Sizulu Moyo
Dados Biográficos
| ID | 7728178 |
|---|---|
| NOME | Sizulu Moyo |
| PRENOMES | Sizulu |
| SOBRENOME | Moyo |
| ASSINATURA | MOYO S |
| AFILIAÇÕES | Human Sciences Research Council |
| ORCID | 0000-0002-5296-3242 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 28 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 19 |
| TOTAL COMO EDITOR | 9 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2016 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Psychometric evaluation of the Kessler 10 measure of psychosocial distress using the 2022 South African population-based household survey
The Kessler Psychological Distress Scale (K10) is widely used in epidemiological research but requires validation within South Africa’s multilingual setting. This study evaluated the psychometric properties of the K10 using national population-based survey data and Item Response Theory (IRT). Graded Response Models (GRM) were used to assess factor loadings, item discrimination, and difficulty parameters, while Test Information Curves evaluated me…
Piloting the feasibility of a population-based joint TB-HIV survey in KwaZulu-Natal Province, South Africa, 2019
South Africa bears a high burden of infectious diseases, including intersecting epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB). Among people living with HIV, TB is the predominant cause of death. Since 2002, South Africa has conducted six national population-based HIV surveys, and its first national TB prevalence survey between 2017 and 2019. Given the epidemiologic overlap of these conditions and dwindling resources, a joi…
Prevalence, associated factors and geospatial patterns of HIV drug resistance in South Africa among the virally unsuppressed adults
South Africa bears the highest HIV burden globally, with substantial antiretroviral therapy (ART) scale-up. HIV drug resistance (HIVDR) threatens progress toward UNAIDS 95–95-95 targets. We assessed national HIVDR prevalence and associated factors among virally unsuppressed adults in 2017, before dolutegravir (DTG)-rollout. Secondary analysis of the 2017 national HIV household survey, included 1 253 virally unsuppressed (defined as ≥ 1 000 copies…
Gaps in TB-related knowledge and practices
Although tuberculosis is a preventable and treatable disease, its management has been challenging for tuberculosis control and prevention programs in low- and middle- income countries such as Mozambique. We assessed the TB knowledge and healthcare-seeking behaviors among adults with HIV and caregivers of paediatric patients with symptoms of TB. The study was conducted between February and October 2023 at Manhiça District Hospital. A total of 60 i…
Tuberculosis laboratory capacity building in the WHO African Region
Tuberculosis remains a leading infectious disease killer in the World Health Organization African Region, with 2.5 million cases and 404,000 deaths in 2023, including 112,000 people with HIV. There is slow progress with only 42% of the 75% targeted reduction in death by 2025. Out of 60,266 estimated multidrug-resistant TB cases in 2023, only 22,515 were notified. Laboratory diagnostic services in the African region still need urgent attention. By…
Characteristics and six-month viral load suppression of clients presenting with advanced HIV disease in South Africa
Despite advances in antiretroviral therapy (ART), a notable proportion of individuals still present with advanced HIV disease (AHD) at treatment initiation, defined by CD4
Improving tuberculosis diagnosis in South Africa’s private sector
While tuberculosis (TB) is primarily addressed in South Africa’s public sector, people with TB also present to private sector General Practitioners (GPs), where TB may be missed or treatment delayed. We introduced a pilot project in a high-TB burden health district to connect private GPs to free public sector TB testing. We aimed to gauge GPs’ willingness to participate and describe TB patterns in the private sector. GPs practicing in metropolita…
Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania
In low-and middle-income countries, missed or delayed tuberculosis (TB) diagnoses contribute to avoidable morbidity, mortality, and transmission. Decentralized testing platforms, such as the Molbio Truenat, may offer solutions by providing accurate point-of-care testing, improving access, and lowering out-of-pocket costs. Despite these advantages, the overall cost and cost-effectiveness of identifying additional TB cases using the Truenat MTB ass…
Provider perspectives on empirical antibiotic treatment for tuberculosis-like symptoms in South Africa’s private general practice sector
While tuberculosis (TB) in South Africa is commonly treated in the public sector, some clients first seek care in the private sector. Research has demonstrated that private general practitioners (GPs) perform less well than do public sector care providers in TB testing and drug-dispensing practices. We aimed to describe GPs’ decision-making practices related to empiric antibiotic treatment when presented with symptoms that may be related to TB, t…
A deadly equation
The recent withdrawal of U.S. financial support threatens essential TB service delivery, including diagnostics, treatment, TB-HIV co-infection interventions and research initiatives critical to eradicating TB. This study analyses the dependency of and potential impact of funding cuts to 26 high-burden TB countries (HBCs). We modelled three recovery scenarios: (1) minimal impact (services recover within three months), (2) moderate impact (recovery…
Determinants of psychological distress among individuals who are aware of their HIV serostatus in South Africa
Introduction Psychological distress is a growing public health challenge among people living with HIV. This study investigated the prevalence of psychological distress among individuals who know their HIV positive or negative serostatus in South Africa using 2017 data from a nationwide cross-sectional household-based population survey. Methods The data for this secondary analysis was collected using a multi-stage stratified cluster randomized sam…
Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys
Tuberculosis (TB) and non-communicable diseases (NCD) share predisposing risk factors. TB-associated NCD might cluster within households affected with TB requiring shared prevention and care strategies. We conducted an individual participant data meta-analysis of national TB prevalence surveys to determine whether NCD cluster in members of households with TB. We identified eligible surveys that reported at least one NCD or NCD risk factor through…
The economic burden of cervical cancer on women in Uganda
There is limited research on how a cervical cancer diagnosis financially impacts women and their families in Uganda. This analysis aimed to describe the economic impact of cervical cancer treatment, including how it differs by socio-economic status (SES) in Uganda. We conducted a cross-sectional study from September 19, 2022 to January 17, 2023. Women were recruited from the Uganda Cancer Institute and Jinja Regional Referral Hospital, and were e…
Covid19Vaxplorer
There are many COVID-19 vaccines currently available, however, Low- and middle-income countries (LMIC) still have large proportions of their populations unvaccinated. Decision-makers must decide how to effectively allocate available vaccines (e.g. boosters or primary series vaccination, which age groups to target) but LMIC often lack the resources to undergo quantitative analyses of vaccine allocation, resulting in ad-hoc policies. We developed C…
Virological and care outcomes of community ART distribution
Introduction Differentiated service delivery models for HIV treatment can minimize unnecessary burdens on health systems and promote efficient delivery of antiretroviral therapy (ART). Under the PODI+ (poste de distribution communautaire) model, ART multi-month dispensation (MMD) was provided by lay workers (peers) in communities. We compared outcomes among clinically stable adults living with HIV receiving MMD via PODI+ or health facility (HF). …
Prediction models of Covid-19 fatality in nine Peruvian provinces
There are initiatives to promote the creation of predictive COVID-19 fatality models to assist decision-makers. The study aimed to develop prediction models for COVID-19 fatality using population data recorded in the national epidemiological surveillance system of Peru. A retrospective cohort study was conducted (March to September of 2020). The study population consisted of confirmed COVID-19 cases reported in the surveillance system of nine pro…
Deception and informed consent in studies with incognito simulated standardized patients
Simulated standardized patients (SPs) are trained individuals who pose incognito as people seeking treatment in a health care setting. With the method’s increasing use and popularity, we propose some standards to adapt the method to contextual considerations of feasibility, and we discuss current issues with the SP method and the experience of consent and ethical research in international SP studies. Since a foundational discussion of the researc…
Seroprevalence survey of anti-Sars-CoV-2 antibody and associated factors in South Africa
Population-based serological testing is important to understand the epidemiology and estimate the true cumulative incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to inform public health interventions. This study reports findings of a national household population SARS-CoV-2 serosurvey in people 12 years and older in South Africa. This cross-sectional multi-stage random stratified cluster survey undertaken from November 2…
Prescribing practices for presumptive TB among private general practitioners in South Africa
INTRODUCTION: Medicine prescribing practices are integral to quality of care for leading infectious diseases such as tuberculosis (TB). We describe prescribing practices in South Africa's private health sector, where an estimated third of people with TB symptoms first seek care. METHODS: Sixteen standardised patients (SPs) presented one of three cases during unannounced visits to private general practitioners (GPs) in Durban and Cape Town: TB sym…
The HIV Epidemic in South Africa
South Africa has the largest number of people living with HIV worldwide. South Africa has implemented five population-based HIV prevalence surveys since 2002 aimed at understanding the dynamics and the trends of the epidemic. This paper presents key findings from the fifth HIV prevalence, incidence, and behaviour survey conducted in 2017 following policy, programme, and epidemic change since the prior survey was conducted in 2012. A cross-section…
Is There Risk Compensation among HIV Infected Youth and Adults 15 Years and Older on Antiretroviral Treatment in South Africa? Findings from the 2017 National HIV Prevalence, Incidence, Behaviour and …
In this paper, risk compensation among individuals on antiretroviral therapy (ART), using the 2017 South African national survey on HIV, is explored. A multi-stage stratified cluster random sampling approach was used to realize 11,130 participants 15 years and older. Logistic regression analysis assessed the association between multiple sexual partners, condom use at last sexual encounter, consistency of condom usage and potential explanatory var…
Quality of care for tuberculosis and HIV in the private health sector
BACKGROUND: South Africa has high burdens of tuberculosis (TB) and TB-HIV, yet the quality of patient care in the private sector is unknown. We describe quality of TB and TB-HIV care among private general practitioners (GPs) in two South African cities using standardised patients (SPs). METHODS: Sixteen SPs presented one of three cases during unannounced visits to private GPs in selected high-TB burden communities in Durban and Cape Town: case 1,…
Association Between ART Adherence and Mental Health
HIV Prevalence and Associated Factors Among Men in South Africa 30 Years into the Epidemic
Towards achieving the 90–90–90 HIV targets
South Africa appears to be on track to achieve the first 90 indicator by 2020. However, it is behind on the second 90 indicator with ART coverage that was ~ 20-percentage points below the target among people who knew their HIV status, this indicates deficiencies around linkage to and retention on ART. Overall viral suppression among those on ART is approaching the target at 87.4%, but this must be interpreted in the context of low reported ART co…
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New insights into HIV epidemic in South Africa
This article presents key findings from the 2012 HIV prevalence, incidence and behaviour survey conducted in South Africa and explores trends in the HIV epidemic. A representative household based survey collected behavioural and biomedical data among people of all ages. Chi-squared test for association and formal trend tests (2002, 2005, 2008 and 2012) were used to test for associations and trends in the HIV epidemic across the four surveys. In 2…
Predictors of knowledge about tuberculosis
To reduce the burden of tuberculosis in South Africa, media campaigns targeting both rural and urban communities should include conveying accurate information about the disease. Policy makers should also address structural barriers that vulnerable communities face
Determinants of excellent/good self-rated health among HIV positive individuals in South Africa
To have positive health effects and improve the perceived health status for PLWH social interventions should seek to enhance to support for the elderly HIV-positive individuals, and address the challenge of socio-economic inequalities and underlying comorbid conditions resulting in hospitalization
Towards achieving the 90–90–90 HIV targets
South Africa appears to be on track to achieve the first 90 indicator by 2020. However, it is behind on the second 90 indicator with ART coverage that was ~ 20-percentage points below the target among people who knew their HIV status, this indicates deficiencies around linkage to and retention on ART. Overall viral suppression among those on ART is approaching the target at 87.4%, but this must be interpreted in the context of low reported ART co…
Quality of care for tuberculosis and HIV in the private health sector
BACKGROUND: South Africa has high burdens of tuberculosis (TB) and TB-HIV, yet the quality of patient care in the private sector is unknown. We describe quality of TB and TB-HIV care among private general practitioners (GPs) in two South African cities using standardised patients (SPs). METHODS: Sixteen SPs presented one of three cases during unannounced visits to private GPs in selected high-TB burden communities in Durban and Cape Town: case 1,…
Association Between ART Adherence and Mental Health
HIV Prevalence and Associated Factors Among Men in South Africa 30 Years into the Epidemic
Prescribing practices for presumptive TB among private general practitioners in South Africa
INTRODUCTION: Medicine prescribing practices are integral to quality of care for leading infectious diseases such as tuberculosis (TB). We describe prescribing practices in South Africa's private health sector, where an estimated third of people with TB symptoms first seek care. METHODS: Sixteen standardised patients (SPs) presented one of three cases during unannounced visits to private general practitioners (GPs) in Durban and Cape Town: TB sym…
The HIV Epidemic in South Africa
South Africa has the largest number of people living with HIV worldwide. South Africa has implemented five population-based HIV prevalence surveys since 2002 aimed at understanding the dynamics and the trends of the epidemic. This paper presents key findings from the fifth HIV prevalence, incidence, and behaviour survey conducted in 2017 following policy, programme, and epidemic change since the prior survey was conducted in 2012. A cross-section…
Is There Risk Compensation among HIV Infected Youth and Adults 15 Years and Older on Antiretroviral Treatment in South Africa? Findings from the 2017 National HIV Prevalence, Incidence, Behaviour and …
In this paper, risk compensation among individuals on antiretroviral therapy (ART), using the 2017 South African national survey on HIV, is explored. A multi-stage stratified cluster random sampling approach was used to realize 11,130 participants 15 years and older. Logistic regression analysis assessed the association between multiple sexual partners, condom use at last sexual encounter, consistency of condom usage and potential explanatory var…
Deception and informed consent in studies with incognito simulated standardized patients
Simulated standardized patients (SPs) are trained individuals who pose incognito as people seeking treatment in a health care setting. With the method’s increasing use and popularity, we propose some standards to adapt the method to contextual considerations of feasibility, and we discuss current issues with the SP method and the experience of consent and ethical research in international SP studies. Since a foundational discussion of the researc…
Seroprevalence survey of anti-Sars-CoV-2 antibody and associated factors in South Africa
Population-based serological testing is important to understand the epidemiology and estimate the true cumulative incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to inform public health interventions. This study reports findings of a national household population SARS-CoV-2 serosurvey in people 12 years and older in South Africa. This cross-sectional multi-stage random stratified cluster survey undertaken from November 2…
Determinants of psychological distress among individuals who are aware of their HIV serostatus in South Africa
Introduction Psychological distress is a growing public health challenge among people living with HIV. This study investigated the prevalence of psychological distress among individuals who know their HIV positive or negative serostatus in South Africa using 2017 data from a nationwide cross-sectional household-based population survey. Methods The data for this secondary analysis was collected using a multi-stage stratified cluster randomized sam…
Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys
Tuberculosis (TB) and non-communicable diseases (NCD) share predisposing risk factors. TB-associated NCD might cluster within households affected with TB requiring shared prevention and care strategies. We conducted an individual participant data meta-analysis of national TB prevalence surveys to determine whether NCD cluster in members of households with TB. We identified eligible surveys that reported at least one NCD or NCD risk factor through…
The economic burden of cervical cancer on women in Uganda
There is limited research on how a cervical cancer diagnosis financially impacts women and their families in Uganda. This analysis aimed to describe the economic impact of cervical cancer treatment, including how it differs by socio-economic status (SES) in Uganda. We conducted a cross-sectional study from September 19, 2022 to January 17, 2023. Women were recruited from the Uganda Cancer Institute and Jinja Regional Referral Hospital, and were e…
Covid19Vaxplorer
There are many COVID-19 vaccines currently available, however, Low- and middle-income countries (LMIC) still have large proportions of their populations unvaccinated. Decision-makers must decide how to effectively allocate available vaccines (e.g. boosters or primary series vaccination, which age groups to target) but LMIC often lack the resources to undergo quantitative analyses of vaccine allocation, resulting in ad-hoc policies. We developed C…
Virological and care outcomes of community ART distribution
Introduction Differentiated service delivery models for HIV treatment can minimize unnecessary burdens on health systems and promote efficient delivery of antiretroviral therapy (ART). Under the PODI+ (poste de distribution communautaire) model, ART multi-month dispensation (MMD) was provided by lay workers (peers) in communities. We compared outcomes among clinically stable adults living with HIV receiving MMD via PODI+ or health facility (HF). …
Prediction models of Covid-19 fatality in nine Peruvian provinces
There are initiatives to promote the creation of predictive COVID-19 fatality models to assist decision-makers. The study aimed to develop prediction models for COVID-19 fatality using population data recorded in the national epidemiological surveillance system of Peru. A retrospective cohort study was conducted (March to September of 2020). The study population consisted of confirmed COVID-19 cases reported in the surveillance system of nine pro…
Gaps in TB-related knowledge and practices
Although tuberculosis is a preventable and treatable disease, its management has been challenging for tuberculosis control and prevention programs in low- and middle- income countries such as Mozambique. We assessed the TB knowledge and healthcare-seeking behaviors among adults with HIV and caregivers of paediatric patients with symptoms of TB. The study was conducted between February and October 2023 at Manhiça District Hospital. A total of 60 i…
Tuberculosis laboratory capacity building in the WHO African Region
Tuberculosis remains a leading infectious disease killer in the World Health Organization African Region, with 2.5 million cases and 404,000 deaths in 2023, including 112,000 people with HIV. There is slow progress with only 42% of the 75% targeted reduction in death by 2025. Out of 60,266 estimated multidrug-resistant TB cases in 2023, only 22,515 were notified. Laboratory diagnostic services in the African region still need urgent attention. By…
Characteristics and six-month viral load suppression of clients presenting with advanced HIV disease in South Africa
Despite advances in antiretroviral therapy (ART), a notable proportion of individuals still present with advanced HIV disease (AHD) at treatment initiation, defined by CD4
Improving tuberculosis diagnosis in South Africa’s private sector
While tuberculosis (TB) is primarily addressed in South Africa’s public sector, people with TB also present to private sector General Practitioners (GPs), where TB may be missed or treatment delayed. We introduced a pilot project in a high-TB burden health district to connect private GPs to free public sector TB testing. We aimed to gauge GPs’ willingness to participate and describe TB patterns in the private sector. GPs practicing in metropolita…
Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania
In low-and middle-income countries, missed or delayed tuberculosis (TB) diagnoses contribute to avoidable morbidity, mortality, and transmission. Decentralized testing platforms, such as the Molbio Truenat, may offer solutions by providing accurate point-of-care testing, improving access, and lowering out-of-pocket costs. Despite these advantages, the overall cost and cost-effectiveness of identifying additional TB cases using the Truenat MTB ass…
Provider perspectives on empirical antibiotic treatment for tuberculosis-like symptoms in South Africa’s private general practice sector
While tuberculosis (TB) in South Africa is commonly treated in the public sector, some clients first seek care in the private sector. Research has demonstrated that private general practitioners (GPs) perform less well than do public sector care providers in TB testing and drug-dispensing practices. We aimed to describe GPs’ decision-making practices related to empiric antibiotic treatment when presented with symptoms that may be related to TB, t…
A deadly equation
The recent withdrawal of U.S. financial support threatens essential TB service delivery, including diagnostics, treatment, TB-HIV co-infection interventions and research initiatives critical to eradicating TB. This study analyses the dependency of and potential impact of funding cuts to 26 high-burden TB countries (HBCs). We modelled three recovery scenarios: (1) minimal impact (services recover within three months), (2) moderate impact (recovery…
Medicine (22 obras) · Environmental health (14 obras) · HIV/AIDS Research and Interventions (13 obras) · Demography (12 obras) · Public health (11 obras) · Tuberculosis Research and Epidemiology (11 obras) · Population (10 obras) · Cross-sectional study (9 obras) · Tuberculosis (9 obras) · Family medicine (8 obras)