Helen D Donoghue
Dados Biográficos
| ID | 92361 |
|---|---|
| NOME | Helen D Donoghue |
| PRENOMES | Helen D |
| SOBRENOME | Donoghue |
| ASSINATURA | DONOGHUE H D |
| AFILIAÇÕES | University College London |
| ORCID | 0000-0003-3918-5252 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 19 |
| TOTAL DE CITAÇÕES | 26 |
| TOTAL COMO AUTOR | 19 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1994 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2020 |
| ÍNDICE H | 4 |
Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis
The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may …
Osteoarcheological and biomolecular evidence of leprosy from an 11–13th century CE Muslim cemetery in Europe (Orosháza, Southeast Hungary)
aDNA, shown to be of genotype 3. Contrary to the general practice of the era, the body of the young female with severe signs of leprosy was interred among the regular graves of the Muslim cemetery in Orosháza, which may reflect the unique cultural background of the community.
Tuberculosis and leprosy associated with historical human population movements in Europe and beyond – an overview based on mycobacterial ancient DNA
Context: Tuberculosis and leprosy are readily recognised in human remains due to their typical palaeopathology. Both Mycobacterium tuberculosis (MTB) and Mycobacterium leprae (ML) are obligate pathogens and have been detected in ancient human populations.Objective: To demonstrate historical tuberculosis and leprosy cases in Europe and beyond using molecular methods, as human populations are associated with different mycobacterial genotypes.Method…
The earliest recorded case of lepromatous leprosy in continental Croatia
The genome sequence of a SNP type 3K strain of Mycobacterium leprae isolated from a seventh-century Hungarian case of lepromatous leprosy
We report on a Mycobacterium leprae genome isolated from the remains of an individual with lepromatous leprosy that were excavated from a seventh-century Hungarian cemetery. We determined that the genome was from a single nucleotide polymorphism (SNP) type 3K0 M. leprae strain, a lineage that diverged early from other M. leprae lineages. This is one of the earliest 3K0 M. leprae genomes to be sequenced to date. A number of novel SNPs as well as S…
A tuberkulózis előfordulása egy XVIII. századi váci családban
Tuberculosis cases in a Hungarian family, 18th century, Vc, Hungary. Two individuals of the Nigrovits family from the Vc Mummy Collection of the Hungarian Natural History Museum were the subjects of multidisciplinary, anthropological, paleopathological, radiological, paleomicrobiological and paleoproteomic studies. The father, Jzsef Nigrovits (No 29), died at the age of 55 on the 11th of November 1793; his son, Antal Nigrovits (No 54), died on th…
Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th–8th century AD)
This study shows that, in the historical population with leprosy, the risk factors for health seem to be constant and distributed across all age classes, similar to what is found today in the antibiotic era. There were no peaks of mortality equivalent to those found in fatal diseases such as the plague, probably due to the long clinical course of leprosy
Éves Dél-Magyarországi Tuberkulózis Esetek Oszteológiai És Molekuláris Biológiai Vizsgálata
This study derives from the macroscopic analysis of a Late Neolithic population from southern Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. Pathological analysis of the 71 individuals revealed numerous cases of infections and non-specific stress indicators, metabolic diseases, and evidence of trauma and mechanical changes. Se…
The challenge of identifying tuberculosis proteins in archaeological tissues
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Golfer and Tennis Elbow in Byzantine Turkey
Both lateral and medial epicondylitis are well known in modern medicine as diseases of occupation, leaving recognizable lesions on the epicondyles. We report on 36 individuals from the 8th-10th century AD Byzantine period from Kovuklukaya, near Sinop, Middle Black Sea region, Northern Anatolia, Turkey. The present study focuses on medial and lateral epicondylitis with lesions of enthesopathies and bony pits, assessing the frequency of these lesio…
New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia)
Biomolecular archaeology of ancient tuberculosis
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
BACKGROUND: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric …
Palaeobacteriology With Special Reference to Pathogenic Mycobacteria
Skeletal deformities and the occasional lesion in a preserved corpse or mummy are often highly suggestive of ancient microbial disease. However, until recently it appeared that archaeologists were doomed never to fully identify the origins, extent, and types of these ancient diseases, thus making it impossible to understand the aetiology of epidemics that were so important in determining the course of history. A new science of palaeomicrobi ology…
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
Brief communication
Hershkovitz et al. (1992) reported on a skeleton from Bet Guvrin, Israel, dating from the Byzantine period (300-600 AD).There were pathological changes in the lower extremities, which presented significant diagnostic problems.Their original diagnosis was Madura foot, based on the absence of typical medullary changes associated with osteomyelitis, and to the presence of severely ankylosed (left calcaneal talar joint) and deformed bilateral foot bo…
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
Biomolecular archaeology of ancient tuberculosis
The challenge of identifying tuberculosis proteins in archaeological tissues
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
DNA of Mycobacterium leprae detected by PCR in ancient bone
We report the extraction and amplification of DNA of Mycobacterium leprae, from ancient skeletal material. The significance of the extraction of ancient bacterial DNA is discussed, as are future directions of research into ancient disease
Brief communication
Hershkovitz et al. (1992) reported on a skeleton from Bet Guvrin, Israel, dating from the Byzantine period (300-600 AD).There were pathological changes in the lower extremities, which presented significant diagnostic problems.Their original diagnosis was Madura foot, based on the absence of typical medullary changes associated with osteomyelitis, and to the presence of severely ankylosed (left calcaneal talar joint) and deformed bilateral foot bo…
Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTB) DNA in ancient human remains but concerns were raised about the article two years after publication. These were based on methodology which, in the field of ancient DNA, was still developing. Here we present a re-examination of the 1993 research conducted on three specimens which exhibited palaeopathologies indicative of tuberculosis. The specimens…
Palaeobacteriology With Special Reference to Pathogenic Mycobacteria
Skeletal deformities and the occasional lesion in a preserved corpse or mummy are often highly suggestive of ancient microbial disease. However, until recently it appeared that archaeologists were doomed never to fully identify the origins, extent, and types of these ancient diseases, thus making it impossible to understand the aetiology of epidemics that were so important in determining the course of history. A new science of palaeomicrobi ology…
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
A large number (265) of burials from 1731–1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available. Contemporary archives enabled the determination of age at death, and the identification of family groups. In some cases, symptoms before death were described and, occasionally, occupation. Initial radiological examination of a small …
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
BACKGROUND: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric …
Biomolecular archaeology of ancient tuberculosis
New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia)
Golfer and Tennis Elbow in Byzantine Turkey
Both lateral and medial epicondylitis are well known in modern medicine as diseases of occupation, leaving recognizable lesions on the epicondyles. We report on 36 individuals from the 8th-10th century AD Byzantine period from Kovuklukaya, near Sinop, Middle Black Sea region, Northern Anatolia, Turkey. The present study focuses on medial and lateral epicondylitis with lesions of enthesopathies and bony pits, assessing the frequency of these lesio…
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
This study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5 years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndro…
Éves Dél-Magyarországi Tuberkulózis Esetek Oszteológiai És Molekuláris Biológiai Vizsgálata
This study derives from the macroscopic analysis of a Late Neolithic population from southern Hungary. Remains were recovered from a tell settlement at Hódmezővásárhely-Gorzsa from graves within the settlement as well as pits, ditches, houses and as stray finds. Pathological analysis of the 71 individuals revealed numerous cases of infections and non-specific stress indicators, metabolic diseases, and evidence of trauma and mechanical changes. Se…
The challenge of identifying tuberculosis proteins in archaeological tissues
A tuberkulózis előfordulása egy XVIII. századi váci családban
Tuberculosis cases in a Hungarian family, 18th century, Vc, Hungary. Two individuals of the Nigrovits family from the Vc Mummy Collection of the Hungarian Natural History Museum were the subjects of multidisciplinary, anthropological, paleopathological, radiological, paleomicrobiological and paleoproteomic studies. The father, Jzsef Nigrovits (No 29), died at the age of 55 on the 11th of November 1793; his son, Antal Nigrovits (No 54), died on th…
Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th–8th century AD)
This study shows that, in the historical population with leprosy, the risk factors for health seem to be constant and distributed across all age classes, similar to what is found today in the antibiotic era. There were no peaks of mortality equivalent to those found in fatal diseases such as the plague, probably due to the long clinical course of leprosy
The genome sequence of a SNP type 3K strain of Mycobacterium leprae isolated from a seventh-century Hungarian case of lepromatous leprosy
We report on a Mycobacterium leprae genome isolated from the remains of an individual with lepromatous leprosy that were excavated from a seventh-century Hungarian cemetery. We determined that the genome was from a single nucleotide polymorphism (SNP) type 3K0 M. leprae strain, a lineage that diverged early from other M. leprae lineages. This is one of the earliest 3K0 M. leprae genomes to be sequenced to date. A number of novel SNPs as well as S…
Osteoarcheological and biomolecular evidence of leprosy from an 11–13th century CE Muslim cemetery in Europe (Orosháza, Southeast Hungary)
aDNA, shown to be of genotype 3. Contrary to the general practice of the era, the body of the young female with severe signs of leprosy was interred among the regular graves of the Muslim cemetery in Orosháza, which may reflect the unique cultural background of the community.
Tuberculosis and leprosy associated with historical human population movements in Europe and beyond – an overview based on mycobacterial ancient DNA
Context: Tuberculosis and leprosy are readily recognised in human remains due to their typical palaeopathology. Both Mycobacterium tuberculosis (MTB) and Mycobacterium leprae (ML) are obligate pathogens and have been detected in ancient human populations.Objective: To demonstrate historical tuberculosis and leprosy cases in Europe and beyond using molecular methods, as human populations are associated with different mycobacterial genotypes.Method…
The earliest recorded case of lepromatous leprosy in continental Croatia
Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis
The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may …
Medicine (16 obras) · Biology (11 obras) · Pathology (11 obras) · Archaeology (10 obras) · Ancient DNA (9 obras) · Tuberculosis (9 obras) · Tuberculosis Research and Epidemiology (9 obras) · History (8 obras) · Mycobacterium research and diagnosis (8 obras) · Yersinia bacterium, plague, ectoparasites research (8 obras)