K Wander
Dados Biográficos
| ID | 76611 |
|---|---|
| NOME | K Wander |
| PRENOMES | K |
| SOBRENOME | Wander |
| ASSINATURA | WANDER K |
| AFILIAÇÕES | Binghamton University |
| ORCID | 0000-0002-4913-5075 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 33 |
| TOTAL DE CITAÇÕES | 102 |
| TOTAL COMO AUTOR | 33 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2008 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 6 |
Nutrition and Handgrip Strength Among Adults in Rural Matlab, Bangladesh
OBJECTIVE: Handgrip strength (HGS) provides a dynamic indicator of overall strength and physical fitness. Population-based investigations of anemia and iron deficiency as predictors of HGS are limited; most studies rely on elderly and/or clinical samples. We assessed iron deficiency, anemia, body mass index (BMI), and body fat percentage as predictors of HGS among a representative cross-sectional sample of adult residents of Matlab, Bangladesh. M…
Reduced Fat Oxidation as a Potential Pathway Linking Early‐Life Adversity to Obesity Risk
The latter finding suggests that adverse environmental conditions during early life may lead to reduced fat oxidation, which has the potential to increase the risk of obesity later in life. This finding might partially explain the so-called double burden of malnutrition (the co-occurrence of undernutrition and obesity) currently affecting many low- and middle-income countries
Inverse Association Between Betel Quid Use and Diabetes in Rural Bangladesh
These models support the hypothesis that betel quid use could decrease, rather than increase, risk for diabetes in the Bangladeshi context, particularly among men (who have more frequent betel quid use than women). Heterogeneity in betel quid preparation across settings, multifactorial effects of betel quid use, and publication bias may contribute to differences between these findings and other observational studies
Dual Behavioral–Physiological Buffering of Mothers' Milk Facilitates Drought Adaptability of Pastoralists and Agropastoralists in Northern Kenya
BACKGROUND: Mothers physiologically buffer key milk nutrient content against nutritional stress. How this is nested in upstream behavioral buffering is not well understood. OBJECTIVES: The study explored whether pastoralists and agropastoralists' economic or other behavioral coping strategies against droughts, such as livestock sales and child fosterage, influence maternal risk for malnutrition or milk nutrient content. METHODS: Using data from 2…
Celebrating Over 10 Years of Human Milk Research in the Human Biology Association
Since we published “Field and Laboratory Methods in Human Milk Research” in 2013, human milk research has increased dramatically in both number and diversity of studies. Anthropological human biologists and biological anthropologists have played key roles in the realization of this research, arguing that evolutionary, developmental, and biocultural perspectives as essential for understanding variation in human milk. The purpose of this review is …
The Attention‐Deficit/Hyperactivity Disorder‐Associated DRD4 7R Allele Predicts Household Economic Status but Not Nutritional Status in Northern Kenyan Rendille Children
OBJECTIVES: Around 11% of U.S. children are diagnosed with attention-deficit/hyperactivity disorder (ADHD). One hypothesis for ADHD's relatively high prevalence is that behaviors associated with ADHD were advantageous in past environments where they were positively selected for. A previous study showed that an allele associated with ADHD-the 7R allele of the gene encoding the D(4) dopamine receptor (DRD4)-had a positive effect on the nutritional …
Lactose in human milk is associated with lower rates of infection during a drought
Mothers' milk may protect infants against infection through a broad range of immune and nutrient components. In the context of severe drought with heightened nutritional and disease stress, lactose may protect against infection or decrease in the presence of an infection
Predictors of milk cortisol in North American women
OBJECTIVES: Human milk content varies across mother-child dyads, environments, and populations. Among the hormones in milk is cortisol, a glucocorticoid; its impact on the breastfeeding child is unknown. Milk cortisol may constitute a signal to the child's developing physiology which can shape characteristics (e.g., growth, temperament) to prevailing environmental conditions. This exploratory study evaluated the maternal, breastfeeding, and infan…
Maternal and infant predictors of proinflammatory milk immune activity in Kilimanjaro , Tanzania
OBJECTIVES: The immune system of milk (ISOM) creates a mother-infant immune axis that plays an important role in protecting infants against infectious disease (ID). Tradeoffs in the immune system suggest the potential for both protection and harm, so we conceive of two dimensions via which the ISOM impacts infants: promotion of protective activity and control of activity directed at benign targets. High variability in ISOM activity across mother-…
Quantitative and qualitative analysis of stability for 16 serum immunoregulators over 50 freeze–thaw cycles
OBJECTIVES: To evaluate the reliability of data from the assay of bio-archived specimens, a 50-freeze-thaw-cycle (FTC) degradation study of fresh sera was conducted to test the stability of 16 immunoregulators. METHODS: Twenty de-identified serum specimens were obtained from volunteers at United Health Services-Wilson Memorial Hospital. Specimens were stored at -20°C and underwent daily 1 h thawing and subsequent freezing for each FTC over 50 con…
Betel quid use is associated with anemia among both men and women in Matlab, Bangladesh
Anemia accounts for 8.8% of total disability burden worldwide. Betel quid use among pregnant women has been found to increase anemia risk. Betel quid is prepared by wrapping the betel (or areca) nut, with spices and other additions, in betel or tobacco leaf and it is chewed or placed in the mouth. We explored the association between betel quid use and anemia among men and non-pregnant women. We collected data from a random sample of women and the…
Associations between milk cortisol and activity of the immune system of milk
OBJECTIVES: Both the immune system of human milk and milk cortisol have complex short- and long-term effects on child health and development. As understanding continues to grow of the independent effects of each of these components of milk, it is also important to investigate their intersection, including how milk cortisol affects the immune system of milk. We began this important endeavor through secondary analyses of archived milk specimens. ME…
Does the immune system of milk increase activity for infants experiencing infectious disease episodes in Kilimanjaro, Tanzania
INTRODUCTION: Multiple studies have reported that milk immune content increases for infants experiencing infectious disease (ID) episodes, suggesting that the immune system of milk (ISOM) offers enhanced protection when needed to combat ID. METHODS: To test the hypothesis that ISOM content and/or activity increases during an infant's ID episode, we characterized milk secretory immunoglobulin A (sIgA; a major ISOM constituent) and in vitro interle…
Maternal stress and hair cortisol among pregnant women following hurricane Florence
Natural disasters represent major stressors, resulting in psychological distress and physiological responses such as increased cortisol. During pregnancy, this impacts not only maternal well-being, but also fetal development. In 2018, Hurricane Florence caused extensive damage across the eastern United States. Studies indicated that compared to married pregnant women, unmarried pregnant women had higher risk of distress. Here we assess hair corti…
Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya
Results suggest that mothers of vulnerable young infants deliver more lactoferrin when they have inflammation/infection but mothers with older infants do not, and that maternal delivery of lactoferrin is unaffected by their IDA. Longitudinal research should verify these findings
Cat Ownership and Rural Residence Are Associated with Lyme Disease Prevalence in the Northeastern United States
Lyme disease (LD) is the most common vector-borne disease in the USA. Beyond its tick-borne nature, however, risk factors for LD are poorly understood. We used an online questionnaire to compare LD patients and non-LD counterparts and elucidate factors associated with LD. We investigated demographic, lifestyle, and household characteristics and use of prevention measures. Associations with LD were modeled using logistic regression, and average ma…
Market integration, income inequality, and kinship system among the Mosuo of China
Increased access to defensible material wealth is hypothesised to escalate inequality. Market integration, which creates novel opportunities in cash economies, provides a means of testing this hypothesis. Using demographic data collected from 505 households among the matrilineal and patrilineal Mosuo in 2017, we test whether market integration is associated with increased material wealth, whether increased material wealth is associated with wealt…
Context Specificity of "Market Integration" among the Matrilineal Mosuo of Southwest China
Market integration (MI) is a complex process through which individuals integrate market-oriented activities into previously subsistence-dominated lifeways. Changes associated with MI alter the landscapes of individual health and reproductive decision-making. While the consequences of MI are often easily detected in aggregate, the specific aspects of MI that affect health and demography are context dependent and underinvestigated. We argue that an…
Labor migration is associated with lower rates of underweight and higher rates of obesity among left-behind wives in rural Bangladesh
BACKGROUND: Among Bangladeshi men, international labor migration has increased ten-fold since 1990 and rural to urban labor migration rates have steadily increased. Labor migration of husbands has increased household wealth and redefined women's roles, which have both positively and negatively impacted the health of wives "left behind". We examined the direct and indirect effects of husband labor migration on chronic disease indicators and outcom…
Gender Differences in Social Networks Based on Prevailing Kinship Norms in the Mosuo of China
Although cooperative social networks are considered key to human evolution, emphasis has usually been placed on the functions of men's cooperative networks. What do women's networks look like? Do they differ from men's networks and what does this suggest about evolutionarily inherited gender differences in reproductive and social strategies? In this paper, we test the 'universal gender differences' hypothesis positing gender-specific network stru…
Biocultural Strategies for Measuring Psychosocial Stress Outcomes in Field-based Research
The goal of assessing psychosocial stress as a process and outcome in naturalistic (i.e., field) settings is applicable across the social, biological, and health sciences. Meaningful measurement of biology-in-context is, however, far from simple or straightforward. In this brief methods review, we introduce theoretical framings, methodological conventions, and ethical concerns around field-collection of markers of psychosocial stress that have em…
Social norm coordination and readiness to change female genital cutting
These findings support the social coordination norm model, and reveal distinct normative schema among cut and uncut women. Furthermore, our findings point to a dynamic reassessment of social benefits and health costs underlying FGC decision-making and readiness to change FGC. The reappraisal of social benefits may be an unrecognized opportunity for programs aiming to discourage FGC
High‐altitude adaptations mitigate risk for hypertension and diabetes‐associated anemia
BACKGROUND: Human populations native to high altitude exhibit numerous genetic adaptations to hypobaric hypoxia. Among Tibetan plateau peoples, these include increased vasodilation and uncoupling of erythropoiesis from hypoxia. OBJECTIVE/METHODS: We tested the hypothesis that these high-altitude adaptations reduce risk for hypertension and diabetes-associated anemia among the Mosuo, a Tibetan-descended population in the mountains of Southwest Chi…
Buffered or impaired
BACKGROUND: Maternal anemia has adverse consequences for the mother-infant dyad. To evaluate whether and how milk nutrient content may change in ways that could "buffer" infants against the conditions underlying maternal anemia, this study assessed associations between milk macronutrients and maternal iron-deficiency anemia (IDA), non-iron-deficiency anemia (NIDA), and inflammation. METHODS: A secondary analysis of cross-sectional data and milk f…
Hay fever, asthma, and eczema and early infectious diseases among children in Kilimanjaro, Tanzania
OBJECTIVES: To investigate the hygiene (or "old friends") hypothesis in a high-infectious disease (ID) environment, rural Kilimanjaro, Tanzania. METHODS: Among a cross-sectional sample of 2- to 7-year-old children, we collected physician-diagnosed hay fever, asthma, and eczema, history of hospitalization, family size, and household environment information via questionnaire; performed active and passive surveillance for ID; and, evaluated total im…
Dynamics of change in the practice of female genital cutting in Senegambia
Legislating Change? Responses to Criminalizing Female Genital Cutting in Senegal
Although the international community has recently promoted legislation as an important reform strategy for ending female genital cutting (FGC), there exist divergent views on its potential effects. Supporters argue that legal prohibition of FGC has a general deterrent effect, while others argue legislation can be perceived as coercive, and derail local efforts to end the practice. This study examines the range of responses observed in rural Seneg…
C‐reactive protein across the menstrual cycle
C‐reactive protein (CRP) is a widely used, sensitive biomarker of inflammation. Studies conducted among users of exogenous hormones suggest that estrogen increases CRP, whereas progesterone decreases CRP. Examinations of CRP in normally cycling women suggest the opposite: CRP is negatively associated with endogenous estrogen and positively associated with endogenous progesterone. This work evaluates the association between menstrual cycle‐related…
Context Specificity of "Market Integration" among the Matrilineal Mosuo of Southwest China
Market integration (MI) is a complex process through which individuals integrate market-oriented activities into previously subsistence-dominated lifeways. Changes associated with MI alter the landscapes of individual health and reproductive decision-making. While the consequences of MI are often easily detected in aggregate, the specific aspects of MI that affect health and demography are context dependent and underinvestigated. We argue that an…
Market integration, income inequality, and kinship system among the Mosuo of China
Increased access to defensible material wealth is hypothesised to escalate inequality. Market integration, which creates novel opportunities in cash economies, provides a means of testing this hypothesis. Using demographic data collected from 505 households among the matrilineal and patrilineal Mosuo in 2017, we test whether market integration is associated with increased material wealth, whether increased material wealth is associated with wealt…
Gender Differences in Social Networks Based on Prevailing Kinship Norms in the Mosuo of China
Although cooperative social networks are considered key to human evolution, emphasis has usually been placed on the functions of men's cooperative networks. What do women's networks look like? Do they differ from men's networks and what does this suggest about evolutionarily inherited gender differences in reproductive and social strategies? In this paper, we test the 'universal gender differences' hypothesis positing gender-specific network stru…
Buffered or impaired
BACKGROUND: Maternal anemia has adverse consequences for the mother-infant dyad. To evaluate whether and how milk nutrient content may change in ways that could "buffer" infants against the conditions underlying maternal anemia, this study assessed associations between milk macronutrients and maternal iron-deficiency anemia (IDA), non-iron-deficiency anemia (NIDA), and inflammation. METHODS: A secondary analysis of cross-sectional data and milk f…
Biocultural Strategies for Measuring Psychosocial Stress Outcomes in Field-based Research
The goal of assessing psychosocial stress as a process and outcome in naturalistic (i.e., field) settings is applicable across the social, biological, and health sciences. Meaningful measurement of biology-in-context is, however, far from simple or straightforward. In this brief methods review, we introduce theoretical framings, methodological conventions, and ethical concerns around field-collection of markers of psychosocial stress that have em…
Lactose in human milk is associated with lower rates of infection during a drought
Mothers' milk may protect infants against infection through a broad range of immune and nutrient components. In the context of severe drought with heightened nutritional and disease stress, lactose may protect against infection or decrease in the presence of an infection
Predictors of delayed‐type hypersensitivity to Candida albicans and anti‐epstein‐barr virus antibody among children in Kilimanjaro, Tanzania
We evaluated sex, age, nutritional status, and infectious disease (ID) as predictors of two biomarkers of cell‐mediated immunity (CMI), delayed‐type hypersensitivity to Candida albicans (DTH‐ Candida ), and anti‐Epstein‐Barr virus antibody (EBV Ab), among 200 children in Kilimanjaro, Tanzania. DTH‐ Candida, which decreases with compromised CMI, was positively associated with age (OR: 1.27; 95% CI: 1.02, 1.57) and triceps skinfold (TSF; OR: 1.16; …
A test of the optimal iron hypothesis among breastfeeding Ariaal mothers in northern Kenya
OBJECTIVE: The optimal iron hypothesis posits a trade-off in iron nutrition-iron deficiency restricts iron available to infectious agents, protecting against severe infection, but also compromises immune defense-such that mild-to-moderate iron deficiency may be more adaptive than either iron-replete or severe deficiency in environments with high infectious disease load. This hypothesis has not been tested among adults. MATERIALS AND METHODS: A se…
High‐altitude adaptations mitigate risk for hypertension and diabetes‐associated anemia
BACKGROUND: Human populations native to high altitude exhibit numerous genetic adaptations to hypobaric hypoxia. Among Tibetan plateau peoples, these include increased vasodilation and uncoupling of erythropoiesis from hypoxia. OBJECTIVE/METHODS: We tested the hypothesis that these high-altitude adaptations reduce risk for hypertension and diabetes-associated anemia among the Mosuo, a Tibetan-descended population in the mountains of Southwest Chi…
C‐reactive protein across the menstrual cycle
C‐reactive protein (CRP) is a widely used, sensitive biomarker of inflammation. Studies conducted among users of exogenous hormones suggest that estrogen increases CRP, whereas progesterone decreases CRP. Examinations of CRP in normally cycling women suggest the opposite: CRP is negatively associated with endogenous estrogen and positively associated with endogenous progesterone. This work evaluates the association between menstrual cycle‐related…
Evaluation of iron deficiency as a nutritional adaptation to infectious disease
An evolutionary perspective suggests that iron deficiency may have opposing effects on infectious disease risk, decreasing susceptibility by restricting iron availability to pathogens, and increasing susceptibility by compromising cellular immunocompetence. In some environments, the trade‐off between these effects may result in optimal iron intake that is inadequate to fully meet body iron needs. Thus, it has been suggested that moderate iron def…
Dynamics of change in the practice of female genital cutting in Senegambia
Sensitivity and specificity of C‐reactive protein and α 1 ‐acid glycoprotein for episodes of acute infection among children in kilimanjaro, tanzania
OBJECTIVES: Biomarkers of inflammation, including C-reactive protein (CRP) and α(1) -acid glycoprotein (AGP), have tremendous potential in anthropological, public health, and nutrition research as objective indicators of acute infection; however, their usage is limited by the lack of widely agreed upon, reliable cutpoints to define infection. We assessed the sensitivity and specificity of CRP and AGP for identifying acute infectious disease (ID) …
Predictors of delayed‐type hypersensitivity to Candida albicans and anti‐epstein‐barr virus antibody among children in Kilimanjaro, Tanzania
We evaluated sex, age, nutritional status, and infectious disease (ID) as predictors of two biomarkers of cell‐mediated immunity (CMI), delayed‐type hypersensitivity to Candida albicans (DTH‐ Candida ), and anti‐Epstein‐Barr virus antibody (EBV Ab), among 200 children in Kilimanjaro, Tanzania. DTH‐ Candida, which decreases with compromised CMI, was positively associated with age (OR: 1.27; 95% CI: 1.02, 1.57) and triceps skinfold (TSF; OR: 1.16; …
Legislating Change? Responses to Criminalizing Female Genital Cutting in Senegal
Although the international community has recently promoted legislation as an important reform strategy for ending female genital cutting (FGC), there exist divergent views on its potential effects. Supporters argue that legal prohibition of FGC has a general deterrent effect, while others argue legislation can be perceived as coercive, and derail local efforts to end the practice. This study examines the range of responses observed in rural Seneg…
Breastfeeding over two years is associated with longer birth intervals, but not measures of growth or health, among children in K ilimanjaro, TZ
OBJECTIVES: Breastfeeding has been associated with numerous health and well-being benefits for both children and their mothers, including prolonging the birth interval to the subsequent sibling. The clearest associations between breastfeeding and health outcomes, per se, reflect exclusive breastfeeding in the first months of postnatal life and are most evident during infancy. Fewer studies explore the consequences of breastfeeding for multiple ye…
Hay fever, asthma, and eczema and early infectious diseases among children in Kilimanjaro, Tanzania
OBJECTIVES: To investigate the hygiene (or "old friends") hypothesis in a high-infectious disease (ID) environment, rural Kilimanjaro, Tanzania. METHODS: Among a cross-sectional sample of 2- to 7-year-old children, we collected physician-diagnosed hay fever, asthma, and eczema, history of hospitalization, family size, and household environment information via questionnaire; performed active and passive surveillance for ID; and, evaluated total im…
A test of the optimal iron hypothesis among breastfeeding Ariaal mothers in northern Kenya
OBJECTIVE: The optimal iron hypothesis posits a trade-off in iron nutrition-iron deficiency restricts iron available to infectious agents, protecting against severe infection, but also compromises immune defense-such that mild-to-moderate iron deficiency may be more adaptive than either iron-replete or severe deficiency in environments with high infectious disease load. This hypothesis has not been tested among adults. MATERIALS AND METHODS: A se…
Buffered or impaired
BACKGROUND: Maternal anemia has adverse consequences for the mother-infant dyad. To evaluate whether and how milk nutrient content may change in ways that could "buffer" infants against the conditions underlying maternal anemia, this study assessed associations between milk macronutrients and maternal iron-deficiency anemia (IDA), non-iron-deficiency anemia (NIDA), and inflammation. METHODS: A secondary analysis of cross-sectional data and milk f…
Social norm coordination and readiness to change female genital cutting
These findings support the social coordination norm model, and reveal distinct normative schema among cut and uncut women. Furthermore, our findings point to a dynamic reassessment of social benefits and health costs underlying FGC decision-making and readiness to change FGC. The reappraisal of social benefits may be an unrecognized opportunity for programs aiming to discourage FGC
High‐altitude adaptations mitigate risk for hypertension and diabetes‐associated anemia
BACKGROUND: Human populations native to high altitude exhibit numerous genetic adaptations to hypobaric hypoxia. Among Tibetan plateau peoples, these include increased vasodilation and uncoupling of erythropoiesis from hypoxia. OBJECTIVE/METHODS: We tested the hypothesis that these high-altitude adaptations reduce risk for hypertension and diabetes-associated anemia among the Mosuo, a Tibetan-descended population in the mountains of Southwest Chi…
Labor migration is associated with lower rates of underweight and higher rates of obesity among left-behind wives in rural Bangladesh
BACKGROUND: Among Bangladeshi men, international labor migration has increased ten-fold since 1990 and rural to urban labor migration rates have steadily increased. Labor migration of husbands has increased household wealth and redefined women's roles, which have both positively and negatively impacted the health of wives "left behind". We examined the direct and indirect effects of husband labor migration on chronic disease indicators and outcom…
Gender Differences in Social Networks Based on Prevailing Kinship Norms in the Mosuo of China
Although cooperative social networks are considered key to human evolution, emphasis has usually been placed on the functions of men's cooperative networks. What do women's networks look like? Do they differ from men's networks and what does this suggest about evolutionarily inherited gender differences in reproductive and social strategies? In this paper, we test the 'universal gender differences' hypothesis positing gender-specific network stru…
Biocultural Strategies for Measuring Psychosocial Stress Outcomes in Field-based Research
The goal of assessing psychosocial stress as a process and outcome in naturalistic (i.e., field) settings is applicable across the social, biological, and health sciences. Meaningful measurement of biology-in-context is, however, far from simple or straightforward. In this brief methods review, we introduce theoretical framings, methodological conventions, and ethical concerns around field-collection of markers of psychosocial stress that have em…
Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya
Results suggest that mothers of vulnerable young infants deliver more lactoferrin when they have inflammation/infection but mothers with older infants do not, and that maternal delivery of lactoferrin is unaffected by their IDA. Longitudinal research should verify these findings
Cat Ownership and Rural Residence Are Associated with Lyme Disease Prevalence in the Northeastern United States
Lyme disease (LD) is the most common vector-borne disease in the USA. Beyond its tick-borne nature, however, risk factors for LD are poorly understood. We used an online questionnaire to compare LD patients and non-LD counterparts and elucidate factors associated with LD. We investigated demographic, lifestyle, and household characteristics and use of prevention measures. Associations with LD were modeled using logistic regression, and average ma…
Market integration, income inequality, and kinship system among the Mosuo of China
Increased access to defensible material wealth is hypothesised to escalate inequality. Market integration, which creates novel opportunities in cash economies, provides a means of testing this hypothesis. Using demographic data collected from 505 households among the matrilineal and patrilineal Mosuo in 2017, we test whether market integration is associated with increased material wealth, whether increased material wealth is associated with wealt…
Context Specificity of "Market Integration" among the Matrilineal Mosuo of Southwest China
Market integration (MI) is a complex process through which individuals integrate market-oriented activities into previously subsistence-dominated lifeways. Changes associated with MI alter the landscapes of individual health and reproductive decision-making. While the consequences of MI are often easily detected in aggregate, the specific aspects of MI that affect health and demography are context dependent and underinvestigated. We argue that an…
Betel quid use is associated with anemia among both men and women in Matlab, Bangladesh
Anemia accounts for 8.8% of total disability burden worldwide. Betel quid use among pregnant women has been found to increase anemia risk. Betel quid is prepared by wrapping the betel (or areca) nut, with spices and other additions, in betel or tobacco leaf and it is chewed or placed in the mouth. We explored the association between betel quid use and anemia among men and non-pregnant women. We collected data from a random sample of women and the…
Associations between milk cortisol and activity of the immune system of milk
OBJECTIVES: Both the immune system of human milk and milk cortisol have complex short- and long-term effects on child health and development. As understanding continues to grow of the independent effects of each of these components of milk, it is also important to investigate their intersection, including how milk cortisol affects the immune system of milk. We began this important endeavor through secondary analyses of archived milk specimens. ME…
Does the immune system of milk increase activity for infants experiencing infectious disease episodes in Kilimanjaro, Tanzania
INTRODUCTION: Multiple studies have reported that milk immune content increases for infants experiencing infectious disease (ID) episodes, suggesting that the immune system of milk (ISOM) offers enhanced protection when needed to combat ID. METHODS: To test the hypothesis that ISOM content and/or activity increases during an infant's ID episode, we characterized milk secretory immunoglobulin A (sIgA; a major ISOM constituent) and in vitro interle…
Maternal stress and hair cortisol among pregnant women following hurricane Florence
Natural disasters represent major stressors, resulting in psychological distress and physiological responses such as increased cortisol. During pregnancy, this impacts not only maternal well-being, but also fetal development. In 2018, Hurricane Florence caused extensive damage across the eastern United States. Studies indicated that compared to married pregnant women, unmarried pregnant women had higher risk of distress. Here we assess hair corti…
Predictors of milk cortisol in North American women
OBJECTIVES: Human milk content varies across mother-child dyads, environments, and populations. Among the hormones in milk is cortisol, a glucocorticoid; its impact on the breastfeeding child is unknown. Milk cortisol may constitute a signal to the child's developing physiology which can shape characteristics (e.g., growth, temperament) to prevailing environmental conditions. This exploratory study evaluated the maternal, breastfeeding, and infan…
Maternal and infant predictors of proinflammatory milk immune activity in Kilimanjaro , Tanzania
OBJECTIVES: The immune system of milk (ISOM) creates a mother-infant immune axis that plays an important role in protecting infants against infectious disease (ID). Tradeoffs in the immune system suggest the potential for both protection and harm, so we conceive of two dimensions via which the ISOM impacts infants: promotion of protective activity and control of activity directed at benign targets. High variability in ISOM activity across mother-…
Medicine (19 obras) · Biology (14 obras) · Internal Medicine (14 obras) · Immunology (11 obras) · Child Nutrition and Water Access (9 obras) · Geography (8 obras) · Infant Nutrition and Health (8 obras) · Physiology (8 obras) · Sociology (8 obras) · Demography (7 obras)