Mark Spigelman
Dados Biográficos
| ID | 92357 |
|---|---|
| NOME | Mark Spigelman |
| PRENOMES | Mark |
| SOBRENOME | Spigelman |
| ASSINATURA | SPIGELMAN M |
| AFILIAÇÕES | University College London |
| VERIFICADO | Não |
| TOTAL DE OBRAS | 20 |
| TOTAL DE CITAÇÕES | 32 |
| TOTAL COMO AUTOR | 17 |
| TOTAL COMO EDITOR | 3 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1993 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2017 |
| ÍNDICE H | 4 |
A tuberkulózis előfordulása egy XVIII. századi váci családban
Tuberculosis cases in a Hungarian family, 18th century, Vc, Hungary. Two individuals of the Nigrovits family from the Vc Mummy Collection of the Hungarian Natural History Museum were the subjects of multidisciplinary, anthropological, paleopathological, radiological, paleomicrobiological and paleoproteomic studies. The father, Jzsef Nigrovits (No 29), died at the age of 55 on the 11th of November 1793; his son, Antal Nigrovits (No 54), died on th…
Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th–8th century AD)
This study shows that, in the historical population with leprosy, the risk factors for health seem to be constant and distributed across all age classes, similar to what is found today in the antibiotic era. There were no peaks of mortality equivalent to those found in fatal diseases such as the plague, probably due to the long clinical course of leprosy
The challenge of identifying tuberculosis proteins in archaeological tissues
Evidence of probable tuberculosis in Lithuanian mummies
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Golfer and Tennis Elbow in Byzantine Turkey
Both lateral and medial epicondylitis are well known in modern medicine as diseases of occupation, leaving recognizable lesions on the epicondyles. We report on 36 individuals from the 8th-10th century AD Byzantine period from Kovuklukaya, near Sinop, Middle Black Sea region, Northern Anatolia, Turkey. The present study focuses on medial and lateral epicondylitis with lesions of enthesopathies and bony pits, assessing the frequency of these lesio…
A Fisk patent metallic burial case from Western Missouri
Biomolecular archaeology of ancient tuberculosis
Eung Tae's tomb
In medieval Korea certain burials were sealed in concrete resulting in the exceptional preservation of organic materials, including, in this case, written documents. As well as studying changes in rank and ideology, archaeologists who investigate tombs are often moved to wonder about the character of the deceased, the thoughts of the mourners and their hopes and fears on the passing of a person dear to them. In this extraordinary burial from Kore…
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
BACKGROUND: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric …
Palaeobacteriology With Special Reference to Pathogenic Mycobacteria
Skeletal deformities and the occasional lesion in a preserved corpse or mummy are often highly suggestive of ancient microbial disease. However, until recently it appeared that archaeologists were doomed never to fully identify the origins, extent, and types of these ancient diseases, thus making it impossible to understand the aetiology of epidemics that were so important in determining the course of history. A new science of palaeomicrobi ology…
Title Pages
Lessons from the past
In two universities I attempted to obtain biosafety guidelines for the culture of amber. The answers, not committed to writing were, ‘These are ordinary environmental microbes, and women have been rubbing their amber beads on their chests for years.’ But still the fears persist. In Italy, when I attempted to culture bones from Pompeii, one student simply freaked out. A question to Jeff Taubenberger: I know that the ‘American expedition’ that exhu…
Emerging Pathogens
Many ancient diseases with a long history of afflicting mankind such as Tuberculosis and Malaria are now re-emerging. Greenblatt brings together palaeopathologists, anthropologists, molecular biologists and modern infectious disease specialists to examine this phenomenon. New techniques allow us to detect ancient pathogen DNA and other biomarkers, in effect the chemical ‘signatures’ of pathogens. These tools could help us develop strategies to co…
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
Guide for authors
Brief communication
Hershkovitz et al. (1992) reported on a skeleton from Bet Guvrin, Israel, dating from the Byzantine period (300-600 AD).There were pathological changes in the lower extremities, which presented significant diagnostic problems.Their original diagnosis was Madura foot, based on the absence of typical medullary changes associated with osteomyelitis, and to the presence of severely ankylosed (left calcaneal talar joint) and deformed bilateral foot bo…
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
The use of the polymerase chain reaction (PCR) to detect Mycobacterium tuberculosis in ancient skeletons
The polymerase chain reaction has been used to extract ancient DNA from a wide range of different types of material. We have considered the possibility of finding residual bacterial DNA in bone that may have been infected with Mycobacterium tuberculosis using this technique. We propose a method of collecting samples and testing for the presence of degraded genetic material in ancient bone. The steps of the polymerase chain reaction are detailed a…
Biomolecular archaeology of ancient tuberculosis
The challenge of identifying tuberculosis proteins in archaeological tissues
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
A Fisk patent metallic burial case from Western Missouri
Eung Tae's tomb
In medieval Korea certain burials were sealed in concrete resulting in the exceptional preservation of organic materials, including, in this case, written documents. As well as studying changes in rank and ideology, archaeologists who investigate tombs are often moved to wonder about the character of the deceased, the thoughts of the mourners and their hopes and fears on the passing of a person dear to them. In this extraordinary burial from Kore…
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
The use of the polymerase chain reaction (PCR) to detect Mycobacterium tuberculosis in ancient skeletons
The polymerase chain reaction has been used to extract ancient DNA from a wide range of different types of material. We have considered the possibility of finding residual bacterial DNA in bone that may have been infected with Mycobacterium tuberculosis using this technique. We propose a method of collecting samples and testing for the presence of degraded genetic material in ancient bone. The steps of the polymerase chain reaction are detailed a…
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
Guide for authors
Brief communication
Hershkovitz et al. (1992) reported on a skeleton from Bet Guvrin, Israel, dating from the Byzantine period (300-600 AD).There were pathological changes in the lower extremities, which presented significant diagnostic problems.Their original diagnosis was Madura foot, based on the absence of typical medullary changes associated with osteomyelitis, and to the presence of severely ankylosed (left calcaneal talar joint) and deformed bilateral foot bo…
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
Palaeobacteriology With Special Reference to Pathogenic Mycobacteria
Skeletal deformities and the occasional lesion in a preserved corpse or mummy are often highly suggestive of ancient microbial disease. However, until recently it appeared that archaeologists were doomed never to fully identify the origins, extent, and types of these ancient diseases, thus making it impossible to understand the aetiology of epidemics that were so important in determining the course of history. A new science of palaeomicrobi ology…
Title Pages
Lessons from the past
In two universities I attempted to obtain biosafety guidelines for the culture of amber. The answers, not committed to writing were, ‘These are ordinary environmental microbes, and women have been rubbing their amber beads on their chests for years.’ But still the fears persist. In Italy, when I attempted to culture bones from Pompeii, one student simply freaked out. A question to Jeff Taubenberger: I know that the ‘American expedition’ that exhu…
Emerging Pathogens
Many ancient diseases with a long history of afflicting mankind such as Tuberculosis and Malaria are now re-emerging. Greenblatt brings together palaeopathologists, anthropologists, molecular biologists and modern infectious disease specialists to examine this phenomenon. New techniques allow us to detect ancient pathogen DNA and other biomarkers, in effect the chemical ‘signatures’ of pathogens. These tools could help us develop strategies to co…
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
BACKGROUND: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric …
Biomolecular archaeology of ancient tuberculosis
Eung Tae's tomb
In medieval Korea certain burials were sealed in concrete resulting in the exceptional preservation of organic materials, including, in this case, written documents. As well as studying changes in rank and ideology, archaeologists who investigate tombs are often moved to wonder about the character of the deceased, the thoughts of the mourners and their hopes and fears on the passing of a person dear to them. In this extraordinary burial from Kore…
A Fisk patent metallic burial case from Western Missouri
Golfer and Tennis Elbow in Byzantine Turkey
Both lateral and medial epicondylitis are well known in modern medicine as diseases of occupation, leaving recognizable lesions on the epicondyles. We report on 36 individuals from the 8th-10th century AD Byzantine period from Kovuklukaya, near Sinop, Middle Black Sea region, Northern Anatolia, Turkey. The present study focuses on medial and lateral epicondylitis with lesions of enthesopathies and bony pits, assessing the frequency of these lesio…
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Evidence of probable tuberculosis in Lithuanian mummies
The challenge of identifying tuberculosis proteins in archaeological tissues
A tuberkulózis előfordulása egy XVIII. századi váci családban
Tuberculosis cases in a Hungarian family, 18th century, Vc, Hungary. Two individuals of the Nigrovits family from the Vc Mummy Collection of the Hungarian Natural History Museum were the subjects of multidisciplinary, anthropological, paleopathological, radiological, paleomicrobiological and paleoproteomic studies. The father, Jzsef Nigrovits (No 29), died at the age of 55 on the 11th of November 1793; his son, Antal Nigrovits (No 54), died on th…
Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th–8th century AD)
This study shows that, in the historical population with leprosy, the risk factors for health seem to be constant and distributed across all age classes, similar to what is found today in the antibiotic era. There were no peaks of mortality equivalent to those found in fatal diseases such as the plague, probably due to the long clinical course of leprosy
Medicine (14 obras) · Biology (10 obras) · Pathology (10 obras) · Archaeology (9 obras) · History (9 obras) · Ancient DNA (8 obras) · Tuberculosis (8 obras) · Tuberculosis Research and Epidemiology (7 obras) · Mycobacterium tuberculosis (6 obras) · Paleopathology and ancient diseases (6 obras)