Anthony G Comuzzie
Dados Biográficos
| ID | 81601 |
|---|---|
| NOME | Anthony G Comuzzie |
| PRENOMES | Anthony G |
| SOBRENOME | Comuzzie |
| ASSINATURA | COMUZZIE A G |
| AFILIAÇÕES | Texas Biomedical Research Institute |
| ORCID | 0000-0001-9345-157X |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 25 |
| TOTAL DE CITAÇÕES | 39 |
| TOTAL COMO AUTOR | 25 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1989 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2016 |
| ÍNDICE H | 4 |
Assessment of cardiovascular disease risk factors in a genetically homogenous population of Parsi Zoroastrians in the United States
OBJECTIVE: Genetically isolated and homogenous populations are ideal for detecting genes underlying common complex diseases. The use of isolated populations with reduced disease heterogeneity has led to significant gene discoveries in the past. The aim of this pilot study was to assess the prevalence of cardiovascular disease (CVD) risk phenotypes in a genetically homogenous population of Parsi Zoroastrians in the United States. METHODS: Anthropo…
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
Obituary—D. Gentry Steele (1941–2014)
AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Body composition and cardiometabolic disease risk factors in captive baboons ( Papio hamadryas sp.)
Baboons ( Papio hamadryas sp.) exhibit significant sexual dimorphism in body size. Sexual dimorphism is also exhibited in a number of circulating factors associated with risk of cardiometabolic disease. We investigated whether sexual dimorphism in body size and composition underlie these differences. We examined data from 28 male and 24 female outdoor group‐housed young adult baboons enrolled in a longitudinal observational study of cardiometabol…
Significant Genotype by Diet (G × D) Interaction Effects on Cardiometabolic Responses to a Pedigree‐Wide, Dietary Challenge in Vervet Monkeys ( Chlorocebus aethiops sabaeus )
Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys ( Chlorocebus aethiops sabaeus ; n = 309) from a multigenerational pedigreed colony initially fed with a pla…
Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia
Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions of the world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known as the “dual nutritional burden”. A recent work (Frisancho 2003 : Am J Hum Biol 15:522–532) suggests that linear growth stunting in early childhood may contribute to adult obesity by reduc…
Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study
Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS), we performed to our knowledge the first genomewide linkage scan for quantitative trait loci (QTLs) that influence the level of plasminogen. The subset of the SAFHS population used for this study consists of 629 individuals distributed across 26 extended Mexican American families. Pedigree-ba…
The Genes Influencing Adiponectin Levels Also Influence Risk Factors for Metabolic Syndrome and Type 2 Diabetes
Results from previous studies suggest that adiponectin levels are associated with risk factors for cardiovascular disease and type 2 diabetes mellitus; however, the genetic and/or environmental components of this relationship have not been characterized. The aims of this study were (1) to assess the presence of pleiotropy between adiponectin levels and risk factors for cardiovascular disease and (2) to study the association of circulating levels …
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos
Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influenc…
Association of Genetic Variation Within UBL5 with Phenotypes of Metabolic Syndrome
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. The human homolog …
Heritability of Hemostasis Phenotypes and Their Correlation with Type 2 Diabetes Status in Mexican Americans
Hypercoagulation often occurs in type 2 diabetes, suggesting pleiotropy of the genes that influence disease liability and hemostasis-related phenotypes. To better understand the relationship between hemostasis and diabetes, we first used maximum-likelihood methods to estimate the relative contribution of additive genetic, measured environmental, and shared household effects to the normal variance of 16 hemostasis-related traits in 813 individuals…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
The Genetics of Obesity in Mexican Americans
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Heritability of Anthropometric Phenotypes in Caste Populations of Visakhapatnam, India
In this study, we used anthropometric data from six Andhra caste populations to examine heritability patterns of 23 anthropometric phenotypes (linear, craniofacial, and soft tissue measures) with special reference to caste differences. We obtained anthropometric data from 342 nuclear families from Brahmin, Reddy, Telaga, Nagara, Ag. Kshatriya, and Mala castes of Visakhapatnam, India. These caste groups represent the existing hierarchical stratifi…
Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans
Shared polygenic effects (i.e., pleiotropy) are assumed to exist for such obesity‐related phenotypes as blood pressure and adiposity. It is possible to identify these shared genetic effects through bivariate genetic analyses. This analysis of 1,342 adult Samoans, across 801 pedigrees, indicates that significant heritable components ( P
A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal e…
Growth and nutritional status of the Evenki reindeer herders of Siberia
This study examines physical growth and nutritional status in a sample of 478 (247 males; 231 females) Evenki herders of Central Siberia. The Evenki display slow growth in stature and body weight, particularly during late childhood and adolescence. Adult males fall below the U.S. 5th percentiles for both stature and body weight. Adult females are below the 5th percentile for stature and approximate the 15th percentile for weight. Despite their di…
Correlates of low serum lipid levels among the Evenki herders of Siberia
This study examines serum lipid levels (total, HDL and LDL cholesterol, and triglycerides) among the Evenki reindeer herders of Central Siberia. Cholesterol and triglyceride levels among the Evenki are low, even relative to other indigenous arctic and herding populations. Total and LDL cholesterol levels are higher in women, while HDL and triglyceride levels are comparable between the sexes. Additionally, residence location (i.e., herding brigade…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Of hominids, fossils, and cladists
More on Human Phylogeny and Linguistic History
Enlarged occlusal surfaces on first molars due to severe attrition and hypercementosis
During an examination of prehistoric samples from the Texas coast, individuals consistently exhibited a suite of traits on the first molars that included severe wear, hypercementosis, and resorption of the buccal margin of the alveolus. The occlusal surface of the tooth was worn below the cervical margin, with the subsequent incorporation of the buccal surface of the buccal roots into the occlusal plane. This expanded occlusal surface, which exte…
Heritability of Anthropometric Phenotypes in Caste Populations of Visakhapatnam, India
In this study, we used anthropometric data from six Andhra caste populations to examine heritability patterns of 23 anthropometric phenotypes (linear, craniofacial, and soft tissue measures) with special reference to caste differences. We obtained anthropometric data from 342 nuclear families from Brahmin, Reddy, Telaga, Nagara, Ag. Kshatriya, and Mala castes of Visakhapatnam, India. These caste groups represent the existing hierarchical stratifi…
Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans
Shared polygenic effects (i.e., pleiotropy) are assumed to exist for such obesity‐related phenotypes as blood pressure and adiposity. It is possible to identify these shared genetic effects through bivariate genetic analyses. This analysis of 1,342 adult Samoans, across 801 pedigrees, indicates that significant heritable components ( P
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Enlarged occlusal surfaces on first molars due to severe attrition and hypercementosis
During an examination of prehistoric samples from the Texas coast, individuals consistently exhibited a suite of traits on the first molars that included severe wear, hypercementosis, and resorption of the buccal margin of the alveolus. The occlusal surface of the tooth was worn below the cervical margin, with the subsequent incorporation of the buccal surface of the buccal roots into the occlusal plane. This expanded occlusal surface, which exte…
More on Human Phylogeny and Linguistic History
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
The Genetics of Obesity in Mexican Americans
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Enlarged occlusal surfaces on first molars due to severe attrition and hypercementosis
During an examination of prehistoric samples from the Texas coast, individuals consistently exhibited a suite of traits on the first molars that included severe wear, hypercementosis, and resorption of the buccal margin of the alveolus. The occlusal surface of the tooth was worn below the cervical margin, with the subsequent incorporation of the buccal surface of the buccal roots into the occlusal plane. This expanded occlusal surface, which exte…
More on Human Phylogeny and Linguistic History
Of hominids, fossils, and cladists
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Growth and nutritional status of the Evenki reindeer herders of Siberia
This study examines physical growth and nutritional status in a sample of 478 (247 males; 231 females) Evenki herders of Central Siberia. The Evenki display slow growth in stature and body weight, particularly during late childhood and adolescence. Adult males fall below the U.S. 5th percentiles for both stature and body weight. Adult females are below the 5th percentile for stature and approximate the 15th percentile for weight. Despite their di…
Correlates of low serum lipid levels among the Evenki herders of Siberia
This study examines serum lipid levels (total, HDL and LDL cholesterol, and triglycerides) among the Evenki reindeer herders of Central Siberia. Cholesterol and triglyceride levels among the Evenki are low, even relative to other indigenous arctic and herding populations. Total and LDL cholesterol levels are higher in women, while HDL and triglyceride levels are comparable between the sexes. Additionally, residence location (i.e., herding brigade…
Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans
Shared polygenic effects (i.e., pleiotropy) are assumed to exist for such obesity‐related phenotypes as blood pressure and adiposity. It is possible to identify these shared genetic effects through bivariate genetic analyses. This analysis of 1,342 adult Samoans, across 801 pedigrees, indicates that significant heritable components ( P
A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal e…
Heritability of Anthropometric Phenotypes in Caste Populations of Visakhapatnam, India
In this study, we used anthropometric data from six Andhra caste populations to examine heritability patterns of 23 anthropometric phenotypes (linear, craniofacial, and soft tissue measures) with special reference to caste differences. We obtained anthropometric data from 342 nuclear families from Brahmin, Reddy, Telaga, Nagara, Ag. Kshatriya, and Mala castes of Visakhapatnam, India. These caste groups represent the existing hierarchical stratifi…
The Genetics of Obesity in Mexican Americans
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
Heritability of Hemostasis Phenotypes and Their Correlation with Type 2 Diabetes Status in Mexican Americans
Hypercoagulation often occurs in type 2 diabetes, suggesting pleiotropy of the genes that influence disease liability and hemostasis-related phenotypes. To better understand the relationship between hemostasis and diabetes, we first used maximum-likelihood methods to estimate the relative contribution of additive genetic, measured environmental, and shared household effects to the normal variance of 16 hemostasis-related traits in 813 individuals…
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos
Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influenc…
Association of Genetic Variation Within UBL5 with Phenotypes of Metabolic Syndrome
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. The human homolog …
Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study
Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS), we performed to our knowledge the first genomewide linkage scan for quantitative trait loci (QTLs) that influence the level of plasminogen. The subset of the SAFHS population used for this study consists of 629 individuals distributed across 26 extended Mexican American families. Pedigree-ba…
The Genes Influencing Adiponectin Levels Also Influence Risk Factors for Metabolic Syndrome and Type 2 Diabetes
Results from previous studies suggest that adiponectin levels are associated with risk factors for cardiovascular disease and type 2 diabetes mellitus; however, the genetic and/or environmental components of this relationship have not been characterized. The aims of this study were (1) to assess the presence of pleiotropy between adiponectin levels and risk factors for cardiovascular disease and (2) to study the association of circulating levels …
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia
Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions of the world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known as the “dual nutritional burden”. A recent work (Frisancho 2003 : Am J Hum Biol 15:522–532) suggests that linear growth stunting in early childhood may contribute to adult obesity by reduc…
Significant Genotype by Diet (G × D) Interaction Effects on Cardiometabolic Responses to a Pedigree‐Wide, Dietary Challenge in Vervet Monkeys ( Chlorocebus aethiops sabaeus )
Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys ( Chlorocebus aethiops sabaeus ; n = 309) from a multigenerational pedigreed colony initially fed with a pla…
AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Body composition and cardiometabolic disease risk factors in captive baboons ( Papio hamadryas sp.)
Baboons ( Papio hamadryas sp.) exhibit significant sexual dimorphism in body size. Sexual dimorphism is also exhibited in a number of circulating factors associated with risk of cardiometabolic disease. We investigated whether sexual dimorphism in body size and composition underlie these differences. We examined data from 28 male and 24 female outdoor group‐housed young adult baboons enrolled in a longitudinal observational study of cardiometabol…
Obituary—D. Gentry Steele (1941–2014)
Assessment of cardiovascular disease risk factors in a genetically homogenous population of Parsi Zoroastrians in the United States
OBJECTIVE: Genetically isolated and homogenous populations are ideal for detecting genes underlying common complex diseases. The use of isolated populations with reduced disease heterogeneity has led to significant gene discoveries in the past. The aim of this pilot study was to assess the prevalence of cardiovascular disease (CVD) risk phenotypes in a genetically homogenous population of Parsi Zoroastrians in the United States. METHODS: Anthropo…
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
Biology (17 obras) · Medicine (15 obras) · Genetics (13 obras) · Internal Medicine (12 obras) · Endocrinology (10 obras) · Obesity (10 obras) · Gene (9 obras) · Internal Medicine (8 obras) · Demography (7 obras) · Genetics (7 obras)