreaks, little was known about the superspreading potential and heterogeneity in the transmission of Omicron BA.5 variants. Methods: In this…
Relationship between temperature variability and daily hospitalisations in Hong Kong over two decades
Background: Studies have highlighted the impacts of temperature variability (TV) on mortality from respiratory diseases and cardiovascular diseases, with inconsistent results specifically in subtropical urban areas than temperate ones. We aimed to fully determine TV-associated health risks over a spectrum of diseases and various subgroups in a subtropical setting. Methods: Using inpatient data from all public hospitals in Hong Kong from 1999 to 2…
The indirect impacts of nonpharmacological Covid-19 control measures on other infectious diseases in Yinchuan, Northwest China
The widespread implementation of NPIs in 2020 may have had significant inhibitory effects on the incidence of respiratory infectious diseases, intestinal infectious diseases and sexually transmitted or bloodborne diseases. The relative reduction in NIDs during different emergency response levels in 2020 showed a declining trend as the response level changed from level 1 to level 3. These results can serve as essential guidance for policy-makers a…
The immune evasion ability of Delta variant is comparable to that of Beta variant in South Africa
We conclude that the immune evasion ability of Beta variant is not stronger than Delta variant, and indeed, the immune evasion abilities of both variants are weak in South Africa
Saponin of Aralia taibaiensis promotes angiogenesis through Vegf/VEGFR2 signaling pathway in cerebral ischemic mice
The results proved that sAT promotes angiogenesis in cerebral ischemia-reperfusion mice and its mechanism is to regulate VEGF/VEGFR2 and then regulate Src/eNOS and PLCγ1/ERK1/2
Reinfection or Reactivation of Severe Acute Respiratory Syndrome Coronavirus 2
As the pandemic continues, individuals with re-detectable positive (RP) SARS-CoV-2 viral RNA among recovered COVID-19 patients have raised public health concerns. It is imperative to investigate whether the cases with re-detectable positive (RP) SARS-CoV-2 might cause severe infection to the vulnerable population. In this work, we conducted a systematic review of recent literature to investigate reactivation and reinfection among the discharged C…
Estimating the Instantaneous Asymptomatic Proportion With a Simple Approach
Background: The asymptomatic proportion is a critical epidemiological characteristic that modulates the pandemic potential of emerging respiratory virus, which may vary depending on the nature of the disease source, population characteristics, source–host interaction, and environmental factors. Methods: We developed a simple likelihood-based framework to estimate the instantaneous asymptomatic proportion of infectious diseases. Taking the COVID-1…
How Transportation Restriction Shapes the Relationship Between Ambient Nitrogen Dioxide and Covid-19 Transmissibility
Background: Several recent studies reported a positive (statistical) association between ambient nitrogen dioxide (NO 2 ) and COVID-19 transmissibility. However, considering the intensive transportation restriction due to lockdown measures that would lead to declines in both ambient NO 2 concentration and COVID-19 spread, the crude or insufficiently adjusted associations between NO 2 and COVID-19 transmissibility might be confounded. This study a…
Using Proper Mean Generation Intervals in Modeling of Covid-19
In susceptible–exposed–infectious–recovered (SEIR) epidemic models, with the exponentially distributed duration of exposed/infectious statuses, the mean generation interval (GI, time lag between infections of a primary case and its secondary case) equals the mean latent period (LP) plus the mean infectious period (IP). It was widely reported that the GI for COVID-19 is as short as 5 days. However, many works in top journals used longer LP or IP w…
The co-circulating transmission dynamics of Sars-CoV-2 Alpha and Eta variants in Nigeria
BACKGROUND: The COVID-19 pandemic poses serious threats to public health globally, and the emerging mutations in SARS-CoV-2 genomes has become one of the major challenges of disease control. In the second epidemic wave in Nigeria, the roles of co-circulating SARS-CoV-2 Alpha (ie, B.1.1.7) and Eta (ie, B.1.525) variants in contributing to the epidemiological outcomes were of public health concerns for investigation. METHODS: We developed a mathema…
Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020
Backgrounds An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and other countries. We present estimates of the basic reproduction number, R 0 , of 2019-nCoV in the early phase of the outbreak. Methods Accounting for the impact of the variations in disease reporting rate, we modelled the epidemic curve of 2019-nCoV cases time se…
Source-Specific Volatile Organic Compounds and Emergency Hospital Admissions for Cardiorespiratory Diseases
Knowledge gaps remain regarding the cardiorespiratory impacts of ambient volatile organic compounds (VOCs) for the general population. This study identified contributing sources to ambient VOCs and estimated the short-term effects of VOC apportioned sources on daily emergency hospital admissions for cardiorespiratory diseases in Hong Kong from 2011 to 2014. We estimated VOC source contributions using fourteen organic chemicals by positive matrix …
Low dispersion in the infectiousness of Covid-19 cases implies difficulty in control
The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number of secondary cases of a typical index case, is conventionally modelled by a negative-binomial (NB) distribution. Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness, i.e., the dispersion parameter k of the NB distribution, at 0.70 (95% confidence interval: 0.59, 0.98). This suggests that t…
Association of time to diagnosis with socioeconomic position and geographical accessibility to healthcare among symptomatic Covid-19 patients
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Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020
Backgrounds An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and other countries. We present estimates of the basic reproduction number, R 0 , of 2019-nCoV in the early phase of the outbreak. Methods Accounting for the impact of the variations in disease reporting rate, we modelled the epidemic curve of 2019-nCoV cases time se…
Source-Specific Volatile Organic Compounds and Emergency Hospital Admissions for Cardiorespiratory Diseases
Knowledge gaps remain regarding the cardiorespiratory impacts of ambient volatile organic compounds (VOCs) for the general population. This study identified contributing sources to ambient VOCs and estimated the short-term effects of VOC apportioned sources on daily emergency hospital admissions for cardiorespiratory diseases in Hong Kong from 2011 to 2014. We estimated VOC source contributions using fourteen organic chemicals by positive matrix …
Low dispersion in the infectiousness of Covid-19 cases implies difficulty in control
The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number of secondary cases of a typical index case, is conventionally modelled by a negative-binomial (NB) distribution. Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness, i.e., the dispersion parameter k of the NB distribution, at 0.70 (95% confidence interval: 0.59, 0.98). This suggests that t…
Association of time to diagnosis with socioeconomic position and geographical accessibility to healthcare among symptomatic Covid-19 patients
Reinfection or Reactivation of Severe Acute Respiratory Syndrome Coronavirus 2
As the pandemic continues, individuals with re-detectable positive (RP) SARS-CoV-2 viral RNA among recovered COVID-19 patients have raised public health concerns. It is imperative to investigate whether the cases with re-detectable positive (RP) SARS-CoV-2 might cause severe infection to the vulnerable population. In this work, we conducted a systematic review of recent literature to investigate reactivation and reinfection among the discharged C…
Estimating the Instantaneous Asymptomatic Proportion With a Simple Approach
Background: The asymptomatic proportion is a critical epidemiological characteristic that modulates the pandemic potential of emerging respiratory virus, which may vary depending on the nature of the disease source, population characteristics, source–host interaction, and environmental factors. Methods: We developed a simple likelihood-based framework to estimate the instantaneous asymptomatic proportion of infectious diseases. Taking the COVID-1…
How Transportation Restriction Shapes the Relationship Between Ambient Nitrogen Dioxide and Covid-19 Transmissibility
Background: Several recent studies reported a positive (statistical) association between ambient nitrogen dioxide (NO 2 ) and COVID-19 transmissibility. However, considering the intensive transportation restriction due to lockdown measures that would lead to declines in both ambient NO 2 concentration and COVID-19 spread, the crude or insufficiently adjusted associations between NO 2 and COVID-19 transmissibility might be confounded. This study a…
Using Proper Mean Generation Intervals in Modeling of Covid-19
In susceptible–exposed–infectious–recovered (SEIR) epidemic models, with the exponentially distributed duration of exposed/infectious statuses, the mean generation interval (GI, time lag between infections of a primary case and its secondary case) equals the mean latent period (LP) plus the mean infectious period (IP). It was widely reported that the GI for COVID-19 is as short as 5 days. However, many works in top journals used longer LP or IP w…
The co-circulating transmission dynamics of Sars-CoV-2 Alpha and Eta variants in Nigeria
BACKGROUND: The COVID-19 pandemic poses serious threats to public health globally, and the emerging mutations in SARS-CoV-2 genomes has become one of the major challenges of disease control. In the second epidemic wave in Nigeria, the roles of co-circulating SARS-CoV-2 Alpha (ie, B.1.1.7) and Eta (ie, B.1.525) variants in contributing to the epidemiological outcomes were of public health concerns for investigation. METHODS: We developed a mathema…
Greenbelt investment with temporal preference in uncertain environments
Changes in all-cause and cause-specific excess mortality before and after the Omicron outbreak of Covid-19 in Hong Kong
Background: While coronavirus 2019 (COVID-19) deaths were generally underestimated in many countries, Hong Kong may show a different trend of excess mortality due to stringent measures, especially for deaths related to respiratory diseases. Nevertheless, the Omicron outbreak in Hong Kong evolved into a territory-wide transmission, similar to other settings such as Singapore, South Korea, and recently, mainland China. We hypothesized that the exce…
Case clustering, contact stratification, and transmission heterogeneity of Sars-CoV-2 Omicron BA.5 variants in Urumqi, China
Background: From August to September 2022, Urumqi, the capital of the Xinjiang Uygur Autonomous Region in China, faced its largest COVID-19 outbreak caused by the emergence of the SARS-CoV-2 Omicron BA.5.2 variants. Although the superspreading of COVID-19 played an important role in triggering large-scale outbreaks, little was known about the superspreading potential and heterogeneity in the transmission of Omicron BA.5 variants. Methods: In this…
Relationship between temperature variability and daily hospitalisations in Hong Kong over two decades
Background: Studies have highlighted the impacts of temperature variability (TV) on mortality from respiratory diseases and cardiovascular diseases, with inconsistent results specifically in subtropical urban areas than temperate ones. We aimed to fully determine TV-associated health risks over a spectrum of diseases and various subgroups in a subtropical setting. Methods: Using inpatient data from all public hospitals in Hong Kong from 1999 to 2…
The indirect impacts of nonpharmacological Covid-19 control measures on other infectious diseases in Yinchuan, Northwest China
The widespread implementation of NPIs in 2020 may have had significant inhibitory effects on the incidence of respiratory infectious diseases, intestinal infectious diseases and sexually transmitted or bloodborne diseases. The relative reduction in NIDs during different emergency response levels in 2020 showed a declining trend as the response level changed from level 1 to level 3. These results can serve as essential guidance for policy-makers a…
The immune evasion ability of Delta variant is comparable to that of Beta variant in South Africa
We conclude that the immune evasion ability of Beta variant is not stronger than Delta variant, and indeed, the immune evasion abilities of both variants are weak in South Africa
Saponin of Aralia taibaiensis promotes angiogenesis through Vegf/VEGFR2 signaling pathway in cerebral ischemic mice
The results proved that sAT promotes angiogenesis in cerebral ischemia-reperfusion mice and its mechanism is to regulate VEGF/VEGFR2 and then regulate Src/eNOS and PLCγ1/ERK1/2
Outcomes and Hospital Service Use Among Patients With COPD in a Nurse- and Allied Health–Led Clinic
In this cohort study, the use of a nurse- and allied health-led clinic in primary care settings was associated with reduced risks of mortality and use of hospital services among patients with COPD. These findings emphasize the important role of health care workers other than physicians in disease management in the primary care setting. The NAHC-Respiratory model and service components can be used to help improve primary care programs to benefit m…
Interpretable machine learning method to predict the risk of pre-diabetes using a national-wide cross-sectional data
The constructed model comprises nine easily accessible predictive factors, which prove highly effective in forecasting the risk of pre-diabetes. Concurrently, we have quantified the specific impact of each predictive factor on the risk and ranked them based on their influence. This result may serve as a convenient tool for early identification of individuals at high risk of pre-diabetes, providing effective guidance for preventing the progression…
Kidney failure-related excess mortality during the first three years of the Covid-19 pandemic in the United States
Our study observed high levels of excess kidney failure-related mortality during the first two years of the pandemic, followed by a notable decline in the third year. This highlights the effectiveness of current policies and prevention measures implemented to mitigate the impact of the pandemic
Medicine (17 obras) · Internal Medicine (13 obras) · Demography (12 obras) · Population (12 obras) · COVID-19 epidemiological studies (11 obras) · Disease (10 obras) · Environmental health (10 obras) · Epidemiology (8 obras) · Outbreak (8 obras) · Geography (7 obras)