Sarah Williams-Blangero
Dados Biográficos
| ID | 88081 |
|---|---|
| NOME | Sarah Williams-Blangero |
| PRENOMES | Sarah |
| SOBRENOME | Williams-Blangero |
| ASSINATURA | WILLIAMS-BLANGERO S |
| AFILIAÇÕES | Texas Biomedical Research Institute |
| VERIFICADO | Não |
| TOTAL DE OBRAS | 13 |
| TOTAL DE CITAÇÕES | 10 |
| TOTAL COMO AUTOR | 13 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1991 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2022 |
| ÍNDICE H | 3 |
Non-alcoholic Fatty Liver Disease and Depression
This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and cont…
Genetic Determinants of Risk Factors for Cardiovascular Disease in a Population from Rural Brazil
We investigate the heritability of and pleiotropic relationships among triglycerides and cholesterol lipoproteins that have long been considered traditional risk factors for cardiovascular disease. Quantitative lipid and lipoprotein phenotypes were determined for a cross-sectional sample of a community in Jequitinhonha valley in northern Minas Gerais state, Brazil. The sample consisted primarily of subsistence farmers. Two hundred sixty-nine indi…
Collection of Pedigree Data for Genetic Analysis in Isolate Populations
Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtai…
The Psychological Disease Burden in Nepal and Its Relationship to Physical Health Problems
Psychological disorders are a substantial part of the disease burden in many developing countries, yet few health services are directed toward the detection and treatment of these disorders. The relationship between psychological disorders and physical health problems was investigated by means of a community survey ( N =653) in a small village in Nepal, using a shortened version of the DSM-III-R Checklist to estimate the prevalence of several psy…
Mental Illness and Disability among Elders in Developing Countries
Documenting the extent of psychiatric disorder among elders in developing societies sensitizes health planners to the growing reality of aging in their societies and the need for expanded physical and psychiatric health care services
The Human Genome Project and Advances in Anthropological Genetics
Keywords Human Genome Project, anthropological genetics, Human Biology journal, editorial. Anthropological genetics is at one of the most exciting points in the history of the field. Never before has so much information been available to facilitate the search for genes that influence normal human variation and human adaptability. For example, sequencing efforts have revealed vast amounts of variation within human populations. The Human Genome Pro…
Measuring Community Mental Health in Developing Societies
Background: There is growing recognition of the importance of mental health problems in developing countries. In large part, however, we have very limited epidemiological data at national and/or community levels about the prevalence of mental illnesses. Aims: The purpose of this paper is to describe the reliability and validity characteristics of an assessment tool that may be useful for conducting community-level surveys (particularly in rural c…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Attitudes towards Chagas' disease in an endemic Brazilian community
Chagas' disease remains a major public health concern throughout much of Latin America. In Brazil, segments of the population experience Trypanosoma cruzi infection rates as high as 65%, indicating that control programs are still needed. Few data are available concerning people's health beliefs related to Chagas' disease in heavily infected populations. Such health beliefs may significantly impact the effectiveness of intervention schemes. The pu…
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Genetics of adult body mass and maintenance of adult body mass in captive baboons (Papio hamadryas subspecies)
Adult body mass and changes in mass during an individual's life are important indicators of general health and reproductive fitness. Therefore, characterization of the factors that influence normal variation in body mass has important implications for colony management and husbandry. The main objective of this study was to quantify the genetic contribution to adult body mass and its maintenance in baboons. Intra-individual mean and variance in bo…
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some …
Recent trends in genetic research on captive and wild nonhuman primate populations
Genetic research on nonhuman primates is flourishing. Population genetic approaches are used to address microevolutionary questions about both wild and captive nonhuman primate populations. Population structure studies of wild groups have traditionally been limited by a lack of accurate pedigree and historical information. Current developments in both statistical and molecular pedigree reconstruction techniques now permit more detailed population…
Attitudes towards Chagas' disease in an endemic Brazilian community
Chagas' disease remains a major public health concern throughout much of Latin America. In Brazil, segments of the population experience Trypanosoma cruzi infection rates as high as 65%, indicating that control programs are still needed. Few data are available concerning people's health beliefs related to Chagas' disease in heavily infected populations. Such health beliefs may significantly impact the effectiveness of intervention schemes. The pu…
Genetic Determinants of Risk Factors for Cardiovascular Disease in a Population from Rural Brazil
We investigate the heritability of and pleiotropic relationships among triglycerides and cholesterol lipoproteins that have long been considered traditional risk factors for cardiovascular disease. Quantitative lipid and lipoprotein phenotypes were determined for a cross-sectional sample of a community in Jequitinhonha valley in northern Minas Gerais state, Brazil. The sample consisted primarily of subsistence farmers. Two hundred sixty-nine indi…
Collection of Pedigree Data for Genetic Analysis in Isolate Populations
Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtai…
Recent trends in genetic research on captive and wild nonhuman primate populations
Genetic research on nonhuman primates is flourishing. Population genetic approaches are used to address microevolutionary questions about both wild and captive nonhuman primate populations. Population structure studies of wild groups have traditionally been limited by a lack of accurate pedigree and historical information. Current developments in both statistical and molecular pedigree reconstruction techniques now permit more detailed population…
Genetics of adult body mass and maintenance of adult body mass in captive baboons (Papio hamadryas subspecies)
Adult body mass and changes in mass during an individual's life are important indicators of general health and reproductive fitness. Therefore, characterization of the factors that influence normal variation in body mass has important implications for colony management and husbandry. The main objective of this study was to quantify the genetic contribution to adult body mass and its maintenance in baboons. Intra-individual mean and variance in bo…
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some …
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Attitudes towards Chagas' disease in an endemic Brazilian community
Chagas' disease remains a major public health concern throughout much of Latin America. In Brazil, segments of the population experience Trypanosoma cruzi infection rates as high as 65%, indicating that control programs are still needed. Few data are available concerning people's health beliefs related to Chagas' disease in heavily infected populations. Such health beliefs may significantly impact the effectiveness of intervention schemes. The pu…
Measuring Community Mental Health in Developing Societies
Background: There is growing recognition of the importance of mental health problems in developing countries. In large part, however, we have very limited epidemiological data at national and/or community levels about the prevalence of mental illnesses. Aims: The purpose of this paper is to describe the reliability and validity characteristics of an assessment tool that may be useful for conducting community-level surveys (particularly in rural c…
The Psychological Disease Burden in Nepal and Its Relationship to Physical Health Problems
Psychological disorders are a substantial part of the disease burden in many developing countries, yet few health services are directed toward the detection and treatment of these disorders. The relationship between psychological disorders and physical health problems was investigated by means of a community survey ( N =653) in a small village in Nepal, using a shortened version of the DSM-III-R Checklist to estimate the prevalence of several psy…
Mental Illness and Disability among Elders in Developing Countries
Documenting the extent of psychiatric disorder among elders in developing societies sensitizes health planners to the growing reality of aging in their societies and the need for expanded physical and psychiatric health care services
The Human Genome Project and Advances in Anthropological Genetics
Keywords Human Genome Project, anthropological genetics, Human Biology journal, editorial. Anthropological genetics is at one of the most exciting points in the history of the field. Never before has so much information been available to facilitate the search for genes that influence normal human variation and human adaptability. For example, sequencing efforts have revealed vast amounts of variation within human populations. The Human Genome Pro…
Collection of Pedigree Data for Genetic Analysis in Isolate Populations
Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtai…
Genetic Determinants of Risk Factors for Cardiovascular Disease in a Population from Rural Brazil
We investigate the heritability of and pleiotropic relationships among triglycerides and cholesterol lipoproteins that have long been considered traditional risk factors for cardiovascular disease. Quantitative lipid and lipoprotein phenotypes were determined for a cross-sectional sample of a community in Jequitinhonha valley in northern Minas Gerais state, Brazil. The sample consisted primarily of subsistence farmers. Two hundred sixty-nine indi…
Non-alcoholic Fatty Liver Disease and Depression
This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and cont…
Biology (8 obras) · Medicine (8 obras) · Population (6 obras) · Evolutionary biology (4 obras) · Genetics (4 obras) · Internal Medicine (4 obras) · Mathematics (4 obras) · Psychiatry (4 obras) · Psychology (4 obras) · Altitude (triangle) (3 obras)