Ben Pascoe
Dados Biográficos
| ID | 8412812 |
|---|---|
| NOME | Ben Pascoe |
| PRENOMES | Ben |
| SOBRENOME | Pascoe |
| ASSINATURA | BEN PASCOE |
| ORCID | 0000-0001-6376-5121 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 18 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 0 |
| TOTAL COMO EDITOR | 18 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2022 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Animal husbandry and environmental conditions are associated with cefotaxime-resistant Escherichia coli in yard soil in peri-urban Malawi
Soil is an important reservoir for antimicrobial resistance (AMR) and increasingly recognized as a pathogen transmission pathway, especially for young children. However, drivers of domestic AMR soil contamination in low-income countries remain unidentified. We conducted a cross-sectional study with 237 peri-urban households in southern Malawi to identify household and environmental factors associated with cefotaxime - resistant E. coli in yard so…
Academic institution extensive, building-by-building wastewater-based surveillance platform for Sars-CoV-2 monitoring, clinical data correlation, and potential national proxy
In this work, we report on the performance of an extensive, building-by-building wastewater surveillance platform deployed across 38 locations of the largest private university system in Mexico, spanning 19 of the 32 states, to detect SARS-CoV-2 genetic materials during the COVID-19 pandemic. Sampling took place weekly from January 2021 and June 2022. Data from 343 sampling sites was clustered by campus and by state and evaluated through its corr…
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital
Pseudomonas aeruginosa , recognized by the World Health Organization as a critical priority pathogen, exhibits significant genomic plasticity and a high potential for developing resistance to multiple antimicrobials. This study provides comprehensive genomic insights into colistin-resistant P. aeruginosa isolates obtained from cancer patients. Phenotypic assays were conducted to evaluate antibiotic susceptibility, biofilm formation, efflux pump a…
Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities
Nursing home acquired pneumonia (NHAP), and its subset – aspiration-associated pneumonia, is a leading cause of morbidity and mortality among residents in long-term care facilities (LTCFs). Understanding colonization dynamics of respiratory pathogens in LTCF residents is essential for effective infection control. This study examines the longitudinal trends in prevalence, persistence, bacterial load, and co-colonization patterns of five respirator…
Prevalence of Shiga toxin-producing Escherichia coli, Salmonella, and Campylobacter species among diarrheal patients from three major hospitals in Ethiopia
Diarrheal illness remains a major global health challenge, causing millions of deaths annually. Non-typhoidal Salmonella (NTS), Shiga toxin-producing Escherichia coli (STEC), and Campylobacter species (CAMPY) significantly contribute to this burden. Given the limited information on these pathogens in Ethiopia, this study aimed to estimate their prevalence among diarrhea patients in Ethiopia and identify risk factors for infection. A cross-section…
Using best-worst scaling experiment to understand factors influencing self-medication practices with antimicrobial drugs
Antimicrobial drugs have saved millions of lives, but their widespread use to treat infections has significantly contributed to healthcare challenges, particularly antimicrobial resistance (AMR), which poses a global threat. This study investigated the factors influencing self-medication practices with antimicrobial drugs among health science students at a tertiary institution. A cross-sectional survey was conducted from July to August 2024, usin…
Prevalence and factors associated with multidrug resistant Escherichia coli carriage on chicken farms in west Nile region in Uganda
Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology and factors associated with MDR Escherichia coli (MDR E . coli ) on Ugandan farms are not well known. This study investigated the prevalence, resistance patterns and factors associated with MDR E . coli carriage on chicken farms. Escherichia coli was isolated from each of the 158 chicken farms sampled. The disc …
The development and validation of a survey to measure fecal-oral child exposure to zoonotic enteropathogens
Child exposure to animal feces and associated enteropathogens contribute to a significant burden of disease in low- and middle-income countries. However, there are no standardized, validated survey-based approaches to enable accurate assessment of child exposure to zoonotic enteropathogens. We developed and validated a survey-based measure of exposure, the fecal-oral child exposure to zoonotic enteropathogens Index (the FECEZ Enteropathogens Inde…
Microbiological assessment reveals that Salmonella, Shigella and Campylobacter infections are widespread in HIV infected and uninfected patients with diarrhea in Mozambique
Diarrhea is an important cause of hospitalizations in Mozambique. However, little attention has been paid to the impact HIV infection on the prevalence or clinical manifestations of enteric bacterial infections. This study aimed to determine the prevalence of Salmonella spp., Shigella spp. and Campylobacter spp. in HIV-infected and HIV-uninfected patients with diarrhea, identify risk factors for infection, and explore the association between HIV …
Anti-Helicobacter pylori antibody status is associated with cancer mortality
Paradoxically, patients with advanced stomach cancer who are Helicobacter pylori -positive (HP + ) have a higher survival rate than those who are HP - . This finding suggests that HP infection has beneficial effects for cancer treatment. The present study examines whether HP + individuals have a lower likelihood of death from cancer than those who are HP - . Prospective cohort data ( n = 4,982 subjects enrolled in the DAIKO study between 2008–201…
Assessment of drug-susceptible and multidrug-resistant tuberculosis (MDR-TB) in the Central Region of Somalia
Background Multidrug-resistant tuberculosis (MDR-TB) remains a public health emergency and a threat globally. Although increasing MDR-TB cases have been recently reported in Somalia, limited information is known. This study aims to determine the prevalence of drug-susceptible and MDR-TB in suspected patients referred to the TB Department in Mudug Hospital, Galkayo, Somalia, and identify potential factors associated with MDR-TB. Methods A 3-year h…
Understanding networks in rural Cambodian farming communities and how they influence antibiotic use
Biosecurity and preventive animal health services in Cambodian smallholder backyard farming systems are often limited, leading to an over-reliance on antibiotics. However, data on factors influencing antibiotic use in these settings are lacking. We conducted a study in two rural Cambodian farming communities to investigate how social and contextual influences affect both human and animal antibiotic use behaviours. Data were collected in three pha…
Dispersal history and bidirectional human-fish host switching of invasive, hypervirulent Streptococcus agalactiae sequence type 283
Human group B Streptococcus (GBS) infections attributable to an invasive, hypervirulent sequence type (ST) 283 have been associated with freshwater fish consumption in Asia. The origin, geographic dispersion pathways and host transitions of GBS ST283 remain unresolved. We gather 328 ST283 isolate whole-genome sequences collected from humans and fish between 1998 and 2021, representing eleven countries across four continents. We apply Bayesian phy…
Prevalence of diarrheagenic Escherichia coli and impact on child health in Cap-Haitien, Haiti
Background Diarrheagenic Escherichia coli (DEC) are common pathogens infecting children during their growth and development. Determining the epidemiology and the impact of DEC on child anthropometric measures informs prioritization of prevention efforts. These relationships were evaluated in a novel setting, Cap-Haitien, Haiti. Methods We performed pre-specified secondary analysis of a case-control study of community-dwelling children, 6–36 month…
The fourth national tuberculosis prevalence survey in Myanmar
Tuberculosis (TB) remains a significant cause of morbidity and mortality in Myanmar. The fourth National TB Prevalence Survey was conducted in 2017–2018 to determine the actual burden of TB not only at the national level but also for three subnational strata (the states, regions other than Yangon, and the Yangon region) and develop a more efficacious country strategy on TB care and control. One hundred and thirty eight clusters were selected by p…
Antibiogram of clinical isolates from primary and secondary healthcare facilities
Antibiogram development and use is a core element of antimicrobial stewardship practice, such data is scarce in healthcare settings in developing countries. The study aims to determine the epidemiology of clinical isolates and their antibiograms in secondary healthcare (SHC) and primary healthcare (PHC) facilities in Benin City, Nigeria. This was a retrospective study in three laboratories in SHC and PHC facilities. Microbial culture and suscepti…
Antibiotic susceptibility patterns of pathogens isolated from laboratory specimens at Livingstone Central Hospital in Zambia
Background Multidrug resistance (MDR) is a global problem that require multifaceted effort to curb it. This study aimed to evaluate the antibiotic susceptibility patterns of routinely isolated bacteria at Livingstone Central Hospital (LCH). Methods A retrospective study was performed on all isolated organisms from patient specimens that were processed from January 2019 to December 2021. Specimens were cultured on standard media and Kirby-Bauer di…
Assessment of independent comorbidities and comorbidity measures in predicting healthcare facility-onset Clostridioides difficile infection in Kenya
Introduction Clostridioides difficile is primarily associated with hospital-acquired diarrhoea. The disease burden is aggravated in patients with comorbidities due to increased likelihood of polypharmacy, extended hospital stays and compromised immunity. The study aimed to investigate comorbidity predictors of healthcare facility-onset C . difficile infection (HO-CDI) in hospitalized patients. Methodology We performed a cross sectional study of 3…
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The fourth national tuberculosis prevalence survey in Myanmar
Tuberculosis (TB) remains a significant cause of morbidity and mortality in Myanmar. The fourth National TB Prevalence Survey was conducted in 2017–2018 to determine the actual burden of TB not only at the national level but also for three subnational strata (the states, regions other than Yangon, and the Yangon region) and develop a more efficacious country strategy on TB care and control. One hundred and thirty eight clusters were selected by p…
Antibiogram of clinical isolates from primary and secondary healthcare facilities
Antibiogram development and use is a core element of antimicrobial stewardship practice, such data is scarce in healthcare settings in developing countries. The study aims to determine the epidemiology of clinical isolates and their antibiograms in secondary healthcare (SHC) and primary healthcare (PHC) facilities in Benin City, Nigeria. This was a retrospective study in three laboratories in SHC and PHC facilities. Microbial culture and suscepti…
Antibiotic susceptibility patterns of pathogens isolated from laboratory specimens at Livingstone Central Hospital in Zambia
Background Multidrug resistance (MDR) is a global problem that require multifaceted effort to curb it. This study aimed to evaluate the antibiotic susceptibility patterns of routinely isolated bacteria at Livingstone Central Hospital (LCH). Methods A retrospective study was performed on all isolated organisms from patient specimens that were processed from January 2019 to December 2021. Specimens were cultured on standard media and Kirby-Bauer di…
Assessment of independent comorbidities and comorbidity measures in predicting healthcare facility-onset Clostridioides difficile infection in Kenya
Introduction Clostridioides difficile is primarily associated with hospital-acquired diarrhoea. The disease burden is aggravated in patients with comorbidities due to increased likelihood of polypharmacy, extended hospital stays and compromised immunity. The study aimed to investigate comorbidity predictors of healthcare facility-onset C . difficile infection (HO-CDI) in hospitalized patients. Methodology We performed a cross sectional study of 3…
Microbiological assessment reveals that Salmonella, Shigella and Campylobacter infections are widespread in HIV infected and uninfected patients with diarrhea in Mozambique
Diarrhea is an important cause of hospitalizations in Mozambique. However, little attention has been paid to the impact HIV infection on the prevalence or clinical manifestations of enteric bacterial infections. This study aimed to determine the prevalence of Salmonella spp., Shigella spp. and Campylobacter spp. in HIV-infected and HIV-uninfected patients with diarrhea, identify risk factors for infection, and explore the association between HIV …
Anti-Helicobacter pylori antibody status is associated with cancer mortality
Paradoxically, patients with advanced stomach cancer who are Helicobacter pylori -positive (HP + ) have a higher survival rate than those who are HP - . This finding suggests that HP infection has beneficial effects for cancer treatment. The present study examines whether HP + individuals have a lower likelihood of death from cancer than those who are HP - . Prospective cohort data ( n = 4,982 subjects enrolled in the DAIKO study between 2008–201…
Assessment of drug-susceptible and multidrug-resistant tuberculosis (MDR-TB) in the Central Region of Somalia
Background Multidrug-resistant tuberculosis (MDR-TB) remains a public health emergency and a threat globally. Although increasing MDR-TB cases have been recently reported in Somalia, limited information is known. This study aims to determine the prevalence of drug-susceptible and MDR-TB in suspected patients referred to the TB Department in Mudug Hospital, Galkayo, Somalia, and identify potential factors associated with MDR-TB. Methods A 3-year h…
Understanding networks in rural Cambodian farming communities and how they influence antibiotic use
Biosecurity and preventive animal health services in Cambodian smallholder backyard farming systems are often limited, leading to an over-reliance on antibiotics. However, data on factors influencing antibiotic use in these settings are lacking. We conducted a study in two rural Cambodian farming communities to investigate how social and contextual influences affect both human and animal antibiotic use behaviours. Data were collected in three pha…
Dispersal history and bidirectional human-fish host switching of invasive, hypervirulent Streptococcus agalactiae sequence type 283
Human group B Streptococcus (GBS) infections attributable to an invasive, hypervirulent sequence type (ST) 283 have been associated with freshwater fish consumption in Asia. The origin, geographic dispersion pathways and host transitions of GBS ST283 remain unresolved. We gather 328 ST283 isolate whole-genome sequences collected from humans and fish between 1998 and 2021, representing eleven countries across four continents. We apply Bayesian phy…
Prevalence of diarrheagenic Escherichia coli and impact on child health in Cap-Haitien, Haiti
Background Diarrheagenic Escherichia coli (DEC) are common pathogens infecting children during their growth and development. Determining the epidemiology and the impact of DEC on child anthropometric measures informs prioritization of prevention efforts. These relationships were evaluated in a novel setting, Cap-Haitien, Haiti. Methods We performed pre-specified secondary analysis of a case-control study of community-dwelling children, 6–36 month…
The development and validation of a survey to measure fecal-oral child exposure to zoonotic enteropathogens
Child exposure to animal feces and associated enteropathogens contribute to a significant burden of disease in low- and middle-income countries. However, there are no standardized, validated survey-based approaches to enable accurate assessment of child exposure to zoonotic enteropathogens. We developed and validated a survey-based measure of exposure, the fecal-oral child exposure to zoonotic enteropathogens Index (the FECEZ Enteropathogens Inde…
Academic institution extensive, building-by-building wastewater-based surveillance platform for Sars-CoV-2 monitoring, clinical data correlation, and potential national proxy
In this work, we report on the performance of an extensive, building-by-building wastewater surveillance platform deployed across 38 locations of the largest private university system in Mexico, spanning 19 of the 32 states, to detect SARS-CoV-2 genetic materials during the COVID-19 pandemic. Sampling took place weekly from January 2021 and June 2022. Data from 343 sampling sites was clustered by campus and by state and evaluated through its corr…
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital
Pseudomonas aeruginosa , recognized by the World Health Organization as a critical priority pathogen, exhibits significant genomic plasticity and a high potential for developing resistance to multiple antimicrobials. This study provides comprehensive genomic insights into colistin-resistant P. aeruginosa isolates obtained from cancer patients. Phenotypic assays were conducted to evaluate antibiotic susceptibility, biofilm formation, efflux pump a…
Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities
Nursing home acquired pneumonia (NHAP), and its subset – aspiration-associated pneumonia, is a leading cause of morbidity and mortality among residents in long-term care facilities (LTCFs). Understanding colonization dynamics of respiratory pathogens in LTCF residents is essential for effective infection control. This study examines the longitudinal trends in prevalence, persistence, bacterial load, and co-colonization patterns of five respirator…
Prevalence of Shiga toxin-producing Escherichia coli, Salmonella, and Campylobacter species among diarrheal patients from three major hospitals in Ethiopia
Diarrheal illness remains a major global health challenge, causing millions of deaths annually. Non-typhoidal Salmonella (NTS), Shiga toxin-producing Escherichia coli (STEC), and Campylobacter species (CAMPY) significantly contribute to this burden. Given the limited information on these pathogens in Ethiopia, this study aimed to estimate their prevalence among diarrhea patients in Ethiopia and identify risk factors for infection. A cross-section…
Using best-worst scaling experiment to understand factors influencing self-medication practices with antimicrobial drugs
Antimicrobial drugs have saved millions of lives, but their widespread use to treat infections has significantly contributed to healthcare challenges, particularly antimicrobial resistance (AMR), which poses a global threat. This study investigated the factors influencing self-medication practices with antimicrobial drugs among health science students at a tertiary institution. A cross-sectional survey was conducted from July to August 2024, usin…
Prevalence and factors associated with multidrug resistant Escherichia coli carriage on chicken farms in west Nile region in Uganda
Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology and factors associated with MDR Escherichia coli (MDR E . coli ) on Ugandan farms are not well known. This study investigated the prevalence, resistance patterns and factors associated with MDR E . coli carriage on chicken farms. Escherichia coli was isolated from each of the 158 chicken farms sampled. The disc …
Animal husbandry and environmental conditions are associated with cefotaxime-resistant Escherichia coli in yard soil in peri-urban Malawi
Soil is an important reservoir for antimicrobial resistance (AMR) and increasingly recognized as a pathogen transmission pathway, especially for young children. However, drivers of domestic AMR soil contamination in low-income countries remain unidentified. We conducted a cross-sectional study with 237 peri-urban households in southern Malawi to identify household and environmental factors associated with cefotaxime - resistant E. coli in yard so…
Medicine (16 obras) · Biology (10 obras) · Environmental health (8 obras) · Internal Medicine (7 obras) · Microbiology (6 obras) · Antibiotic Resistance in Bacteria (5 obras) · Antibiotics (5 obras) · Pathology (5 obras) · Antibiotic resistance (4 obras) · Antibiotic Use and Resistance (4 obras)