Manuel J Cuesta
Dados Biográficos
| ID | 7121550 |
|---|---|
| NOME | Manuel J Cuesta |
| PRENOMES | Manuel J |
| SOBRENOME | Cuesta |
| ASSINATURA | CUESTA M J |
| AFILIAÇÕES | Complejo Hospitalario de Navarra |
| ORCID | 0000-0003-0250-5718 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 8 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 8 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1998 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 0 |
Applied pharmacogenetics to predict response to treatment of first psychotic episode
The application of personalized medicine in patients with first-episode psychosis (FEP) requires tools for classifying patients according to their response to treatment, considering both treatment efficacy and toxicity. However, several limitations have hindered its translation into clinical practice. Here, we describe the rationale, aims and methodology of Applied Pharmacogenetics to Predict Response to Treatment of First Psychotic Episode (the …
Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis
Introduction Previous research has shown that lower lactate dehydrogenase (LDH) concentrations in cerebrospinal fluid (CSF) are associated with longer prodromal symptoms in first-episode psychosis (FEP). We aimed to study whether there is a relationship between the duration of untreated psychosis (DUP) and LDH and other CSF biomarkers in FEP and whether stressful life events moderate this association. Methods Ninety-five inpatients with FEP and w…
Impact of traumatic life events on clinical variables of individuals with first-episode psychosis and healthy controls
BACKGROUND: Traumatic life events (TLEs) are one of the most robust environmental risk factors for the onset of first-episode psychosis (FEP). AIMS: To explore TLEs in FEP patients and healthy controls (HC), to analyze gender differences and to examine whether TLEs were associated with sociodemographic, clinical and psychofunctional variables in all FEP sample and split by age. METHODS: Descriptive and cross-sectional study. Three hundred and thi…
Dependence Graphs Based on Association Rules to Explore Delusional Experiences
Methods to estimate dependence graphs among variables, have quickly gained popularity in psychopathology research. To date, multiple methods have been proposed but recent studies report several drawbacks impacting on the validity of the conclusions as it is argued that assumptions and conditions underlying the methods commonly used and the nature of the data is lacking alignment. A particularly important issue is that underlying dynamics potentia…
Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis
Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended
Prospective Long-Term Cohort Study of Subjects With First-Episode Psychosis Examining Eight Major Outcome Domains and Their Predictors
Background: Our current ability to predict the long-term course and outcome of subjects with a first-episode of psychosis (FEP) is limited. To improve our understanding of the long-term outcomes of psychotic disorders and their determinants, we designed a follow-up study using a well-characterized sample of FEP and a multidimensional approach to the outcomes. The main goals were to characterize the long-term outcomes of psychotic disorders from a…
Test-Retest Reliability of the Frankfurt Complaint Questionnaire
Long-term reliability of the Frankfurt Complaint Questionnaire (FCQ) was investigated in two follow-up studies of participants with psychosis using a test-retest method. In the first study (N = 56), the duration of the follow-up ranged from 6 months to 2 years; Spearman rho was .62 for the abridged (18 items) Spanish version of the questionnaire. In Study 2 (N = 21), in participants with stable schizophrenia, the follow-up ranged from 8 to 11 yea…
Psychopathological Dimensions and Lack of Insight in Schizophrenia
The present study investigated the relationships of psychopathological dimensions of schizophrenia with Insight in a sample of 100 acute schizophrenic patients. Lack of insight was significantly correlated with disorganized, excited and negative schizophrenic dimensions but not with other Positive and Negative Syndrome Scale dimensions. In addition, when insight was assessed through a multidimensional approach, a variety of relationships with the…
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Psychopathological Dimensions and Lack of Insight in Schizophrenia
The present study investigated the relationships of psychopathological dimensions of schizophrenia with Insight in a sample of 100 acute schizophrenic patients. Lack of insight was significantly correlated with disorganized, excited and negative schizophrenic dimensions but not with other Positive and Negative Syndrome Scale dimensions. In addition, when insight was assessed through a multidimensional approach, a variety of relationships with the…
Test-Retest Reliability of the Frankfurt Complaint Questionnaire
Long-term reliability of the Frankfurt Complaint Questionnaire (FCQ) was investigated in two follow-up studies of participants with psychosis using a test-retest method. In the first study (N = 56), the duration of the follow-up ranged from 6 months to 2 years; Spearman rho was .62 for the abridged (18 items) Spanish version of the questionnaire. In Study 2 (N = 21), in participants with stable schizophrenia, the follow-up ranged from 8 to 11 yea…
Prospective Long-Term Cohort Study of Subjects With First-Episode Psychosis Examining Eight Major Outcome Domains and Their Predictors
Background: Our current ability to predict the long-term course and outcome of subjects with a first-episode of psychosis (FEP) is limited. To improve our understanding of the long-term outcomes of psychotic disorders and their determinants, we designed a follow-up study using a well-characterized sample of FEP and a multidimensional approach to the outcomes. The main goals were to characterize the long-term outcomes of psychotic disorders from a…
Dependence Graphs Based on Association Rules to Explore Delusional Experiences
Methods to estimate dependence graphs among variables, have quickly gained popularity in psychopathology research. To date, multiple methods have been proposed but recent studies report several drawbacks impacting on the validity of the conclusions as it is argued that assumptions and conditions underlying the methods commonly used and the nature of the data is lacking alignment. A particularly important issue is that underlying dynamics potentia…
Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis
Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended
Impact of traumatic life events on clinical variables of individuals with first-episode psychosis and healthy controls
BACKGROUND: Traumatic life events (TLEs) are one of the most robust environmental risk factors for the onset of first-episode psychosis (FEP). AIMS: To explore TLEs in FEP patients and healthy controls (HC), to analyze gender differences and to examine whether TLEs were associated with sociodemographic, clinical and psychofunctional variables in all FEP sample and split by age. METHODS: Descriptive and cross-sectional study. Three hundred and thi…
Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis
Introduction Previous research has shown that lower lactate dehydrogenase (LDH) concentrations in cerebrospinal fluid (CSF) are associated with longer prodromal symptoms in first-episode psychosis (FEP). We aimed to study whether there is a relationship between the duration of untreated psychosis (DUP) and LDH and other CSF biomarkers in FEP and whether stressful life events moderate this association. Methods Ninety-five inpatients with FEP and w…
Applied pharmacogenetics to predict response to treatment of first psychotic episode
The application of personalized medicine in patients with first-episode psychosis (FEP) requires tools for classifying patients according to their response to treatment, considering both treatment efficacy and toxicity. However, several limitations have hindered its translation into clinical practice. Here, we describe the rationale, aims and methodology of Applied Pharmacogenetics to Predict Response to Treatment of First Psychotic Episode (the …
Psychology (8 obras) · Clinical Psychology (7 obras) · Psychiatry (7 obras) · Schizophrenia research and treatment (7 obras) · Psychosis (6 obras) · Clinical Psychology (5 obras) · Medicine (4 obras) · Schizophrenia (object-oriented programming (4 obras) · Mental Health and Psychiatry (3 obras) · Mental Health Research Topics (3 obras)