Salim S Abdool Karim

• Written on the Skin

  Open Access•Emma Durden, Eliza Govender et al.•ARTICLE•AIDS and Behavior•2026

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  To address challenges associated with the uptake of daily oral pre-exposure prophylaxis (PrEP) by young women at high risk of acquiring HIV, a range of novel, long-acting, slow-release products are being developed and clinically evaluated. One such technology is an annual implant of tenofovir alafenamide (TAF). This study explores the perspectives of participants from a first-in-human trial of an annual TAF implant to inform considerations for fu…

• “There is nobody who wouldn’t like to”

  Open Access•Emma Durden, Eliza Govender et al.•ARTICLE•AIDS Care•2026

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  A novel long-acting HIV oral pre-exposure prophylaxis (PrEP) implant was first tested in a Phase I clinical trial in South Africa, and this study sought to understand motivations behind trial participants enrolment, highlighting considerations for recruitment in future studies. Qualitative research was conducted using in-depth interviews (IDIs) with 29 study participants, 18 of whom also participated in focus group discussions (FGDs). Participant…

• Vaccine access, equity and justice

  Open Access•Lois Privor-Dumm, Jean-Louis Excler et al.•ARTICLE•BMJ Global Health•2023

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  Although significant progress has been made in achieving goals for COVID-19 vaccine access, the quest for equity and justice remains an unfinished agenda. Vaccine nationalism has prompted calls for new approaches to achieve equitable access and justice not only for vaccines but also for vaccination. This includes ensuring country and community participation in global discussions and that local needs to strengthen health systems, address issues re…

• Covid-19 vaccines and the pandemic

  Open Access•Peter J Hotez, Sarah Gilbert et al.•ARTICLE•BMJ Global Health•2023

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  Through the experiences gained by accelerating new vaccines for both Ebola virus infection and COVID-19 in a public health emergency, vaccine development has benefited from a ‘multiple shots on goal’ approach to new vaccine targets. This approach embraces simultaneous development of candidates with differing technologies, including, when feasible, vesicular stomatitis virus or adenovirus vectors, messenger RNA (mRNA), whole inactivated virus, nan…

• Factors, enablers and challenges for Covid-19 vaccine development

  Open Access•Jean-Louis Excler, Melanie Saville et al.•ARTICLE•BMJ Global Health•2023

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  The COVID-19 pandemic triggered a sense of vulnerability and urgency that led to concerted actions by governments, funders, regulators and industry to overcome traditional challenges for the development of vaccine candidates and to reach authorisation. Unprecedented financial investments, massive demand, accelerated clinical development and regulatory reviews were among the key factors that contributed to accelerating the development and approval…

• Covid-19

  Safura Abdool Karim, Quarraisha Abdool Karim et al.•ARTICLE•Social research•2023

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  Several safe and effective COVID-19 vaccines were developed, evaluated, and made available in record time during the pandemic. But hopes of equitable access to COVID-19 vaccines were dashed by corporate greed, political expediency, global trade agreements, and intellectual property ownership, delaying or denying access for poor countries. Once vaccines became widely available, their benefits were curtailed by anti-science sentiment and anti-vacci…

• The Lancet Commission on lessons for the future from the Covid-19 pandemic

  Open Access•Jeff Sachs, Jeffrey D Sachs et al.•ARTICLE•The Lancet•2022

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• Covid-19 vaccine wastage in the midst of vaccine inequity

  Open Access•Jeffrey V Lazarus, Salim S Abdool Karim et al.•ARTICLE•BMJ Global Health•2022

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• Public understanding of science

  Open Access•Salim S Abdool Karim•ARTICLE•Public Understanding of Science•2022

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  While Covid-19 created unprecedented transparency with real-time reporting across the globe, the pandemic’s politically charged environment made public communication of scientific information particularly challenging. Scientists, as authoritative voices, were thrust into the public eye to explain the evidence amid uncertainty, a changing virus, distrust in government and concerns about their self-interest and hidden agendas. Honest communication …

• Omicron Sars-CoV-2 variant

  Open Access•Salim S Abdool Karim, Quarraisha Abdool Karim•ARTICLE•The Lancet•2021

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• Acceptability of Early Antiretroviral Therapy Among South African Women

  Open Access•Nigel Garrett, Emily Norman et al.•ARTICLE•AIDS and Behavior•2017

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• Social Context of Adherence in an Open-Label 1 % Tenofovir Gel Trial

  Open Access•Kathleen M Macqueen, Sarah Dlamini et al.•ARTICLE•AIDS and Behavior•2016

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  CAPRISA 008, an open-label extension study of tenofovir gel with coitally-related dosing, provided an opportunity to explore the relationship between product adherence and gender dynamics in a context where women knew they were receiving an active product with evidence of HIV prevention effectiveness. Interviews with 63 CAPRISA 008 participants and 13 male partners in KwaZulu-Natal, South Africa, highlighted that the process of negotiating gel us…

• Risk Factors for HIV Acquisition in High Risk Women in a Generalised Epidemic Setting

  Open Access•Nivashnee Naicker, Ayesha B M Kharsany et al.•ARTICLE•AIDS and Behavior•2015

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• HIV-Positive Status Disclosure in Patients in Care in Rural South Africa

  Open Access•Quarraisha Abdool Karim, Rachael Dellar et al.•ARTICLE•AIDS and Behavior•2015

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• Trial participation disclosure and gel use behavior in the Caprisa 004 tenofovir gel trial

  Stacey Succop, Stacey M Succop et al.•ARTICLE•AIDS Care•2014

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  Disclosure, or open communication, by female microbicide trial participants of their trial participation and use of an investigational HIV prevention drug to a sexual partner may affect participants' trial product usage behavior and contribute to poor adherence. With mixed results from recent microbicide clinical trials being linked to differing participant adherence, insights into the communication dynamics between trial participants and their s…

• Impact of Antiretroviral Therapy on Health-Related Quality of Life among South African Women in the Caprisa 002 Acute Infection Study

  Open Access•Andrew Tomita, Nigel Garrett et al.•ARTICLE•AIDS and Behavior•2014

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• Disclosure of Microbicide Gel Use to Sexual Partners

  Open Access•Kathryn Mngadi, Kathryn Therese Mngadi et al.•ARTICLE•AIDS and Behavior•2014

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• Assessing Adherence in the Caprisa 004 Tenofovir Gel HIV Prevention Trial

  Open Access•Kathleen M Macqueen, Mark A Weaver et al.•ARTICLE•AIDS and Behavior•2014

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  Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has proven challenging to quantify using routinely collected behavioral data. We explored this relationship using a nested case-control study in the CAPRISA 004 Tenofovir (TFV) gel HIV prevention trial. Detailed 3-month recall data on sex events, condom and gel use were collected from 72 incident cases and 205 uninfected controls. We then assessed how the…

• Monitoring Microbicide Gel Use with Real-Time Notification of the Container’s Opening Events

  Open Access•Tanuja N Gengiah, Michele Upfold et al.•ARTICLE•AIDS and Behavior•2014

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• The Preventive Misconception

  Open Access•Rachael Dellar, Rachael C Dellar et al.•ARTICLE•AIDS and Behavior•2014

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• Impact of an Adherence Intervention on the Effectiveness of Tenofovir Gel in the Caprisa 004 Trial

  Open Access•Leila E Mansoor, Quarraisha Abdool Karim et al.•ARTICLE•AIDS and Behavior•2014

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• Adherence in the Caprisa 004 Tenofovir Gel Microbicide Trial

  Open Access•Leila E Mansoor, Quarraisha Abdool Karim et al.•ARTICLE•AIDS and Behavior•2014

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• Individualised Motivational Counselling to Enhance Adherence to Antiretroviral Therapy is not Superior to Didactic Counselling in South African Patients

  Open Access•Francois van Loggerenberg, Anne D Grant et al.•ARTICLE•AIDS and Behavior•2014

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• Health-Related Quality of Life Dynamics of HIV-positive South African Women up to ART Initiation

  Open Access•Andrew Tomita, Nigel Garrett et al.•ARTICLE•AIDS and Behavior•2013

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• Health in South Africa

  Open Access•Bongani M Mayosi, Joy Elizabeth Lawn et al.•ARTICLE•The Lancet•2012

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• Reducing the risk of HIV infection among South African sex workers

  Quarraisha Abdool Karim, S S Karim et al.•ARTICLE•American Journal of Public Health•1995•Citada por: 24•Referências: 11

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  OBJECTIVES. The social context within which women engaged in sex work at a popular truck stop in South Africa are placed at risk of human immunodeficiency virus (HIV) infection and the factors that influence their ability to reduce their risk were assessed. METHODS. Using qualitative and quantitative techniques, an elected sex worker from within the group collected all data. RESULTS. Given the various pressing needs for basic survival, the risk o…

• Informed consent for HIV testing in a South African hospital

  Quarraisha Abdool Karim, Salim S Abdool Karim et al.•ARTICLE•American Journal of Public Health•1998•Citada por: 16•Referências: 6

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  OBJECTIVE: The purpose of this study was to assess informed consent to human immunodeficiency virus (HIV) testing in a perinatal HIV transmission study in a major referral hospital serving a largely Black population in South Africa. METHODS: First-time antenatal clinic attenders who were randomly selected from those enrolled in the perinatal HIV study (n = 56) answered questionnaires before and after counseling. RESULTS: Knowledge of HIV transmis…

• Anal sex and HIV transmission in women

  S S Karim, Salim S Abdool Karim et al.•ARTICLE•American Journal of Public Health•1998•Citada por: 6•Referências: 12

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  Anal sex and HIV transmission in women. S S Karim, and G RamjeeCopyRight https://doi.org/10.2105/AJPH.88.8.1265-a Published Online: October 07, 2011

• Placebo controls in HIV perinatal transmission trials

  Salim S Abdool Karim•ARTICLE•American Journal of Public Health•1998•Citada por: 5•Referências: 6

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  Placebo controls in HIV perinatal transmission trials: a South African's viewpoint. S S Abdool KarimCopyRight https://doi.org/10.2105/AJPH.88.4.564 Published Online: October 07, 2011

• High prevalence of hepatitis B virus infection in rural black adults in Mseleni, South Africa

  Salim S Abdool Karim, Rajendra Thejpal et al.•ARTICLE•American Journal of Public Health•1989•Referências: 8

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  A community-based study in northern Natal/KwaZulu, South Africa, assessed the prevalence of hepatitis B virus (HBV) infection in rural Black adults. The prevalence of HBV carriers was 4.4 percent in women (N = 342) and 7.1 percent in men (N = 99). At least one marker of HBV infection was present in 81 percent of women and 86 percent of men. The relative risk (RR) of HBV marker positivity in women due to scarification, adjusted for the presence of…

• Reducing the risk of HIV infection among South African sex workers

  Quarraisha Abdool Karim, S S Karim et al.•ARTICLE•American Journal of Public Health•1995•Citada por: 24•Referências: 11

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  OBJECTIVES. The social context within which women engaged in sex work at a popular truck stop in South Africa are placed at risk of human immunodeficiency virus (HIV) infection and the factors that influence their ability to reduce their risk were assessed. METHODS. Using qualitative and quantitative techniques, an elected sex worker from within the group collected all data. RESULTS. Given the various pressing needs for basic survival, the risk o…

• Anal sex and HIV transmission in women

  S S Karim, Salim S Abdool Karim et al.•ARTICLE•American Journal of Public Health•1998•Citada por: 6•Referências: 12

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  Anal sex and HIV transmission in women. S S Karim, and G RamjeeCopyRight https://doi.org/10.2105/AJPH.88.8.1265-a Published Online: October 07, 2011

• Placebo controls in HIV perinatal transmission trials

  Salim S Abdool Karim•ARTICLE•American Journal of Public Health•1998•Citada por: 5•Referências: 6

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  Placebo controls in HIV perinatal transmission trials: a South African's viewpoint. S S Abdool KarimCopyRight https://doi.org/10.2105/AJPH.88.4.564 Published Online: October 07, 2011

• Informed consent for HIV testing in a South African hospital

  Quarraisha Abdool Karim, Salim S Abdool Karim et al.•ARTICLE•American Journal of Public Health•1998•Citada por: 16•Referências: 6

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  OBJECTIVE: The purpose of this study was to assess informed consent to human immunodeficiency virus (HIV) testing in a perinatal HIV transmission study in a major referral hospital serving a largely Black population in South Africa. METHODS: First-time antenatal clinic attenders who were randomly selected from those enrolled in the perinatal HIV study (n = 56) answered questionnaires before and after counseling. RESULTS: Knowledge of HIV transmis…

• Who infects whom? HIV-1 concordance and discordance among migrant and non-migrant couples in South Africa

  Mark N Lurie, Brian Williams et al.•ARTICLE•AIDS•2003

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  OBJECTIVES: To measure HIV-1 discordance among migrant and non-migrant men and their rural partners, and to estimate the relative risk of infection from inside versus outside primary relationships. DESIGN: A cross-sectional behavioural and HIV-1 seroprevalence survey among 168 couples in which the male partner either a migrant, or not. METHODS: A detailed questionnaire was administered and blood was collected for laboratory analysis. A mathematic…

• The Impact of Migration on HIV-1 Transmission in South Africa

  Mark N Lurie, Brian Williams et al.•ARTICLE•Sexually Transmitted Diseases•2003

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  BACKGROUND: To investigate the association between migration and HIV infection among migrant and nonmigrant men and their rural partners. GOAL: The goal was to determine risk factors for HIV-1 infection in South Africa. STUDY DESIGN: This was a cross-sectional study of 196 migrant men and 130 of their rural partners, as well as 64 nonmigrant men and 98 rural women whose partners are nonmigrant. Male migrants were recruited at work in two urban ce…

• The influence of Aids stigma and discrimination and social cohesion on HIV testing and willingness to disclose HIV in rural KwaZulu-Natal, South Africa

  Open Access•Quarraisha Abdool Karim, Anna Meyer-Weitz et al.•ARTICLE•Global Public Health•2008

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  This study aims to understand the influence of AIDS stigma and discrimination, and social cohesion to HIV testing, and willingness to disclose an HIV status. A cross-sectional, interviewer administered survey (N=594) was conducted. Independent sample t-tests explored the mean differences between sex and age groups on stigma, discrimination, and social cohesion measurement. Logistic regression models were fitted with the above independent variable…

• HIV infection and tuberculosis in South Africa

  Open Access•Salim S Abdool Karim, Gavin Churchyard et al.•ARTICLE•The Lancet•2009

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• Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

  Open Access•Quarraisha Abdool Karim, Salim S Abdool Karim et al.•ARTICLE•Science•2010

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  Vaginal Gel Versus HIV HIV prevention technologies for women are urgently needed, especially in sub-Saharan Africa where young women bear the greatest burden of the HIV epidemic. Abdool Karim et al. (p. 1168 ; published online 19 July) present the results of the CAPRISA 004 randomized control trial. The nearly 3-year-long trial, conducted in urban and rural South African women, tested the efficacy of a vaginal gel containing the antiretroviral dr…

• Uptake of provider-initiated HIV testing and counseling among women attending an urban sexually transmitted disease clinic in South Africa – missed opportunities for early diagnosis of HIV infection

  Ayesha B M Kharsany, Quarraisha Abdool Karim et al.•ARTICLE•AIDS Care•2010

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  This study assessed the uptake of provider-initiated HIV testing and counseling (PITC) among women attending an urban sexually transmitted diseases (STD) clinic in South Africa. From July 2005 to June 2006, women were offered HIV testing following group information and education on HIV and STDs in the clinic waiting area. Of those who were provided with education, information, and offered HIV testing, uptake was 43.5% (2439/5612). The overall HIV…

• Health in South Africa

  Open Access•Bongani M Mayosi, Joy Elizabeth Lawn et al.•ARTICLE•The Lancet•2012

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• HIV prevalence among high school learners - opportunities for schools-based HIV testing programmes and sexual reproductive health services

  Open Access•Ayesha Bm Kharsany, Ayesha B M Kharsany et al.•ARTICLE•BMC Public Health•2012

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  The high HIV prevalence in female learners underscores the importance of sexual reproductive health and schools-based HIV testing programs as an important gateway to prevention and treatment services

• HIV Incidence in Young Girls in KwaZulu-Natal, South Africa-Public Health Imperative for Their Inclusion in HIV Biomedical Intervention Trials

  Open Access•Quarraisha Abdool Karim, Ayesha B M Kharsany et al.•ARTICLE•AIDS and Behavior•2012

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• Health-Related Quality of Life Dynamics of HIV-positive South African Women up to ART Initiation

  Open Access•Andrew Tomita, Nigel Garrett et al.•ARTICLE•AIDS and Behavior•2013

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• Trial participation disclosure and gel use behavior in the Caprisa 004 tenofovir gel trial

  Stacey Succop, Stacey M Succop et al.•ARTICLE•AIDS Care•2014

  Incluir item

  Disclosure, or open communication, by female microbicide trial participants of their trial participation and use of an investigational HIV prevention drug to a sexual partner may affect participants' trial product usage behavior and contribute to poor adherence. With mixed results from recent microbicide clinical trials being linked to differing participant adherence, insights into the communication dynamics between trial participants and their s…

• Impact of Antiretroviral Therapy on Health-Related Quality of Life among South African Women in the Caprisa 002 Acute Infection Study

  Open Access•Andrew Tomita, Nigel Garrett et al.•ARTICLE•AIDS and Behavior•2014

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• Disclosure of Microbicide Gel Use to Sexual Partners

  Open Access•Kathryn Mngadi, Kathryn Therese Mngadi et al.•ARTICLE•AIDS and Behavior•2014

  Incluir item

• Assessing Adherence in the Caprisa 004 Tenofovir Gel HIV Prevention Trial

  Open Access•Kathleen M Macqueen, Mark A Weaver et al.•ARTICLE•AIDS and Behavior•2014

  Incluir item

  Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has proven challenging to quantify using routinely collected behavioral data. We explored this relationship using a nested case-control study in the CAPRISA 004 Tenofovir (TFV) gel HIV prevention trial. Detailed 3-month recall data on sex events, condom and gel use were collected from 72 incident cases and 205 uninfected controls. We then assessed how the…

• Monitoring Microbicide Gel Use with Real-Time Notification of the Container’s Opening Events

  Open Access•Tanuja N Gengiah, Michele Upfold et al.•ARTICLE•AIDS and Behavior•2014

  Incluir item

• The Preventive Misconception

  Open Access•Rachael Dellar, Rachael C Dellar et al.•ARTICLE•AIDS and Behavior•2014

  Incluir item

• Impact of an Adherence Intervention on the Effectiveness of Tenofovir Gel in the Caprisa 004 Trial

  Open Access•Leila E Mansoor, Quarraisha Abdool Karim et al.•ARTICLE•AIDS and Behavior•2014

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• Adherence in the Caprisa 004 Tenofovir Gel Microbicide Trial

  Open Access•Leila E Mansoor, Quarraisha Abdool Karim et al.•ARTICLE•AIDS and Behavior•2014

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• Individualised Motivational Counselling to Enhance Adherence to Antiretroviral Therapy is not Superior to Didactic Counselling in South African Patients

  Open Access•Francois van Loggerenberg, Anne D Grant et al.•ARTICLE•AIDS and Behavior•2014

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• Risk Factors for HIV Acquisition in High Risk Women in a Generalised Epidemic Setting

  Open Access•Nivashnee Naicker, Ayesha B M Kharsany et al.•ARTICLE•AIDS and Behavior•2015

  Incluir item

Medicine (34 obras) · HIV/AIDS Research and Interventions (26 obras) · Adolescent Sexual and Reproductive Health (21 obras) · Public health (18 obras) · Environmental health (16 obras) · Family medicine (16 obras) · Internal Medicine (16 obras) · Human immunodeficiency virus (HIV (15 obras) · Nursing (13 obras) · Demography (12 obras)