John Blangero
Dados Biográficos
| ID | 94833 |
|---|---|
| NOME | John Blangero |
| PRENOMES | John |
| SOBRENOME | Blangero |
| ASSINATURA | BLANGERO J |
| AFILIAÇÕES | Texas Biomedical Research Institute |
| ORCID | 0000-0001-6250-5723 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 53 |
| TOTAL DE CITAÇÕES | 70 |
| TOTAL COMO AUTOR | 53 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1982 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2025 |
| ÍNDICE H | 4 |
Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children
Early-life exposure to organic chemicals (OCs) may influence childhood obesity and associated cardiometabolic risk. These conditions have been shown to disproportionately affect minority populations such as Mexican Americans (MAs). However, information on the impact of organic chemicals on cardiometabolic risk in MA children is limited. Therefore, we conducted a pilot study to assess the extent to which exposure to organic chemicals influences ca…
Non-alcoholic Fatty Liver Disease and Depression
This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and cont…
Rare genetic variants explain missing heritability in smoking
Quantitative physical activity assessment of children and adolescents in a rural population from E astern N epal
OBJECTIVES: We report cross-sectional, objectively measured physical activity data for 399 children and adolescents aged 6 to 18 years. We evaluated physical activity of children and adolescents, considered time spent in each activity intensity category, and explored the impact of growth disruption (stunting and wasting) on physical activity patterns. METHODS: Participants wore an Actical (Mini-Mitter, Bend, OR) omnidirectional accelerometer for …
Familial Studies
Genetic studies of body mass index yield new insights for obesity biology
Nonsyndromic brachydactyly type D and type E mapped to 7p15 in healthy children and adults from the jirel ethnic group in eastern nepal
OBJECTIVES: There is phenotypic overlap between Brachydactyly Type D (BDD) and Brachydactyly Type E (BDE) that suggests a possible common underlying etiology. We seek to understand the genetic underpinnings of, and relationship between, these skeletal anomalies. METHODS: The Jirel ethnic group of eastern Nepal participates in various genetic epidemiologic studies, including those in which hand-wrist radiographs have been taken to examine skeletal…
Genetic risk for earlier menarche also influences peripubertal body mass index
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928–1992, a genetic risk score (GRS 42 ) was computed as the sum of the number of risk alleles in 42 putative menarche S…
Quantitative Trait Nucleotide Analysis Using Bayesian Model Selection
Although much attention has been given to statistical genetic methods for the initial localization and fine mapping of quantitative trait loci (QTLs), little methodological work has been done to date on the problem of statistically identifying the most likely functional polymorphisms using sequence data. In this paper we provide a general statistical genetic framework, called Bayesian quantitative trait nucleotide (BQTN) analysis, for assessing t…
The F7 Gene and Clotting Factor VII Levels
Localization of human quantitative trait loci (QTLs) is now routine. However, identifying their functional DNA variants is still a formidable challenge. We present a complete dissection of a human QTL using novel statistical techniques to infer the most likely functional polymorphisms of a QTL that influence plasma levels of clotting factor VII (FVII), a risk factor for cardiovascular disease. Resequencing of 15 kb in and around the F7 gene ident…
Update to Blangero's "Statistical Genetic Approaches to Human Adaptability" (1993)
Update to Blangero's "Statistical Genetic Approaches to Human Adaptability" (1993):A Unified Theory of Genotype × Environment Interaction John Blangero Keywords Genotype × Environment Interaction, Human Adaptability, Family Studies, Quantitative Trait Loci My 1993 paper, "Statistical Genetic Approaches to Human Adaptability," originally was part of a special issue of Human Biology edited by Sarah Williams-Blangero and me (Williams-Blangero and Bl…
Statistical Genetic Approaches to Human Adaptability
The genetic determinants of physiological and developmental responses to environmental stress are poorly understood. This has been primarily due to the difficulty of direct measurement of response and the lack of appropriate statistical genetic methods. Here, I present a unified statistical genetic methodology for human adaptability studies that permits evaluation of the inheritance of quantitative trait response to environmental stressors. The f…
Update to Blangero's “Statistical Genetic Approaches to Human Adaptability” (1993)
Autosomal Genome-Wide Linkage Analysis to Identify Loci for Gallbladder Wall Thickness in Mexican Americans
The significance of gallbladder wall thickness (GBWT) in regard to gallbladder disease (GBD) is not completely understood. Thickening of the gallbladder wall has been observed in patients with acute calculous and acalculous cholecystitis and chronic cholecystitis. However, various pathologic processes, such as gallbladder cancer and nonbiliary disorders such as liver cirrhosis and viral hepatitis, could also cause thickening of the gallbladder wa…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Presentation, Heritability, and Genome-Wide Linkage Analysis of the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Genetic and environmental influences on infant weight and weight change
Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and …
Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study
Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS), we performed to our knowledge the first genomewide linkage scan for quantitative trait loci (QTLs) that influence the level of plasminogen. The subset of the SAFHS population used for this study consists of 629 individuals distributed across 26 extended Mexican American families. Pedigree-ba…
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Multiple QTLs Influence Variation in Paraoxonase 1 Activity in Mexican Americans
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additiona…
Association of Genetic Variation Within UBL5 with Phenotypes of Metabolic Syndrome
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. The human homolog …
Pleiotropic QTL on Chromosome 12q23-q24 Influences Triglyceride and High-Density Lipoprotein Cholesterol Levels
To determine whether a common quantitative trait locus (QTL) influences the variation of fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels, we used a bivariate multipoint linkage analysis with 654 polymorphic markers in 99 white and 101 black families. The phenotypes were investigated under two conditions: at baseline and after a 20-week exercise training intervention. A maximum genome-wide bivariate LOD score of 3…
A Locus on Chromosome 13 Influences Levels of Tafi Antigen in Healthy Mexican Americans
When activated, thrombin activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis by modifying fibrin, depressing its plasminogen binding potential. Polymorphisms in the TAFI structural gene (CPB2) have been associated with variation in TAFI levels, but the potential occurrence of influential quantitative trait loci (QTLs) located elsewhere in the genome has been explored only in families ascertained in part through probands affected by th…
Collection of Pedigree Data for Genetic Analysis in Isolate Populations
Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtai…
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Heritability of age at menarche in girls from the Fels Longitudinal Study
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic met…
Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders
This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O 2 saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O 2 saturation have a selective advantage at high altitude. Studies of the biologically distincti…
Skin color variation in Eastern Nepal
The purpose of this paper is to provide skin color data on several endogamous groups of eastern Nepal and to demonstrate genetic microdifferentiation in skin color. Skin reflectance measures were taken at the upper inner arm and forehead sites, using the British DSL Model 99 Reflectance Spectrophotometer fitted with blue, green, and red filters. Measurements on 484 males representing six endogamous groups (Jirel, Sunwar, Sherpa, Tamang, Brahman, …
Attitudes towards helminthic infection in the Jirel population of eastern Nepal
Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal
Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the Jirel ethnic group in eastern Nepal. As part of the Jiri Growth Study, a hand-wrist radiograph is taken annually of each child to assess skeletal dev…
Collection of Pedigree Data for Genetic Analysis in Isolate Populations
Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtai…
Presentation, Heritability, and Genome-Wide Linkage Analysis the Midchildhood Growth Spurt in Healthy Children from the Fels Longitudinal Study
Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in growth velocity observed in some, but not necessarily all, children in early to middle childhood. If present, the midchildhood growt…
Pleiotropic QTL on Chromosome 12q23-q24 Influences Triglyceride and High-Density Lipoprotein Cholesterol Levels
To determine whether a common quantitative trait locus (QTL) influences the variation of fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels, we used a bivariate multipoint linkage analysis with 654 polymorphic markers in 99 white and 101 black families. The phenotypes were investigated under two conditions: at baseline and after a 20-week exercise training intervention. A maximum genome-wide bivariate LOD score of 3…
Genetic Influences on Plasma Cytokine Variation in a Parasitized Population
The soil-transmitted helminths are the most common helminthic infections, affecting about one-fourth of the world's population. There is a significant genetic component to susceptibility to infection with these organisms. Substantial changes in plasma cytokine levels are associated with helminthic infections, and there may be significant genetic components to this cytokine variation. Six plasma cytokine levels were assessed for 367 members of a s…
Gene by Smoking Interaction
We seek to determine whether significant gene x smoking interaction effects exist on plasma triglyceride (TG) levels, HDL cholesterol (HDL-C) level, and median LDL particle diameter (LDL-MPD) in Mexican American families enrolled in the San Antonio Family Heart Study. The sample consisted of 1,392 individuals distributed in 42 extended pedigrees, ranging in age from 16 years to 92 years. Separate quantitative genetic analyses were carried out for…
Rare genetic variants explain missing heritability in smoking
Statistical Genetic Approaches to Human Adaptability
The genetic determinants of physiological and developmental responses to environmental stress are poorly understood. This has been primarily due to the difficulty of direct measurement of response and the lack of appropriate statistical genetic methods. Here, I present a unified statistical genetic methodology for human adaptability studies that permits evaluation of the inheritance of quantitative trait response to environmental stressors. The f…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
The Genetics of Obesity in Mexican Americans
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Part 6
This paper suggests that the P2 allele of the P blood group system serves as an adaptation to a hypothesized Generalized Helminthic Antigenic Complex shared by many helminthic zoonoses. Since helminthic zoonoses are largely dependent on subsistence practices requiring animal contact, higher P2 frequencies should be observed where there is heavy dependence on such practices. Subsistence data and P2 gene frequencies for 187 groups are analyzed. Sig…
Proximate determinants of fertility in the Kathmandu valley, Nepal
This article employs the analytical model of Bongaarts and Potter to compare the proximate determinants of fertility among three populations in Nepal's Kathmandu valley with the following characteristics: (1) high and low caste, (2) urban and urban fringe residence, and (3) users and non-users of contraception. It is shown that while Nepal, as a whole, is firmly entrenched in Phase 1 of the fertility transition, each of the populations studied ha…
Genetic differentiation between baboon subspecies
The use of common names which may encompass a number of subspecies or species is pervasive in the biomedical literature. Failure to identify the complete taxonomic classification of research subjects presents a source of error for scientists attempting to evaluate results or to repeat experiments. This paper examines the problem in a common animal model, the baboon. Analyses of the genetic distances among five baboon subspecies ( Papio hamadryas …
Skin color variation in Eastern Nepal
The purpose of this paper is to provide skin color data on several endogamous groups of eastern Nepal and to demonstrate genetic microdifferentiation in skin color. Skin reflectance measures were taken at the upper inner arm and forehead sites, using the British DSL Model 99 Reflectance Spectrophotometer fitted with blue, green, and red filters. Measurements on 484 males representing six endogamous groups (Jirel, Sunwar, Sherpa, Tamang, Brahman, …
Genetic structure of three populations of rhesus macaques ( Macaca mulatta )
One of the prime concerns at zoos and at primate breeding facilities is to maintain genetic variability. This can be accomplished by avoiding inbreeding. It is relatively easy to assess genetic variability and the level of inbreeding by using pedigree information and genetic markers. In this study we used genetic markers controlled by 6 independent polymorphic loci ( GPI , PGD , CA2 , MPI , DIA1 , Tf ) to ascertain genetic variation in two captiv…
Assessing the effects of candidate genes on quantitative traits in primate populations
Recent progress in molecular and biochemical genetics has led to the identification of numerous polymorphic candidate genes likely to be important in the determination of quantitative variation in physiological processes. In this paper, we review a statistical framework (“measured genotype analysis”) for assessing the effects of candidate genes on quantitative traits in primate populations. We consider situations in which pedigree information is …
Genetic analysis of sexual dimorphism in serum apo AI and HDL‐C concentrations in baboons
Sexual dimorphism is evident in many quantitative genetic traits, and there has been much speculation on the evolution of primate sexual dimorphism. Morphological characters have been the main focus of attention, while sexual dimorphism in physiological quantitative traits has been neglected. In either case, the genetic basis of primate sexual dimorphism has received little attention. This study characterizes genotype by sex (GxS) interactions in…
Quantitative genetics of sexual dimorphism in body fat measurements
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked…
Genetic analysis of chest dimensions in a high altitude Tibetan population from upper Chumik, Nepal
Studies of high altitude Andean natives generally report large chest dimensions relative to sea level groups, while results from studies of Himalayan populations are not consistent. One hypothesis is that this may represent different adaptive patterns in the two geographic areas. The purpose of this study is to explore the determinants of chest dimensions by assessing the genetic components of variation in chest width and chest depth in a Tibetan…
Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders
This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O 2 saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O 2 saturation have a selective advantage at high altitude. Studies of the biologically distincti…
Heritability of age at first birth in captive olive baboons
The evolution of life history traits is a topic of growing interest in primatology. Traits associated with fertility, such as age at menarche and age at first birth, have great significance for natural selection, and knowing the genetic basis of such demographic traits may improve our understanding of population dynamics. Knowledge of the heritability of reproductive traits may also have practical implications for the management of captive breedi…
Genetics of adult body mass and maintenance of adult body mass in captive baboons (Papio hamadryas subspecies)
Adult body mass and changes in mass during an individual's life are important indicators of general health and reproductive fitness. Therefore, characterization of the factors that influence normal variation in body mass has important implications for colony management and husbandry. The main objective of this study was to quantify the genetic contribution to adult body mass and its maintenance in baboons. Intra-individual mean and variance in bo…
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some …
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Hemoglobin concentration of high‐altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Attitudes towards helminthic infection in the Jirel population of eastern Nepal
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900–4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
The relationship of soluble Icam-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women
There were no sex differences in the concentrations of sICAM-1, sVCAM-1 and sPSEL, but men had higher sESEL levels than women (p < 0.0001). Male and female smokers had higher sICAM-1 and sESEL levels than non-smokers and soluble cell adhesion molecules (CAMs) were correlated with the pack-years of cigarette smoking (r = 0.3-0.4, p < 0.0001, significant in women only). Significant independent associations were found between soluble CAMs and smokin…
A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19
Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal e…
The Genetics of Obesity in Mexican Americans
Recent estimates indicate that approximately 18% of the population in the United States can be considered obese (defined as a body mass index [BMI] > or = 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic diseases including type 2 diabetes mellitus and coronary heart disease. The search for…
Genetic Influences on Plasma Cytokine Variation in a Parasitized Population
The soil-transmitted helminths are the most common helminthic infections, affecting about one-fourth of the world's population. There is a significant genetic component to susceptibility to infection with these organisms. Substantial changes in plasma cytokine levels are associated with helminthic infections, and there may be significant genetic components to this cytokine variation. Six plasma cytokine levels were assessed for 367 members of a s…
Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans
Metabolic syndrome refers to the clustering of disease conditions such as insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The subjects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Ant…
Biology (45 obras) · Genetics (32 obras) · Gene (26 obras) · Medicine (24 obras) · Genetics (20 obras) · Demography (18 obras) · Population (17 obras) · Genetic Associations and Epidemiology (16 obras) · Internal Medicine (16 obras) · Quantitative trait locus (16 obras)